Article
Biochemistry & Molecular Biology
Qun Zhang, Junyao Li, Haixia Zhong, Yanling Xu
Summary: The study found that nicotinamide (NAM) can reduce proinflammatory mediator release in acute lung injury by inhibiting the MAPK and AKT/NF-kappa B signaling pathways, ultimately alleviating lung injury.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Zu -An Shi, Cheng-Xiu Yu, Zhi-Chao Wu, Chang -Lin Chen, Fa -Ping Tu, Yong Wan
Summary: The study investigated the protective effect of Fingolimod in a rat model of acute lung injury induced by LPS, showing inhibition of NF-kappa B activation, reduction of inflammatory cytokines, and improvement in lung tissue injury. These results suggest a promising therapeutic potential for Fingolimod in LPS-induced ALI by regulating the inflammatory pathway and barrier dysfunction of alveolar capillaries.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Xiao-Long Zhang, Jian An, Yong-Zhi Deng, Xuan-Zheng Fang, Cai-Yun Xu, Xu-Fang Liu, Ze-Hong Bai, Gang Zhang, Ming-Yuan Cui
Summary: Severe acute lung injury (ALI) is a major cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for ALI. This study reveals a significant role for the miR-762/NFIX pathway in the pathogenesis of ALI, suggesting that targeting this pathway could be beneficial for the diagnosis, prevention, and treatment of ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rundong Jiang, Jiaqi Xu, Yuezhong Zhang, Xuanmeng Zhu, Jiachen Liu, Yurong Tan
Summary: Ligustrazine has been shown to inhibit the occurrence and development of ALI through multiple pathways, including reducing inflammatory cell infiltration, inhibiting the secretion of inflammatory factors, and decreasing cell pyroptosis and apoptosis. This provides a theoretical basis for the future use of ligustrazine in the treatment of ALI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jia Zhang, Zhao Zhang, Xinran Nie, Yingli Liu, Yong Qi, Jing Wang
Summary: Sympathetic denervation attenuates sepsis-induced acute lung injury by modulating the expression of circRNAs, lncRNAs, miRNAs, and mRNAs in the lungs. The regulatory networks in the SD + ALI group reveal enrichment of immune and inflammation-related signaling pathways.
Article
Environmental Sciences
Chien-Ying Lee, Shih-Pin Chen, Rosa Huang-Liu, Shuo-Yan Gau, Yi-Ching Li, Chun-Jung Chen, Wen-Ying Chen, Chun-Nan Wu, Yu-Hsiang Kuan
Summary: Fucoxanthin, a natural pigment, shows various biological activities and can alleviate acute lung injury by inhibiting multiple cellular signaling pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Hui Zhao, Lin Fu, Hui-Xian Xiang, Ying Xiang, Meng-Die Li, Bian-Bian Lv, Zhu-Xia Tan, Lan Gao, Cheng Zhang, De-Xiang Xu
Summary: The study found that Benzo[a]pyrene can cause acute lung injury and inflammation, while the antioxidant N-acetylcysteine (NAC) can alleviate the pulmonary inflammatory response induced by Benzo[a]pyrene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Hongwei Lin, Min Chen, Yanjun Gao, Zaiqiang Wang, Faguang Jin
Summary: This study demonstrates that temporary exposure to PM2.5 induces lung epithelial cell apoptosis through promoting cytokines expression and inflammatory factors secretion. The cytotoxicity of PM2.5 can be alleviated by tussilagone (TSL), which restores the Hif-1 alpha protein level and decreases NF-kappa B activation. TSL treatment effectively relieves the damage caused by PM2.5 and decreases the expression of inflammatory cytokines.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Du Lei-lei, Liu Ying, Wan Li, Chen Chu, Fan Gang
Summary: The study showed that SBE could maintain the integrity of alveolar-capillary barrier under endotoxin challenge in mice, significantly alleviating lung injury induced by LPS.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Cell Biology
Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, Lianxiang Luo
Summary: Fucoxanthin alleviates lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and the TLR4/MyD88 signaling axis, indicating a potential therapeutic strategy for controlling ALI.
Article
Medicine, Research & Experimental
Jin Li, Liang Chen, Changsheng Li, Yu Fan, Mengsi Zhan, Huxiao Sun, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen, Xiangyang Shi
Summary: A new nanomedicine platform based on tyramine-bearing two dimethylphosphonate sodium salt (TBP)-modified amphiphilic phosphorus dendron (C11G3) nanomicelles encapsulated with curcumin (Cur) was developed for anti-inflammatory and antioxidative therapy of acute lung injury (ALI). The nanomicelles exhibited excellent cytocompatibility, intrinsic anti-inflammatory activity, and strong ROS scavenging property, providing effective therapy for inflammatory alveolar macrophages in vitro and in vivo.
Article
Plant Sciences
Lianghua Chen, Qiujuan Ma, Gongye Zhang, Yongbin Lei, Weiwei Wang, Yuqi Zhang, Tingting Li, Wei Zhong, Yanlin Ming, Gang Song
Summary: This study found that loganin and morroniside have a protective effect against acute lung injury and pulmonary fibrosis by inhibiting the expression of pro-inflammatory factors and regulating the NF-κB/STAT3 signaling pathway. In addition, they also suppressed the expression of fibrosis-related indicators in the pulmonary fibrosis model.
Article
Immunology
Gaoyan Chen, Yan Hou, Xiaogang Li, Rui Pan, Dongchi Zhao
Summary: This study shows that Calycosin can effectively alleviate sepsis-induced acute lung injury in young rats by inhibiting the HMGB1/MyD88/NF-κB pathway and NLRP3 inflammasome activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Luyao Yang, Hongqing Chen, Qiongying Hu, Lu Liu, Yun Yuan, Chuantao Zhang, Jianyuan Tang, Xiaofei Shen
Summary: This study found that eupalinolide B (EB) derived from Eupatorium lindleyanum effectively alleviated acute lung injury (ALI) in mice by inhibiting the activation of TAK1 and its downstream NF-κB and MAPKs pathways, leading to reduced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)