Article
Chemistry, Physical
Dening Chang, Chenglin Du, Jinyu Liu, Wanqing Sun, Yuxuan Su, Dejin Zang, Teng Liu
Summary: In recent years, the structure-property relationship of block copolymers in administrable drug delivery has been a topic of interest. This study investigated the self-assembling behavior of four block copolymers with different hydrophobic modification groups and found that the enhancement of hydrophobicity led to the formation of smaller micelles or vesicles and improved solubilization and release capacities for hydrophobic drugs. The findings highlight the potential application of hydrophobic modification in sustained release drug carriers.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Feng Shen, Hao Ling, Wenjiao Ge, Yang Yang, Xiaoying Wang, Junli Ren, Xiaohui Wang
Summary: A series of amphiphilic hemicellulose-based grafting polymers were synthesized by esterification with various hydrophobic chain fatty acids, forming hard sphere micelles in aqueous solution. These micelles exhibit potential as drug carriers with controlled release behavior.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Dan Meng, Chen Li, Changlong Hao, Wenxiong Shi, Jun Xu, Maozhong Sun, Hua Kuang, Chuanlai Xu, Liguang Xu
Summary: In this study, chiral selenium nanoparticles were synthesized using cysteine and the interfacial assembly strategy, leading to the generation of self-assembled nanomembranes with controllable morphology and handedness on a large scale. The nanomembranes demonstrated ultrasensitive recognition of enantioselective kynurenine (Kyn) and could accurately distinguish L-Kyn in serum and cerebrospinal fluid samples from Alzheimer's disease patients and healthy subjects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Inorganic & Nuclear
Atsushi Kobayashi, Shin-ya Takizawa, Masanari Hirahara
Summary: This review focuses on the photofunctional molecular assemblies on the surfaces of rigid semiconductors or soft lipid membranes to overcome backward reactions in Z-scheme water-splitting photocatalysis. Approaches based on the dye-sensitization mechanism can improve photoinduced charge-separation efficiency and regulate the reaction field and pathway in photocatalytic O-2 and H-2 evolution reactions, providing powerful techniques for improving photocatalytic activity.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Daria Sokolova, GiovanniMaria Piccini, Konrad Tiefenbacher
Summary: This study presents the first examples of optically active hexameric resorcin[4]arene capsules and demonstrates the possibility of chirality transfer inside a relatively large molecular container. These capsules are able to enantioselectively catalyze tail-to-head terpene cyclizations and exhibit surprisingly high sensitivity to structural modifications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ryo Miyazaki, Mahmuda Nargis, Abu Bin Ihsan, Noriyuki Nakajima, Masahiro Hamada, Yasuhito Koyama
Summary: The study investigated the self-assembly behaviors of alpha-Galactosyl ceramide (GalCer) and its aglycon in water, revealing the significant role of the glycon moiety in inhibiting the formation of second associates and in plasticizing the hydrophobe. The results provide insights for evaluating the self-assembly behaviors of other natural glycosides for supramolecular and pharmacological applications in the future.
Article
Chemistry, Multidisciplinary
Jin Yan, Yang Wang, Xiao Li, Dongnan Guo, Zhengjun Zhou, Ge Bai, Jianhui Li, Na Huang, Jiajie Diao, Yong Li, Wangxiao He, Wenjia Liu, Kaishan Tao
Summary: Self-assembling peptide hydrogels present a promising approach for treating liver bleeding, with a nano-band-aid (NBA) developed through a three-stage self-assembly process of two functionalized peptides demonstrating rapid and effective control of bleeding in animal experiments.
Review
Chemistry, Multidisciplinary
Jingjing Han, Haoning Gong, Xiaokang Ren, Xuehai Yan
Summary: This article introduces the research field of peptide-based supramolecular nanozymes, emphasizing the importance and versatility of peptides as building blocks, as well as the potential for regulating catalytic performance.
Article
Polymer Science
Hong Qiu, Xiaopeng Chen, Xiaojie Wei, Jiezhen Liang, Dan Zhou, Weixiang Tang, Linlin Wang
Summary: An environmentally friendly oil-soluble surfactant colophony xylitol ester (CXE) was successfully synthesized and found to have high thermal stability and effective reduction of surface tension in various organic solvents. Additionally, CXE self-assembled into micelles, vesicles, and heteromorphic vesicles in different organic solvents. The thermodynamic parameters of aggregate formation were investigated through critical micelle concentration curves at different temperatures.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Xin-Jie Shi, Zhen Liu, Yang-Chun Xie, Min Xu, Xiao-Hua He
Summary: This study investigated the key factors for the formation of homopolypeptide vesicles using multiple spectroscopic techniques, and confirmed the existence of vesicular structures through microscopy observations. In comparison, copolypeptides with the same peptide backbone could only form micelles due to the differences in hydrophobicity of their side-chains.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Review
Chemistry, Inorganic & Nuclear
Basudev Maity, Mohd Taher, Shyamalava Mazumdar, Takafumi Ueno
Summary: Metalloenzymes play vital roles in biology, and artificial metalloenzymes use synthetic metal cofactors to promote non-natural reactions. Significant progress has been made in manipulating artificial metalloenzymes for various organic transformation reactions, such as C-H activation and C-C coupling. Advanced methods like Directed evolution, high throughput screening, and rational design have driven the research of artificial metalloenzymes. The applications of artificial metalloenzymes have expanded to control cellular functions such as prodrug activation. However, the study of artificial metalloenzymes in more complex processes and reaction environments is relatively limited.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Stephane Gineste, Christophe Mingotaud
Summary: Hybrid polyionic complexes (HPICs), composed of double-hydrophilic block copolymers and metal ions, have been extensively studied in the past decade due to their stability and versatile chemical properties. They hold great potential in the fields of catalysis, materials science, and biological applications.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Yubo Jiang, Ryan E. McNamee, Philip J. Smith, Ana Sozanschi, Zixuan Tong, Edward A. Anderson
Summary: Cascade reactions, also known as domino reactions, are a powerful means to construct multiple ring systems in a single step. This review discusses highlights in cascade polycyclizations applied to natural product syntheses over the last five years, including various processes such as pericyclic, ionic, metal-catalyzed, organocatalytic, and radical processes. Emphasis is placed on significant advancements in each field, such as photochemical and electrochemical methods, novel biomimetic routes, and enantioselective cascades.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
I. Caglar Tanrikulu, Lianna Dang, Lekha Nelavelli, Aubrey J. Ellison, Bradley D. Olsen, Song Jin, Ronald T. Raines
Summary: This study successfully designed synthetic collagen hydrogels by maximizing the interactions of the triple helix structure of collagen. It further explored the relationship between self-assembly of short CMPs and interfiber association.
Article
Chemistry, Multidisciplinary
Oleksii Zozulia, Ivan Korendovych
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Nanoscience & Nanotechnology
Areetha D'Souza, Jennifer H. Yoon, Henry Beaman, Pallavi Gosavi, Zsofia Lengyel-Zhand, Alex Sternisha, Garrick Centola, Liam R. Marshall, Matthew D. Wehrman, Kelly M. Schultz, Mary Beth Monroe, Olga V. Makhlynets
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Liam R. Marshall, Megha Jayachandran, Zsofia Lengyel-Zhand, Caroline M. Rufo, Austin Kriews, Min-Chul Kim, Ivan V. Korendovych
Article
Neurosciences
Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M. -Y. Lee, John Q. Trojanowski, Robert H. Mach
MOLECULAR NEUROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Zsofia Lengyel-Zhand, Liam R. Marshall, Maximilian Jung, Megha Jayachandran, Min-Chul Kim, Austin Kriews, Olga Makhlynets, H. Christopher Fry, Armin Geyer, Ivan Korendovych
Summary: The self-assembly of short peptides into catalytic amyloid-like nanomaterials is a powerful tool for understanding the evolution of early proteins and identifying new catalysts. This study demonstrates that different arrangements of beta-sheets can accommodate metal ions for catalysis, and synergistic relationships in catalytic amyloid mixtures can be found in various species offering faster rates of assembly.
Article
Chemistry, Multidisciplinary
Oleksii Zozulia, Liam R. Marshall, Inhye Kim, Eric M. Kohn, Ivan V. Korendovych
Summary: Self-assembly of short peptides can produce versatile nanomaterials with efficient catalytic activity, showing practical utility and evolutionary connection.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Liam R. Marshall, Ivan Korendovych
Summary: Amyloids, originally considered as disease symptoms, have diverse functions including biologically beneficial ones. Instead of being seen as 'misfolding,' the aggregation of polypeptides into amyloid-like structures should be viewed as 'alternative folding,' with recent studies showing that these structures can be used to create highly efficient catalysts with specific catalytic efficiencies.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eric M. Kohn, David J. Shirley, Nicole M. Hinds, H. Christopher Fry, Gregory A. Caputo
Summary: Electronics made from biological materials have unique properties that current inorganic technologies cannot achieve. Researchers have developed a series of cationic peptides that can self-assemble with anionic porphyrins into supramolecular light-harvesting wires known as J-aggregates. The J-aggregates can readily interconvert with soluble monomers upon cycling the pH, which has practical and conceptual relevance to the development of new bioelectronic materials.
Article
Multidisciplinary Sciences
Sagar Bhattacharya, Eleonora G. Margheritis, Katsuya Takahashi, Alona Kulesha, Areetha D'Souza, Inhye Kim, Jennifer H. Yoon, Jeremy R. H. Tame, Alexander N. Volkov, Olga V. Makhlynets, Ivan V. Korendovych
Summary: Directed evolution is a powerful tool for improving protein properties and functionality. However, the vast number of possible amino acid sequences limits its potential. Current predictive methods rely on structural and bioinformatics information, which may not be available for all proteins, and they have limited ability to identify beneficial mutations outside of the active site. Machine learning methods show promise but require large training datasets. This study demonstrates the use of NMR spectroscopy to identify mutagenic hot spots in enzymes, providing a simple and a priori knowledge-free approach for directed enzyme evolution.
Article
Chemistry, Multidisciplinary
Rohit Batra, Troy D. Loeffler, Henry Chan, Srilok Srinivasan, Honggang Cui, Ivan Korendovych, Vikas Nanda, Liam C. Palmer, Lee A. Solomon, H. Christopher Fry, Subramanian K. R. S. Sankaranarayanan
Summary: Peptide materials have a wide range of functions, but increasing the sequence length leads to a larger number of candidate sequences. Traditional design methods guided by human expertise and intuition are not easily scalable or free from bias. This article introduces a machine learning-based computational search engine that efficiently discovers peptide sequences with high self-assembly potential, overcoming human bias and accelerating peptide discovery.
Article
Chemistry, Multidisciplinary
Wei Luo, Hironaga Noguchi, Chen Chen, Yoshiki Nakamura, Chishu Homma, Oleksii Zozulia, Ivan Korendovych, Yuhei Hayamizu
Summary: Researchers demonstrate a novel nanoarchitecture based on self-assembled short peptides on a graphite surface, which exhibits catalytic activity comparable to natural enzymes and forms highly ordered and uniform structures. This new approach has the potential to create highly efficient and practical electrocatalysts.
