Article
Polymer Science
Wei Ma, Sihan Zhang, Chong Xie, Xing Wan, Xiaofeng Li, Kebing Chen, Guanglei Zhao
Summary: In this study, two types of organic-inorganic composite scaffolds were prepared using modified chitosan and polyvinyl alcohol. The scaffolds displayed interconnected pore and surface nanofiber structures, high porosity, outstanding swelling properties, and controllable degradation rate. The mechanical properties of the scaffolds were significantly improved compared to traditional chitosan scaffolds. Cell experiments confirmed the excellent biocompatibility of the composite scaffolds.
Article
Chemistry, Applied
Salita Demeyer, Anan Athipornchai, Pariya Pabunrueang, Thanida Trakulsujaritchok
Summary: The development of hybrid materials with organic-inorganic co-network molecular structure is a promising method to enhance the stability and mechanical properties of biopolymers. By incorporating plant-derived active compounds into the scaffolds, properties such as physicochemical characteristics and mechanical strength can be improved and tailored for bone tissue engineering applications. Furthermore, the inclusion of bioactive components has been shown to further promote the potential use of the scaffolds in guided bone regeneration applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Geeta Kumari Wasupalli, Devendra Verma
Summary: This study developed a thermosensitive injectable hydrogel based on chitosan and polygalacturonic acid. By optimizing biocompatibility and gelation time, the researchers improved the cellular activity and mechanical properties of the hydrogel. The addition of gelatin and hydrothermally treated PEC fibers showed superior results.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Juliana Domingues dos Santos Carvalho, Renata Santos Rabelo, Klycia Fidelis Cerqueira e Silva, Miriam Dupas Hubinger
Summary: This research investigated the effects of different polymer ratios (HPMC and MC with CHI) on the stability, microstructure, and rheology of emulgels. The results showed that mixing HPMC:CHI or MC:CHI stabilized the oil-in-water emulgels. Both HPMC:CHI and MC:CHI emulgels exhibited gel behavior throughout the entire temperature range studied. Microscopy revealed that the stored emulsions maintained similar characteristics to the fresh emulsion. The emulgels demonstrated good thermal resistance, elastic behavior, and high oil retention.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Katarzyna Pieklarz, Jacek Jenczyk, Zofia Modrzejewska, Piotr Owczarz, Stefan Jurga
Summary: Recent research has shown a trend of hydrogels obtained from chitosan replacing solutions based on synthetic materials in the field of medicine. This study focused on the sol-gel transition of chitosan salt solutions and the influence of cross-linking agents, with particular interest in hydrogels prepared from chitosan lactate for biomedical applications.
Article
Biochemistry & Molecular Biology
Lumin Yang, Xiaoduo Zhao, Yunsong Kong, Renjie Li, Tao Li, Rui Wang, Zhengfeng Ma, Yong-min Liang, Shuanhong Ma, Feng Zhou
Summary: In this study, a novel macromolecular/microsphere-based injectable hydrogel (CMC-ODex NPs) was developed for dual functionalities of drug release and lubrication. The hydrogel exhibited viscosity-thinning phenomenon and gel-sol transition feature, resulting in low friction coefficient at the sliding interface of articular cartilages. The encapsulated anti-inflammatory drug (dexamethasone, DXM) in the hydrogel showed sustainable drug release, leading to good and stable anti-inflammatory effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Inorganic & Nuclear
Mariyam Mariyam, Siti Sunarintyas, Nuryono Nuryono
Summary: Chitosan was added to modify the synthesized white mineral trioxide aggregate (WMTA) in this study. The modified WMTA showed improved antibacterial, mechanical, and adhesive properties. The addition of 4 wt% chitosan resulted in the best performance.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Agathe Heyraud, Francesca Tallia, David Sory, Hung-Kai Ting, Anna Tchorzewska, Jingwen Liu, Hannah L. Pilsworth, Peter D. Lee, John V. Hanna, Sara M. Rankin, Julian R. Jones
Summary: This study introduces a new bioactive hybrid scaffold for bone regeneration. By incorporating calcium ions into a flexible bioglass and using 3D printing technology, the scaffold exhibited excellent mechanical properties and biocompatibility.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Elisa Fiume, Jonathan Massera, Daniele D'Ambrosio, Enrica Verne, Francesco Baino
Summary: This experimental work describes a new method for manufacturing sol-gel bioactive silicate scaffolds using dried gels as basic material within the ink composition. The scaffolds were characterized in terms of morphological-compositional features and bioactivity in simulated body fluid. The results showed the possibility of using robocast sol-gel-derived scaffolds in bone tissue engineering approaches.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Robert Adamski, Dorota Siuta
Summary: Novel bioactive composites based on chitosan and non-organic silica were fabricated using the sol-gel method, reinforced with calcium beta-glycerophosphate, sodium beta-glycerophosphate pentahydrate, and hydroxyapatite powder. The mechanical properties of the hybrid composites were analyzed, microstructure visualized by SEM, molecular interactions examined with FTIR analysis, and biocompatibility evaluated. The developed composite showed well-developed surface porosity that positively influenced cell proliferation and growth, as well as mechanical properties suitable for tissue engineering applications.
Article
Polymer Science
Mahinur Alemdar, Deniz Ceylan Tuncaboylu, Hatice Kubra Batu, Binnur Aydogan Temel
Summary: Temperature responsive Pluronic F127 micelles were combined with light-responsive coumarin bearing amphiphilic copolymers to obtain injectable gels with mechanical strength. The gels were prepared using two different methods and their rheological properties were evaluated. The study suggests that hydrogels based on PF127 and coumarin functional terpolymer amphiphiles have potential as injectable biomaterials.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Applied
Ting-Chieh Chen, Chui-Wei Wong, Shan-hui Hsu
Summary: This study developed a 3D-printable chitosan cryogel using difunctional polyurethane nanoparticles as the crosslinker, which showed properties similar to those of bulk cryogel and provided good mechanical integrity for proliferation and chondrogenic differentiation of human adipose-derived adult stem cells in cell experiments. The 3D-printed chitosan cryogel scaffolds with injectability and shape recovery property are potential biomaterials for customized tissue engineering and minimally invasive surgery.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Applied
Farnoush Sadat Rezaei, Fariborz Sharifianjazi, Amirhossein Esmaeilkhanian, Ehsan Salehi
Summary: Chitosan has shown unparalleled characteristics for regenerative medicine applications, offering biocompatibility, biodegradability, and film-forming capabilities. Recent advances in chitosan films and scaffolds in tissue engineering, wound healing, and drug delivery fields have been surveyed and discussed.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Gamal Abdel Nasser Atia, Hany K. Shalaby, Mehrukh Zehravi, Mohamed Mohamady Ghobashy, Hager Abdel Nasser Attia, Zubair Ahmad, Farhat S. Khan, Abhijit Dey, Nobendu Mukerjee, Athanasios Alexiou, Md. Habibur Rahman, Joanna Klepacka, Agnieszka Najda
Summary: This article examined and summarized the current developments in chitosan-based materials, focusing on the modification of chitosan and its use in periodontal regeneration. The study critically reviewed various preparation and modification techniques to enhance chitosan performance and discussed the uses of chitosan-based products in depth.
Article
Chemistry, Physical
Ricardo Bento, Anuraag Gaddam, Parastu Oskoei, Helena Oliveira, Jose M. F. Ferreira
Summary: This study focuses on the sol-gel synthesis of an alkali-free bioactive glass and its application in robocasting for fabricating porous scaffolds. By adjusting milling procedures and heat treatment temperature, milling efficiency was improved and mesoporous powders' surface area was affected. Rheological tests were conducted on robocasting inks with 35 vol.% solids, and a customizable CAD scaffold geometry script was developed. The printing process was optimized for higher resolution, while the mechanical properties of the scaffolds were evaluated through compressive strength tests. The scaffolds showed good biomineralization activity and biocompatibility with human keratinocytes, indicating their potential for biomedical applications.
Article
Chemistry, Applied
Piotr Owczarz, Magdalena Orczykowska, Anna Ryl, Patryk Ziolkowski
Article
Chemistry, Applied
Jacek Tyczkowski, Hanna Kierzkowska-Pawlak, Ryszard Kapica, Jacek Balcerzak, Jan Sielski
Article
Polymer Science
Jacek Tyczkowski, Jacek Balcerzak, Jan Sielski, Iwona Krawczyk-Klys
Article
Polymer Science
Jacek Tyczkowski, Hanna Kierzkowska-Pawlak, Jan Sielski, Iwona Krawczyk-Klys
Article
Chemistry, Multidisciplinary
Elzbieta Sobiecka, Piotr Jasniewski, Kamila Szymanska, Piotr Owczarz, Tomasz P. Olejnik
PRZEMYSL CHEMICZNY
(2020)
Article
Polymer Science
Anna Ryl, Piotr Owczarz
Article
Chemistry, Applied
Anna Ryl, Piotr Owczarz
Summary: Thermoresponsive colloidal chitosan systems can be used as injectable scaffolds or drug carriers, and the introduction of an external shear field accelerates the aggregation process, potentially leading to spontaneous gelation.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Piotr Owczarz, Anna Ryl, Jaroslaw Sowinski
Summary: The study focused on the impact of using different types of glycerophosphate salts on the gelation properties and phase transition conditions of thermosensitive chitosan systems, highlighting the significant differences in viscoelastic properties observed. The findings indicated that the type of glycerophosphate salt used played a crucial role in the gelation process, with calcium glycerophosphate leading to the fastest gelation and magnesium glycerophosphate delaying gelation due to heat-induced dissolution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Ryl, Piotr Owczarz
Summary: Low shear rates accelerate gelation, while high shear rates prolong gelation time; the highest shear rates may either slow down or speed up gelation, depending on the thixotropic properties of the materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Katarzyna Pieklarz, Jacek Jenczyk, Zofia Modrzejewska, Piotr Owczarz, Stefan Jurga
Summary: Recent research has shown a trend of hydrogels obtained from chitosan replacing solutions based on synthetic materials in the field of medicine. This study focused on the sol-gel transition of chitosan salt solutions and the influence of cross-linking agents, with particular interest in hydrogels prepared from chitosan lactate for biomedical applications.
Article
Materials Science, Biomaterials
Anna Ryl, Piotr Owczarz
PROGRESS ON CHEMISTRY AND APPLICATION OF CHITIN AND ITS DERIVATIVES
(2020)
Article
Materials Science, Biomaterials
Piotr Owczarz, Anna Ryl, Zaneta Wichlacz
PROGRESS ON CHEMISTRY AND APPLICATION OF CHITIN AND ITS DERIVATIVES
(2019)
Article
Engineering, Chemical
Anna Ryl, Piotr Owczarz
CHEMICAL AND PROCESS ENGINEERING-INZYNIERIA CHEMICZNA I PROCESOWA
(2019)
