Article
Biotechnology & Applied Microbiology
Hang Yang, Guoyan Zhu, Weizhen Zhou, Mingyao Luo, Yujing Zhang, Yinhui Zhang, Chang Shu, Zhou Zhou
Summary: This study systematically evaluated the frequency of mosaicisms in both asymptomatic parents and affected patients with thoracic aortic aneurysm and dissection (TAAD). Six mosaic variants were detected in the cohort, with potential implications for clinical heterogeneity. The findings suggest that implementing mosaicism analysis in routine molecular diagnosis is necessary and feasible.
Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Lise Tchouta, Rudra Pampati, Daniel R. Liesman, Minhajuddin S. Khaja
Summary: This study describes a new technique, laser aortic septotomy, for thoracic endovascular aortic repair in patients with chronic type B aortic dissection. The technique effectively optimizes the distal landing zone and achieves positive outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Minhaj S. Khaja, David M. Williams, Xhorlina Marko, Bo Yang, Himanshu J. Patel, Karen M. Kim
Summary: The role of thoracic endovascular aortic repair for chronic type B aortic dissection is controversial. This study compared the outcomes of thoracic endovascular aortic repair with and without adjunctive aortic septotomy. The results demonstrate that aortic septotomy resulted in a higher positive aortic remodeling rate.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Hang Yang, Huayan Shen, Guoyan Zhu, Xinyang Shao, Qianlong Chen, Fangfang Yang, Yinhui Zhang, Yujing Zhang, Kun Zhao, Mingyao Luo, Zhou Zhou, Chang Shu
Summary: This study investigated the clinical and molecular characteristics of patients with thoracic aortic aneurysm and dissection and found that causative variants and variants of uncertain significance were associated with younger age of aortic events and higher risk of aortic reintervention. Positive genetic results may have a predictive value for the severity of aortic events and postoperative risk stratification.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Juliet Blakeslee-Carter, Hellen A. Potter, Charles A. Banks, Marc Passman, Benjamin Pearce, Graeme McFarland, Sukgu M. Han, Salvatore Scali, Gregory A. Magee, Emily Spangler, Adam W. Beck
Summary: This study investigated the behavior of the visceral aorta after TEVAR for acute and subacute TBAD and identified predictable TAD growth and the occurrence of VSI. Preoperative anatomical features may play a more significant role in VSI occurrence.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaolang Jiang, Yifan Liu, Lingwei Zou, Bin Chen, Junhao Jiang, Weiguo Fu, Zhihui Dong
Summary: The 5-year clinical outcomes of thoracic endovascular aortic repair for chronic type B aortic dissection were analyzed in this study. It was found that patients with adverse aortic events (AAEs) had higher rates of residual type A aortic dissection and aortic diameter >= 5.5 cm, as well as lower rate of complete false lumen thrombosis, and a longer interval from symptom onset to intervention. Partial or no false lumen thrombosis and aortic diameter >= 5.5 cm were identified as independent risk factors for AAEs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Medicine, General & Internal
Irbaz Hameed, Adam S. Cifu, Prashanth Vallabhajosyula
Summary: This JAMA Clinical Guidelines Synopsis provides a summary of the 2021 guidelines from the American Association for Thoracic Surgery and the Society of Thoracic Surgeons on the management of type A and type B thoracic aortic dissection.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zhengbiao Zha, Youmin Pan, Zhi Zheng, Xiang Wei
Summary: This study analyzed the predictors of stroke after TEVAR in patients with TBAD. The study found that LSCA coverage, diabetes mellitus, and general anesthesia were independent risk factors for stroke after TEVAR in TBAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Takuya Ogami, George J. Arnaoutakis, Himanshu J. Patel, Chih-Wen Pai, Kim A. Eagle, Santi Trimarchi, Derek Serna-Gallegos, Ibrahim Sultan
Summary: This study aimed to characterize acute kidney injury (AKI) after thoracic endovascular aortic repair (TEVAR) in patients with acute type B aortic dissection (ATBAD). The incidence of postoperative AKI was found to be 16.2% in patients undergoing TEVAR for ATBAD. Patients with postoperative AKI had a higher rate of in-hospital morbidities and mortality than those without AKI. A history of chronic kidney disease (CKD) and preoperative AKI were independently associated with postoperative AKI.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Li Cheng, Dongqiao Xiang, Shan Zhang, Chuansheng Zheng, Xiaoyan Wu
Summary: In this retrospective study, reintervention after TEVAR was observed in 11.3% of patients with uncomplicated TBAD, and the main reasons included endoleak, aneurysmal dilation, and dissection progression. Larger initial aortic diameter and excessive proximal landing zone oversizing were identified as significant risk factors for reintervention. Reintervention did not significantly affect long-term survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Daniel J. Torrent, Graeme E. McFarland, Grace Wang, Mahmoud Malas, Benjamin J. Pearce, Victoria Aucoin, Dan Neal, Emily L. Spangler, Zdenek Novak, Salvatore T. Scali, Adam W. Beck
Summary: This analysis examined the correlation between the timing of TEVAR for UATBAD patients and postoperative complications. While timing did not predict mortality or long-term complications, there was a higher risk of reintervention within 1-14 days post-operation. This suggests the importance of further study on optimal timing for intervention in TEVAR trials.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Jeniann A. Yi, Ryan Gupta, Quy Tat, Helen A. Potter, Sukgu M. Han, Fernando Fleischman, Donald Jacobs, Mark Nehler, Gregory A. Magee
Summary: In this study, medical management of acute uncomplicated TBAD was associated with higher rates of readmission and the need for unplanned operation compared with TEVAR. However, no differences were found in the 1-year mortality for the patients for whom medical management had failed. This finding suggests clinical equipoise for the treatment of acute uncomplicated TBAD and supports the need for a larger randomized trial to determine whether early TEVAR provides clear benefits.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Qian-hui Tang, Jing Chen, Zhen Long, Yu-Lin Wang, Xuan-an Su, Jian-ye Qiu, Qiu-ning Lin, Jiang-feng Zhang, Xiao Qin
Summary: This study aimed to investigate the factors influencing distal false lumen enlargement after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection. The results revealed that Marfan syndrome, chronic obstructive pulmonary disease (COPD), and the primary tear size were associated with distal false lumen dilatation.
Review
Surgery
Erin C. Saricilar, Kiraati Patel, Raleene Gatmaitan, Vikram Puttaswamy
Summary: This systematic review found that early intervention in Type B aortic dissections can improve aorta related events in the one year follow up period without changing the mortality rate compared to late intervention. Therefore, performing TEVAR surgery within 3 to 14 days after symptom onset is both safe and beneficial.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Elizabet N. N. Robertson, Paul G. G. Bannon, Richmond W. W. Jeremy
Summary: Heritable aortic aneurysm is a recognized cause of morbidity and mortality, with different genetic syndromes showing varying clinical presentation and prognosis. There is a lack of knowledge regarding clinical outcomes for non-syndromal heritable aortic disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Scott A. LeMaire, Ying H. Shen
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Ourania Preventza, Davut Cekmecelioglu, Subhasis Chatterjee, Susan Y. Green, Hiruni Amarasekara, Qianzi Zhang, Scott A. LeMaire, Joseph S. Coselli
Summary: After proximal aortic operations, there were no significant differences between men and women in terms of operative mortality, stroke, and renal failure rates. However, women had poorer outcomes in terms of respiratory failure and intensive care unit length of stay.
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Scott A. LeMaire
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Alexander Schutz, Scott A. LeMaire, Barbara W. Trautner, Todd K. Rosengart
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Ping Gao, Pan Gao, Jinjing Zhao, Shengshuai Shan, Wei Luo, Orazio J. Slivano, Wei Zhang, Akiko Tabuchi, Scott A. LeMaire, Lars Maegdefessel, Ying H. Shen, Joseph M. Miano, Harold A. Singer, Xiaochun Long
Summary: The study demonstrated the critical role of MKL1 in AAA, showing that its deficiency can reduce the risk of AAA formation and aortic rupture, as well as decrease aging and pro-inflammatory effects in the vessel wall and VSMCs. This research revealed a molecular pathway of AAA formation involving MKL1/p38MAPK stimulation, suggesting that targeting the MKL1/p38MAPK pathway may be an effective treatment for AAA.
Article
Cardiac & Cardiovascular Systems
Ourania Preventza, Andre Critsinelis, Katherine Simpson, Jacqueline K. Olive, Scott A. LeMaire, Lorraine D. Cornwell, Ernesto Jimenez, John Byrne, Subhasis Chatterjee, Todd K. Rosengart, Joseph S. Coselli
Summary: The study evaluated the representation of female patients and racial and ethnic minorities in U.S. cardiovascular trials, highlighting the low participation rates of female patients and non-Asian minorities. Efforts are needed to address these disparities and achieve better balance in clinical trial representation.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Arsalan Amin, Ravi K. Ghanta, Qianzi Zhang, Rodrigo Zea-Vera, Todd K. Rosengart, Ourania Preventza, Scott A. LeMaire, Joseph S. Coselli, Subhasis Chatterjee
Summary: This study investigated the readmission rates after surgical repair of acute Stanford type A aortic dissection (TAAD) and identified acute kidney injury and a higher Elixhauser comorbidity index as independent risk factors for readmission. Approximately 30% of patients were readmitted within 90 days, with the majority of readmissions occurring between days 31 and 90 after surgery. Targeted improvements in perioperative care and postdischarge follow-up, as well as efforts to reduce comorbidities, could help mitigate readmission rates.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
William C. Frankel, Susan Y. Green, Hiruni S. Amarasekara, Qianzi Zhang, Ourania Preventza, Scott A. LeMaire, Joseph S. Coselli
Summary: The present study investigated the incidence, predictors, and impact of early gastrointestinal complications after open thoracoabdominal aortic aneurysm repair. Gastrointestinal complications were found to be associated with higher rates of operative mortality, adverse events, and longer hospitalization, highlighting the need for perioperative strategies to mitigate these complications.
ANNALS OF THORACIC SURGERY
(2021)
Article
Surgery
Matthew Janko, Grant Hubbard, Karen Woo, Vikram S. Kashyap, Megan Mitchell, Arun Murugesan, Lin Chen, Rachel Gardner, Donald Baril, Robert I. Hacker, Zoltan Szeberin, Ramsey ElSayed, Gregory A. Magee, Fernando Motta, Wei Zhou, Gary Lemmon, Dawn Coleman, Christian-Alexander Behrendt, Faisal Aziz, James H. Black, Kimberly Tran, Allen Dao, William Shutze, H. Edward Garrett, Giovanni De Caridi, Rhusheet Patel, Christos D. Liapis, George Geroulakos, John Kakisis, Konstantinos Moulakakis, Starvos K. Kakkos, Hideaki Obara, Grace Wang, Jordan Stoecker, Pascal Rheaume, Victor Davila, Reid Ravin, Randall DeMartino, Ross Milner, Sherene Shalhub, Jeffrey Jim, Jason Lee, Celine Dubuis, Jean-Baptiste Ricco, Joseph Coselli, Scott Lemaire, Javairiah Fatima, Jennifer Sanford, Winston Yoshida, Marc L. Schermerhorn, Matthew Menard, Michael Belkin, Stuart Blackwood, Mark Conrad, Linda Wang, Sara Crofts, Thomas Nixon, Timothy Wu, Roberto Chiesa, Saideep Bose, Jason Turner, Ryan Moore, Justin Smith, Ali Irshad, Jeffrey Hsu, Martin Czerny, Jonathan Cullen, Andrea Kahlberg, Carlo Setacci, Jin Hyun Joh, Eric Senneville, Pedro Garrido, Timur P. Sarac, Anthony Rizzo, Michael R. Go, Martin Bjorck, Hamid Gavali, Anders Wanhainen, Mario D'Oria, Sandro Lepidi, Davide Mastrorilli, Gianfranco Veraldi, Michele Piazza, Francesco Squizzato, Adam Beck, Rebecca St John, Andrew Wishy, Misty Humphries, Samir K. Shah, Martin Back, Jayer Chung, Peter F. Lawrence, Jonathan Bath, Matthew R. Smeds
Summary: Patients undergoing partial resection of infected aortic grafts, especially older patients with abdominal infection not isolated to a single graft limb, or with Candida infection or aortoenteric fistula, may be at high risk of death or post-repair infection. Late reinfection correlated strongly with early persistent postoperative infection, raising concern for occult retained infected graft material.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Genetics & Heredity
Enrique Audain, Anna Wilsdon, Jeroen Breckpot, Jose M. G. Izarzugaza, Tomas W. Fitzgerald, Anne-Karin Kahlert, Alejandro Sifrim, Florian Wunnemann, Yasset Perez-Riverol, Hashim Abdul-Khaliq, Mads Bak, Anne S. Bassett, Woodrow D. Benson, Felix Berger, Ingo Daehnert, Koenraad Devriendt, Sven Dittrich, Piers E. F. Daubeney, Vidu Garg, Karl Hackmann, Kirstin Hoff, Philipp Hofmann, Gregor Dombrowsky, Thomas Pickardt, Ulrike Bauer, Bernard D. Keavney, Sabine Klaassen, Hans-Heiner Kramer, Christian R. Marshall, Dianna M. Milewicz, Scott Lemaire, Joseph S. Coselli, Michael E. Mitchell, Aoy Tomita-Mitchell, Siddharth K. Prakash, Karl Stamm, Alexandre F. R. Stewart, Candice K. Silversides, Reiner Siebert, Brigitte Stiller, Jill A. Rosenfeld, Inga Vater, Alex V. Postma, Almuth Caliebe, J. David Brook, Gregor Andelfinger, Matthew E. Hurles, Bernard Thienpont, Lars Allan Larsen, Marc-Phillip Hitz
Summary: This study conducted an integrative analysis of CNVs and DNVs in CHD patients, identifying a set of genes significantly affected by rare genomic variants in probands. The analysis strengthened disease association of known CHD genes and identified novel haploinsufficient CHD candidate genes.
Article
Cardiac & Cardiovascular Systems
Joseph S. Coselli, William C. Frankel, Susan Y. Green, Hiruni S. Amarasekara, Qianzi Zhang, Ourania Preventza, Scott A. LeMaire
Summary: Staged repair of extensive aortic aneurysms using the elephant trunk technique is associated with significant morbidity and mortality. Patients with acute symptoms are at higher risk of operative death and adverse events.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Abhijit Chakraborty, Yang Li, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen
Summary: Rupture of aortic aneurysm and dissection remains a leading cause of death, with progressive smooth muscle cell loss being a crucial feature. Understanding programmed cell death pathways is critical for preventing aortic destruction and disease progression in AAD.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Genetics & Heredity
Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. LeMaire
Summary: This study used single-cell RNA sequencing to analyze the changes in cell populations and gene expression in aortic aneurysm tissues from patients with Marfan syndrome (MFS). The results showed alterations in cell populations, with increased de-differentiated proliferative smooth muscle cells (SMCs) and downregulation of key SMC genes MYOCD and MYH11 in MFS samples. Fibroblasts in MFS also showed upregulation of COL1A1/2. Additionally, TGF-beta signaling was impaired in MFS, despite the upregulation of TGFB1. These findings provide insights into the potential mechanisms underlying aortic aneurysm development in MFS.
Article
Surgery
Waleed Ageedi, Chen Zhang, William Case Frankel, Ashley Dawson, Yang Li, Joseph S. Coselli, Hu Ying Shen, Scott A. LeMaire
Summary: The AIM2 inflammasome plays a crucial role in the development of aortic aneurysms and dissections by promoting pyroptosis in smooth muscle cells, leading to tissue inflammation and extracellular matrix destruction.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph S. Coselli, Heidi M. Krause, Susan Y. Green, Qianzi Zhang, Hiruni S. Amarasekara, Matt D. Price, Ourania Preventza, Scott A. LeMaire
Summary: In this study, the authors present their 23-year experience with the reversed elephant trunk technique for the repair of extensive thoracic aortic aneurysm. The results show that this technique yields acceptable short-term outcomes and is particularly effective in patients who require distal aortic repair. However, the low number of patients returning for completion repair is concerning, highlighting the need for rigorous surveillance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)