Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 28, Pages 25054-25065Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b07557
Keywords
ulcerative colitis; Turkish galls; gallotannins; TGTs-Fe-III microcapsules; self-assembly
Funding
- National Natural Science Foundation of China [81560699, 81760756]
- Young and Middle-Aged Scientific and Technological Innovation Leading Talent Program of the Production and Construction Corps [2016BC001]
- Outstanding Young Scientific Personnel Training Plan of Shihezi University [2015-ZRKXJQ08]
- Achievement Transformation and Technology Promotion Plan of Shihezi University [CGZH201806]
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Ulcerative colitis (UC) has been listed as one of the refractory diseases of modern society by the World Health Organization. Our previous studies found that Turkish galls Gallotannins (TGTs) have a significant effect on anti-UC. Here, TGTs were extracted using a simple method and TGTs-Fe-III microcapsules were prepared by a self-assembly technique. Micro-capsules were characterized by liquid chromatography-mass spectrometry, scanning electron microscopy, and so forth. The results verified that hollow spheres of TGTs-Fe-III microcapsules were successfully prepared. It is interesting that microcapsules were more likely to accumulate on the inflammatory surface from ex vivo and in vivo adhesion experiments, and effectively alleviate UC symptoms. This study will provide valuable insight into the development of safe and efficient drug delivery system platforms for further biomedical usages.
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