Article
Oncology
Martyna Borowczyk, Kosma Wolinski, Barbara Wieckowska, Elzbieta Jodlowska-Siewert, Ewelina Szczepanek-Parulska, Frederik A. Verburg, Marek Ruchala
Summary: The key sonographic features associated with an increased risk of FTC include tumor protrusion, microcalcifications or mixed type of calcifications, irregular margins, marked hypoechogenicity, and irregular shape.
Article
Oncology
Wen Li, Qing Song, Yu Lan, Jie Li, Ying Zhang, Lin Yan, Yingying Li, Yan Zhang, Yukun Luo
Summary: The study aimed to explore the sonographic features of follicular thyroid carcinoma (FTC) and differentiate it from follicular thyroid adenoma (FTA). Results showed that an interrupted halo and satellite nodule(s) with or without halo ring are specific sonographic features for FTC. Sonography could play a role in distinguishing FTC from FTA.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Michiyo Hayakawa, J. Nicholas Taylor, Ryuta Nakao, Kentaro Mochizuki, Yuki Sawai, Kosuke Hashimoto, Koji Tabata, Yasuaki Kumamoto, Katsumasa Fujita, Eiichi Konishi, Shigeru Hirano, Hideo Tanaka, Tamiki Komatsuzaki, Yoshinori Harada
Summary: This study evaluated the accumulation of lipid droplets and the expression of adipophilin in follicular thyroid carcinoma (FTC) cells. It was found that FTC cells had abundant lipid droplets and adipophilin expression, while follicular thyroid adenoma (FTA) had less. Therefore, assessing adipophilin expression can help differentiate FTC from FTA in surgical specimens.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rui Zhang, Guanxiu Yi, Shunfan Pu, Qin Wang, Chao Sun, Qian Wang, Li Feng, Xiabi Liu, Zhengjiang Li, Lijuan Niu
Summary: This study investigates the feasibility and value of using deep learning based on grayscale ultrasonography to differentiate atypical and typical medullary thyroid carcinoma from follicular thyroid adenoma. The results show that the ResNet-34 model has higher diagnostic ability compared to the junior sonographer, and successfully identifies a significant number of atypical MTC cases.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ming-Hsun Wu, Kuen-Yuan Chen, Min-Shu Hsieh, Argon Chen, Chiung-Nien Chen
Summary: This study aimed to determine whether preoperative ultrasonographic findings obtained from the computer-aided detection system were sufficient to stratify the risk of malignancy for thyroid nodules with a cytological diagnosis of follicular neoplasm. The results showed that quantitative features and classification patterns were helpful in risk stratification, with the presence of certain ultrasound characteristics correlating with a higher risk of malignancy. The computer-aided detection software demonstrated higher accuracy compared to human observers, especially in cases with poor agreement.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Dongdong Huang, Huifang Zhang, Lu Li, Weigang Ge, Wei Liu, Zhen Dong, Jinlong Gao, Nan Yao, Wenxin Fu, Lingling Huang, Tiannan Guo, Yaoting Sun, Xiaodong Teng
Summary: This study investigated the molecular differences among follicular-patterned thyroid tumors through proteomic analysis. The results identified differentially regulated proteins that can differentiate between different types of thyroid tumors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Jingjing Yang, Yu Sun, Xingjia Li, Yueting Zhao, Xue Han, Guofang Chen, Wenbo Ding, Ruiping Li, Jianhua Wang, Fangsen Xiao, Chao Liu, Shuhang Xu
Summary: This study compared the diagnostic performances of six commonly used ultrasound-based risk stratification systems for distinguishing follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). The results showed that all six systems have potential in the differential diagnosis of FTA and FTC. The Chinese guideline C-TIRADS demonstrated the best diagnostic performance among Chinese patients. ATASPS exhibited high sensitivity, while K-TIRADS had high specificity in distinguishing FTA from FTC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Haruhiko Yamazaki, Ryohei Katoh, Kiminori Sugino, Kenichi Matsuzu, Chie Masaki, Junko Akaishi, Kiyomi Yamada Hames, Chisato Tomoda, Akifumi Suzuki, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Yasushi Rino, Koichi Ito
Summary: This study found a correlation between the extent of invasion and prognosis in patients with encapsulated angioinvasive follicular thyroid carcinoma. Patients with two or more foci of vascular invasion, especially those aged 55 years and above, should be closely monitored.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Sufang Zhang, Liyan Huang, Qingshan Huang, Weili Wei, Lijun Xie, Jinshu Zeng, Qiuyang Gu, Ling Chen, Shuqiang Chen
Summary: The relative size (M/S value) is found to be valuable in distinguishing between solid follicular thyroid neoplasm and solid nodular goiter, serving as a quantitative indicator for ultrasound diagnosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, General & Internal
Qingshan Huang, Lijun Xie, Liyan Huang, Weili Wei, Haiying Li, Yunfang Zhuang, Xinxiu Liu, Shuqiang Chen, Sufang Zhang
Summary: Using LASSO regression analysis, this study identified 10 clinical and ultrasonic features to construct an ultrasonic diagnostic model for distinguishing FTC from FA, which demonstrated high accuracy and good performance in the validation group.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ji Eun Park, Sook Min Hwang, Ji-Young Hwang, Jin Hee Moon, Ik Yang, Ji Young Woo, Hye Jin Lee
Summary: The study showed an association between decreased echogenicity and heterogeneity on thyroid ultrasound and thyroid dysfunction in pediatric and adolescent AITD patients. Severe thyroid dysfunction was significantly associated with higher ultrasound grade, and levels of TSH differed significantly according to ultrasound grades in hyperthyroid and hypothyroid states.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
So Yeong Jeong, Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Summary: Sonographic features of posterior capsular abutment are sensitive and reliable for the diagnosis of posterior minor extrathyroidal extension (ETE) and are associated with lymphovascular invasion and lateral neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC) patients. The assessment of posterior minor ETE is important for considering candidates for active surveillance among PTMC patients.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Zhang, Xia Zhang, Jie Li, Qian Cai, Zhi Qiao, Yu kun Luo
Summary: CEUS is a more valuable and non-invasive imaging modality compared to conventional US in detecting extracapsular extension in papillary thyroid carcinoma. Single capsular invasion was a poor predictor of cervical lymph node metastasis, while extracapsular extension assessments were clinically significant for predicting cervical lymph node metastasis. Among the thyroid papillary carcinoma nodules with differential enhancement, hyper-enhanced nodules had the highest incidence of single capsule invasion (41.9%), while hypo-enhanced ones had a higher incidence of ECE (47.4%).
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Hoon Lee, Eun Ju Ha, Da Hyun Lee, Miran Han, Jung Hyun Park, Ji-Hoon Kim
Summary: This multicenter cohort study analyzed the clinicoradiological characteristics of different histological types of follicular-patterned lesions in thyroid nodules. The study found that distinguishing features for these lesions compared to benign follicular nodules included patient age, lesion diameter, composition, echogenicity, and presence of halo. The study also identified specific features that distinguished follicular carcinoma and follicular variant of papillary thyroid carcinoma from follicular adenoma. The most important distinguishing features were lesion diameter, composition, echogenicity, orientation, and patient age.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Hee Mang Yoon, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee, Jin Seong Lee, Ah Young Jung, Young Ah Cho, Boram Bak, Dong Gyu Na
Summary: This study evaluated the diagnostic performance of the 2021 K-TIRADS biopsy criteria for detecting malignant thyroid nodules in a pediatric population and compared it with the 2016 K-TIRADS. The results showed that the 2021 K-TIRADS had superior diagnostic accuracy to the 2016 K-TIRADS, especially with a biopsy cut-off of 0.5 cm for K-TIRADS 5 and 1.0-1.5 cm for K-TIRADS 4.
EUROPEAN RADIOLOGY
(2023)
Article
Nutrition & Dietetics
Chiu-Li Yeh, Jin-Ming Wu, Po-Jen Yang, Po-Chu Lee, Kuen-Yuan Chen, Chun-Chieh Huang, Sung-Ling Yeh, Ming-Tsan Lin
Summary: This study investigated the effect of calcitriol treatment on CD4(+) T-cell polarization and intestinal injury in obese mice with sepsis. The results demonstrated that calcitriol treatment can balance CD4 T-cell subsets and alleviate intestinal inflammation and injury in obese mice complicated with sepsis.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Medicine, General & Internal
Shyang-Rong Shih, Kuan-Hua Chen, Kuan-Yu Lin, Pan-Chyr Yang, Kuen-Yuan Chen, Chun-Wei Wang, Chun-Nan Chen, Chih-Feng Lin, Chia-Chi Lin
Summary: This study analyzed four cases of immunotherapy for unresectable anaplastic thyroid cancer (ATC). The results showed significant variability in treatment responses, highlighting the need for careful monitoring of both treatment efficacy and side effects in ATC patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Wei-Che Lin, Cheng-Kang Wang, Wen-Hung Wang, Chi-Yu Kuo, Pi-Ling Chiang, An-Ni Lin, Jung Hwan Baek, Ming-Hsun Wu, Kai-Lun Cheng
Summary: This study evaluated the effectiveness and safety of radiofrequency ablation (RFA) treatment for benign thyroid nodules (BTNs) in five medical centers in Taiwan. The results showed that RFA had established reliability and safety for treating BTNs, and it has become an alternative to surgery in Taiwan. Different specialists may have varying outcomes in terms of volume reduction ratio (VRR) after 6 months of follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Surgery
Ting-Chun Kuo, Kuen-Yuan Chen, Chieh-Wen Lai, Yi-Chia Wang, Ming-Tsan Lin, Chin-Hao Chang, Ming-Hsun Wu
Summary: This study aimed to report the experience with the use of intraoperative transcutaneous laryngeal ultrasonography (TLUSG) in evaluating vocal cord twitch response in thyroid surgeries and compared it with laryngeal twitch palpation (LTP). TLUSG showed better reliability in assessing vocal cord twitch response compared to LTP, providing practical troubleshooting guidance for patients with no intraoperative neuromonitoring (IONM) signals.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Nutrition & Dietetics
Chiu-Li Yeh, Jin-Ming Wu, Po-Jen Yang, Po-Chu Lee, Kuen-Yuan Chen, Sung-Ling Yeh, Ming-Tsan Lin
Summary: The study investigated the effects of calcitriol on CD4(+) T-cell polarization and kidney injury during sepsis in obese mice. The results showed that calcitriol administration maintained blood CD4(+) T-cell levels, reduced the percentages of Th2 and Th17 cells, and modulated the Th17:Treg ratio. Additionally, calcitriol increased cathelicidin levels, decreased inflammatory chemokines and kidney injury markers, and promoted M1 macrophage polarization toward the M2 type.
Article
Biochemistry & Molecular Biology
Hao-Chih Tai, Kuen-Yuan Chen, Ming-Hsun Wu, King-Jen Chang, Chiung-Nien Chen, Argon Chen
Summary: This study validates the accuracy of computerized sonographic features (CSF) in thyroid nodules imaging and assesses how the reading performance of clinicians can be improved with the assistance of CSF. The study finds that the sequential reading performance of clinicians is significantly improved with CSF, indicating the importance of computerized features in assisting sonographic diagnosis.
Article
Nutrition & Dietetics
Chiu-Li Yeh, Jin-Ming Wu, Kuen-Yuan Chen, Ming-Hsun Wu, Po-Jen Yang, Po-Chu Lee, Po-Da Chen, Sung-Ling Yeh, Ming-Tsan Lin
Summary: This study compared the effects of oral cholecalciferol and/or intravenous calcitriol on intestinal barrier damage and T cell distribution in obese mice with sepsis. The results showed that both treatments improved intestinal inflammation and epithelial integrity.
Article
Medicine, Research & Experimental
Chiu-Li Yeh, Jin-Ming Wu, Kuen-Yuan Chen, Ming-Hsun Wu, Po-Jen Yang, Po-Chu Lee, Po -Da Chen, Sung-Ling Yeh, Ming-Tsan Lin
Summary: This study investigated the effects of enteral cholecalciferol and/or intravenous calcitriol administration on immune cell subsets, the renin-angiotensin system, and acute lung injury in obese mice. The results suggest that calcitriol administration has a stronger impact on immune cell balance and anti-inflammatory pathways in the lungs, while both forms of vitamin D attenuate sepsis-induced lung injury in obese animals.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Yuan Wang, Shyang-Rong Shih, Kuen-Yuan Chen, Pei-Jie Huang
Summary: Finding non-invasive and sensitive biomarkers for early screening of high-risk patients is crucial in clinical practice. This prospective study analyzed urine exosomal proteins in patients with thyroid cancer, aiming to identify new prognostic biomarkers for decision-making before surgery. The study found a significant association between urine exosomal TIMP and lymph node metastasis. However, no association was found between MACIS score and urine exosomal proteins. Further research is needed to determine the potential of urine exosomal proteins as prognostic indicators.
Article
Surgery
Ting-Chun Kuo, Kuen-Yuan Chen, Chieh-Wen Lai, Yi-Chia Wang, Ming-Tsan Lin, Chin-Hao Chang, Ming-Hsun Wu
Summary: This study retrospectively reviewed 327 patients who underwent endoscopic thyroidectomy and compared the use of a smoke evacuation system. The results showed that the group using the evacuation system had better field of view and shorter operating time. The conclusion is that using evacuators in low-pressure and small-space endoscopic thyroid procedures can enhance the field of view and optimize the operating time.
Article
Oncology
Young-Jen Lin, Te-Wei Ho, Chien-Hui Wu, Ting-Chun Kuo, Ching-Yao Yang, Jin-Ming Wu, Yu-Wen Tien
Summary: This study retrospectively collected the bile culture results of PD patients between 2007 and 2019, and found a significant association between bile contamination and the development of IAA. Specific bile microorganisms were identified as important factors in the occurrence of IAA.
