Journal
AIDS
Volume 33, Issue 12, Pages 1945-1947Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000002282
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Funding
- National 13th Five-Year Grand Program on Key Infectious Disease Control [2017ZX10202102-005-003, 2017ZX10202101-004-001, 2018ZX10721102-003-003, 2018ZX10302-102]
- National Natural Science Foundation of China (NSFC) [81772165, 81601795]
- Capital Health Research and Development of Special Found [2016-2-2182]
- Beijing Key Laboratory for HIV/AIDS Research [BZ0089]
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Reports of resistance to integrase strand transfer inhibitors (INSTIs) are now not uncommon. We analyzed the HIV int gene from plasma of antiretroviral-naive individuals during acute and chronic HIV-1 infection. No individual with major INSTI mutations was identified. Two individuals harbored INSTI accessory mutations E157Q/T97A were detected for the first time. Our results emphasize the need to consider testing for INSTI resistance at baseline as this class of drugs is increasingly used in clinical routine.
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