Review
Medicine, General & Internal
Vincenzo Russo, Antonio Capolongo, Roberta Bottino, Andreina Carbone, Alberto Palladino, Biagio Liccardo, Gerardo Nigro, Michal Marchel, Paolo Golino, Antonello D'Andrea
Summary: Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults and is associated with cardiac involvement in 80% of cases. Echocardiography is recommended at the time of diagnosis and periodic reevaluation, and its findings play a prognostic role in predicting cardiac arrhythmias and sudden death in DM1 patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alexander Isaak, Tiyasha H. Ayub, Waltraut M. Merz, Anton Faron, Christoph Endler, Alois M. Sprinkart, Claus C. Pieper, Daniel Kuetting, Darius Dabir, Ulrike Attenberger, Sebastian Zimmer, Ulrich M. Becher, Julian A. Luetkens
Summary: This study evaluated the diagnostic and prognostic value of cardiac magnetic resonance in acute peripartum cardiomyopathy (PPCM). The results showed that patients with acute PPCM displayed biventricular dysfunction, myocardial edema, and impaired strain parameters, and these factors may have predictive value for left ventricular ejection fraction (LVEF) recovery.
Article
Cardiac & Cardiovascular Systems
Oscar Calvillo-Arguelles, Babitha Thampinathan, Emily Somerset, Tamar Shalmon, Eitan Amir, Chun-Po Steve Fan, Sangkyu Moon, Husam Abdel-Qadir, Yobiga Thevakumaran, Jennifer Day, Anna Woo, Bernd J. Wintersperger, Thomas H. Marwick, Paaladinesh Thavendiranathan
Summary: Myocardial work indices (MWIs) can help diagnose or prognosticate cancer treatment-related cardiac dysfunction (CTRCD), and echocardiographic global longitudinal strain (GLS) can be used to diagnose and prognosticate CTRCD defined by cardiac magnetic resonance (CMR).
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Oncology
Xuyang Ma, Ying Ding, Li Zeng
Summary: In this study, it was found that H2AFY is significantly overexpressed in HCC and is positively correlated with clinical characteristics of HCC patients. H2AFY may serve as a potential diagnostic and prognostic marker for HCC, as high expression predicts a poor prognosis.
Review
Medicine, General & Internal
Mina Wang, Feiyu Xie, Jiaran Lin, Yihan Zhao, Qian Zhang, Zehuan Liao, Peng Wei
Summary: Circular RNAs (circRNAs) are valuable biomarkers for cancer diagnosis and prognosis due to their abundant, stable, and specific presence in body fluids. With their multifunctionality in miRNA modulation, protein translation, and protein regulation, circRNAs show high sensitivity and specificity across various types of cancer, making them promising tools for cancer management.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Peter R. Huntjens, Kathleen W. Zhang, Yuko Soyama, Maria Karmpalioti, Daniel J. Lenihan, John Gorcsan
Summary: In patients with cardiac amyloidosis, echocardiographic strain imaging of all four cardiac chambers was found to be significantly associated with survival. Among the strain values, peak longitudinal LA strain showed the strongest association with prognosis. Atrial and ventricular strain have potential clinical utility in predicting outcomes in these patients.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Neurosciences
San F. A. Haridy, Nancy N. Shahin, Marwa I. Shabayek, Mae M. Selim, Mohamed A. Abdelhafez, Tarek K. Motawi
Summary: This study investigates the role of RUNX1 and its lncRNA RUNXOR in the development and progression of multiple sclerosis (MS) and explores their mechanism of action. The expression levels of RUNXOR, RUNX1, MAP2, NGF, BDNF and IL-10 were significantly decreased in MS patients compared to healthy controls. Furthermore, RUNXOR, RUNX1 mRNA, and its protein levels were identified as predictors of disease progression and RUNX1 mRNA exhibited diagnostic potential. These findings suggest the involvement of the RUNXOR-RUNX1 axis in MS development and highlight the potential utility of these parameters as diagnostic/prognostic biomarkers for MS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Zongting Gu, Yongxing Du, Xueping Zhao, Chengfeng Wang
Summary: This study investigates the role of the m(6)A writer complex in hepatocellular carcinoma (HCC). The expression levels of different m(6)A writers were analyzed and found to be associated with clinicopathological factors and tumor-promoting pathways in HCC. Additionally, the m(6)A writer complex was found to be correlated with immune cell infiltration and immunoregulator expression in HCC. These findings suggest that the m(6)A writer complex may serve as a promising biomarker and therapeutic target for HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Matthias Schneider, Varius Dannenberg, Andreas Koenig, Welf Geller, Thomas Binder, Christian Hengstenberg, Georg Goliasch
Summary: Severe tricuspid regurgitation significantly impacts the assessment of right ventricular function in transthoracic echocardiography. This study confirmed that RVF is a major driver of mortality in patients with severe isolated TR, but established echocardiographic parameters did not accurately predict survival. Further research should investigate higher thresholds for RVF parameters in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Juehui Wu, Laisheng Li, Jinmei Luo
Summary: Monocyte distribution width (MDW) is a parameter that can be detected by an automated hemocyte analyzer and provides important information about cell volume variability in peripheral blood monocyte populations. Research has shown that MDW has diagnostic and predictive value for sepsis in neonates and COVID-19 patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Savino Sciascia, Nicola Bizzaro, Pier Luigi Meroni, Bogdanos Dimitrios, Maria Orietta Borghi, Xavier Bossuyt, Claudia Grossi, David Tornai, Maria Papp, Yehuda Shoenfeld, Daniele Ielo, Marvin J. Fritzler
Summary: Diagnosing autoimmune diseases is challenging due to the lack of specific markers, but this review focuses on the role of autoantibodies testing in various diseases. The diagnostic and prognostic values of autoantibodies testing in interstitial lung disease are also explored. In addition to disease phenotypes, research has investigated the molecular action of autoantibodies on immune regulation and disease pathogenesis.
AUTOIMMUNITY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Ketsanee Srinamon, James A. Watson, Kamolrat Silamut, Benjamas Intharabut, Nguyen Hoan Phu, Pham Thi Diep, Kirsten E. Lyke, Caterina Fanello, Lorenz von Seidlein, Kesinee Chotivanich, Arjen M. Dondorp, Nicholas P. J. Day, Nicholas J. White
Summary: Malaria diagnosis by microscopy is crucial for clinical management, providing rapid and valuable diagnostic and prognostic information. In this meta-analysis, the authors examined the diagnostic and prognostic value of polymorphonuclear leukocytes and monocytes containing malaria pigment in peripheral blood film counts of severe malaria patients. They found that the proportion of pigment-containing polymorphonuclear leukocytes can predict in-hospital mortality, especially in African children, aiding in differentiating severe malaria from other life-threatening febrile illnesses.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
L. Legrand, C. Heuze, A. Diallo, M. L. Monin, C. Ewenczyk, E. Vicaut, G. Montalescot, R. Isnard, A. Durr, F. Pousset
Summary: Friedreich's ataxia (FA) is a rare mitochondria! disease with cardiac disease as the major cause of death. This study found that, in FA patients, LVEF was a better independent predictor of mortality compared to LS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Respiratory System
Tian-Xin Dong, Qing Zhu, Shi-Tong Wang, Yong-Huai Wang, Guang-Yuan Li, Fan-Xin Kong, Chun-Yan Ma
Summary: Echocardiography is recommended for the detection and prognosis of pulmonary hypertension based on existing evidence. Systolic pulmonary arterial pressure and right ventricular outflow tract acceleration time can be utilized for detection, while factors such as pericardial effusion, right atrial area, tricuspid annular systolic displacement, and right ventricular longitudinal strain have demonstrated prognostic significance.
BMC PULMONARY MEDICINE
(2023)
Review
Multidisciplinary Sciences
Tetsuji A. Kitano, Yosuke A. Nabeshima, Yasufumi A. Nagata, Masaaki A. Takeuchi
Summary: The prognostic value of right ventricular ejection fraction (RVEF) assessed by three-dimensional echocardiography (3DE) was examined and compared to left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LVGLS). RVEF was found to have a higher predictive power than LVEF in certain populations and was similar to LVGLS in terms of prognostic value. Individual patient data analysis confirmed these findings.
Meeting Abstract
Oncology
Robert William Lentz, Shuo Ma, Nausheen Akhter
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Meeting Abstract
Oncology
Joyce Njoroge, Robert William Lentz, Jered Linares, Christopher Gans, Nausheen Akhter
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Gayan Rubasinghege, Robert W. Lentz, Heaweon Park, Michelle M. Scherer, Vicki H. Grassian
Article
Multidisciplinary Sciences
Gayan Rubasinghege, Robert W. Lentz, Michelle M. Scherer, Vicki H. Grassian
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Review
Oncology
Robert Lentz, Al B. Benson, Sheetal Kircher
JOURNAL OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Robert Lentz, Joseph Feinglass, Shuo Ma, Nausheen Akhter
LEUKEMIA & LYMPHOMA
(2019)
Meeting Abstract
Oncology
Andrew A. Davis, Wade Thomas Iams, David Chan, Michael S. Oh, Robert William Lentz, Rohith Srivas, Nicole Lambert, Alex Robertson, Neil Peterman, Abhik Shah, Timothy Wilson, Jason Close, Peter George, Haleigh Wood, Ayse Tezcan, Ram Yalamanchili, Ken Nesmith, John C. Spinosa, Haluk Tezcan, Young Kwang Chae
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Andrew A. Davis, Wade Thomas Iams, David Chan, Michael S. Oh, Robert William Lentz, Neil Peterman, Alex Robertson, Abhik Shah, Rohith Srivas, Nicole Lambert, Timothy Wilson, Peter George, Becky Wong, Ayse Tezcan, Ram Yalamanchili, Ken Nesmith, John C. Spinosa, Haluk Tezcan, Young Kwang Chae
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Andrew A. Davis, Wade T. Iams, David Chan, Michael S. Oh, Robert W. Lentz, Neil Peterman, Alex Robertson, Abhik Shah, Rohith Srivas, Timothy J. Wilson, Nicole J. Lambert, Peter S. George, Becky Wong, Haleigh W. Wood, Jason C. Close, Ayse Tezcan, Ken Nesmith, Haluk Tezcan, Young Kwang Chae
MOLECULAR CANCER THERAPEUTICS
(2020)
Review
Oncology
Robert W. Lentz, Meryl D. Colton, Siddhartha S. Mitra, Wells A. Messersmith
Summary: While immunotherapy has revolutionized the treatment of many types of advanced cancer, most patients still do not derive benefit. Innate immune checkpoint inhibitors are a promising new target that can disrupt inhibitory interactions between tumor and both phagocytes and natural killer cells. This area of drug development targeting phagocytosis and natural killer-cell checkpoints could revolutionize immune-based cancer therapies.
MOLECULAR CANCER THERAPEUTICS
(2021)
Editorial Material
Oncology
Robert W. Lentz, Wells A. Messersmith
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Andrew A. Davis, Wade T. Iams, David Chan, Michael S. Oh, Robert W. Lentz, Neil Peterman, Alex Robertson, Abhik Shah, Rohith Srivas, Nicole Lambert, Tim Wilson, Peter George, Becky Wong, Ayse Tezcan, Ram Yalamanchili, Ken Nesmith, John C. Spinosa, Haluk Tezcan, Young Kwang Chae