Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35
Volume 35, Issue -, Pages 381-406Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100818-125403
Keywords
transcription factors; hematopoiesis; dendritic cells; innate lymphoid cells; T cells
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.
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