Journal
ATHEROSCLEROSIS
Volume 285, Issue -, Pages 93-101Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2019.04.212
Keywords
Diet; Inflammation; Cardiovascular health; Child; Adult; CheckPoint
Funding
- National Health and Medical Research Council of Australia (NHMRC) [1041352, 1109355]
- Royal Children's Hospital Foundation [2014-241]
- Murdoch Children's Research Institute
- University of Melbourne
- National Heart Foundation of Australia [100660]
- Financial Markets Foundation for Children [2014-055, 2016-310]
- Victoria Deaf Education Institute
- NHMRC [APP1114567, APP1046518, APP1064629, APP1091124]
- Melbourne Research Scholarship
- Juho Vainio Foundation
- NHMRC (Cure Kids New Zealand)
- Honorary Future Leader Fellowship of the National Heart Foundation of Australia [100369]
- National Heart Foundation Postdoctoral Fellowship [101239]
- Victorian Government's Operational Infrastructure Program
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Background and aims: Pro-inflammatory diet may be a modifiable risk factor for cardiovascular disease. We examine associations of two inflammatory diet scores with preclinical cardiovascular phenotypes at two life course stages. Methods: Participants: 1771 children (49% girls) aged 11-12 years and 1793 parents (87% mothers, mean age 43.7 (standard deviation 5.2) years) in the Child Health CheckPoint Study. Measures: 23 items in the Australian National Secondary Students' Diet and Activity (NaSSDA) survey were used to derive two inflammatory diet scores based on: 1) published evidence of associations with C-reactive protein (literature-derived score), and 2) empirical associations with CheckPoint's inflammatory biomarker (glycoprotein acetyls, GlycA-derived score). Cardiovascular phenotypes assessed vascular structure (carotid intima-media thickness, retinal vessel calibre) and function (pulse wave velocity, blood pressure). Analyses: Linear regression models were conducted, adjusted for age, sex, socioeconomic position and child pubertal status, plus a sensitivity analysis also including BMI (zscore for children). Results: In adults, both inflammatory diet scores showed small associations with adverse cardiovascular function and microvascular structure. Per standard deviation higher GlycA-derived diet score, pulse wave velocity was 0.17 m/s faster (95% CI 0.11 to 0.22), mean arterial pressure was 1.85 mmHg (1.34-2.37) higher, and retinal arteriolar calibre was 1.29 mu m narrower (-2.10 to -0.49). Adding BMI to models attenuated associations to-wards null. There was little evidence of associations in children. Conclusions: Our findings support cumulative adverse effects of a pro-inflammatory diet on preclinical cardiovascular phenotypes across the life course. Associations evident by mid-life were not present in childhood, when preventive measures should be instituted.
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