Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

Irisin serum levels are positively correlated with bone mineral status in a population of healthy children

(2019) Graziana Colaianni et al.   PEDIATRIC RESEARCH

A novel interplay between irisin and PTH: from basic studies to clinical evidence in hyperparathyroidism

(2019) Andrea Palermo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6–8 years of age – The Physical Activity and Nutrition in Children (PANIC) study

(2018) Sonja Soininen et al.   BONE

High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

(2018) Maria Felicia Faienza et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients

(2018) Lian He et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Irisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial

(2018) Alberto Osella et al.   Nutrients

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Association of “Weekend Warrior” and Other Leisure Time Physical Activity Patterns With Risks for All-Cause, Cardiovascular Disease, and Cancer Mortality

(2017) Gary O’Donovan et al.   JAMA Internal Medicine

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

(2017) Graziana Colaianni et al.   Scientific Reports

High Sclerostin and Dickkopf-1 (DKK-1) serum levels in children and adolescents with type 1 diabetes mellitus

(2016) Maria Felicia Faienza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-α

(2016) G. Brunetti et al.   OSTEOPOROSIS INTERNATIONAL

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

(2015) Andrea Palermo et al.   CLINICAL ENDOCRINOLOGY

Parathyroid hormone: anabolic and catabolic actions on the skeleton

(2015) Barbara C Silva et al.   CURRENT OPINION IN PHARMACOLOGY

Type 1 Diabetes Is Associated With an Increased Risk of Fracture Across the Life Span: A Population-Based Cohort Study Using The Health Improvement Network (THIN)

(2015) David R. Weber et al.   DIABETES CARE

Interplay of atherogenic factors, protein intake and betatrophin levels in obese–metabolic syndrome patients treated with hypocaloric diets

(2015) A B Crujeiras et al.   INTERNATIONAL JOURNAL OF OBESITY

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

(2015) Dennis Löffler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The myokine irisin increases cortical bone mass

(2015) Graziana Colaianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update on childhood bone health

(2015) Aviva B. Sopher et al.   Current Opinion in Endocrinology Diabetes and Obesity

Leisure Time Physical Activity and Mortality

(2015) Hannah Arem et al.   JAMA Internal Medicine

Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

(2014) Athanasios D. Anastasilakis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Longitudinal Tracking of Dual-Energy X-ray Absorptiometry Bone Measures Over 6 Years in Children and Adolescents: Persistence of Low Bone Mass to Maturity

(2014) Tishya A.L. Wren et al.   JOURNAL OF PEDIATRICS

Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months

(2014) A. D. Anastasilakis et al.   OSTEOPOROSIS INTERNATIONAL

Optimizing Bone Health in Children and Adolescents

(2014) N. H. Golden et al.   PEDIATRICS

Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates

(2014) Vibha Singhal et al.   PLoS One

High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption

(2014) Yoshifumi Tsuchiya et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes

(2014) Theerawut Klangjareonchai et al.   International Journal of Endocrinology

Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

(2013) Rocio de la Iglesia et al.   CLINICAL ENDOCRINOLOGY

Association between bone mineral density and type 1 diabetes mellitus: a meta-analysis of cross-sectional studies

(2013) Hong Pan et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Effects of lifestyle modification on metabolic syndrome: a systematic review and meta-analysis

(2012) Kazue Yamaoka et al.   BMC Medicine

The Metabolic Syndrome Predicts Cardiovascular Events: Results of a 13-Year Follow-Up in Initially Healthy 58-Year-Old Men

(2012) Caroline Schmidt et al.   Metabolic Syndrome and Related Disorders

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Glucocorticoid-Induced Osteoporosis in Children with 21-Hydroxylase Deficiency

(2012) Annamaria Ventura et al.   Biomed Research International

Exercise and T2DM—move muscles more often!

(2011) David Dunstan   Nature Reviews Endocrinology

Effect of puberty on body composition

(2011) Lindsey A Loomba-Albrecht et al.   Current Opinion in Endocrinology Diabetes and Obesity

Simulated resistance training during hindlimb unloading abolishes disuse bone loss and maintains muscle strength

(2009) Joshua M Swift et al.   JOURNAL OF BONE AND MINERAL RESEARCH