Review
Biochemistry & Molecular Biology
Huidan Luo, Bin Yi
Summary: Exosomes, as nanoscale membrane vesicles, are important for cell communication and can serve as non-invasive liquid biopsy biomarkers in nasopharyngeal carcinoma. They play a role in regulating physiological processes of the tumor and have implications in cell growth, angiogenesis, metastasis, immunosuppression, radiation resistance, and chemotherapy resistance in NPC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Ke Wei, Zijian Ma, Fengming Yang, Xin Zhao, Wei Jiang, Chunfeng Pan, Zhihua Li, Xianglong Pan, Zhicheng He, Jing Xu, Weibing Wu, Yang Xia, Liang Chen
Summary: The study demonstrates that exosomes derived from M2 macrophages play a role in promoting invasion and migration of LUAD cells through miRNA regulation, providing a new therapeutic target for metastatic LUAD.
Review
Biochemistry & Molecular Biology
Maliha Tabassum Munir, Matthew K. Kay, Min H. Kang, Md Mizanur Rahman, Ahmed Al-Harrasi, Mahua Choudhury, Naima Moustaid-Moussa, Fazle Hussain, Shaikh Mizanoor Rahman
Summary: Breast cancer is the most common cancer in women in Western countries, with TAMs playing a key role in the breast cancer microenvironment and high TAM density being associated with poor prognosis. Altering TAM function may be a potential therapeutic target for treating breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Anne Natalie Prigol, Michele Patricia Rode, Adny Henrique Silva, Julia Cisilotto, Tania Beatriz Creczynski-Pasa
Summary: This study investigated the relationship between the progression to castration-resistant prostate cancer, exosome communication, and tumor angiogenesis. The study showed that PC-3 exosomes could promote invasion and tube formation in HUVEC cells, possibly mediated by miR-27a-3p.
CELLULAR SIGNALLING
(2021)
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Ying Li, Di Jiang, Zhi-Xin Zhang, Jun-Jun Zhang, Hong-Yu He, Jian-Li Liu, Ting Wang, Xia-Xia Yang, Bang-Dong Liu, Li-Li Yang, Xiao Zhi, Xiao-Bei Zhang, Tian-Lun Li, Yan-Rong Liu
Summary: Tumor cells secrete miRNA N-72 which is associated with CRC patients. The secreted miRNA N-72 can promote migration, tubulogenesis, and permeability of endothelial cells. It is delivered into endothelial cells via exosomes, targeting CLDN18, and consequently promoting angiogenesis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Cell Biology
Sadaf Jahan, Shouvik Mukherjee, Shaheen Ali, Urvashi Bhardwaj, Ranjay Kumar Choudhary, Santhanaraj Balakrishnan, Asma Naseem, Shabir Ahmad Mir, Saeed Banawas, Mohammed Alaidarous, Hadeel Alyenbaawi, Danish Iqbal, Arif Jamal Siddiqui
Summary: Cancer is a leading cause of death worldwide, and extracellular vesicles (EVs) play a crucial role in cancer initiation and progression. EVs can help body functions in healthy individuals and promote cancer at different stages in the tumor microenvironment. Tumor-derived EVs alter the genetics of normal cells through transferring mutations and histone modifications, and they also exhibit therapy resistance. Additionally, EVs can serve as biomarkers for cancer diagnosis.
Article
Multidisciplinary Sciences
Kylie G. Nairon, Thomas J. DePalma, Joshua M. Zent, Jennifer L. Leight, Aleksander Skardal
Summary: Primary tumors secrete factors that can influence the microenvironment and promote metastasis. In this study, biofabricated models were used to investigate the matrix changes induced by colorectal cancer-secreted factors. The findings suggest that these factors can activate fibroblasts, inhibit pericytes, and lead to collagen degradation, deposition, and remodeling. These results provide insights into the mechanisms of tumor metastasis.
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Suwen Bai, Zunyun Wang, Minghua Wang, Junai Li, Yuan Wei, Ruihuan Xu, Juan Du
Summary: Tumor-derived exosomes play a critical role in tumor metastasis by transporting proteins and RNA, promoting migration, and influencing interactions with normal cells like vascular endothelial cells and immune cells. Their function in facilitating tumor metastasis underlines the importance of further research in this area.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Claudia Palazzo, Alessio D'Alessio, Luca Tamagnone
Summary: Extracellular vesicles (EVs) play an important role in the communication mechanisms between cancer and endothelial cells, and may have potential implications in the treatment of vascular pathologies. EVs are able to transport a variety of cell constituents and regulate the functions of endothelial cells. Cancer cell-derived EVs have been found to have a controlling effect on endothelial cell functions and are involved in tumor angiogenesis and cancer progression.
Review
Biochemistry & Molecular Biology
Mina Homayoonfal, Zatollah Asemi, Bahman Yousefi
Summary: Cancer is a global health priority due to its high mortality rate, and the bioactive compound thymoquinone (TQ) from black cumin seeds has shown promising anti-cancer characteristics by regulating microRNA expression. This study aimed to review the various molecular mechanisms through which TQ exerts its potential as an anti-cancer agent.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Review
Oncology
Evelyn Lattmann, Mitchell P. Levesque
Summary: Melanoma, the deadliest form of skin cancer, can be diagnosed and treated using extracellular vesicles as biomarkers, which also reveal important signaling pathways for cancer progression.
Review
Clinical Neurology
Beddome C. Allen, Sahil Kapoor, Anthony Anzalone, Kirby P. Mayer, Stacey Q. Wolfe, Pam Duncan, Andrew W. Asimos, Ralph D'Agostino Jr, James Tripp Winslow, Aarti Sarwal
Summary: This study reviewed the feasibility of transcranial ultrasonography (TCU) as a diagnostic tool for evaluating intracranial pathology in critical care or austere settings. The results showed that TCU has reasonable sensitivity and specificity in detecting intracranial pathology including intracranial hemorrhage and tumors. This suggests that TCU can be clinically valuable in remote areas or where standard imaging is unavailable.
JOURNAL OF NEUROIMAGING
(2023)
Article
Multidisciplinary Sciences
Liping Guo, Zhirong Wang, Dan Zhao, Kun Zhao, Pinkun Guo
Summary: Emergency response plays a crucial role in mitigating the domino effects, but it is often overlooked in the consequence analysis of the domino effect due to its complexity and uncertainty. This paper adopts the Fuzzy Analytic Hierarchy Process (FAHP) to evaluate the reliability of emergency response process and models the domino effect under the influence of emergency response using Bayesian Network (BN) model. The consequences of the domino effect are determined based on the total duration of the emergency response process, taking into account the safety barriers. A case study demonstrates the application of this approach, showing a significant reduction in the probability of domino effect when active barriers, passive barriers, and emergency response are considered together. This work provides a relevant basis for formulating safety protection measures in the chemical process industry.
Article
Health Care Sciences & Services
Annika Hoyer, Ralph Brinks, Thaddaeus Toennies, Sharon H. Saydah, Ralph B. D'Agostino Jr, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan, Giuseppina Imperatore
Summary: This study aimed to examine whether a partial differential equation (PDE) can be used to estimate the incidence of diabetes from prevalence. The results showed that the PDE method can accurately estimate the incidence rates of diabetes, and it has the advantage of cost savings compared to traditional methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Review
Oncology
Ryan T. Hughes, Rediet R. Gebeyehu, John Mason Kalada, Thomas W. Lycan, Bart A. Frizzell, Rebecca D. Kinney, Ralph B. D'Agostino, Paul M. Bunch, Pierre Triozzi, Wei Zhang, Cristina M. Furdui, Mercedes Porosnicu
Summary: Effective treatment options for advanced/recurrent head and neck squamous-cell carcinoma are limited. The combination of the immune checkpoint inhibitor pembrolizumab and quad-shot, a hypofractionated palliative radiotherapy regimen, shows promise as a potential treatment strategy. This study aims to evaluate the response rates, survival outcomes, and treatment toxicity of this combined therapy, as well as identify molecular biomarkers and immune-related impacts using correlative multiomics analysis.
Article
Clinical Neurology
Christine Henry, Sahil Kapoor, Vivek Krishnan, John Levi, Kyle Fargen, Ralph D'Agostino, Sheryl Hendrix, Dana Foster, Patrick Brown, Charles A. Tegeler, Aarti Sarwal
Summary: This study used transcranial color-coded duplex (TCCD) to examine the transverse venous sinus (TVS), establish normative values, analyze physiological variability, and explore the validity of using TCCD to diagnose transverse venous sinus stenosis (TVSS).
JOURNAL OF NEUROIMAGING
(2023)
Article
Endocrinology & Metabolism
Allison L. B. Shapiro, Anna Bellatorre, Dana Dabelea, Jeanette M. Stafford, Ralph D'Agostino, Amy S. Shah, Elaine M. Urbina, Catherine E. Barrett, Catherine Pihoker, Santica Marcovina, Angela D. Liese, Amy K. Mottl, Elizabeth T. Jensen, Greta Wilkening
Summary: This study examined the relationship between diabetes complications and cognitive dysfunction in young adults with type 1 or type 2 diabetes. The results showed that hypoglycemia and peripheral neuropathy were associated with cognitive deficits in type 1 diabetes, while high blood pressure was associated with cognitive deficits in type 2 diabetes. These findings provide insights for targeting specific factors to mitigate cognitive issues in young people with diabetes.
PEDIATRIC DIABETES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
W. Gregory Hundley, Ralph D'Agostino
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine A. A. Sauder, Deborah H. H. Glueck, Kylie K. K. Harrall, Ralph D'Agostino, Lawrence M. M. Dolan, Abbi D. D. Lane, Angela D. D. Liese, Eva Lustigova, Faisal S. S. Malik, Santica Marcovina, Elizabeth Mayer-Davis, Amy Mottl, Catherine Pihoker, Kristi Reynolds, Amy S. S. Shah, Elaine M. M. Urbina, Lynne E. E. Wagenknecht, Stephen R. R. Daniels, Dana Dabelea
Summary: This study examined arterial stiffness in individuals with type 1 diabetes and explored the differences between Hispanic, non-Hispanic Black, and non-Hispanic White individuals. The results showed that cardiovascular and socioeconomic factors explain a quarter of the racial and ethnic differences in arterial stiffness, but non-Hispanic Black individuals still experienced higher arterial stiffness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Kerui Wu, Feng Lyu, Shih-Ying Wu, Sambad Sharma, Ravindra Pramod Deshpande, Abhishek Tyagi, Dan Zhao, Fei Xing, Ravi Singh, Kounosuke Watabe
Summary: An active immunotherapy using a smart nanovesicle has been developed to overcome the resistance of breast cancer to immunotherapies. The nanovesicle, called IL2-ep13nsEV, carries bioactive interleukin 2 (IL2) and T cell-promoting costimulatory factors on its surface, allowing for personalized treatment. It also presents antigens inherited from tumor lysate-pulsed dendritic cells and performs antigen presentation. In experiments, IL2-ep13nsEV induced a strong immune reaction, sensitized cancer cells to immune checkpoint inhibitors, and prevented tumor recurrence.
Article
Oncology
Yin Liu, Margaret R. R. Smith, Yuezhu Wang, Ralph D'Agostino Jr, Jimmy Ruiz, Thomas Lycan, Gregory L. L. Kucera, Lance D. D. Miller, Wencheng Li, Michael D. D. Chan, Michael Farris, Jing Su, Qianqian Song, Dawen Zhao, Arvind Chandrasekaran, Fei Xing
Summary: This study reveals that tumor-infiltrating neutrophils secrete high levels of lipocalin 2 (LCN2), which enhances the stemness of tumor cells in brain metastasis. The interactions between neutrophils and brain metastatic cells provide new insights into treating brain metastasis.
Article
Oncology
Margaret R. Smith, Yuezhu Wang, Ralph D'Agostino, Yin Liu, Jimmy Ruiz, Thomas Lycan, George Oliver, Lance D. Miller, Umit Topaloglu, Jireh Pinkney, Mohammed N. Abdulhaleem, Michael D. Chan, Michael Farris, Jing Su, Kathryn F. Mileham, Fei Xing
Summary: Different therapy options are used for NSCLC based on tumor stage and genetic mutations. However, biomarkers to guide treatment selection are limited. A study collected clinical and sequencing data from 524 NSCLC patients to examine the association between mutation profiles and treatment response. Mutation composite scores (MCS) were generated for different treatments, and MCS showed superior predictive power compared to other biomarkers in immune therapy-treated patients.
NPJ PRECISION ONCOLOGY
(2023)
Editorial Material
Oncology
Abhishek Tyagi
FRONTIERS IN ONCOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Warren Szewczyk, Kerryn Reding, Richard Kar-Hang Cheng, Laura Johnson, Oxana Palesh, Alexi Vasbinder, Amy Ladd, Ralph Dagostino, Kathryn Weaver, Glenn J. Lesser, W. Gregory Hundley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
HORMONE RESEARCH IN PAEDIATRICS
(2023)