Article
Chemistry, Physical
Wen-chan Ji, Ping Hu, Xiao-yu Wang, Bo Chen, Tian Chang, Fairy Fan Yang, Qi-gao Cao, Wen Zhang, Rui Dang, Kuai-she Wang
Summary: This paper optimized a one-step carbothermal reduction method for producing Fe3O4 nanoparticles with small size, strong magnetism, and high heating rates. The influence of alternating magnetic field parameters on heating rates was studied, leading to the identification of the optimal heating conditions under specific parameters.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biochemistry & Molecular Biology
Santosh L. Gawali, Sandeep B. Shelar, Jagriti Gupta, K. C. Barick, P. A. Hassan
Summary: A facile approach for the preparation of protein conjugated glutaric acid functionalized Fe3O4 magnetic nanoparticles is reported, showing improved colloidal stability and heating efficacy in different media. These nanoparticles exhibit good stability and superparamagnetism, with enhanced heating efficacy compared to the original nanoparticles due to surface passivation by protein. Additionally, they demonstrate biocompatibility with normal cells and substantial cellular internalization in cancer cells, suggesting potential application in hyperthermia therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
N. A. Usov, R. A. Rytov, V. A. Bautin
Summary: Detailed calculations of the specific absorption rate (SAR) of dilute iron oxide nanoparticles with effective uniaxial anisotropy dispersed in a liquid were performed, showing different behaviors depending on particle diameters and the alternating magnetic field, with the relationship to viscosity being dependent on nanoparticle size. The behavior of SAR was explained by viscous and magnetic oscillation modes, with SAR practically independent of viscosity in the magnetic mode.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Xiang Yu, Tianyu Yang, Ruoshui Liu, Di'an Wu, Daming Tian, Tianshi Zhou, Haitao Yan, Shuli He, Hao Zeng
Summary: In this study, the efficiency of alternating current magnetic field and near-infrared heating is enhanced by co-doping Zn and Co in magnetite nanoparticles. Optimum magnetic anisotropy is achieved by tuning the doping concentration to maximize the loss power under each magnetic field. The specific loss power of the nanoparticles greatly exceeds previous levels, making it a promising nanoplatform for multi-modal local hyperthermia therapy.
Article
Chemistry, Physical
Anastasiia Kobyliukh, Karolina Olszowska, Marcin Godzierz, Aleksandra Kordyka, Jerzy Kubacki, Yevgen Mamunya, Slawomira Pusz, Ivanka Stoycheva, Urszula Szeluga
Summary: Various facile approaches were used to prepare hybrids of graphene nanoplatelets and graphene oxide with iron oxides nanoparticles. The effects of graphene material and preparation procedures on the hybrids' structural characteristics were studied, and potential applications in various fields were discussed.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Alexandra Maier, Rogier van Oossanen, Gerard C. van Rhoon, Jean-Philippe Pignol, Iulian Dugulan, Antonia G. Denkova, Kristina Djanashvili
Summary: Heterostructured magnetic nanoparticles have great potential in biomedical applications due to their ability to express multiple functionalities in a single structure. Their magnetic properties are influenced by the morphology and composition of the nanoparticles, which in turn depend on the synthetic conditions. Incorporation of a non-magnetic heterometal also affects the final magnetic behavior. This study focuses on palladium/iron oxide nanoparticles for combined brachytherapy and MRI-guided hyperthermia of tumors. The synthetic mechanisms and their effects on the magnetic properties of the nanoparticles were investigated. The results revealed the most relevant synthetic parameters leading to promising performance in hyperthermia and MRI.
Article
Chemistry, Multidisciplinary
O. M. Lemine, Saja Algessair, Nawal Madkhali, Basma Al-Najar, Kheireddine El-Boubbou
Summary: This study reports the self-heating mechanisms of magnetite nanoparticles (MNPs) prepared by the Ko-precipitation Hydrolytic Basic (KHB) method. The MNPs exhibit favorable heating responses under magnetic excitation, making them promising candidates for magnetically triggered biomedical hyperthermia applications.
Article
Materials Science, Multidisciplinary
Jakub Musial, Andrzej Skumiel, Rafal Bielas
Summary: This study investigates the calorimetric effect in iron oxide-containing ferrogels when exposed to a high-frequency rotating magnetic field. The heating efficiency of the rotating magnetic field was found to be approximately twice as effective as an equivalent alternating field in the experiments. The specific loss power exhibited a decreasing trend with the increase in magnetic nanoparticle concentration and the decrease in magnetic field strength.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Physics, Applied
Suko Bagus Trisnanto, Yasushi Takemura
Summary: The coexisting Neel and Brownian relaxation behaviors of magnetic nanoclusters in a viscous medium result in a highly nonlinear field-dependent magnetization response. Spectroscopic susceptometry and static magnetometry were used to assess the frequency-dependent complex magnetic susceptibility and predict effective core sizes, respectively. The different estimates of the effective Neel relaxation time constant from frequency-dependent and static magnetization responses indicate the activation energies limiting the relaxation behavior of magnetic nanoclusters.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Shaghayegh Kohzadi, Najmeh Najmoddin, Hadi Baharifar, Mahdi Shabani
Summary: This study investigates the use of graphene oxide (GO) decorated with superparamagnetic iron oxide nanoparticles (SPION), polyethylene glycol functionalized SPION (GO/SPION@PEG), and chitosan functionalized SPION (GO/SPION@CS) to control the outbreak of diseases such as cancer and coronavirus. The results show that these nanocomposites have high magnetization, absorption rate, and cytotoxicity against cancer cells, as well as neutralizing properties against the SARS-CoV-2 virus.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liliana P. Ferreira, Cesar P. Reis, Tiago T. Robalo, M. E. Melo Jorge, Paula Ferreira, Joana Goncalves, Abdollah Hajalilou, Maria Margarida Cruz
Summary: Magnetite nanoparticles were synthesized using gelatin, agar-agar, or pectin as additives, achieving a higher reproducibility of the particle morphology and magnetic characteristics.
Article
Chemistry, Multidisciplinary
Diana Zahn, Joachim Landers, Juliana Buchwald, Marco Diegel, Soma Salamon, Robert Mueller, Moritz Koehler, Gernot Ecke, Heiko Wende, Silvio Dutz
Summary: This paper describes the preparation and magnetic properties of large single domain iron oxide nanoparticles. The particles exhibit single domain ferrimagnetic behavior and their properties are size-dependent. Additionally, the particles show promising potential for magnetic hyperthermia applications.
Article
Chemistry, Multidisciplinary
Tamas Veres, Constantinos Voniatis, Kristof Molnar, Daniel Nesztor, Daniella Feher, Andrea Ferencz, Ivan Gresits, Gyorgy Thuroczy, Bence Gabor Markus, Ferenc Simon, Norbert Marcell Nemes, Mar Garcia-Hernandez, Lilla Reiniger, Ildiko Horvath, Domokos Mathe, Krisztian Szigeti, Etelka Tombacz, Angela Jedlovszky-Hajdu
Summary: The aim of this study was to synthesize an implantable, biodegradable membrane infused with magnetite nanoparticles for long-term treatment and MRI contrast. The results showed excellent MRI contrast, superparamagnetic properties, and biocompatibility of the membrane.
Review
Chemistry, Multidisciplinary
Julian Palzer, Lea Eckstein, Ioana Slabu, Oliver Reisen, Ulf P. Neumann, Anjali A. Roeth
Summary: Iron oxide nanoparticle-based hyperthermia is a promising emerging field in cancer treatment, primarily achieved through magnetic fluid hyperthermia and photothermal therapy. Both methods show potential as tools in cancer treatment and are explored for gastrointestinal malignancies.
Article
Materials Science, Biomaterials
Cristina de la Encarnacion, Felix Jungwirth, David Vila-Liarte, Carlos Renero-Lecuna, Safiyye Kavak, Inaki Orue, Claire Wilhelm, Sara Bals, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Hyperthermia has been shown to be an effective and selective cancer therapy strategy by heating malignant cells above 42 degrees C to trigger cell death. Magnetic and photothermal hyperthermia can benefit from the use of nanomaterials. This hybrid colloidal nanostructure, consisting of plasmonic gold nanorods covered by a silica shell and subsequently grown with iron oxide nanoparticles, is responsive to both external magnetic fields and near-infrared irradiation, enabling targeted magnetic separation and photothermal heating.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Fei Gao, Tingbin Zhang, Xiaoli Liu, Anujit Ghosal, Dan Wang, Wensheng Xie, Yongsan Li, Xing Wang, Lei Tao, Jing Yu, Yen Wei, Hai Ming Fan, Lingyun Zhao
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Engineering, Biomedical
Wei Zhang, Yan Wen, Dong-Xuan He, Yi-Feng Wang, Xiao-Li Liu, Chan Li, Xing-Jie Liang
Article
Chemistry, Multidisciplinary
Xiaoli Liu, Bin Yan, Yao Li, Xiaowei Ma, Wangbo Jiao, Kejian Shi, Tingbin Zhang, Shizhu Chen, Yuan He, Xing-Jie Liang, Haiming Fan
Article
Chemistry, Multidisciplinary
Yao Li, Xiao Zhao, Xiaoli Liu, Keman Cheng, Xuexiang Han, Yinlong Zhang, Huan Min, Guangna Liu, Junchao Xu, Jian Shi, Hao Qin, Haiming Fan, Lei Ren, Guangjun Nie
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Xiaoli Liu, Yifan Zhang, Yu Guo, Wangbo Jiao, Xiao Gao, Wee Siang Vincent Lee, Yanyun Wang, Xia Deng, Yuan He, Ju Jiao, Ce Zhang, Guoqing Hu, Xing-Jie Liang, Haiming Fan
Summary: A strategy is described to induce a succession of magnetoresponses in magnetic nanovehicles by employing sequential EF frequencies, aiming to achieve cascaded tissue penetration and nuclear accumulation. Programming the order of low frequency and medium frequency EF operations enables effective delivery of 86.2% drug into the nucleus by DOX-PI/FVIOs.
Review
Chemistry, Medicinal
Yihan Zhang, Xiao Gao, Bin Yan, Nana Wen, Wee Siang Vincent Lee, Xing-Jie Liang, Xiaoli Liu
Summary: Magnetic hyperthermia (MHT) utilizes magnetic iron oxide nanoparticles to heat up in an alternating magnetic field, triggering biological effects for tumor killing. Combining MHT with immunotherapy can enhance antitumor effects synergistically, preventing cancer recurrence and metastasis, and prolonging survival.
Article
Nanoscience & Nanotechnology
Gwendolyn Jia Hao Lim, Zeshi Yang, Yi Hou, Pon Janani Sugumaran, Zhi Qiao, Jun Ding, Wentao Yan, Yong Yang
Summary: This study demonstrates the well-controlled alignment of silicon carbide nanowires (SiCNW) in a silicone matrix using direct ink writing (DIW)-based 3D printing. The optimized alignment leads to a significant improvement in both reflection loss (RL) and effective attenuation bandwidth (EAB). DIW can play an important role in materials design for high-efficiency microwave attenuation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Chen Liu, Bin Yan, Nana Wen, Wenqi Li, Jing Wang, Hugang Li, Siyao Wang, Kejian Shi, Xiaoli Liu
Summary: Effective diagnosis and treatment of cancer remain a major challenge in modern medicine. The emergence of immunotherapy has revolutionized cancer research, but drug toxicity and low responsive rates are major concerns in current treatment approaches. Magnetic nanoparticles, with their advantages of biocompatibility, low toxicity, and high responsivity to external stimuli, offer a novel and effective way to enhance the anti-tumor immune response when combined with dendritic cell immunotherapy.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Yupeng Cao, Xiaohan Zhou, Xiaoli Liu, Mei Yang, Wentao Liu, Dong Han
Summary: Fluorine-19 (F-19) MRI is a method that can accurately quantify biomedical research and clinical applications without background interference. However, its applicability is limited by the dependence on high-field MRI systems. The development of F-19 MRI at low-field MRI devices can promote its translation in medical diagnosis. In this study, a hardware-friendly ultra-short echo time (UTE) imaging method called k-space scaling imaging (KSSI) MRI sequence was introduced, which enabled F-19 MRI compatible with low-field MRI systems. The experiments demonstrated the feasibility and sensitivity of KSSI in imaging, as well as the potential for clinical translation of fluorine probes at low-field MRI systems.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Siyao Wang, Nana Wen, Bin Yan, Xuan Wang, Zhiye Cai, Yao Li, Xiaoli Liu
Summary: In this study, rugby ball-shaped magnetic microcapsules were developed as efficient agents for magnetic hyperthermia (MH). The size and shape of the microcapsules can be precisely controlled, and they showed excellent thermal conversion efficiency. In vivo anti-tumor studies on mice demonstrated that MH mediated by these microcapsules effectively inhibited the advancement of hepatocellular carcinoma. The porous structure of the microcapsules also allows for efficient loading of therapeutic drugs and functional species, making them ideal candidates for medical applications.
Article
Biology
Yuan He, Xiaoyong Chen, Ye Zhang, Yanyun Wang, Mengyao Cui, Galong Li, Xiaoli Liu, Haiming Fan
Summary: This study investigated the effect of magnetic field stimulation on the peroxidase activity of IONPs with different magneto-thermal conversion abilities. It was found that the activity was effectively amplified without solution temperature rise, and the degree of enhancement was closely related to the magnetic heating ability of the IONPs.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Pon Janani Sugumaran, Yong Yang, Yanyun Wang, Xiaoli Liu, Jun Ding
Summary: The study focuses on examining the magnetic shape anisotropy of iron oxide nanorods of different lengths and aspect ratios to achieve higher hysteresis loss for better hyperthermia efficiency. The results show that nanorods with lower aspect ratio performed better in terms of hysteresis loss and specific absorption rate.
ACS APPLIED BIO MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Penggao Dai, Wenjing Zhu, Bin Yan, Yuqing Miao, Shanshuang Hu, Xiao Gao, Xiaoli Liu, Yifan Zhang, Galong Li, Tingbin Zhang, Huan Zhang, Haiming Fan
Summary: The study demonstrates that manipulation of magnetothermal-related gene expression can enhance the therapeutic efficacy of magnetic nanoparticle-mediated magnetothermal therapy (MTT), with ID4 gene playing a key role in sensitizing breast cancer cells for efficient MTT.
ADVANCED THERAPEUTICS
(2021)
Article
Chemistry, Physical
Xiaowei Ma, Yanyun Wang, Xiao-Li Liu, Huijun Ma, Galong Li, Yao Li, Fei Gao, Mingli Peng, Hai Ming Fan, Xing-Jie Liang
NANOSCALE HORIZONS
(2019)