Article
Infectious Diseases
Kenaw Dessie Alehegne, Birhan Agmas Mitiku
Summary: This study revealed a moderate prevalence of schistosomiasis in different hosts in the Aleffa and Takusa districts of northwest Ethiopia, with factors such as female sex, working with bare foot, skin cut/abrasion history, and swimming habits identified as potential determinants for intestinal schistosomiasis in school children. Further research and multi-host interventions are crucial in interrupting the transmission of schistosomiasis in the study area.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Environmental Sciences
Paula Ribeiro Prist, Amanda Prado, Leandro Reverberi Tambosi, Fabiana Umetsu, Adriana de Arruda Bueno, Renata Pardini, Jean Paul Metzger
Summary: This study found that forest restoration in the Brazilian Atlantic forest can significantly reduce the abundance of Hantavirus reservoir rodents, decreasing the risk of HCPS transmission and creating a healthier environment for approximately 2.8 million people living in the area.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Microbiology
Wissem Ghawar, Melek Chaouch, Afif Ben Salah, Mohamed Ali Snoussi, Sadok Salem, Ghassen Kharroubi, Said Chouchen, Amor Bouaoun, Dhafer Laouini, Jihene Bettaieb, Souha Ben Abderrazak
Summary: This study reveals the first evidence of natural Leishmania infection among Jaculus spp. in South Tunisia, suggesting that these rodent species may serve as potential reservoir hosts of Old World Leishmania parasites in Tunisia and North Africa.
Article
Parasitology
Guilherme Silva Miranda, Joao Gustavo Mendes Rodrigues, Jeferson Kelvin Alves de Oliveira Silva, Genil Mororo Araujo Camelo, Neuton Silva-Souza, Renata Heisler Neves, Jose Roberto Machado-Silva, Deborah Aparecida Negrao-Correa
Summary: Schistosomiasis is a widespread parasitic disease caused by trematodes from the genus Schistosoma. The ability of Schistosoma to infect multiple vertebrate hosts, including wild rodents, poses a major obstacle to eradicating the disease. Climate change and increased human-wild animal contact have led to more frequent interactions between different Schistosoma species, potentially increasing the frequency of hybridization and the establishment of new genotypes and strains. These variants may negatively impact control strategies, treatment regimens, and disease burden in humans.
Review
Medicine, General & Internal
Cristina Carbonell, Beatriz Rodriguez-Alonso, Amparo Lopez-Bernus, Hugo Almeida, Inmaculada Galindo-Perez, Virginia Velasco-Tirado, Miguel Marcos, Javier Pardo-Lledias, Moncef Belhassen-Garcia
Summary: Schistosomiasis is a helminthic infection caused by blood flukes of the genus Schistosoma, with diverse clinical manifestations affecting practically all organs. It is a significant public health issue, particularly prevalent in poverty-stricken areas within the tropics and subtropics. The disease can go undiagnosed for a long period of time, leading to secondary clinical lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Coline Mortier, Camille Aubry, Coralie L'Ollivier, Philippe Gautret, Jean-Christophe Lagier, Philippe Parola
Summary: Schistosomiasis is highly prevalent in sub-Saharan Africa, making diagnosis challenging for travel medicine practitioners due to its atypical manifestations affecting different organs. Pulmonary schistosomiasis can present as acute or chronic, with potential nodular lesions. Physicians need to be aware of non-specific symptoms to avoid chronic complications from parasitic diseases like schistosomiasis.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Si-Yue Huang, Ying-Si Lai, Yue-Yi Fang
Summary: This study developed high-resolution, age- and gender-specific risk maps of soil-transmitted helminth (STH) infections in Guangdong Province based on data from three national surveys conducted between 1988 and 2016. The overall infection risk of STHs has decreased over time, but remains higher than the national average. The maps show that areas with moderately endemic risk are mostly located in western Guangdong, with prevalence below 5% in other areas. Females have a higher infection risk than males. Children are more likely to be infected with A. lumbricoides and T. trichiura, while middle-aged and elderly people are more at risk of hookworm infection.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Anurag Kumar Kushwaha, Ashish Shukla, Breanna M. Scorza, Tulika Kumari Rai, Rahul Chaubey, Dharmendra Kumar Maurya, Shweta Srivastva, Shreya Upadhyay, Abhishek Kumar Singh, Paritosh Malviya, Om Prakash Singh, Vivek Kumar Scholar, Puja Tiwary, Shakti Kumar Singh, Phillip Lawyer, Edgar Rowton, Scott A. Bernhardt, Christine A. Petersen, Shyam Sundar
Summary: This study provides clinical evidence that domestic animals, other than humans, do not play a significant role in transmitting Leishmania donovani to sand flies on the Indian subcontinent. Monitoring the absence of transmission in the post-elimination phase is crucial to prevent the establishment of a non-human reservoir.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Hammed O. Mogaji, Ikenna M. Odoh, Concilia I. Iyeh, Abdulhakeem A. Adeniran, Segun Oyedeji, Hilary Okoh, Adedotun A. Bayegun, Olaitan O. Omitola, Cynthia U. Umunnakwe, Francisca O. Olamiju, Olatunwa J. Olamiju, Uwem F. Ekpo
Summary: This study surveyed attendees at the inaugural 2020 World NTD Day event in Ekiti, Nigeria to assess their knowledge and awareness about Neglected Tropical Diseases (NTDs) and its control activities. The results showed low levels of knowledge and awareness among attendees, highlighting the need for regular promotional activities such as media engagement to improve awareness and community involvement in NTD control programs.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Stefan L. Debbert, Mikaela J. Hintz, Christian J. Bell, Kenya R. Earl, Grant E. Forsythe, Cecile Haeberli, Jennifer Keiser
Summary: Some quinoxaline compounds showed promising activity against Schistosoma mansoni in vitro, but exhibited only moderate activity in vivo, indicating the need for optimization of their pharmacokinetic properties to improve in vivo efficacy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Gregorio Basile, Francesca Tamarozzi, Joaquin Salas-Coronas, Manuel Jesus Soriano-Perez, Pilar Luzon-Garcia, Lucia Moro, Spinello Antinori, Marta Arsuaga, Alessandro Bartoloni, Lina Rachele Tomasoni, Federico Giovanni Gobbi, Carsten Koehler, Fernando Salvador, Cristina Bocanegra, Lorenzo Zammarchi
Summary: This study investigated the clinical presentations and management strategies of complicated urogenital schistosomiasis. The study found an underdiagnosis of this condition, with hydronephrosis being the most frequently observed complication and most patients requiring surgical management. Therefore, there is an urgent need for the development of common protocols for early diagnosis and treatment.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Juan Hernandez-Goenaga, Julio Lopez-Aban, Adrian Blanco-Gomez, Belen Vicente, Francisco Javier Burguillo, Jesus Perez-Losada, Antonio Muro
Summary: The genetic basis of susceptibility to schistosomiasis and the location of chromosomal regions involved were investigated using a backcross strategy. 19 new quantitative trait loci (QTL) associated with parasite burden, liver lesions, white blood cell populations, and antibody responses were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Larissa C. Anderson, Eric S. Loker, Helen J. Wearing
Summary: Research indicates that snail population age structure alters the force of infection experienced by humans and the relationship between snail and human infection prevalence, emphasizing the importance of accounting for heterogeneous intermediate host populations in schistosomiasis transmission models.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Silvia Roure, Olga Perez-Quilez, Xavier Valles, Lluis Valerio, Israel Lopez-Munoz, Laura Soldevila, Ariadna Torrella, Gema Fernandez-Rivas, Anna Chamorro, Bonaventura Clotet
Summary: This study aimed to characterize the clinical manifestations of Schistosoma infection among migrant women and determine the degree of underdiagnosis. The results showed a high prevalence of schistosomiasis infection among migrant women, particularly female genital schistosomiasis, and a low diagnosis rate.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Behavioral Sciences
Mathew E. Diamond, Alessandro Toso
Summary: Since the discovery of the ordered representation of whiskers in somatosensory cortex, the rodent tactile sensory system has provided valuable insights into sensory processing. In recent years, researchers have adopted new approaches by posing complex perceptual and memory problems to investigate the underlying mechanisms of rodent problem solving. By studying whisker-based behavioral tasks, it has been shown that rodents achieve high performance through accessible and manipulable neural circuits. This review presents leading psychophysical paradigms and their neural correlates as a means to explore tactile cognition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Plant Sciences
Joao Gustavo Mendes Rodrigues, Paula Sibelly Veras Albuquerque, Johnny R. Nascimento, Jaianna Andressa Viana Campos, Andressa S. S. Godinho, Sulayne Janayna Araujo, Jefferson Mesquita Brito, Caroline M. Jesus, Guilherme Silva Miranda, Michelle C. Rezende, Deborah Aparecida Negrao-Correa, Claudia Q. Rocha, Lucilene Amorim Silva, Rosane N. M. Guerra, Flavia R. F. Nascimento
Summary: Chenopodium ambrosioides extract showed antiparasitic and immunomodulatory effects by increasing the mortality of schistosoma in vitro, reducing eggs in feces and liver in vivo, decreasing liver granulomas, and improving cellular immune response.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Guilherme Silva Miranda, Samira Diniz Resende, Diogo Tavares Cardoso, Genil Mororo Araujo Camelo, Jeferson Kelvin Alves Oliveira Silva, Vanessa Normandio de Castro, Stefan Michael Geiger, Mariangela Carneiro, Deborah Negrao-Correa
Summary: The study found that individuals with a history of previous American Tegumentary Leishmaniasis (ATL) are more susceptible to Schistosoma mansoni infection. Among the study population, 36.2% of S. mansoni-infected individuals reported a history of ATL, showing a significantly higher infection rate compared to individuals with no ATL history.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Dharliton Soares Gomes, Deborah Aparecida Negrao-Correa, Guilherme Silva Miranda, Joao Gustavo Mendes Rodrigues, Tamna Joanan Farias Lima Guedes, Waldecy de Lucca Junior, Jose Carlos Freitas de Sa Filho, Daniela Aparecida de Castro Nizio, Arie Fitzgerald Blank, Vera Lucia Correa Feitosa, Silvio Santana Dolabella
Summary: The study found that the essential oils from Lippia gracilis and Lippia alba showed high efficacy against adult Schistosoma mansoni worms, while the effects on schistosomula were slightly different. This research suggests that these plants could be a potential source of bioactive compounds against S. mansoni.
Article
Parasitology
Guilherme Silva Miranda, Joao Gustavo Mendes Rodrigues, Michelle Carvalho de Rezende, Samira Diniz Resende, Genil Mororo Araujo Camelo, Jeferson Kelvin Alves de Oliveira Silva, Laura Maggi, Vanessa Fernandes Rodrigues, Vinicius Gustavo de Oliveira, Deborah Aparecida Negrao-Correa
Summary: This study compared the parasitological and immunopathological effects of a Schistosoma mansoni strain isolated from a wild rodent and a strain isolated from a human on mice. The results showed that mice infected with the wild rodent strain had a reduced number of worms but higher fecundity rate, and exhibited a predominance of Th1/Th17 immune response, leading to increased tissue inflammation and disease severity.
Review
Parasitology
Irlla Correia Lima Lica, Gleycka Cristine Carvalho Gomes Frazao, Ranielly Araujo Nogueira, Maria Gabriela Sampaio Lira, Vitor Augusto Ferreira dos Santos, Joao Gustavo Mendes Rodrigues, Guilherme Silva Miranda, Rafael Cardoso Carvalho, Lucilene Amorim Silva, Rosane Nassar Meireles Guerra, Flavia Raquel Fernandes Nascimento
Summary: Human schistosomiasis is caused by helminths of the genus Schistosoma, and macrophages play a crucial role in immune regulation. These cells can acquire different phenotypes depending on the stimulus they receive.
Article
Parasitology
Guilherme Silva Miranda, Joao Gustavo Mendes Rodrigues, Samira Diniz Resende, Genil Mororo Araujo Camelo, Jeferson Kelvin Alves de Oliveira Silva, Jose Carlos Reis dos Santos, Neuton Silva-Souza, Felipe Bisaggio Pereira, Luis Fernando Viana Furtado, Elida Mara Leite Rabelo, Deborah Negrao-Correa
Summary: In this study, a Schistosoma strain called HS was isolated and characterized from naturally infected Holochilus sciureus from a schistosomiasis endemic region in Brazil. The miracidia obtained from infected mice were able to infect Biomphalaria glabrata, allowing maintenance of the isolated parasite. Genetic characterization confirmed the conspecificity of the HS strain with isolates from America and Kenya. The experimental infection of B. glabrata SB with S. mansoni HS showed two peaks of cercariae shedding and higher mortality compared to B. glabrata BH.
PARASITOLOGY RESEARCH
(2023)
Article
Microbiology
Ludmila Gouveia-Eufrasio, Gustavo Jose Cota de Freitas, Marliete Carvalho Costa, Eluzia Castro Peres-Emidio, Paulo Henrique Fonseca Carmo, Joao Gustavo Mendes Rodrigues, Michelle Carvalho de Rezende, Vanessa Fernandes Rodrigues, Camila Bernardo de Brito, Guilherme Silva Miranda, Pamela Aparecida de Lima, Livia Mara Vitorino da Silva, Jefferson Bruno Soares Oliveira, Tatiane Alves da Paixao, Daniele da Gloria de Souza, Caio Tavares Fagundes, Nalu Teixeira de Aguiar Peres, Deborah Aparecida Negrao-Correa, Daniel Assis Santos
Summary: In this study, the interaction between Cryptococcus gattii and Strongyloides venezuelensis in a murine coinfection model was investigated. The results showed that exposure of murine macrophage to Strongyloides venezuelensis antigens reduced their ability to engulf Cryptococcus gattii and increased fungal growth intracellularly. In a coinfection model, Strongyloides venezuelensis infection skewed the host's response to fungal infection, resulting in increased lethality and worsened pathological outcomes.
Review
Chemistry, Medicinal
Maria Gabriela Sampaio Lira, Ranielly Araujo Nogueira, Irlla Correia Lima Lica, Gleycka Cristine Carvalho Gomes Frazao, Vitor Augusto Ferreira dos Santos, Antonio Camilo Correia Mendes, Joao Gustavo Mendes Rodrigues, Guilherme Silva Miranda, Lucilene Amorim Silva, Rosane Nassar Meireles Guerra, Rafael Cardoso Carvalho, Flavia Raquel Fernandes Nascimento
Summary: This review collected original research articles on the use of plant extracts, essential oils, and their bioactive compounds for the treatment of schistosomiasis mansoni. These plant products directly affect the parasite, reducing its survival and causing damage to the host. They also modulate the host's immune response, reducing inflammation and promoting the survival of the host.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Parasitology
Joao Gustavo Mendes Rodrigues, Maria Gabriela Sampaio Lira, Ranielly Araujo Nogueira, Gleycka Cristine Carvalho Gomes, Irlla Correia Lima Lica, Jeferson Kelvin Alves de Oliveira Silva, Guilherme Silva Miranda, Neuton Silva-Souza
Summary: In Holochilus sciureus rodents infected with Schistosoma mansoni, glucose concentrations decreased in males but remained relatively stable in females. Male rodents also exhibited a more severe hepatic inflammatory reaction than females histopathologically. Other factors such as weight and length of the animals did not affect glucose levels.
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2022)
Article
Agriculture, Dairy & Animal Science
D. J. Saraiva, A. C. C. Campina, F. C. S. Goncalves, D. Melo-Viegas, A. C. G. Santos, R. M. S. Nogueira, A. P. Costa
Summary: Brazilian poultry production is booming due to the cost-effective benefits of chicken meat, but free-range chickens in Santa Rita, Maranhao, Brazil are facing serious parasitic infections of nematodes and cestodes. The study identified a high occurrence of these parasites in the free-range hens raised in the region.
BRAZILIAN JOURNAL OF POULTRY SCIENCE
(2021)
Article
Infectious Diseases
Joao Gustavo Mendes Rodrigues, Maria Gabriela Sampaio Lira, Ranielly Araujo Nogueira, Gleycka Cristine Carvalho Gomes, Irlla Correia Lima Lica, Davi Viegas-Melo, Andrea Teles-Reis, Guilherme Silva Miranda, Neuton Silva-Souza
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2020)