How to Get the Most from Methotrexate (MTX) Treatment for Your Rheumatoid Arthritis Patient?—MTX in the Treat-to-Target Strategy

Superiority of a Treat-to-Target Strategy over Conventional Treatment with Fixed csDMARD and Corticosteroids: A Multi-Center Randomized Controlled Trial in RA Patients with an Inadequate Response to Conventional Synthetic DMARDs, and New Therapy with Certolizumab Pegol

(2019) Ruediger Mueller et al.   Journal of Clinical Medicine

Impact of temporary methotrexate discontinuation for 2 weeks on immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial

(2018) Jin Kyun Park et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments?

(2018) Alice Mason et al.   AUTOIMMUNITY REVIEWS

Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis

(2018) Lijun Liu et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

A Pilot Randomized Controlled Double-Blind Trial of High- Versus Low-Dose Weekly Folic Acid in People With Rheumatoid Arthritis Receiving Methotrexate

(2018) Lisa K. Stamp et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Concomitant use of low-dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis

(2018) Henrik Svanström et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Evaluation of a clinical pharmacogenetics model to predict methotrexate response in patients with rheumatoid arthritis

(2018) Rosario López-Rodríguez et al.   PHARMACOGENOMICS JOURNAL

Drug immunogenicity in patients with inflammatory arthritis and secondary failure to tumour necrosis factor inhibitor therapies: the REASON study

(2018) Alejandro Balsa et al.   RHEUMATOLOGY

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Long-Term Increase of Radiographic Damage and Disability in Patients with RA in Relation to Disease Duration in the Era of Biologics. Results from the SCQM Cohort

(2018) Katja Heinimann et al.   Journal of Clinical Medicine

Inadequate response to treat-to-target methotrexate therapy in patients with new-onset rheumatoid arthritis: development and validation of clinical predictors

(2018) Xavier M Teitsma et al.   ANNALS OF THE RHEUMATIC DISEASES

The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients

(2018) Lisa Schapink et al.   RHEUMATOLOGY

Treat to target strategy in early rheumatoid arthritis versus routine care – A comparative clinical practice study

(2018) Gina Hetland Brinkmann et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The effect of immunosuppressive agents on immunogenicity of pneumococcal vaccination: A systematic review and meta-analysis

(2018) Mariëlle van Aalst et al.   VACCINE

Intensive therapy and remissions in rheumatoid arthritis: a systematic review

(2018) Catherine D. Hughes et al.   BMC MUSCULOSKELETAL DISORDERS

Chronic lung disease in U.S. Veterans with rheumatoid arthritis and the impact on survival

(2018) Bryant R. England et al.   CLINICAL RHEUMATOLOGY

Update of French society for rheumatology recommendations for managing rheumatoid arthritis

(2018) Claire Daien et al.   JOINT BONE SPINE

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

(2018) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk of Adverse Pregnancy Outcome After Paternal Exposure to Methotrexate Within 90 Days Before Pregnancy

(2017) Lasse Karlsen Eck et al.   OBSTETRICS AND GYNECOLOGY

Vaccines and Disease-Modifying Antirheumatic Drugs

(2017) Marcia A. Friedman et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Rheumatoid Arthritis Treatment After Methotrexate: The Durability of Triple Therapy Versus Etanercept

(2017) Shana M. Peper et al.   ARTHRITIS CARE & RESEARCH

Meta-Regression of a Dose-Response Relationship of Methotrexate in Mono- and Combination Therapy in Disease-Modifying Antirheumatic Drug-Naive Early Rheumatoid Arthritis Patients

(2017) S. A. Bergstra et al.   ARTHRITIS CARE & RESEARCH

Underuse of Methotrexate in the Treatment of Rheumatoid Arthritis: A National Analysis of Prescribing Practices in the US

(2017) Melanie K. Rohr et al.   ARTHRITIS CARE & RESEARCH

Addition of an immunomodulator can reverse antibody formation and loss of response in patients treated with adalimumab

(2016) B. Ungar et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Certolizumab pegol in combination with dose-optimised methotrexate in DMARD-naïve patients with early, active rheumatoid arthritis with poor prognostic factors: 1-year results from C-EARLY, a randomised, double-blind, placebo-controlled phase III study

(2016) P Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

The toxicity of methotrexate in male fertility and paternal teratogenicity

(2016) Jennifer Christine Gutierrez et al.   Expert Opinion on Drug Metabolism & Toxicology

Oral Methotrexate in split dose weekly versus oral or parenteral Methotrexate once weekly in Rheumatoid Arthritis: a short-term study

(2016) Pooja Dhaon et al.   International Journal of Rheumatic Diseases

Methotrexate Dosage Reduction Upon Adalimumab Initiation: Clinical and Ultrasonographic Outcomes from the Randomized Noninferiority MUSICA Trial

(2016) G. S. Kaeley et al.   JOURNAL OF RHEUMATOLOGY

The Rate of Adherence to Antiarthritis Medications and Associated Factors among Patients with Rheumatoid Arthritis: A Systematic Literature Review and Metaanalysis

(2016) A. Scheiman-Elazary et al.   JOURNAL OF RHEUMATOLOGY

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT)

(2016) Ru Li et al.   MEDICINE

Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers

(2016) Philip M. Brown et al.   Nature Reviews Rheumatology

Nonadherence to disease modifying antirheumatic drugs in the first year after diagnosis: comparing three adherence measures in early arthritis patients

(2016) Annelieke Pasma et al.   RHEUMATOLOGY

Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events

(2016) Lien T. Quach et al.   RHEUMATOLOGY

BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding—Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids: Table 1

(2016) Julia Flint et al.   RHEUMATOLOGY

Evolution of Patient Decision-Making Regarding Medical Treatment of Rheumatoid Arthritis

(2016) Alexandra L. Mathews et al.   ARTHRITIS CARE & RESEARCH

Smoking-Related Mortality in Patients With Early Rheumatoid Arthritis: A Retrospective Cohort Study Using the Clinical Practice Research Datalink

(2016) Rebecca M. Joseph et al.   ARTHRITIS CARE & RESEARCH

Folic Acid Supplementation Is Suboptimal in a National Cohort of Older Veterans Receiving Low Dose Oral Methotrexate

(2016) Gabriela Schmajuk et al.   PLoS One

The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression

(2015) Tatsuya Atsumi et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden Early Arthritis Clinic and ESPOIR cohorts

(2015) J A B van Nies et al.   ANNALS OF THE RHEUMATIC DISEASES

The comparative effectiveness of oral versus subcutaneous methotrexate for the treatment of early rheumatoid arthritis

(2015) Glen S Hazlewood et al.   ANNALS OF THE RHEUMATIC DISEASES

Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force

(2015) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

APLAR rheumatoid arthritis treatment recommendations

(2015) Chak Sing Lau et al.   International Journal of Rheumatic Diseases

An Examination of the Mechanisms Involved in Secondary Clinical Failure to Adalimumab or Etanercept in Inflammatory Arthropathies

(2015) Sara Bandrés Ciga et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Management of neutropenia in patients with rheumatoid arthritis

(2015) Estibaliz Lazaro et al.   JOINT BONE SPINE

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

(2015) Josef S. Smolen et al.   Nature Reviews Rheumatology

Effectiveness, tolerability, and safety of subcutaneous methotrexate in early rheumatoid arthritis: A retrospective analysis of real-world data from the St. Gallen cohort

(2015) Rüdiger B. Müller et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Rheumatoid arthritis: Perioperative management of biologics and DMARDs

(2015) Susan M. Goodman   SEMINARS IN ARTHRITIS AND RHEUMATISM

Low rate of influenza and pneumococcal vaccine coverage in rheumatoid arthritis: Data from the international COMORA cohort

(2015) Ihsane Hmamouchi et al.   VACCINE

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

(2015) Jasvinder A. Singh et al.   ARTHRITIS CARE & RESEARCH

Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials

(2015) R. Conway et al.   BMJ-British Medical Journal

Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials

(2015) R. Conway et al.   BMJ-British Medical Journal

Clinical Utility of Random Anti-Tumor Necrosis Factor Drug-Level Testing and Measurement of Antidrug Antibodies on the Long-Term Treatment Response in Rheumatoid Arthritis

(2015) Meghna Jani et al.   Arthritis & Rheumatology

Anti-adalimumab antibodies and adalimumab concentrations in psoriatic arthritis; an association with disease activity at 28 and 52 weeks of follow-up

(2014) Erik H Vogelzang et al.   ANNALS OF THE RHEUMATIC DISEASES

A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial

(2014) Mette Bjørndal Axelsen et al.   ANNALS OF THE RHEUMATIC DISEASES

Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses ≥15 mg may be overcome with subcutaneous administration

(2014) Michael H Schiff et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial

(2014) Gerd-Rűdiger Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Patient participation in decisions about disease modifying anti-rheumatic drugs: a cross-sectional survey

(2014) Ingrid Nota et al.   BMC MUSCULOSKELETAL DISORDERS

Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs

(2014) Helga Radner et al.   ARTHRITIS RESEARCH & THERAPY

Treatment of Very Early Rheumatoid Arthritis With Symptomatic Therapy, Disease-Modifying Antirheumatic Drugs, or Biologic Agents

(2013) Axel Finckh et al.   ANNALS OF INTERNAL MEDICINE

Validation of the Methotrexate-First Strategy in Patients With Early, Poor-Prognosis Rheumatoid Arthritis: Results From a Two-Year Randomized, Double-Blind Trial

(2013) James R. O'Dell et al.   ARTHRITIS AND RHEUMATISM

Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?

(2013) Vasco Crispim Romão et al.   BMC Medicine

Cost-minimisation analysis of subcutaneous methotrexate versus biologic therapy for the treatment of patients with rheumatoid arthritis who have had an insufficient response or intolerance to oral methotrexate

(2013) Ray Fitzpatrick et al.   CLINICAL RHEUMATOLOGY

Factors associated with methotrexate dosing and therapeutic decisions in veterans with rheumatoid arthritis

(2013) Bernard Ng et al.   CLINICAL RHEUMATOLOGY

Lung involvement and drug-induced lung disease in patients with rheumatoid arthritis

(2013) Fabiola Atzeni et al.   Expert Review of Clinical Immunology

Does methotrexate administration for ectopic pregnancy after in vitro fertilization impact ovarian reserve or ovarian responsiveness?

(2013) Christina E. Boots et al.   FERTILITY AND STERILITY

The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases

(2013) M. Jani et al.   RHEUMATOLOGY

Effect of Methotrexate, Anti-Tumor Necrosis Factor α, and Rituximab on the Immune Response to Influenza and Pneumococcal Vaccines in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

(2013) Charlotte Hua et al.   ARTHRITIS CARE & RESEARCH

Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials

(2013) Richard Conway et al.   Arthritis & Rheumatology

Performance of the 2011 ACR/EULAR preliminary remission criteria compared with DAS28 remission in unselected patients with rheumatoid arthritis

(2012) Katja Thiele et al.   ANNALS OF THE RHEUMATIC DISEASES

Methotrexate reduces immunogenicity in adalimumab treated rheumatoid arthritis patients in a dose dependent manner

(2012) Charlotte L Krieckaert et al.   ANNALS OF THE RHEUMATIC DISEASES

Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study)

(2012) Kirsten Wevers-de Boer et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study

(2012) Arthur Kavanaugh et al.   ANNALS OF THE RHEUMATIC DISEASES

A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: The Treatment of Early Aggressive Rheumatoid Arthritis trial

(2012) Larry W. Moreland et al.   ARTHRITIS AND RHEUMATISM

Propensity-adjusted association of methotrexate with overall survival in rheumatoid arthritis

(2012) Mary Chester M. Wasko et al.   ARTHRITIS AND RHEUMATISM

S1-Leitlinie der DGRh zur sequenziellen medikamentösen Therapie der rheumatoiden Arthritis 2012

(2012) K. Krüger et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

A decision tool to improve the quality of care in rheumatoid arthritis

(2012) Liana Fraenkel et al.   ARTHRITIS CARE & RESEARCH

In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial

(2011) Hamed Rezaei et al.   ANNALS OF THE RHEUMATIC DISEASES

American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials

(2011) D. T. Felson et al.   ANNALS OF THE RHEUMATIC DISEASES

The effects of golimumab on radiographic progression in rheumatoid arthritis: Results of randomized controlled studies of golimumab before methotrexate therapy and golimumab after methotrexate therapy

(2011) Paul Emery et al.   ARTHRITIS AND RHEUMATISM

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of Changing from Oral to Subcutaneous Methotrexate on Red Blood Cell Methotrexate Polyglutamate Concentrations and Disease Activity in Patients with Rheumatoid Arthritis

(2011) LISA K. STAMP et al.   JOURNAL OF RHEUMATOLOGY

Canadian Rheumatology Association Recommendations for Pharmacological Management of Rheumatoid Arthritis with Traditional and Biologic Disease-modifying Antirheumatic Drugs

(2011) VIVIAN P. BYKERK et al.   JOURNAL OF RHEUMATOLOGY

The long-term impact of early treatment of rheumatoid arthritis on radiographic progression: a population-based cohort study

(2011) D. Kyburz et al.   RHEUMATOLOGY

Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis

(2011) D. Pascual-Salcedo et al.   RHEUMATOLOGY

Inadequate Therapy Behavior Is Associated to Disease Flares in Patients With Rheumatoid Arthritis Who Have Achieved Remission With Disease-Modifying Antirheumatic Drugs

(2010) Irazú Contreras-Yáñez et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial

(2010) S. Saevarsdottir et al.   ANNALS OF THE RHEUMATIC DISEASES

Treating rheumatoid arthritis to target: recommendations of an international task force

(2010) J. S. Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study

(2010) M. F. Bakker et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: Observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg

(2010) Saedis Saevarsdottir et al.   ARTHRITIS AND RHEUMATISM

When should we use parenteral methotrexate?

(2010) Hayley Mainman et al.   CLINICAL RHEUMATOLOGY

Subcutaneous methotrexate is well tolerated and superior to oral methotrexate in the treatment of rheumatoid arthritis

(2010) Beena HAMEED et al.   International Journal of Rheumatic Diseases

Methotrexate—how does it really work?

(2010) Edwin S. L. Chan et al.   Nature Reviews Rheumatology

BSR and BHPR rheumatoid arthritis guidelines on eligibility criteria for the first biological therapy

(2010) C. Deighton et al.   RHEUMATOLOGY

Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes

(2010) Emilie Quintin et al.   ARTHRITIS RESEARCH & THERAPY

Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment

(2009) Lisa K. Stamp et al.   ARTHRITIS AND RHEUMATISM

Adherence Rates and Associations with Nonadherence in Patients with Rheumatoid Arthritis Using Disease Modifying Antirheumatic Drugs

(2009) B. J.F. van den BEMT et al.   JOURNAL OF RHEUMATOLOGY

Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial

(2009) RF van Vollenhoven et al.   LANCET

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

(2009) Sherine E Gabriel et al.   ARTHRITIS RESEARCH & THERAPY

Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

(2008) K Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis

(2008) Judith M. Dalrymple et al.   ARTHRITIS AND RHEUMATISM

Discontinuation of Methotrexate Therapy in Older Patients with Newly Diagnosed Rheumatoid Arthritis

(2008) Sasha Bernatsky et al.   DRUGS & AGING

Clinical and Radiological Features of Pneumocystis Pneumonia in Patients with Rheumatoid Arthritis, in comparison with Methotrexate Pneumonitis and Pneumocystis Pneumonia in Acquired Immunodeficiency Syndrome: A Multicenter Study

(2008) Hitoshi Tokuda et al.   INTERNAL MEDICINE

Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial

(2008) Paul Emery et al.   LANCET