Article
Immunology
Moritz B. Immohr, Payam Akhyari, Charlotte Bottger, Arash Mehdiani, Hannan Dalyanoglu, Ralf Westenfeld, Daniel Oehler, Igor Tudorache, Hug Aubin, Artur Lichtenberg, Udo Boeken
Summary: CMV infections are associated with complications following heart transplantation. The impact of serologic mismatch and the necessity of prophylactic virostatic medication remain concerns. Different serologic CMV matching did not significantly affect postoperative morbidity, but seropositive recipients had a higher risk for CMV-DNAemia.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Transplantation
Rachel Hellemans, Daniel Abramowicz
Summary: CMV-related complications after kidney transplantation present a significant challenge. Tailoring preventive strategies based on individual patient risk levels can improve outcomes. CMV-specific T-cell assays can help predict CMV risk pre-transplantation. Immunosuppressive regimens including mammalian target of rapamycin inhibitors can reduce CMV risk. New antiviral agents and adoptive T-cell therapy hold promise for future treatment options.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Ophthalmology
Anastasia Tasiopoulou, Cristhian A. Urzua, Susan Lightman
Summary: This study retrospectively analyzed seven cases of patients with systemic lymphoma and CMV retinitis who received treatment from oncologists. The combination of oral and intravitreal antiviral agents resulted in effective disease control.
Article
Virology
Andrea Gilioli, Andrea Messerotti, Paola Bresciani, Angela Cuoghi, Valeria Pioli, Corrado Colasante, Francesca Bettelli, Davide Giusti, Fabio Forghieri, Leonardo Potenza, Francesca Donatelli, Rachele Giubbolini, Laura Galassi, Roberto Marasca, Federico Banchelli, Roberto D'Amico, Monica Pecorari, William Gennari, Tommaso Trenti, Patrizia Comoli, Mario Luppi, Franco Narni
Summary: The study retrospectively analyzed a cohort of patients who underwent HSCT and found that CMV clinically significant infection (CS-CMVi) occurred in 48% of prophylactically treated patients, but it did not impact relapse incidence or overall survival. Additionally, the use of CMV-IG alone as prophylactic therapy did not effectively prevent CMV reactivation.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Jessica Leung, Scott D. Grosse, Bryan Yockey, Tatiana M. Lanzieri
Summary: The study investigated the use of antiviral treatment in 342 US infants with congenital cytomegalovirus. Among them, 33% received ganciclovir (with or without valganciclovir) and 67% received valganciclovir only. The duration of treatment and the timing of initiation differed for the two drugs, with neutropenia being a common side effect.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Review
Biology
Markus J. Barten, Fausto Baldanti, Alexander Staus, Christian M. Hueber, Kyriaki Glynou, Andreas Zuckermann
Summary: This meta-analysis suggests that prophylactic CMVIG treatment in solid organ transplantation patients can reduce the risk of CMV infection. This is particularly beneficial for patients at high risk of CMV infection or disease.
Review
Infectious Diseases
Su Ann Ho, Monica Slavin, Jason A. Roberts, Michelle Yong
Summary: Ganciclovir therapeutic drug monitoring is crucial for optimizing efficacy in selected patient groups, but there is currently no defined pharmacokinetic exposures that correlate with treatment efficacy and toxicity. Prospective clinical studies are needed to clarify this issue.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Letter
Cell & Tissue Engineering
Carla de Castro Sant' Anna, Silvia Regina da Cruz Migone, Carlos Alberto Machado da Rocha, Fernando Augusto Rodrigues Mello, Aline Damasceno Seabra, Thais Brilhante Pontes, Joao Marildo Rodrigues, Salome Aparecida Soares, Viviane de Paiva Rego, Joana Paula Figueira, Ana Paula Monteiro Rodrigues, Rommel Mario Rodriguez Burbano
Summary: This study aimed to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance, which have become a major problem related to high mortality in kidney transplant patients. The study found mutations in CMV genes in kidney transplant patients that are associated with resistance to conventional antivirals.
CELL TRANSPLANTATION
(2023)
Article
Immunology
Shu-Li Yang, Ting-Wei Lin, Hsin-Chieh Lin, Hsin-Yao Wang, Pi-Yueh Chang, Po-Nan Wang, Shuan Yang, Jang-Jih Lu
Summary: This study in Taiwan identified various mutations in the UL54 and UL97 regions of CMV in patients with CMV infections. A subset of patients displayed antiviral resistance mutations in UL54 and UL97, emphasizing the need to determine genetic profiles of UL54 and UL97 in immunocompromised populations with refractory CMV infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Hematology
Po-Hsien Li, Cheng-Hsien Lin, Yu-Hui Lin, Tsung-Chih Chen, Chiann-Yi Hsu, Chieh-Lin Jerry Teng
Summary: The study suggests that low-dose valganciclovir prophylaxis may be an effective strategy to prevent CMV infection in patients undergoing allo-HSCT, particularly in resource-limited countries.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2021)
Review
Immunology
Narisa Ruenroengbun, Tunlanut Sapankaew, Kamolpat Chaiyakittisopon, Pakpoom Phoompoung, Thundon Ngamprasertchai
Summary: This study evaluated and ranked the drugs for allograft rejection prevention following CMV prophylaxis in high-risk kidney transplant patients. Valganciclovir was considered the most effective and safest drug, while valacyclovir was the optimal alternative. Dose-related toxicities and patient compliance should be closely monitored.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Kjersti B. Blom, Grete K. Birkeland, Karsten Midtvedt, Trond G. Jenssen, Anna V. Reisaeter, Halvor Rollag, Anders Hartmann, Solbjorg Sagedal, Ivar Sjaastad, Garth Tylden, Gro Njolstad, Einar Nilsen, Andreas Christensen, Anders Asberg, Jon A. Birkeland
Summary: This study compares the long-term outcomes of prophylactic and preemptive CMV preventive strategies in kidney transplant recipients. The study found that there were no significant differences in long-term outcomes such as patient death and graft loss between the two strategies in D+/R- kidney transplant recipients.
Article
Hematology
Joshua A. Hill, Danniel Zamora, Hu Xie, Laurel A. Thur, Colleen Delaney, Ann Dahlberg, Steven A. Pergam, Wendy M. Leisenring, Michael Boeckh, Filippo Milano
Summary: Letermovir is effective in preventing clinically significant CMV infection after CBT, but there is a higher incidence of delayed-onset infections after discontinuation, requiring close monitoring and consideration for extended prophylaxis.
Review
Immunology
Dipesh Kumar Yadav, Vishnu Prasad Adhikari, Rajesh Kumar Yadav, Alina Singh, Xing Huang, Qi Zhang, Prabesh Pandit, Qi Ling, Tingbo Liang
Summary: This meta-analysis compared the outcomes of antiviral prophylaxis and preemptive therapy for the prevention of cytomegalovirus (CMV) infection in liver transplant recipients. The results showed that antiviral prophylaxis reduced the incidence of CMV infection in the high-risk group, while preemptive therapy reduced the incidence of late-onset CMV disease. There were no significant differences in other outcomes between the two interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Chieh-Lin Jerry Teng, Po-Nan Wang, Yee-Chun Chen, Bor-Sheng Ko
Summary: CMV infection is a common and severe complication of allo-HSCT in Taiwan due to high CMV seropositivity in the population. A CMV management strategy focusing on monitoring, prophylaxis, and treatment is proposed, including weekly monitoring with the COBAS (R) AmpliPrep system, a 14-week prophylactic course of letermovir for allo-HSCT recipients, and preemptive ganciclovir therapy when CMV viral load exceeds 1000 copies/mL. Limited availability of foscarnet is a crucial issue for patients not responsive to ganciclovir in Taiwan.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Substance Abuse
Alan Manivannan, Morten Schou, Kevin M. Monahan, Robert Helm, Darae Ko, Emil Fosbol, Lars Kober, Finn Gustafsson, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson
Summary: Alcoholic cardiomyopathy (ACM) is associated with poor outcomes, but the high mortality is not driven by atrial fibrillation. Oral anticoagulation in ACM has similar stroke and bleeding risks as in dilated cardiomyopathy.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Endocrinology & Metabolism
Niels H. Brandt-Jacobsen, Mikkel Jurgens, Philip Hasbak, Peter Gaede, Peter Rossing, Jon J. Rasmussen, Camillla Fuchs Andersen, Julie L. Forman, Jens Faber, Silvio E. Inzucchi, Finn Gustafsson, Morten Schou, Caroline Kistorp
Summary: This study investigated the effects of short-term empagliflozin therapy on cardiac adipose tissue accumulation in patients with type 2 diabetes. The results showed that empagliflozin can reduce cardiac adipose tissue accumulation and improve weight and glucose metabolism. However, no correlation was observed between changes in cardiac volumetrics and cardiac adipose tissue accumulation.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Abbas Ali Qayyum, Mette Mouridsen, Brian Nilsson, Ida Gustafsson, Morten Schou, Olav Wendelboe Nielsen, Jens Dahlgaard Hove, Anders Bruun Mathiasen, Erik Jorgensen, Steffen Helqvist, Francis Richard Joshi, Ellen Monsted Johansen, Bjarke Follin, Morten Juhl, Lisbeth Drozd Hojgaard, Mandana Haack-Sorensen, Annette Ekblond, Jens Kastrup
Summary: This study aimed to investigate the efficacy of allogeneic cell therapy for chronic ischaemic heart failure. Injections of Cardiology Stem Cell Centre Adipose tissue derived mesenchymal Stromal Cell (CSCC_ASC) were used as an add-on therapy, but no improvement in myocardial function, structure, or clinical symptoms was observed.
Article
Immunology
Signe Marie Wulff, Michael Perch, Jannik Helweg-Larsen, Pia Bredahl, Maiken Cavling Arendrup, Jens Lundgren, Marie Helleberg, Cornelia Geisler Crone
Summary: Early diagnosis and treatment of cytomegalovirus (CMV) and invasive aspergillosis (IA) can improve outcomes for lung transplant recipients (LTXr). This study examined the rates of CMV after IA and vice versa, and found that the risk of CMV was high in the first 3 months after IA, while the risk of IA was significantly increased in the first 3 months after CMV. Systematic screening for CMV following the diagnosis of IA, and vice versa, may improve timeliness of diagnosis and outcomes for LTXr.
Article
Cardiac & Cardiovascular Systems
Karoline Amalie Rask, Tania Deis, Johan Erik Larsson, Kasper Rossing, Finn Gustafsson
Summary: Hyponatremia is associated with worse outcomes in patients with chronic heart failure and reduced ejection fraction (HFrEF). This study aimed to investigate the potential association between hemodynamic derangement and hyponatremia in HFrEF patients. The study included 502 HFrEF patients who underwent a right heart catheterization. The results showed that lower sodium levels were associated with more deranged invasive hemodynamic measurements and hyponatremia was significantly associated with a composite endpoint in these patients.
Editorial Material
Immunology
Jens Lundgren
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Morten H. Malmborg, Ali Assad Turky Al-Kahwa, Lars D. Kober, Christian K. Torp-Pedersen, Jawad Butt, Deewa Zahir, Christian Tuxen, Mikael Poulsen, Christian Madelaire, Emil Fosbol, Gunnar Gislason, Per Hildebrandt, Charlotte Andersson, Finn Gustafsson, Morten Schou
Summary: This study found that continued follow-up in specialized heart failure clinics did not improve long-term outcomes in HFrEF patients who had already received guideline-directed therapy. There is a need for the development and implementation of new monitoring strategies.
Article
Infectious Diseases
Mark P. Khurana, Sabiha Essack, Ghada Zoubiane, Nandini Sreenivasan, Gloria Cristina Cordoba, Erica Westwood, Anders Dalsgaard, Robinson H. Mdegela, Mirfin Mpundu, Rodrigo Scotini, Augustine B. Matondo, Alexanda Mzula, Nina Chanishvili, Dimitri Gogebashvili, Maia Beruashvili, Marika Tsereteli, Talant Sooronbaev, Jesper Kjaergaard, Joakim Bloch, Elvira Isaeva, Geoffrey Mainda, Geoffrey Muuka, Ntombi B. Mudenda, Fusya Y. Goma, Duc-Huy Chu, Duncan Chanda, Uchizi Chirwa, Kaunda Yamba, Kenneth Kapolowe, Sombo Fwoloshi, Lawrence Mwenge, Robert Skov
Summary: Despite the increasing burden of AMR, the global response has been insufficient, particularly in LMICs. The implementation of national action plans to combat AMR has been delayed due to resource constraints, coordination issues, and a lack of technical capacity. Tailored and sustainable AMR interventions require multidisciplinary IIR, which involves quantitative and qualitative approaches across different phases and domains. IR provides a practical framework for implementing evidence-based and sustainable AMR mitigation interventions.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Geriatrics & Gerontology
Alexandros Katsiferis, Laust Hvas Mortensen, Mark P. Khurana, Swapnil Mishra, Majken Karoline Jensen, Samir Bhatt
Summary: A prognostic model based on health care spending patterns can predict 1-year mortality for individuals aged 65+ presenting at the emergency department with a fall, guiding clinical decision-making. The study shows that health care spending patterns significantly improve predictive accuracy and demonstrate good performance and clinical benefit.
Letter
Cardiac & Cardiovascular Systems
Jawad H. Butt, Adelina Yafasova, Seiko N. Doi, Jens C. Nielsen, Jens Haarbo, Hans Eiskjaer, Axel Brandes, Anna M. Thogersen, Finn Gustafsson, Christian Hassager, Jesper H. Svendsen, Dan E. Hofsten, Lars Videbaek, Christian Torp-Pedersen, Steen Pehrson, Jens Jakob Thune, Lars Kober
Letter
Cardiac & Cardiovascular Systems
Seiko Nakajima Doi, Jens Jakob Thune, Jens Cosedis Nielsen, Jens Haarbo, Lars Videbaek, Rasmus Rorth, Soren Lund Kristensen, Niels Eske Bruun, Finn Gustafsson, Hans Eiskjaer, Christian Hassager, Jesper Hastrup Svendsen, Dan Eik Hofsten, Christian Torp-Pedersen, Steen Pehrson, Lars Kober, Jawad Haider Butt
CIRCULATION-HEART FAILURE
(2023)
Article
Oncology
C. Terrones-Campos, B. Ledergerber, N. Forbes, A. G. Smith, J. Petersen, M. Helleberg, J. Lundgren, L. Specht, I. R. Vogelius
Summary: This study investigated the association between mean heart dose (MHD) and radiation-induced lymphopenia, and explored the impact of end-of-radiation-therapy (EoRT) lymphocyte count on clinical outcomes.
Article
Endocrinology & Metabolism
Mikkel Jurgens, Morten Schou, Philip Hasbak, Andreas Kjaer, Emil Wolsk, Bo Zerahn, Niels H. Brandt-Jacobsen, Peter Gaede, Peter Rossing, Jens Faber, Silvio E. Inzucchi, Finn Gustafsson, Caroline Kistorp
Summary: Empagliflozin has been found to reduce measured glomerular filtration rate (mGFR), estimated plasma volume (PV), and estimated extracellular volume (ECV) in patients with type 2 diabetes (T2D) and high risk of cardiovascular events. The 13-week randomized controlled trial showed a decrease in mGFR, ECV, and PV with the use of the drug.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Finn Gustafsson
Summary: Catheter-based creation of atrial shunts to relieve left atrial hypertension is being investigated as a treatment for heart failure. Trials so far have shown safety and efficacy in reducing left-sided cardiac filling pressures, and ongoing trials will determine the impact on clinical outcomes.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sasha A. S. Kjeldsen, Lise L. Gluud, Mikkel P. Werge, Julie S. Pedersen, Flemming Bendtsen, Kleopatra Alexiadou, Tricia Tan, Signe S. Torekov, Eva W. Iepsen, Nicole J. Jensen, Michael M. Richter, Jens P. Goetze, Jorgen Rungby, Bolette Hartmann, Jens J. Holst, Birgitte Holst, Joachim Holt, Finn Gustafsson, Sten Madsbad, Maria S. Svane, Kirstine N. Bojsen-Moller, Nicolai J. Wewer Albrechtsen
Summary: Inhibitors of neprilysin improve glycemia in patients with heart failure and type 2 diabetes. NEPa, but not neprilysin protein, was enhanced in obesity, T2D, and MASLD. MASLD may drive exaggerated NEPa, and lowered NEPa following bariatric surgery or liraglutide therapy may contribute to the reported improved cardiometabolic effects.