Article
Oncology
Jiajia Hu, Runjie Huang, Chengcai Liang, Yingnan Wang, Min Wang, Yanxing Chen, Chenyi Wu, Jinling Zhang, Zekun Liu, Qi Zhao, Zexian Liu, Feng Wang, Shuqiang Yuan
Summary: This study identifies TRIM50 as a novel coordinator in gastric cancer cells, with the ability to suppress gastric cancer cell growth and migration. Through ubiquitination, TRIM50 regulates the nuclear translocation of transcription factor JUP, thereby inhibiting the MYC signaling pathway. These findings provide a potential target for the development of new gastric cancer treatment strategies.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Markus A. Brown, Thomas Ried
Summary: The major signaling pathways in colon cancer are WNT, RAS, and TGF-beta. Mutations in these pathways reflect the behavior of intestinal stem cells and play a role in the progression of colon cancer. Understanding the intersection and interaction between these pathways can provide insights into the regulation of cell proliferation and the development of colon cancer.
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Reproductive Biology
Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici, Luciana Madeira da Silva
Summary: A leading theory suggests that inflammation from constant ovulation is a driving factor for ovarian carcinogenesis. Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown potential in chemoprevention of ovarian cancer, although their long-term use is associated with toxicity. PDE10A, a novel therapeutic target, has been identified as a potential treatment for ovarian cancer, as its inhibition can reduce cancer cell growth and induce apoptosis.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yanlin Chen, Liping Yang, Yilu Qin, Shuiqing Liu, Yina Qiao, Xueying Wan, Huan Zeng, Xiaoli Tang, Manran Liu, Yixuan Hou
Summary: The study revealed that the cellular localization of JUP in gastric cancer is closely related to tumor progression and invasion, with a loss of membrane and/or cytoplasmic JUP exacerbating the malignancy, while the nuclear function of JUP in cooperation with B-catenin promotes gastric cancer cell invasion.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tian-Huei Chu, Chou-Yuan Ko, Po-Han Tai, Yi-Chen Chang, Chao-Cheng Huang, Tung-Yang Wu, Hoi-Hung Chan, Ping-Hsuan Wu, Chien-Hui Weng, Yu-Wei Lin, Mei-Lang Kung, Cheng-Chieh Fang, Jian-Ching Wu, Zhi-Hong Wen, Yung-Kuo Lee, Tsung-Hui Hu, Ming-Hong Tai
Summary: In this study, it was found that LECT2 expression in HCC is associated with tumor development and patient survival. Functional assays revealed that LECT2 can suppress oncogenic behaviors in hepatoma cells and inhibit CSC functions. Increasing LECT2 expression through therapy could effectively treat HCC by suppressing the HGF/c-MET axis to reduce CSC expansion.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jung Kyu Choi, Ihn-Sil Kwak, Sae-Bom Yoon, Heeyeong Cho, Byoung-San Moon
Summary: CPD0857 has been found to inhibit tumor stem cells in colorectal cancer, reducing proliferation and promoting differentiation, which may serve as a potential drug targeting CSCs.
Article
Biochemical Research Methods
Fei Wen, Shangyu Yang, WeiWen Cai, Mengyuan Zhao, Long Qin, Zuoyi Jiao
Summary: Elevated PMEPA1 expression is associated with worse prognosis and weaker anti-tumor immunity in gastric cancer patients. PMEPA1 not only affects cell proliferation, clone formation, invasion, and migration in vitro but also plays a significant role in gastric cancer progression in vivo through activating the Wnt/beta-catenin signaling pathway.
MOLECULAR AND CELLULAR PROBES
(2023)
Review
Oncology
Mingtang Zeng, Chao Pi, Ke Li, Lin Sheng, Ying Zuo, Jiyuan Yuan, Yonggen Zou, Xiaomei Zhang, Wenmei Zhao, Robert J. Lee, Yumeng Wei, Ling Zhao
Summary: Gastric cancer, the third leading cause of cancer-related death, requires the establishment of relevant animal models for further research. Patient-derived models replicate the heterogeneity of gastric cancer and serve as valuable preclinical tools.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Qingjiang Hu, Takaaki Masuda, Kensuke Koike, Kuniaki Sato, Taro Tobo, Shotaro Kuramitsu, Akihiro Kitagawa, Atsushi Fujii, Miwa Noda, Yusuke Tsuruda, Hajime Otsu, Yosuke Kuroda, Shuhei Ito, Eiji Oki, Koshi Mimori
Summary: OSBPL3 is identified as a potential driver gene in gastric cancer, its overexpression activates the R-Ras/Akt signaling pathway and is associated with poor prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Hanne-Line Rabben, Goran Troseth Andersen, Magnus Kringstad Olsen, Anders Overby, Aleksandr Ianevski, Denis Kainov, Timothy Cragin Wang, Steinar Lundgren, Jon Erik Gronbech, Duan Chen, Chun-Mei Zhao
Summary: The study identified a link between neural signaling and tumor metabolism, proposing a therapeutic strategy targeting nerve-cancer metabolism which demonstrated efficacy in mouse models and feasibility in patients.
Article
Oncology
Yu Zhang, Jiapeng Xu, Hongbing Fu, Ziran Wei, Dejun Yang, Ronglin Yan
Summary: The study shows that UBE3C promotes GC progression by activating the beta-catenin signaling pathway through degradation of AXIN1.
Article
Medicine, Research & Experimental
Yan-Jie Chen, Shu-Neng Luo, Hao Wu, Ning-Ping Zhang, Ling Dong, Tao-Tao Liu, Li Liang, Xi-Zhong Shen
Summary: This study found that the expression of IRF-2 was downregulated in gastric cancer tissues and was negatively correlated with the prognoses of gastric cancer patients. IRF-2 inhibits tumor growth by regulating the transcription of AMER-1 and the Wnt/β-catenin signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Chuan Zhou, Zisheng Fan, Zehui Zhou, Yupeng Li, Rongrong Cui, Chaoyi Liu, Guizhen Zhou, Xingxing Diao, Hualiang Jiang, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Summary: Regulating SOS1 functions may lead to targeted therapy for pan-KRAS. Small-molecule SOS1 inhibitors have shown promise as anticancer agents, and the most advanced one, BI 1701963, is currently in phase I clinical studies. SOS1 agonists offer new opportunities for cancer treatment, but the underlying mechanisms still need further investigation. This study reports the discovery of the first SOS1 PROTACs, designed by connecting a VHL ligand to a known SOS1 agonist, ensuring that the observed inhibitory activity is due to degraders. The best compound, 9d, induced SOS1 degradation in various KRAS-driven cancer cells and exhibited superior antiproliferation activity compared to the agonist itself. Tumor xenograft study demonstrated the promising antitumor potency of 9d against human lung cancer. The study provides strong evidence for using agonists to design SOS1 PROTACs and demonstrates that targeted SOS1 degradation is an effective therapeutic strategy for overcoming KRAS-driven cancers.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hosne Ara, Utsab Subedi, Papori Sharma, Susmita Bhattarai, Sudha Sharma, Shrivats Manikandan, Xiuping Yu, Md. Shenuarin Bhuiyan, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Lysophosphatidic acid (LPA) plays a critical role in beta-catenin-mediated gastric cancer by promoting proliferation, migration, and invasion of cancer cells. LPA exposure increases beta-catenin expression and nuclear localization, phosphorylation of GSK-3 beta, and target gene expression. LPA also affects energy metabolism and contributes to gastric cancer initiation and progression.
Article
Biochemistry & Molecular Biology
Yohan Yang, Eunyoung Kim, Sangwoo Kim
Summary: The study analyzed data from patients receiving immune checkpoint blockade treatment and found that HLA allelic copy loss was not significantly associated with treatment response rates, showing a better response in urothelial cancer. Regardless of HLA copy status, the proportion of cytotoxic immune cells in the patient's immune environment was correlated with treatment response, which was higher in the loss of heterozygosity group in the urothelial cohort.
Article
Multidisciplinary Sciences
Yoo-Jin Ha, Myung Joon Oh, Junhan Kim, Jisoo Kim, Seungseok Kang, John D. Minna, Hyun Seok Kim, Sangwoo Kim
Summary: This study provides a set of ultra-deep sequenced data for somatic mosaicism detection strategies based on cell line mixtures. By mimicking the cumulative nature of mosaic variant acquisition, the study reveals the inter-sample relationships and holds significance for optimizing detection strategies and developing algorithms.
Article
Cell & Tissue Engineering
Sun-Ho Lee, Jaewon Oh, Seung-Tae Lee, Dongju Won, Sangwoo Kim, Hyo-Kyoung Choi, Seok-Jun Kim, Hyunho Han, Minjae Yoon, Jong Rak Choi, Ho-Geun Yoon, Sahng Wook Park, Seok-Min Kang, Seung-Hyun Lee
Summary: Dilated cardiomyopathy (DCM) is a heart muscle disease that causes heart failure, and one of the most prevalent genetic causes is a protein-truncating variant in the Titin gene (TTNtv). Researchers have generated hiPSCs from patients who underwent heart transplantation due to DCM carrying a TTNtv mutation, and successfully differentiated them into cardiomyocytes.
STEM CELL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Yun-Ji Cha, Sae-Bom Jeon, Jaewon Oh, Seung-Tae Lee, Sangwoo Kim, Hyoeun Kim, Jungyoon Choi, Hyo-Kyoung Choi, Dongju Won, Jong Rak Choi, Seok-Jun Kim, Sahng Wook Park, Seok-Min Kang, Seung-Hyun Lee
Summary: In this study, a human-induced pluripotent stem cell (hiPSC) line was generated from a patient with dilated cardiomyopathy (DCM). The hiPSC line showed normal karyotype and high expression of pluripotency markers, and its differentiation potential was confirmed by staining of three germ layer markers.
STEM CELL RESEARCH
(2022)
Article
Oncology
Ji-Yong Sung, Jae-Ho Cheong
Summary: This study identifies a signature gene for predicting immune checkpoint blockade response in gastric cancer patients using machine learning algorithms. The marker gene signature, VCAN, distinguishes responders from non-responders, and has potential as a drug target for non-responders. The findings provide insights into the treatment of stem-like immuno-oncology through precision medicine.
Article
Cell Biology
Ji-Yong Sung, Jae-Ho Cheong
Summary: Metabolic alterations and direct cell-cell interactions in the tumor microenvironment have significant impact on tumor prognosis, highlighting the importance of investigating single-cell metabolic activity and intercellular communication in understanding the mechanistic influences on tumor cells.
Article
Oncology
Ji-Yong Sung, Jae-Ho Cheong
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon. B. B. Mills, Sung Hoon Noh, Jae-Ho Cheong
Summary: In this study, the role of PGC1 alpha in regulating cancer cell viability under metabolic and genotoxic stress was investigated. The findings suggest that PGC1 alpha is a key regulator of anti-apoptosis in metabolic and genotoxic stress-resistant cells, and it may serve as a potential therapeutic target for refractory cancers.
Article
Multidisciplinary Sciences
Bo Kyung Yoon, Hyeonhui Kim, Tae Gyu Ohd, Se Kyu Oh, Sugyeong Jo, Minki Kim, Kyu-Hye Chun, Nahee Hwang, Suji Lee, Suyon Jin, Annette R. Atkins, Ruth T. Yu, Michael Downes, Jae-woo Kim, Hyunkyung Kim, Ronald M. Evans, Jae-Ho Cheong, Sungsoon Fang
Summary: Molecular classification of gastric cancer identified a subgroup of patients with poor prognosis and chemoresistance, called SEM type, which exhibits a distinct metabolic profile characterized by high levels of glutaminase. These SEM type gastric cancer cells are resistant to glutaminolysis inhibition due to the upregulation of the PHGDH-mediated mitochondrial folate cycle pathway under glutamine starvation. The metabolic plasticity in SEM type GC cells is associated with open chromatin structure and driven by ATF4/CEBPB. The coinhibition of GLS and PHGDH effectively eliminates stemness-high cancer cells, providing a potential treatment strategy for chemoresistant GC patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell & Tissue Engineering
Sae-Bom Jeon, Hyoeun Kim, Kyeong-Hyeon Chun, Jaewon Oh, Chulan Kwon, Hyo-Kyoung Choi, Sangwoo Kim, Hyoung-Pyo Kim, In-Cheol Kim, Jung-Yoon Yoo, Sahng Wook Park, Seok-Min Kang, Seung-Hyun Lee
Summary: TNNT2 gene with p. Arg205Trp mutation is strongly linked to dilated cardiomyopathy (DCM). A human induced pluripotent stem cell (hiPSC) line, YCMi007-A, was generated from a DCM patient and showed high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Therefore, YCMi007-A could be a valuable tool for investigating DCM.
STEM CELL RESEARCH
(2023)
Article
Immunology
Han Sang Kim, Chang Gon Kim, Won Kyu Kim, Kyung-A Kim, Jinseon Yoo, Byung Soh Min, Soonmyung Paik, Sang Joon Shin, Hyukmin Lee, Kyungwon Lee, Hoguen Kim, Eui-Cheol Shin, Tae-Min Kim, Joong Bae Ahn
Summary: This study found that Fusobacterium nucleatum (FN) in colorectal cancer tissues is associated with immune regulation in the tumor microenvironment, and its infection is correlated with poor prognosis and altered distribution of immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Yun Sun Lee, Hyung Sun Kim, Hyo Jung Kim, Hyeon Woong Kang, Da Eun Lee, Myeong Jin Kim, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Joon Seong Park
Summary: LOXL2 plays a significant role in drug resistance and EMT regulation in pancreatic cancer, and its inhibition reduces cancer stemness by regulating MAPK signaling activity. The activation of glucose metabolism and regulation of NF-kappa B signaling contribute to LOXL2 induction and cancer progression in gemcitabine-resistant pancreatic cancer.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Se-Young Jo, Namki Hong, Seunghyun Lee, Jong Ju Jeong, Jeongsoo Won, Jiho Park, Gi Jeong Kim, Sang Kyum Kim, Sangwoo Kim, Yumie Rhee
Summary: Genomic and transcriptomic profiling of parathyroid tissues revealed multiple two-hit mutation patterns in the CDC73 gene, suggesting potential therapeutic targets. Transcriptomic analysis identified upregulated expression of E2F targets, KRAS and TNF-alpha signaling, and epithelial-mesenchymal transition pathways in parathyroid carcinomas. A molecular classification model based on carcinoma-specific genes could effectively distinguish between carcinomas, adenomas, and normal tissues, with potential clinical utility.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jaeyong Shin, Minkyu Jung
Summary: The COVID-19 pandemic has led to a significant decrease in the overall number of gastric cancer diagnoses, with cases being diagnosed at more advanced stages, especially among men and patients aged 40 and older in 2021. Further studies are needed to explore the impact of the pandemic on global gastric cancer detection.
JOURNAL OF GASTRIC CANCER
(2023)
