Review
Pharmacology & Pharmacy
Panangattukara Prabhakaran Praveen Kumar, Dong-Kwon Lim
Summary: Gold nanoparticles (AuNPs) have unique physicochemical properties and have found extensive applications in medicine. The photothermal effect of AuNPs plays a crucial role in diagnostic and therapeutic applications, including photoacoustic imaging, photonic PCR, and thermotherapy. This review examines the applications of the photothermal effect of AuNPs in nanomedicine, discussing the principles, advantages, and disadvantages of each technology, and emphasizing the importance of a multidisciplinary approach.
Article
Instruments & Instrumentation
Rui Zhang, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Summary: Gold nanoparticles with unique physicochemical features are being investigated for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are transitioning into clinical trials. The current consensus is to focus on specific disorders for therapeutic applications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tania Ferreira-Goncalves, Maria Manuela Gaspar, Joao M. P. Coelho, Vanda Marques, Ana S. Viana, Lia Ascensao, Lina Carvalho, Cecilia M. P. Rodrigues, Hugo Alexandre Ferreira, David Ferreira, Catarina Pinto Reis
Summary: Breast cancer is a burdensome malignancy for society, and researchers have developed a strategy using gold nanoparticles combined with near infrared irradiation as a photothermal therapy for diagnosis and treatment. The synthesized gold nanoparticles have favorable properties and are safe for use.
Article
Engineering, Environmental
Xiaodong He, Gnanasekar Sathishkumar, Kasi Gopinath, Kai Zhang, Zhisong Lu, Changming Li, En-Tang Kang, Liqun Xu
Summary: This study developed a novel biomaterial for medical devices with excellent antibacterial and antifouling properties, providing an effective strategy to combat medical device-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy, Jonathan A. Coulter
Summary: The study demonstrated that using RALA can enhance the uptake efficiency of negatively charged AuNPs in tumor cells, resulting in increased tumor cell radiation sensitivity. The nano-complexes formed at specific ratios showed positively charged nanoparticles and significantly increased AuNP internalization without causing toxicity. Furthermore, RALA-AuNP formulations enhanced prostate cancer cell radiosensitivity through nuclear accumulation, leading to increased DNA damage yields.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Noor Essa, Fiona O'Connell, Adriele Prina-Mello, Jacintha O'Sullivan, Simone Marcone
Summary: The relationship between obesity and cancer has been well characterized, but the biological mechanisms in obese cancer patients are still unclear. The obese tumor microenvironment provides additional benefits to tumor cells against anticancer therapies by altering the extracellular matrix composition and immune cell profile, while nanotechnology, particularly gold nanoparticles, is being researched for cancer treatment due to their sensitizing abilities for cancer cells and enhancement of drug delivery.
Review
Chemistry, Multidisciplinary
Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng, Sheng Wang
Summary: Phototherapies have made significant progress in cancer treatment, but face challenges. Gas therapy, which improves the level of specific gas at the tumor site, shows potential to overcome these challenges. Nanomedicine-based gas-assisted phototherapy has emerged as a promising strategy to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C. Tam, Sunil Krishnan, Devika B. Chithrani
Summary: Pancreatic cancer is a major cause of cancer deaths worldwide. The use of nanoparticles as radiosensitizers and drug delivery vehicles can overcome current obstacles in cancer treatments. The study found that a DTX prodrug encapsulated in lipid nanoparticles can enhance the uptake of gold nanoparticles in pancreatic cancer, providing a potential strategy for radiotherapy.
Article
Chemistry, Multidisciplinary
Jihui Wang, Na Liu, Qing Su, Yulong Lv, Chang Yang, Honglei Zhan
Summary: This study selected hyaluronic acid to synthesize gold nanoparticles with potent anti-cancer activity, which showed improved physico-chemical properties and enhanced biological effects against bulk cancer cells as well as cancer stem cells. The nano-scaled structure of the gold nanoparticles and the combined effect from NIR-induced hyperthermia contributed to the intensified bioactivity. The biocompatible nature of these nanoparticles supported their potential as a candidate for the development of novel chemotherapeutic drugs.
Article
Chemistry, Multidisciplinary
Mohamad Zandieh, Juewen Liu
Summary: This study compared the effects of adding polyvalent metal ions during the synthesis of PDA NPs (called metal-doped) with adding them after the synthesis (metal-adsorbed). Zn2+ showed excellent ability for promoting DNA adsorption and metal-doped NPs were more efficient than metal-adsorbed NPs. The Zn2+-doped PDA NPs were applied for sensitive DNA detection with a low detection limit and resistance to nonspecific protein and phosphate displacement.
Article
Biochemistry & Molecular Biology
Niloofar Heshmati Aghda, Susana Torres Hurtado, Shahad M. Abdulsahib, Emilio J. Lara, James W. Tunnell, Tania Betancourt
Summary: This study focuses on using nanomedicine-mediated combination therapy to induce immunogenic cell death in melanoma cells by delivering ICD inducers Dox and ICG loaded into BSA nanoparticles, which inhibits tumor growth by enhancing the immunogenicity of the tumor microenvironment.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Marta Miola, Cristina Multari, Nina Kostevsek, Roberto Gerbaldo, Francesco Laviano, Enrica Verne
Summary: The aim of this study was to design new hybrid nanoplatforms through the eco-friendly use of tannic acid for biomedical applications. The results demonstrate that the synthesized nanoparticles possess both magnetic and plasmonic properties and are non-toxic.
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Chemistry, Multidisciplinary
Jifa Liu, Xinglong Shi, Yangcui Qu, Guannan Wang
Summary: This study presents a novel biomimetic nanoparticle platform (ZnMnFe2O4-PEG-FA) that enables combined photothermal therapy and nanozyme-catalyzed therapy. These nanoparticles exhibit excellent photothermal effect and catalytic ability, alleviating the limitations of conventional treatments. Furthermore, they also have imaging capabilities for monitoring and guiding cancer treatment.
Article
Engineering, Biomedical
Jeane Chen, Sarah B. White, Kathleen R. Harris, Weiguo Li, Jonathan W. T. Yap, Dong-Hyun Kim, Robert J. Lewandowski, Lonnie D. Shea, Andrew C. Larson
Article
Nanoscience & Nanotechnology
Wooram Park, Jeane Chen, Soojeong Cho, Sin-jung Park, Andrew C. Larson, Kun Na, Dong-Hyun Kim
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Nanoscience & Nanotechnology
Soojeong Cho, Wooram Park, Dong-Hyun Kim
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Engineering, Biomedical
Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim
Article
Engineering, Biomedical
Mm Jeong Jeon, Andrew C. Gordon, Andrew C. Larson, Jin Wook Chung, Young Il Kim, Dong-Hyun Kim
Article
Engineering, Biomedical
Ken Zhao, Soojeong Cho, Daniel Procissi, Andrew C. Larson, Dong-Hyun Kim
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Article
Chemistry, Multidisciplinary
Wooram Park, Sin-Jung Park, Soojeong Cho, Heejun Shin, Young-Seok Jung, Byeongdu Lee, Kun Na, Dong-Hyun Kim
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Multidisciplinary
Wooram Park, Soojeong Cho, Xiaoke Huang, Andrew C. Larson, Dong-Hyun Kim
Article
Multidisciplinary Sciences
Dong-Hyun Kim, Weiguo Li, Jeane Chen, Zhuoli Zhang, Richard M. Green, Sui Huang, Andrew C. Larson
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Multidisciplinary
Hongping Xia, Fangyuan Li, Wooram Park, Shuaifei Wang, Youngjin Jang, Yang Du, Seungmin Baik, Soojeong Cho, Taegyu Kang, Dong-Hyun Kim, Daishun Ling, Kam Man Hui, Taeghwan Hyeon
ACS CENTRAL SCIENCE
(2016)
Article
Chemistry, Multidisciplinary
Ji Sun Park, Wooram Park, A. Young Kang, Andrew C. Larson, Dong-Hyun Kim, Keun-Hong Park
Article
Chemistry, Multidisciplinary
Ji Sun Park, Wooram Park, Sin-Jung Park, Andrew C. Larson, Dong-Hyun Kim, Keun-Hong Park
ADVANCED FUNCTIONAL MATERIALS
(2017)
Article
Physiology
Seok-Jo Kim, Paul Cheresh, Mesut Eren, Renea P. Jablonski, Anjana Yeldandi, Karen M. Ridge, G. R. Scott Budinger, Dong-Hyun Kim, Myles Wolf, Douglas E. Vaughan, David W. Kamp
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Soojeong Cho, Tae Soup Shim, Ju Hyeon Kim, Dong-Hyun Kim, Shin-Hyun Kim
ADVANCED MATERIALS
(2017)
Article
Nanoscience & Nanotechnology
Wooram Park, Andrew C. Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R. Harris, Andrew C. Larson, Dong-Hyun Kim
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.