3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
Authors
Keywords
-
Journal
ACTA PHARMACOLOGICA SINICA
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-06-14
DOI
10.1038/s41401-019-0254-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function
- (2019) L C S De Vries et al. INFLAMMATORY BOWEL DISEASES
- STAT3 and apoptosis challenges in cancer
- (2018) Nazanin Fathi et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer
- (2018) Katherine Hughes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect
- (2018) Zhe-Ling Feng et al. Journal of Natural Medicines
- Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases
- (2018) Man Liu et al. MOLECULES
- Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway
- (2018) Chuanlan Liu et al. PHYTOTHERAPY RESEARCH
- Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay
- (2018) Joseph Shaw et al. Scientific Reports
- “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway
- (2018) Emira Bousoik et al. Frontiers in Oncology
- JAK inhibitors in dermatology: The promise of a new drug class
- (2017) William Damsky et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- JAK1/2 Inhibitors AZD1480 and CYT387 Inhibit Canine B-Cell Lymphoma Growth by Increasing Apoptosis and Disrupting Cell Proliferation
- (2017) Z. Lu et al. JOURNAL OF VETERINARY INTERNAL MEDICINE
- The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions
- (2017) Ryan Ferrao et al. Frontiers in Endocrinology
- Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth
- (2016) Gang Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases
- (2016) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Crystal Structure of the FERM-SH2 Module of Human Jak2
- (2016) Randall McNally et al. PLoS One
- Constitutive activation of STAT3 in breast cancer cells: A review
- (2015) Kasturi Banerjee et al. INTERNATIONAL JOURNAL OF CANCER
- Ruxolitinib for the treatment of primary myelofibrosis
- (2014) S. J. Swaim AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- 2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase
- (2014) Shan Kuang et al. CANCER SCIENCE
- AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway
- (2014) SHU-WEI WANG et al. ONCOLOGY REPORTS
- Regulation of JAK2 Activation by Janus Homology 2: Evidence from Molecular Dynamics Simulations
- (2012) Shunzhou Wan et al. Journal of Chemical Information and Modeling
- Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways
- (2011) Taiga Tamiya et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway
- (2010) Stephanos Ioannidis et al. JOURNAL OF MEDICINAL CHEMISTRY
- 17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells
- (2009) Y. Wang et al. CANCER RESEARCH
- Small Molecules ATP-Competitive Inhibitors of FLT3: A Chemical Overview
- (2008) S. Schenone et al. CURRENT MEDICINAL CHEMISTRY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started