Article
Medicine, General & Internal
Shuoshan Wang, Xiansheng Yang, Chang Liu, Jinlun Hu, Mei Yan, Chan Ding, Yue Fu
Summary: This study systematically explored the core genes and crucial pathways in gastric cancer, providing insights into clinical management and individualized treatment.
Article
Pathology
Zhenpeng Wen, Chunjiao Yang, Dan Zou, Jiaqing Liu, Song Wang, Xuqin Liu, Yi Zhang, Ye Zhang
Summary: PSAP is highly expressed in gastric cancer and is associated with poor prognosis. It serves as an independent prognostic factor in gastric cancer patients. A risk model based on PSAP-associated genes was developed to evaluate the immunotherapy outcomes of gastric adenocarcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Shengbo Li, Xiaofan Yang, Wenqing Li, Zhenbing Chen
Summary: E2F1/2/3/5/8 play important roles in the tumor progression of gastric cancer, serving as potential biomarkers or therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Meng-jie Shan, Ling-bing Meng, Peng Guo, Yuan-meng Zhang, Dexian Kong, Ya-bin Liu
Summary: This study identified CDH3, LEF1, and MMP7 as potential biomarkers for gastric cancer through gene expression analysis, and established a neural network model for early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gang Chen, Mingwei Yu, Jianqiao Cao, Huishan Zhao, Yuanping Dai, Yizi Cong, Guangdong Qiao
Summary: This study identified 11 key genes as potential prognosis biomarkers for breast cancer through bioinformatics analysis, which are mainly related to cell cycle and cell proliferation, significantly influencing the prognosis of breast cancer patients.
Article
Immunology
Yan Xia, Rongzheng Zhang, Mingzhu Wang, Jiaqi Li, Jianming Dong, Kaitong He, Ting Guo, Xiaomei Ju, Jiaqiu Ru, Shuyun Zhang, Yihua Sun
Summary: This study identified three necroptosis-related genes that can be used to predict the prognosis and immunotherapy efficacy of gastric cancer. The high-NRGPS group showed characteristics related to immune escape, highlighting the importance of these issues in gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Reproductive Biology
Jinshan Xing, Jingyan Yi
Summary: This study revealed the expression and function of LASS6 in ovarian cancer, indicating that it may play a key role in the development and prognosis of ovarian cancer, potentially serving as a therapeutic target and prognostic marker.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Shiyu Zhang, Xuelian Xiang, Li Liu, Huiying Yang, Dongliang Cen, Guodu Tang
Summary: This study identified hub genes associated with gastric cancer prognosis and explored potential drugs for treatment by analyzing differentially expressed genes. The findings provide new insights into the molecular mechanisms and treatment options for gastric cancer.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Genetics & Heredity
Li Wang, Shan Cao, Rujun Zhai, Yang Zhao, Guodong Song
Summary: This study systematically analyzed the expression, prognostic values, mutations, and functional networks of the lysyl oxidase (LOX) family in gastric cancer (GC) using various databases. The results suggested that LOX and LOXL2 may play crucial roles in the oncogenesis of GC and could potentially serve as biomarkers for predicting tumor prognosis and targets for therapy.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Zhiyue Zhao, Zhibin Hao, Zheng Zhang, Xianbao Zhan
Summary: Using weighted gene co-expression network analysis, we identify Aldo-Keto Reductase Family 1 Member B (AKR1B1) as a key gene for immune regulation in gastric cancer. AKR1B1 is associated with immune infiltration level and histologic grade of gastric cancer. In vitro experiments show that AKR1B1-overexpressed THP-1-derived macrophages promote the proliferation and migration of gastric cancer cells.
DNA AND CELL BIOLOGY
(2023)
Article
Cell Biology
Lihua Yao, Xiaowu Zhong, Guangcheng Huang, Qiang Ma, Lei Xu, Hong Xiao, Xiaolan Guo
Summary: This study identified a correlation between high mRNA expression of TP53 family members (TP53, TP63, and TP73) and clinical cancer stages and nodal metastasis status in ESCA patients. TP53 expression was also significantly associated with the overall survival of ESCA patients. Additionally, downregulation of TP53 expression reduced ESCC cell migration and proliferation, potentially activating the mTOR signaling pathway and inhibiting TP53-dependent autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
YaLing Liu, Dan Li, Yong Chen, YiJuan Liu, YiJuan Lin, XunRu Huang, Ting Wu, ChengDang Wang, Jian Ding
Summary: This study constructed an immune-related risk score (IRRS) model and identified immunotherapeutic targets for gastric cancer patients by exploring immune genes and the tumor microenvironment. The low-risk group, characterized by elevated tumor mutation burden (TMB), had higher survival rate. The risk level was correlated with tumor-infiltrating immune cells, immune checkpoint molecule expression, and immunophenoscore.
BMC BIOINFORMATICS
(2023)
Article
Genetics & Heredity
Yan Xia, Xin Lin, Yangyang Cheng, Huimin Xu, Jingya Zeng, Wanlin Xie, Mingzhu Wang, Yihua Sun
Summary: The platelet-function-related genes prognostic score (PFRGPS) can serve as an independent indicator for predicting overall survival in gastric cancer patients and aid in the development of more successful immunotherapy strategies.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Xiaoji Niu, Liman Ren, Aiyan Hu, Shuhui Zhang, Hongjun Qi
Summary: This study identified four key genes with important diagnostic and prognostic value in gastric cancer, providing important reference for related research.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Hui Li, Jing Guo, Guang Cheng, Yucheng Wei, Shihai Liu, Yaoyue Qi, Gongjun Wang, Ruoxi Xiao, Weiwei Qi, Wensheng Qiu
Summary: This study aimed to identify and verify key SNPs in genes with prognostic value for gastric cancer. Through analysis of SNP data from gastric cancer patients, a network of mutated genes was constructed, leading to the identification of six key genes (TP53, HRAS, BRCA1, PIK3CA, AKT1, and SMARCA4) closely related to patient survival rates. This research provides a foundation for further exploration of gastric cancer molecular pathogenesis and patient prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Massimiliano Salati, Michele Ghidini, Matteo Paccagnella, Luca Reggiani Bonetti, Alessandro Bocconi, Andrea Spallanzani, Fabio Gelsomino, Francesca Barbin, Ornella Garrone, Bruno Daniele, Massimo Dominici, Antonio Facciorusso, Angelica Petrillo
Summary: Recent advances in molecular subtyping of gastric cancer have identified new clinically relevant biomarkers and potential therapeutic targets. Checkpoint inhibitors have also expanded treatment options, showing promising results in certain subgroups of gastric cancer patients. However, cytotoxic chemotherapy remains the only choice for patients who do not have these biomarkers. This study aims to investigate the prevalence, clinicopathologic features, and treatment outcomes of molecular subtypes in a new-diagnosed cohort of Western gastric cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
A. Bongiovanni, V. Colazingari, A. Messineo, A. Del Cimmuto, M. De Giusti, G. La Torre
Summary: This study systematically reviewed the literature on healthcare workers' (HCWs) exposure to legionella and assessed whether there is an occupational risk. The findings suggest a higher risk of legionella exposure for HCWs, but clinical evidence is currently lacking. Further research with appropriate study design is needed to determine whether legionella infection is an occupational risk for HCWs.
Article
Immunology
Marianna Riccio, Mattia Marte, Valentin Imeshtari, Francesca Vezza, Vanessa India Barletta, David Shaholli, Corrado Colaprico, Maria Di Chiara, Elena Caresta, Gianluca Terrin, Paola Papoff, Giuseppe La Torre
Summary: This study aimed to evaluate the knowledge, attitudes, and behaviors of healthcare workers (HCWs) in relation to national vaccination recommendations. The study found that half of the HCWs were aware of the vaccination recommendations, with occupation and age being predictive factors. Although a majority of the sample perceived the diseases as a risk to their patients' health, this perception was lower in the over-40 age group. There were statistically significant differences between the care units. Approximately three-quarters of the sample agreed that vaccination should be mandatory, and willingness to undergo a future booster vaccination was correlated with age and care unit. The protection of health in the workplace can be achieved through strategic actions such as educational strategies, monitoring of immunocompetence, and improvement of vaccination.
Review
Public, Environmental & Occupational Health
G. La Torre, T. Vitello, R. A. Cocchiara, C. Della Rocca
Summary: The study aimed to investigate the correlation between formaldehyde exposure and irritant diseases (mainly asthma) and neoplastic diseases. The results showed a strong association between formaldehyde exposure and asthma, but a weak association with cancer. Although the associations were not strong, the World Health Organisation recommends limiting formaldehyde levels to 0.1 mg/m3 (0.08 ppm).
Article
Medicine, General & Internal
Giuseppe La Torre, Gianluca Paglione, Lavinia Camilla Barone, Vittoria Cammalleri, Augusto Faticoni, Mattia Marte, Roberta Noemi Pocino, Carlo Maria Previte, Andrea Bongiovanni, Corrado Colaprico, Eleonora Ricci, Valentin Imeshtari, Maria Vittoria Manai, David Shaholli, Vanessa India Barletta, Giovanna Carluccio, Luca Moretti, Francesca Vezza, Lorenzo Volpicelli, Anna Paola Massetti, Lilia Cinti, Piergiorgio Roberto, Anna Napoli, Guido Antonelli, Claudio Maria Mastroianni, Sabina Sernia
Summary: The aim of this study was to evaluate the factors that increase the risk of reinfection with SARS-CoV-2, and it found that female gender, moderate to high alcohol consumption, diabetes, and increased red blood cell counts are associated with higher odds of reinfection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Valentin Imeshtari, Francesca Vezza, Vanessa India Barletta, Andrea Bongiovanni, Corrado Colaprico, David Shaholli, Eleonora Ricci, Giovanna Carluccio, Luca Moretti, Maria Vittoria Manai, Marta Chiappetta, Riccardo Paolini, Mattia Marte, Carlo Maria Previte, Lavinia Camilla Barone, Augusto Faticoni, Vittoria Cammalleri, Roberta Noemi Pocino, Filippo Picchioni, Shizuka Kibi, Gloria Deriu, Pasquale Serruto, Barbara Dorelli, Elena Mazzalai, Monica Giffi, Daniela Marotta, Mattia Manzi, Valentina Marasca, Rosario Andrea Cocchiara, Federica Ciccone, Patrizia Pasculli, Paola Massetti, Guido Antonelli, Claudio Maria Mastroianni, Giuseppe La Torre
Summary: This study aims to analyze the role of vaccination status in modulating the pattern of symptomatology associated with COVID-19 infection. The results showed that females were at a higher risk of developing symptoms. Four SARS-CoV-2 waves were identified, with pharyngitis and rhinitis being more frequent during the fourth wave among vaccinated subjects, while cough, fever, flu syndrome, headache, anosmia, ageusia, arthralgia/arthritis, and myalgia were more frequent during the first three waves among unvaccinated subjects. The study concluded that vaccination status and viruses' mutations had a synergic effect in mitigating the symptomatology caused by SARS-CoV-2.
Article
Biochemistry & Molecular Biology
Simona Laurino, Mariarita Brancaccio, Tiziana Angrisano, Giovanni Calice, Sabino Russi, Pellegrino Mazzone, Giuseppina Di Paola, Michele Aieta, Vitina Grieco, Gabriella Bianchino, Geppino Falco, Tiziana Notarangelo
Summary: Gastric cancer, a leading cause of death globally, is difficult to treat with chemotherapy due to multidrug resistance. This study investigated the role of STAT3 in gastric cancer drug efficiency through gene expression analysis. The study found that gastric cancer cells become resistant to chemotherapy by activating alternative signaling pathways. However, inhibiting IL-6/STAT3 in combination with cisplatin treatment prevented STAT3 activation and increased lethality compared to single-agent treatment. This suggests that IL-6/STAT3 axis blockage may be a strategy to overcome resistance.
Editorial Material
Medicine, General & Internal
Giuseppe La Torre, David Shaholli, Corrado Colaprico, Maria Vittoria Manai, Salvatore Ammirati, Giorgia Mantione, Sabina Sernia
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Eleonora Ricci, Anamaria Glavasc, Barbara Morandini, Maria Caterina Grassi, Giuseppe La Torre
Summary: Prophylactic use of paracetamol can reduce the adverse effects of COVID-19 vaccination, with significant effects in reducing asthenia.
Article
Medicine, Research & Experimental
Ilaria Laurenzana, Luciana De Luca, Pietro Zoppoli, Giovanni Calice, Alessandro Sgambato, Angelo Michele Carella, Antonella Caivano, Stefania Trino
Summary: The methylation profile of HSPCs following AHSCT was analyzed and found to undergo changes that may be useful in transplant diagnostics. The methylation signature was also found to be related to patient outcome. This study suggests that the methylation profile of HSPCs can provide prognostic information for engraftment success and graft failure prediction in AHSCT.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Medicine, General & Internal
Alessandra Logoteta, Maria Grazia Piccioni, Riccardo Nistri, Laura De Giglio, Valentina Bruno, Giuseppe La Torre, Stefano Ianni, Luana Fabrizi, Ludovico Muzii, Carlo Pozzilli, Serena Ruggieri
Summary: The impact of pregnancy and breastfeeding on the development and outcomes of Multiple sclerosis (MS) is uncertain and debated. Two cases of late-onset MS in parous women who breastfed their children and one of them received hormone replacement therapy were reported. Studies suggest that the beneficial effects of pregnancy and breastfeeding on MS outcome may only occur with multiple pregnancies. However, further research is needed to evaluate the protective role of multiparity in larger prospective studies.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Shima Gholamalishahi, Seyed Ali Hosseini, Evaristo Ettorre, Alice Mannocci, Chidiebere Emmanuel Okechukwu, Mohamad Javad Keshavarz, Giuseppe La Torre
Summary: There is an association between the levels of physical activity and the lifestyle, life expectancy, and quality of life in patients with Alzheimer's disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
