Article
Biochemical Research Methods
Yaru Xing, Yu Liu, Rifei Chen, Yuyan Li, Chengzhi Zhang, Youwei Jiang, Yao Lu, Bingcheng Lin, Peizhong Chen, Ruijun Tian, Xianming Liu, Xing Cheng
Summary: This study addresses the scalability and reliability issues of low-cost printed circuit board digital microfluidic platforms by using active-matrix circuitry. The reliable actuation of aqueous and organic droplets using a free-standing double-layer hydrophobic membrane demonstrates the versatility of the platform. By implementing these improvements, a fully automatic, scalable, robust, reusable, and low-cost digital microfluidic platform capable of parallel manipulation of a large number of droplets can be realized for various applications in chemical engineering, bioengineering, and biomedical engineering.
Article
Nanoscience & Nanotechnology
Zizheng Wang, Hao Jiang, Guangfu Wu, Yi Li, Teng Zhang, Yi Zhang, Xueju Wang
Summary: This study reports a method for programmable three-dimensional microfluidic structures assembled from polydimethylsiloxane (PDMS) and shape-memory polymers (SMPs). The approach allows for the creation of diverse geometries and the ability to program temporary shapes, with well-maintained fluid flow during deformation and shape recovery.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Acoustics
Arthur Luiz Baiao Dias, Ana Carolina de Aguiar, Mauricio A. Rostagno
Summary: This study provides a comprehensive assessment of high-pressure systems, specifically supercritical fluid extraction and pressurized liquid extraction assisted by ultrasound, as emerging technologies for extracting bioactive compounds from natural products. The extraction mechanisms, applications, and the influence of operational parameters in the process are addressed, along with an analysis of the main challenges for widespread application.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Maryam Farahmandi, Yadollah Yamini, Mahroo Baharfar, Monireh Karami
Summary: A customized microfluidic system was utilized for magnetic solid phase extraction of parabens, achieving efficient extraction and magnetic separation. Magnetite nanoparticles were synthesized and various chemical and instrumental parameters were optimized for characterization and stability of the particles. The method was successfully applied for the extraction of parabens from fruit juice, sunscreen, and urine samples with favorable accuracy and precision.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Feixia Peng, Mei Liu, Xuelian Wang, Xueqin Ding
Summary: This study synthesized two low-viscosity hydrophobic magnetic deep eutectic solvents (HMDESs) and developed a DNA extraction method that can quickly collect DNA using an external magnet. After optimization, the method was capable of extracting DNA from a series of complex samples and was suitable for PCR amplifications.
ANALYTICA CHIMICA ACTA
(2021)
Article
Polymer Science
Haoying Wang, Xiaoxia Song, Junfeng Xiong, U. Kei Cheang
Summary: In this study, bilayer magnetic microrobots with an achiral planar design were fabricated using a biocompatible natural polymer and Fe3O4 nanoparticles. These microrobots demonstrated excellent cell biocompatibility and high mobility, providing a solution for biomedical applications.
Article
Biochemical Research Methods
Mohammad Javad Kiani, Amin Dehghan, Mohammad Saadatbakhsh, Shahin Jamali Asl, Norouz Mohammad Nouri, Esmail Pishbin
Summary: Developing automated platforms for point-of-need testing is crucial worldwide. Robotic digital microfluidics provides precise and inexpensive manipulation of micro/nanoliter droplets, offering a promising solution for integrated testing devices.
Article
Mechanics
Shubham Agrawal, Prashanta K. Das, Purbarun Dhar
Summary: This article explores the theoretical aspects of thermo-capillarity driven hydrodynamics at the interface of an immiscible binary-fluid system within a microfluidic domain. The influence of different governing parameters on thermal and hydrodynamic transport is examined, with full solutions deduced in an analytical framework.
Article
Medical Laboratory Technology
Alexandros A. Sklavounos, Julian Lamanna, Dimpy Modi, Sidharth Gupta, Alex Mariakakis, Jeannie Callum, Aaron R. Wheeler
Summary: A point-of-care hemagglutination system using digital microfluidics and an automated readout tool was developed for rapid blood typing and other blood tests at the bedside. The results of the study demonstrate that the system has the potential to provide rapid and reliable results in high-stakes environments such as trauma centers.
CLINICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Zhixin Xiao, Min Liu, Wentao Bi, David Da Yong Chen
Summary: In-depth studies of extraction mechanism using deep eutectic solvents (DES) and ionic liquids (IL) reveal similarities between the two systems. New applications of ILs and DES in the extraction of nutritional natural products are presented. The study systematically investigates the extraction behavior of ChCl and [HMIm][Cl] in DES and IL, respectively, for target compound extraction from Moringa oleifera leaves. The results show that both extraction methods are based on the formation of a DESys, which can be improved by the formation of a new IL deep eutectic system based on hydrogen bond interaction.
Article
Engineering, Electrical & Electronic
Rahul Eswar, C. Harrison Brodie, Hajer Reguigui, Christopher M. Collier
Summary: Digital microfluidics is utilized in on-site dairy testing to address the challenges of device integration and biofouling. The device developed in this work features a modular and inexpensive design, allowing for reconfiguration and automation. Experimental analyses show that an open system with thin-film dielectric layers is advantageous in reducing and mitigating biofouling.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2023)
Article
Materials Science, Multidisciplinary
Ben Wang, Yun Wang, Jiajia Lin, Yabin Zhang, Xuechang Zhou
Summary: The developed nanocatalysts showed exceptional catalytic properties in water remediation, with improved efficiency and recyclability. The catalysts can be easily collected using a magnet, and their inner liquid metal microdroplets can be recycled by treating them with a base.
APPLIED MATERIALS TODAY
(2023)
Review
Chemistry, Multidisciplinary
A. O. Adeeyo, J. A. Oyetade, M. A. Alabi, R. O. Adeeyo, A. Samie, R. Makungo
Summary: The environmental impact and denaturing propensity of organic solvents are challenges in the extraction of plant bioactives. Tuning water properties offers a greener and efficient alternative with high yield and preserved bioactivities.
Review
Polymer Science
Sazlinda Kamaruzaman, Najihah Mohammad Nasir, Siti Munirah Mohd Faudzi, Noorfatimah Yahaya, Nor Suhaila Mohamad Hanapi, Wan Nazihah Wan Ibrahim
Summary: MIPs, synthetic polymers with predetermined selectivity, are ideal for separation processes and have been widely studied in natural product applications.
Article
Chemistry, Analytical
Lidia Akemi Akamine, Deyber Arley Vargas Medina, Fernando Mauro Lancas
Summary: In this study, a graphene oxide/magnetite (GO-Fe3O4) nanocomposite was synthesized and utilized in the magnetic solid-phase extraction (MSPE) of gingerols from various ginger products. The developed MSPE method combined with HPLC-MS/MS analysis demonstrated high selectivity and consistent analytical confidence, with LODs ranging between 2 and 3 μg L-1. The technique showed good linearity, accuracy, and practicality, making it a valuable tool for quality control of commercial ginger-containing products.
Article
Biochemical Research Methods
Prashant Agrawal, Kyle J. Bachus, Gabrielle Carriere, Phoenix Grouse, Richard D. Oleschuk
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2019)
Article
Microbiology
Marshall L. Timmermans, Katherine J. Picott, Lorena Ucciferri, Avena C. Ross
Review
Biotechnology & Applied Microbiology
Hailey A. Tomm, Lorena Ucciferri, Avena C. Ross
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2019)
Article
Chemistry, Analytical
Saeed Rismani Yazdi, Prashant Agrawal, Erick Morales, Corey A. Stevens, Laura Oropeza, Peter L. Davies, Carlos Escobedo, Richard D. Oleschuk
ANALYTICA CHIMICA ACTA
(2019)
Article
Biochemistry & Molecular Biology
Katherine J. Picott, Julie A. Deichert, Ella M. DeKemp, Victor Snieckus, Avena C. Ross
Article
Biochemical Research Methods
Haidy Metwally, Prashant Agrawal, Rachael Smith, Chang Liu, Yves LeBlanc, Thomas R. Covey, Richard Oleschuk
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2020)
Article
Biology
Audrey K. Gruneberg, Laurie A. Graham, Robert Eves, Prashant Agrawal, Richard D. Oleschuk, Peter L. Davies
Summary: Ice-binding proteins inhibit ice growth through surface adsorption, with different IBPs showing varying levels of ice recrystallization inhibition activity. Differences in IRI activity are seen between IBPs of different sizes and sources.
Article
Biochemistry & Molecular Biology
Neil L. Grenade, Dragos S. Chiriac, A. R. Ola Pasternak, Jonathan L. Babulic, Bronwyn E. Rowland, Graeme W. Howe, Avena C. Ross
Summary: The study reveals the biosynthetic pathways of two structurally similar tambjamine molecules produced by Pseudoalteromonas and Streptomyces, demonstrating the convergence of evolutionary processes in producing structurally similar natural products.
ACS CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Analytical
Jian Yu, Matthias Hermann, Rachael Smith, Hailey Tomm, Haidy Metwally, Jennifer Kolwich, Chang Liu, J. C. Yves Le Blanc, Thomas R. Covey, Avena C. Ross, Richard Oleschuk
Summary: The liquid micro-junction surface sampling probe (LMJ-SSP)-based mass spectrometry imaging (MSI) allows for rapid profiling of natural products from Gram-negative marine bacteria Pseudoalteromonas without sample preparation. By creating a hyperspectral image using a conductance-based autosampling platform and multivariant analysis, different natural products can be quickly identified by color differences. This approach provides an efficient and sensitive strategy for direct and rapid natural product profiling from different Pseudoalteromonas strains.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Amir R. Bunyat-zada, Avena C. Ross
Summary: Recent advances in genome sequencing science have shown that bacteria have a vast potential for producing natural products, and researchers can use bioinformatic tools and experimental methods to study these molecules.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Analytical
Jian Yu, Matthias Hermann, Rachael Smith, Hailey Tomm, Haidy Metwally, Jennifer Kolwich, Chang Liu, J. C. Yves Le Blanc, Thomas R. Covey, Avena C. Ross, Richard Oleschuk
Summary: Mass spectrometry imaging (MSI) has limitations in terms of surface topography and sample preparation. In this study, a conductance-based autosampling platform and multivariant analysis-driven method were used to create a hyperspectral image for the sampling area. Through straightforward color differences, different mass-to-charge ratios (m/z) were annotated. Various natural products were quickly identified, and the dynamic extracellular environment was shown using compound heatmaps. Hyperspectral visualization-based MSI is an efficient strategy for direct and rapid natural product profiling.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Katherine J. Picott, Julie A. Deichert, Ella M. deKemp, Gabriele Schatte, Francoise Sauriol, Avena C. Ross
Article
Biochemical Research Methods
Matthias Hermann, Prashant Agrawal, Iris Koch, Richard Oleschuk