Article
Immunology
Xiang Liu, Zhuofan Lei, Dylan Gilhooly, Junyun He, Yun Li, Rodney M. Ritzel, Hui Li, Long-Jun Wu, Shaolin Liu, Junfang Wu
Summary: This study investigated the impact of traumatic brain injury (TBI) on olfactory deficits (OD) and identified the underlying mechanisms in mice. It was found that TBI caused inflammation and neuronal dysfunction in the olfactory bulb (OB), leading to OD. Targeting Hv1/NOX2 may be a potential intervention for improving post-traumatic anosmia.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Seyed Kamran Kamrava, Zeinab Tavakol, Atefeh Talebi, Mohammad Farhadi, Maryam Jalessi, Seyedeh Fahimeh Hosseini, Elahe Amini, Ben Chen, Thomas Hummel, Rafieh Alizadeh
Summary: Post-traumatic olfactory dysfunction (PTOD) is associated with increased depression and decreased sexual satisfaction, but does not have a significant impact on marital satisfaction. Understanding the connection between olfactory dysfunction, depression, and sexuality can help with managing the consequences of this disorder.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Alexander W. Fjaeldstad, Therese Ovesen, Thomas Hummel
Summary: This study investigated olfactory function and smoking habits in patients with olfactory loss caused by different etiologies, finding an association between current smoking and posttraumatic olfactory loss, but no association between a history of smoking and lower olfactory scores.
Review
Multidisciplinary Sciences
Ali Jafar, Andrea Lasso, Risa Shorr, Brian Hutton, Shaun Kilty
Summary: Loss of smell is a common symptom associated with COVID-19 infection, with most patients recovering their sense of smell within 30 days. Patients with severe initial olfactory loss have lower recovery rates. Additional trials on olfactory retraining and steroid therapy are ongoing.
Review
Clinical Neurology
Rosaria De Luca, Mirjam Bonanno, Carmela Rifici, Angelo Quartarone, Rocco Salvatore Calabro
Summary: Post-traumatic Olfactory Dysfunction (PTOD) refers to the loss of olfactory function after a traumatic brain injury (TBI), which may be linked to neuropsychiatric symptoms and can be diagnosed through medical history, clinical data, and objective/subjective measures. Olfactory training (OT), a non-pharmacological and non-invasive treatment option, can improve olfactory function through central and peripheral processes. Early detection and proper treatment of PTOD using various therapeutic approaches, including neuromodulation, is important in managing TBI patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Turki Aldrees, Sharif Almatrafi, Mohammad Mokhatrish, Turki Aldriweesh
Summary: The study showed that the Saudi population has a good understanding of common COVID-19 symptoms, with over 90% of participants recognizing them. However, there is a lack of knowledge regarding smell and taste dysfunction, with over 80% unaware of the link to COVID-19.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Otorhinolaryngology
Jennifer Eva Payandeh, Mehras Motamed, Keshinisuthan Kirubalingam, Neil K. Chadha
Summary: This scoping review examines olfactory dysfunction in pediatric patients, including the causes, smell testing methods, and therapies. The study identifies 45 causes of olfactory dysfunction, with 22 being congenital and 23 acquired. Limited therapies are available, highlighting the importance of patient education and safety awareness.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Psychology, Clinical
Katherine Tai, Evelyn M. Leland, Stella M. Seal, Andrea L. C. Schneider, Nicholas R. Rowan, Vidyulata Kamath
Summary: Objective reports have shown that smell loss is a common phenomenon following traumatic brain injury (TBI) but has not been thoroughly studied. This study conducted a systematic review and meta-analysis to characterize psychophysical olfactory dysfunction in individuals with moderate to severe TBI. The results demonstrated that patients with moderate to severe TBI have significant olfactory dysfunction compared to healthy controls.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Biochemistry & Molecular Biology
Yuhua Chen, Kai Gong, Quanhua Xu, Jiao Meng, Tianlin Long, Cuicui Chang, Zhanxiang Wang, Wei Liu
Summary: The study evaluated the effects of PGAM5 on neuronal injury and mitochondrial dysfunction in traumatic brain injury (TBI) models, showing that PGAM5 plays a critical role in TBI progression via Drp1 activation-mediated mitochondrial dysfunction.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biotechnology & Applied Microbiology
Pasquale Arpaia, Andrea Cataldo, Sabatina Criscuolo, Egidio De Benedetto, Antonio Masciullo, Raissa Schiavoni
Summary: The human sense of smell is crucial for many important functions, but there is a lack of objective and non-invasive methods for diagnosing smell disorders. Olfactory event-related potentials (OERPs) have gained increasing attention as a viable tool for objectively assessing olfactory dysfunctions. This review describes the main features of OERPs signals, widely used recording and processing techniques, and the scientific progress and relevance in various application fields.
BIOENGINEERING-BASEL
(2022)
Article
Multidisciplinary Sciences
Robert Pellegrino, Michael C. Farruggia, Dana M. Small, Maria G. Veldhuizen
Summary: The study found that besides changes in the olfactory cortex after head trauma, other cortical areas play a significant role in olfactory impairment. The neural responses and connectivity in higher-order areas have complex relationships with olfactory perceptual function, which can help distinguish functional anosmia from normosmia.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Yasin Yilmaz, Bengi Gul Turk, Merve Hazal Ser, Nursah Yeniay Sut, Suleyman Sahin, Edibe Pembegul Yildiz, Gonca Bektas, Serap Tiras Teber, Hakan Tekeli, Cigdem Ozkara
Summary: The study found that olfactory training can reduce the frequency and duration of seizures, improve the quality of life, and enhance olfactory function in patients with drug-resistant epilepsy. Olfactory training is considered a successful complementary therapy with no adverse reactions in this population.
NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Younghyun Yoon, SuHyun Kim, YunHee Seol, Hyoenjoo Im, Uiyeol Park, Hio-Been Han, Jee Hyun Choi, Hoon Ryu
Summary: Traumatic brain injury (TBI) can lead to olfactory dysfunction and increase the risk of neurodegenerative and psychiatric disorders. This study on mice found that repetitive TBI caused behavioral, neuropathological, and physiological changes in the olfactory system. Alterations in phosphorylated Tau and impairments in electroencephalography (EEG) may serve as important biomarkers of olfactory-track-associated dysfunctions in repetitive TBI.
Article
Otorhinolaryngology
Fabio Ferreli, Francesca Gaino, Elena Russo, Matteo Di Bari, Vanessa Rossi, Armando De Virgilio, Luca Malvezzi, Giovanni Colombo, Giovanni Cristalli, Giuseppe Spriano, Giuseppe Mercante
Summary: The study aimed to describe the recovery of gustatory dysfunction (GD) and olfactory dysfunction (OD) in COVID-19 patients. More than 80% of patients reported complete recovery of taste and smell functions within 3 months after symptom onset. At the 18-month follow-up, the percentages of patients reporting complete recovery of gustatory and olfactory functions were 93% and 87%, respectively. The severity of chemosensory dysfunction at onset was negatively correlated with recovery, while improvement within the first 7 days from symptom onset was significantly associated with early resolution.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Psychology, Multidisciplinary
Vasudeva Murthy Challakere Ramaswamy, Tony Butler, Bianca Ton, Kay Wilhelm, Philip B. Mitchell, Lee Knight, David Greenberg, Andrew Ellis, Val Gebski, Peter William Schofield
Summary: This study examined the relationship between olfactory deficits and traumatic brain injury in impulsive violent offenders. The results showed that olfactory identification ability was associated with age, cognitive ability, impulsivity, TBI severity, social connectedness, childhood sexual abuse, suicidality, and heroin use. These findings suggest that olfactory testing may have utility in further studies of offenders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Elias A. El-Habr, Luiz G. Dubois, Fanny Burel-Vandenbos, Alexandra Bogeas, Joanna Lipecka, Laurent Turchi, FranOois-Xavier Lejeune, Paulo Lucas Cerqueira Coehlo, Tomohiro Yamaki, Bryan M. Wittmann, Mohamed Fareh, Emna Mahfoudhi, Maxime Janin, Ashwin Narayanan, Ghislaine Morvan-Dubois, Charlotte Schmitt, Maite Verreault, Lisa Oliver, Ariane Sharif, Johan Pallud, Bertrand Devaux, Stephanie Puget, Penelope Korkolopoulou, Pascale Varlet, Chris Ottolenghi, Isabelle Plo, Vivaldo Moura-Neto, Thierry Virolle, Herve Chneiweiss, Marie-Pierre Junier
ACTA NEUROPATHOLOGICA
(2017)
Article
Clinical Neurology
Tomohiro Yamaki, Yoshio Uchino, Haruko Henmi, Mizuho Kamezawa, Miyoko Hayakawa, Tomoki Uchida, Yoshihiro Ozaki, Shinji Onodera, Nobuo Oka, Masaru Odaki, Daisuke Itou, Shigeki Kobayashi
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Tomohiro Yamaki, Yusuke Suenaga, Toshihiko Iuchi, Jennifer Alagu, Atsushi Takatori, Makiko Itami, Akinobu Araki, Miki Ohira, Masahiro Inoue, Hajime Kageyama, Sana Yokoi, Naokatsu Saeki, Akira Nakagawara
SCIENTIFIC REPORTS
(2013)
Article
Multidisciplinary Sciences
Tomohiro Yamaki, Shinji Onodera, Tomoki Uchida, Yoshihiro Ozaki, Kazuaki Yokoyama, Haruko Henmi, Mizuho Kamezawa, Miyoko Hayakawa, Daisuke Itou, Nobuo Oka, Masaru Odaki, Yasuo Iwadate, Shigeki Kobayashi
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Multidisciplinary Sciences
Seiichiro Hirono, Ko Ozaki, Masayoshi Kobayashi, Ayaka Hara, Tomohiro Yamaki, Tomoo Matsutani, Yasuo Iwadate
Summary: In this study comparing SupTR and GTR in GBM patients, it was found that SupTR led to improved local control and survival without postoperative neurocognitive decline. The different patterns of disease progression and distant recurrences observed in the SupTR group highlight the benefits of aggressive resection of both CE tumors and areas with Met uptake, especially under awake craniotomy with functional mapping.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomohiro Yamaki, Yoshinori Higuchi, Hajime Yokota, Yasuo Iwadate, Tomoo Matsutani, Seiichiro Hirono, Hikaru Sasaki, Ryota Sasao, Masahiro Toda, Shinji Onodera, Nobuo Oka, Shigeki Kobayashi
Summary: The study investigated the role of 11C-METPET in differentiating brain tumors from non-neoplastic lesions. The use of optimal cutoff values showed high specificity, indicating a high likelihood of brain tumor.
Article
Neurosciences
Tomohiro Yamaki, Naoya Hatakeyama, Takemi Murayama, Mika Funakura, Takuya Hara, Shinji Onodera, Daisuke Ito, Maidinamu Yakufujiang, Masaru Odaki, Nobuo Oka, Shigeki Kobayashi
Summary: In this pilot study, the researchers investigated whether assessing regional brain glucose metabolism using FDG-PET at rest could predict voluntary movement in severe TBI patients, particularly those with sufficient upper limb capacity. The results showed that glucose uptake in specific areas of the primary motor cortex may reflect contralateral voluntary movement. FDG-PET may be a useful biomarker for predicting long-term recovery of motor function in severe TBI patients with disorders of consciousness.
HUMAN BRAIN MAPPING
(2023)
Review
Clinical Neurology
Erika Molteni, Liane dos Santos Canas, Marie-Michele Briand, Anna Estraneo, Carolina Colomer Font, Rita Formisano, Ekaterina Fufaeva, Olivia A. Gosseries, Robyn Howarth, Paola Lanteri, Gimena Ines L. Licandro, Wendy Magee, Vigneswaran Veeramuthu, Pamela Wilson, Tomohiro S. Yamaki, Beth Slomine
Summary: Comprehensive guidelines for the diagnosis, prognosis, and treatment of disorders of consciousness (DoC) in pediatric patients have not yet been released. This scoping review aimed to summarize available evidence for DoC with >14 days duration to support the future development of guidelines for children, adolescents and young adults aged 6 months-18 years.
Article
Medicine, General & Internal
Tomohiro Yamaki, Kyoko Takahashi, Osamu Azuhata, Daisuke Itou, Madinum Yakufujiang, Nobuo Oka, Masaru Odaki, Shigeki Kobayashi
Summary: This study presents four cases of severe chronic brain injury patients who suffered from recurrent aspiration pneumonia due to excessive saliva production. Transdermal scopolamine, applied as a patch, was found to decrease pleural effusion associated with continuous aspiration pneumonia in all four cases, as shown in longitudinal computed tomography.
SAGE OPEN MEDICAL CASE REPORTS
(2022)
Article
Psychiatry
Tomohiro Yamaki, Kosuke Suzuki, Yusuke Sudo, Tomihisa Niitsu, Masahiko Okai, Nobuo Oka, Masaru Odaki
BIOPSYCHOSOCIAL MEDICINE
(2018)
Meeting Abstract
Neurosciences
Tomohiro Yamaki, Yoshio Uchino, Masahiko Okai, Nobuo Oka, Masaru Odaki
Article
Oncology
T Iuchi, K Hatano, Y Narita, T Kodama, T Yamaki, K Osato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2006)
Article
Health Care Sciences & Services
Shinichi Oka, Tomohiro Yamaki, Masanori Sasaki, Ryo Ukai, Mitsuhiro Takemura, Takahiro Yokoyama, Yuko Kataoka-Sasaki, Rie Onodera, Yoichi M. Ito, Shigeki Kobayashi, Jeffery D. Kocsis, Yasuo Iwadate, Osamu Honmou
Summary: This study aims to evaluate the safety and potential efficacy of autologous MSCs intravenous infusion for patients with chronic brain injury. The use of STR-01 has shown promising results in other diseases, and assessing its therapeutic efficacy for chronic brain injury is essential. This research is crucial in exploring potential treatments for brain injuries.
JMIR RESEARCH PROTOCOLS
(2022)