Journal
ANNALS OF NEUROLOGY
Volume 86, Issue 3, Pages 463-467Publisher
WILEY
DOI: 10.1002/ana.25542
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Funding
- National Heart Foundation of Australia Future Leader Fellowship [102052]
- National Heart, Lung, and Blood Institute [N01-HC-25195, HHSN268201500001I]
- National Institute on Aging [R01 AG0059421, R01 AG054076, R01 AG049607, R01 AG058589, R01 AG059421, U01 AG049505, U01 AG052409, R01AG054076-02S1]
- National Institute of Neurological Disorders and Stroke [NS017950, UH2 NS100605]
- Boston University School of Medicine's Jack Spivack Neuroscience Scholarship
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Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32-3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019
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