Article
Obstetrics & Gynecology
Alvaro Hernaez, Robyn E. Wootton, Christian M. Page, Karoline H. Skara, Abigail Fraser, Tormod Rogne, Per Magnus, Pal R. Njolstad, Ole A. Andreassen, Stephen Burgess, Deborah A. Lawlor, Maria Christine Magnus
Summary: Smoking intensity in women is associated with increased infertility odds, while later smoking initiation and smoking cessation are linked to decreased infertility in women. However, the association between greater smoking intensity in men and infertility is not robust.
FERTILITY AND STERILITY
(2022)
Article
Immunology
Luofei Zhang, Kefu Yu, Jiping Huo, Shenghui Mei, Zhigang Zhao, Bin Zhu
Summary: This study suggests that the possible causative effects of spondyloarthritis predicted by genetics on stroke may be limited to any stroke, any ischemic stroke, and cardioembolic stroke, especially the last.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
H. Zhao, J. Zhu, L. Ju, L. Sun, L. A. Tse, S. Kinra, Y. Li
Summary: This study provides genetic support that hip osteoarthritis (OA) is a potential risk factor for overall stroke, ischemic stroke (IS), and small vessel IS. Further research is needed to elucidate the underlying mechanisms of causal associations between site-specific OA and stroke subtypes.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Medicine, General & Internal
Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong, Tie-Lin Yang
Summary: This study used two-sample bidirectional Mendelian randomization analysis to explore the causal associations between brain imaging-derived phenotypes (IDPs) and stroke. The study identified 14 IDPs that were associated with stroke and revealed the potential causal effects of stroke on one IDP.
Article
Cardiac & Cardiovascular Systems
Yinan Wang, Yiming Jia, Qingyun Xu, Pinni Yang, Lulu Sun, Yi Liu, Xinyue Chang, Yu He, Mengyao Shi, Daoxia Guo, Yonghong Zhang, Zhengbao Zhu
Summary: This study investigated the associations between genetically predicted plasma prekallikrein concentrations and various types of stroke using Mendelian randomization. The results showed that genetically predicted high plasma prekallikrein levels were associated with increased risks of different types of stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Genetics & Heredity
Jiannan Lv, Lianghua Wu, Sheng Sun, Huifang Yu, Zekai Shen, Jun Xu, Jiahao Zhu, Dingwan Chen, Minmin Jiang
Summary: Using the two-sample Mendelian randomization design, this study explored the causal relationship between smoking, alcohol consumption, and frailty. The results suggest that smoking is a causal risk factor for frailty, while alcohol consumption may have a negative association with frailty, although further research is needed to determine causality.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Soryoung Lee, Eue-Keun Choi, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study found that a genetic predisposition for AF is significantly associated with lower gray matter volume but not with white matter volume. The total effect of AF on gray matter volume may be mediated by ischemic stroke.
Article
Anesthesiology
Shuai Yuan, Iyas Daghlas, Susanna C. Larsson
Summary: This study used Mendelian randomization to investigate the causal associations between alcohol and coffee consumption, smoking, and the risk of developing migraine. The results suggested that genetically predicted alcohol consumption and coffee consumption were negatively associated with migraine risk, while smoking initiation was positively associated. The study also found that genetic liability to migraine was inversely associated with alcohol consumption, but not with coffee consumption or smoking initiation.
Article
Oncology
Hongzhan Jiang, Yi Li, Jiali Shen, Huihui Lin, Siyue Fan, Rongliang Qiu, Jiaxi He, Ende Lin, Lijuan Chen
Summary: This study used Mendelian randomization methodology to investigate the causative impact of smoking on thyroid cancer incidence. The results did not find evidence of a causative link between smoking exposure and elevated incidence rates of thyroid malignancies.
Article
Clinical Neurology
Hong-Qi Li, Yi-Wei Feng, Yu-Xiang Yang, Xin-Yi Leng, Can Zhang, Shi-Dong Chen, Kevin Kuo, Shu-Yi Huang, Xue-Qing Zhang, Yi Dong, Xiang Han, Xin Cheng, Mei Cui, Lan Tan, Qiang Dong, Jin-Tai Yu
Summary: This study explores the causal relationships between elements of the exposome and ischemic stroke and its subtypes at the omics level. The findings show that higher blood pressure, atrial fibrillation, and diabetes are significantly associated with ischemic stroke, while higher education level decreases the risk of stroke.
Article
Geriatrics & Gerontology
Yi Huang, Ruijie Zhang, Liyuan Han, Yiwen Wu, Xinpeng Deng, Tianqi Xu, Yuefei Wu, Xiang Gao, Chenhui Zhou, Jie Sun
Summary: Based on genome-wide association study and observational data, the study suggests that genetically predicted higher Lp(a) may increase the risk of total stroke, ischemic stroke, and large-artery atherosclerotic stroke.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Derrick A. Bennett, Sarah Parish, Iona Y. Millwood, Yu Guo, Yiping Chen, Iain Turnbull, Ling Yang, Jun Lv, Canqing Yu, George Davey Smith, Yongjun Wang, Yilong Wang, Richard Peto, Rory Collins, Robin G. Walters, Liming Li, Zhengming Chen, Robert Clarke
Summary: In Chinese adults, the MTHFR C677T polymorphism is associated with an increased risk of stroke, highlighting the importance of further trials involving folic acid and mandatory folic acid fortification programs for stroke prevention in low-folate populations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Mei-Jun Shu, Jia-Rui Li, Yi-Cheng Zhu, Hang Shen
Summary: This study did not find significant associations between migraine and ischemic stroke and its subtypes, with the results being consistent with sensitivity analyses. Conducting a series of causal inference approaches supported the conclusion that there is no causal effect of migraine on ischemic stroke and its subtypes.
NEUROLOGY AND THERAPY
(2022)
Article
Clinical Neurology
Shiyuan Fang, Xinzhi Hu, Tao Wang, Yutong Yang, Ran Xu, Xiao Zhang, Jichang Luo, Yan Ma, Aman B. Patel, Adam A. Dmytriw, Liqun Jiao
Summary: This study aimed to assess the potential causal association between Parkinson's disease (PD) and ischemic stroke (IS) using Mendelian randomization methods. The results showed that PD may be a potential cause of cardioembolic stroke and large artery stroke, but not small-vessel stroke.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yisong Wang, Longtao Yang, Jun Liu
Summary: This study used genetic data on functional and structural connectivity levels to determine the causal relationship between brain resting-state networks and stroke. The findings suggest that the levels of connectivity within different networks have contrasting causal effects on stroke and its subtypes.
Article
Gastroenterology & Hepatology
Shuai Yuan, Susanna C. Larsson
Summary: This study conducted a bidirectional Mendelian randomization to explore the association between serum 25-hydroxyvitamin D and NAFLD. It found that increased vitamin D levels may play a role in preventing NAFLD in European populations.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Shuai Yuan, Amy M. Mason, Olga E. Titova, Mathew Vithayathil, Siddhartha Kar, Jie Chen, Xue Li, Stephen Burgess, Susanna C. Larsson
Summary: Morning chronotype is associated with a reduced risk of digestive tract cancer, particularly stomach and colorectal cancers. This Mendelian randomization study provides evidence of the association between morning chronotype and digestive tract cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Genetics & Heredity
Stephen Burgess, Amy M. Mason, Andrew J. Grant, Eric A. W. Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G. Haynes, G. Kees Hovingh, Lotte Bjerre Knudsen, John C. Whittaker, Dipender Gill
Summary: Evidence from randomized trials is reliable but expensive and slow, while evidence from observational studies is less reliable due to potential bias. Mendelian randomization is a quasi-experimental method that utilizes naturally occurring genetic variations as instrumental variables to investigate the effects of drug targets. This approach can provide rapid and diverse opportunities for studying drug mechanisms, biomarkers, and population subgroups.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Hematology
John DePaolo, Michael G. Levin, Catherine Tcheandjieu, James R. Priest, Dipender Gill, Stephen Burgess, Scott M. Damrauer, Julio A. Chirinos
Summary: Observational studies have shown that high blood pressure is a significant risk factor for thoracic aortic dilation, and reducing blood pressure is recommended for preventing the progression of aortic aneurysms. However, the causal relationship between blood pressure and aortic size has not been conclusively established.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Snehal M. Pinto Pereira, Victoria Garfield, Thomas Norris, Stephen Burgess, Dylan M. Williams, Richard Dodds, Avan A. Sayer, Sian M. Robinson, Rachel Cooper
Summary: This study found a nonlinear relationship between circulating vitamin D concentration and grip strength, with higher vitamin D levels associated with stronger grip. Mendelian randomization analysis also showed a modest positive effect of higher vitamin D concentration on grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jie Chen, Shuai Yuan, Tian Fu, Xixian Ruan, Jie Qiao, Xiaoyan Wang, Xue Li, Dipender Gill, Stephen Burgess, Edward L. Giovannucci, Susanna C. Larsson
Summary: We conducted an MR study to examine the associations between type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). It was found that genetic liability to type 2 diabetes was associated with an increased risk of 12 GDs.
Letter
Public, Environmental & Occupational Health
Yu Hao, Jinyu Xiao, Yu Liang, Xueyao Wu, Haoyu Zhang, Chenghan Xiao, Li Zhang, Stephen Burgess, Nan Wang, Xunying Zhao, Peter Kraft, Jiayuan Li, Xia Jiang
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maddalena Ardissino, Eric A. W. Slob, Paul Carter, Tormod Rogne, Joanna Girling, Stephen Burgess, Fu Siong Ng
Summary: This study used Mendelian randomization to explore the causal relevance of reproductive factors on cardiovascular disease in women. The results showed that earlier genetically predicted age at first birth, higher genetically predicted number of live births, and earlier genetically predicted age at menarche were associated with increased risk of cardiovascular disease. These findings support the role of reproductive factors in the development of cardiovascular disease in women and identify potential modifiable mediators for clinical intervention.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Hematology
Shuai Yuan, Yuhao Sun, Jie Chen, Xue Li, Susanna C. Larsson
Summary: This prospective cohort study found that patients with gallbladder and biliary tract cancer, pancreatic cancer, cirrhosis, Crohn's disease, or pancreatitis have a 50% higher risk of developing venous thromboembolism.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin Woolf, Helene T. Cronje, Loukas Zagkos, Stephen Burgess, Dipender Gill, Susanna C. Larsson
Summary: A Mendelian randomization study found a causal association between higher plasma caffeine levels and the risk of neuropsychiatric disorders (anorexia nervosa, bipolar disorder, major depressive disorder, and schizophrenia).
Article
Sport Sciences
Nikola Drca, Susanna C. Larsson, David Grannas, Mats Jensen-Urstad
Summary: This study found that female elite endurance athletes are at a higher risk of atrial fibrillation compared to the general population. The findings suggest that participation in endurance sports may influence the risk of atrial fibrillation in women.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maddalena Ardissino, Alec P. Morley, Eric A. W. Slob, Art Schuermans, Bilal Rayes, Zahra Raisi-Estabragh, Antonio de Marvao, Stephen Burgess, Tormod Rogne, Michael C. Honigberg, Fu Siong Ng
Summary: This study found that natural birth weight, independent of the intrauterine environment, is associated with cardiovascular disease and adverse cardiac structure and function.
EUROPEAN HEART JOURNAL
(2023)
Article
Genetics & Heredity
Haodong Tian, Amy M. Mason, Cunhao Liu, Stephen Burgess
Summary: Non-linear Mendelian randomization is an extension of standard Mendelian randomization that explores the causal relationship between an exposure and outcome using an instrumental variable. The current stratification method, referred to as the residual method, relies on strong parametric assumptions and can yield misleading results. We propose a new stratification method, called the doubly-ranked method, that relaxes these assumptions and provides unbiased estimates even in non-linear or heterogeneous scenarios.
Review
Cardiac & Cardiovascular Systems
Andrea N. Georgiou, Loukas Zagkos, Georgios Markozannes, Christos V. Chalitsios, Alexandros G. Asimakopoulos, Wei Xu, Lijuan Wang, Ines Mesa-Eguiagaray, Xuan Zhou, Eleni M. Loizidou, Nikolaos Kretsavos, Evropi Theodoratou, Dipender Gill, Stephen Burgess, Evangelos Evangelou, Konstantinos K. Tsilidis, Ioanna Tzoulaki
Summary: This systematic review evaluated the evidence for causality between a broad range of exposures and coronary artery disease and stroke using Mendelian randomization (MR) studies. The findings showed that only a limited number of associations were supported by robust evidence, highlighting the need for further research on sensitivity MR analyses and mediation effects.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Sanne A. E. Peters, Yvonne T. van der Schouw, Anniek C. van Westing, Tammy Y. N. Tong, Peter Willeit, Lisa Seekircher, Conchi Moreno-Iribas, Jose Maria Huerta, Marta Crous-Bou, Martin Soderholm, Matthias B. Schulze, Cecilia Johansson, Sara Sjalander, Alicia K. Heath, Alessandra Macciotta, Christina C. Dahm, Daniel B. Ibsen, Valeria Pala, Lene Mellemkjaer, Stephen Burgess, Angela Wood, Rudolf Kaaks, Verena Katzke, Pilar Amiano, Miguel Rodriguez-Barranco, Gunnar Engstrom, Elisabete Weiderpass, Anne Tjonneland, Jytte Halkjaer, Salvatore Panico, John Danesh, Adam Butterworth, N. Charlotte Onland-Moret
Summary: Early menopause is associated with a higher risk of stroke, but the relationships with stroke subtypes are inconsistent. However, genetically proxied age at menopause is not significantly associated with stroke risk, suggesting no causal relationship.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
