Article
Public, Environmental & Occupational Health
Cristina Villanueva-Bueno, Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Jose Luis Revuelta-Herrero, Maria Belen Marzal-Alfaro, Eva Gonzalez-Haba, Jose Angel Arranz-Arija, Santiago Osorio, Ana Herranz-Alonso, Maria Sanjurjo-Saez
Summary: This study analyzed the impact of the eOncosalud app on the management and follow-up of adverse effects in patients receiving oral antineoplastic agents. The app enabled real-time monitoring of patients and provided automatic recommendations, optimizing healthcare resources and improving treatment safety.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Nadine Alvina Kong, Foong Ming Moy, Shu Hwa Ong, Ghalib Ahmed Tahir, Choo Kiong Loo
Summary: This study aims to develop a mobile diet application that helps users track their diet and provides detailed nutrient analysis through food recognition. The results show that the application has high usability scores and can help users sustain their diet monitoring habit to improve health outcomes.
Article
Health Care Sciences & Services
Alessandro Passardi, Flavia Foca, Orazio Caffo, Carlo Alberto Tondini, Alberto Zambelli, Roberto Vespignani, Giulia Bartolini, Francesco Giulio Sullo, Daniele Andreis, Marco Dianti, Claudio Eccher, Enrico Maria Piras, Stefano Forti
Summary: This study tested a platform called ONCO-TreC, which is designed to support home management of oral anticancer treatments and provide secure communication between patients and health care professionals. The results showed that the system has a high ability to measure adherence to treatment and is highly usable and acceptable. However, there is room for improvement in the system's reliability in recording toxicities.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Chemistry, Analytical
Ignasi Ferrer-Lluis, Yolanda Castillo-Escario, Josep Maria Montserrat, Raimon Jane
Summary: This study aims to investigate how smartphones can be used to monitor and treat sleep position at home. The development of an Android application successfully monitored sleep positions and demonstrated effectiveness in managing desaturation events.
Article
Oncology
Laura Porcher, Valerie Perron, Julie Blanc, Coureche-Guillaume Kaderbhai, Zoe Tharin, Antonin Schmitt, Matthieu Gallet
Summary: This study described nurses' interventions and medical changes after alerts triggered by a web-based platform designed to support the management of oral anticancer agents-related toxicities. Results showed that more than 90% of patients in the cancer center declared that they took their medication as prescribed. Up to 60% of patients recorded all grade symptoms, including 8% who recorded Grades 3-4 symptoms during the month, mostly anorexia, fatigue, and diarrhea.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)
Article
Oncology
Xiomara Skrabal Ross, Kate M. Gunn, Vijayaprakash Suppiah, Pandora Patterson, Terry Boyle, Christine Carrington, Shir Ley Tan, Marissa Ryan, Rohit Joshi, Ian Olver
Summary: This study demonstrated the proof-of-concept of a smartphone program to support adherence to oral chemotherapy in cancer patients. While the intervention did not improve medication adherence, it was effective in increasing knowledge about oral chemotherapy among participants. Further research should focus on evaluating the program's impact on nonadherent patients.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Etienne Camire-Bernier, Erwan Nidelet, Amel Baghdadli, Gabriel Demers, Marie-Christine Boulanger, Marie-Claude Brisson, Bruno Michon, Sophie Lauzier, Isabelle Laverdiere
Summary: The study found that parents of children with ALL had a positive attitude towards home-based oral chemotherapies, demonstrating high motivation to follow treatment recommendations. Adequate information received enabled parents to feel knowledgeable and capable of taking charge of the treatment at home. Adapting to the impact of oral chemotherapies on family daily life was identified as the biggest challenge faced by parents.
Review
Biochemistry & Molecular Biology
Feng-Wei Guo, Qun Zhang, Yu-Cheng Gu, Chang-Lun Shao
Summary: In this paper, we reviewed 95 new sulfur-containing marine natural products isolated between 2021 and March 2023. We also discussed the strategies and emerging technologies, such as natural product-based antibody drug conjugates (ADCs), small-molecule-based proteolysis targeting chimeras (PROTACs), nanotechnology-based drug carriers, and artificial intelligence-driven drug discovery, that have been used to improve the efficiency and success rate of NP-based drug development. Additionally, we provided perspectives on the challenges, opportunities, and future research directions in sulfur-containing marine natural product-based drug discovery and development.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Review
Oncology
Marco Di Nitto, Fabio Sollazzo, Valentina Biagioli, Gianluca Pucciarelli, Francesco Torino, Rosaria Alvaro, Ercole Vellone
Summary: This review examined self-care behaviors in patients treated with oral anticancer agents. The findings showed that most behaviors focused on medication adherence and there is a need for future interventions to improve self-care in this vulnerable population.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Computer Science, Information Systems
Pamela J. Surkan, Lisa B. Puglisi, Karim Butler, Nika Elmi, Wayne W. Zachary
Summary: Individuals returning from incarceration face multiple barriers to accessing care for cardiovascular health, including medication and health insurance. A smartphone app that addresses social services and healthcare access issues may help these individuals meet their cardiovascular disease needs.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Clinical Neurology
Alejandro Porras-Segovia, Aurora Cobo, Isaac Diaz-Olivan, Antonio Artes-Rodriguez, Sofian Berrouiguet, Jorge Lopez-Castroman, Philippe Courtet, Maria Luisa Barrigon, Maria A. Oquendo, Enrique Baca-Garcia
Summary: This study examines the association of wish to die with disturbed sleep, altered appetite, and negative feelings using smartphone monitoring and machine learning techniques. Findings suggest a significant correlation between sleep problems and wish to die.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Peripheral Vascular Disease
Eline H. Groenland, Jean-Paul A. C. Vendeville, Remy H. H. Bemelmans, Houshang Monajemi, Michiel L. Bots, Frank L. J. Visseren, Wilko Spiering
Summary: This study evaluated the agreement between app-assisted home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring, and found significant disagreement between the two methods. App-assisted home blood pressure monitoring had high sensitivity in diagnosing sustained and masked hypertension, and can be used as a complement to 24-hour ambulatory blood pressure monitoring.
Article
Chemistry, Analytical
Eloi Figueiredo, Ionut Moldovan, Pedro Alves, Hugo Rebelo, Laura Souza
Summary: This paper presents a smartphone application called App4SHM, which uses the phone's internal accelerometer to measure accelerations and employs a machine learning algorithm to detect structural damage. It shows reliable precision and accurate damage detection, making it a low-cost solution for long-term SHM and post-disaster assessment.
Article
Clinical Neurology
Kaito Kageyama, Yudai Kato, Takanori Mesaki, Hiroyuki Uchida, Kana Takahashi, Risako Marume, Yoshiyuki Sejima, Kazuki Hirao
Summary: A pilot RCT was conducted to assess the efficacy of SPSRS application intervention for people with subthreshold depression. The results showed that the experimental group displayed medium, small, and small improvements in depressive symptoms compared to the control group after the 5-week intervention.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Computer Science, Information Systems
Anisbed Naranjo-Rojas, Luis Angel Perula-de Torres, Freiser Eceomo Cruz-Mosquera, Guillermo Molina-Recio
Summary: This study aimed to assess the usability and satisfaction of a mobile app designed for patients with chronic obstructive pulmonary disease (COPD). The results showed that participants found the app intuitive and easy to use, and reported a high level of satisfaction.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Health Care Sciences & Services
Maria Belen Marzal-Alfaro, Vicente Escudero-Vilaplana, Carmen Guadalupe Rodriguez-Gonzalez, Eva Gonzalez-Haba, Aitana Calvo, Santiago Osorio, Irene Iglesias-Peinado, Ana Herranz, Maria Sanfurjo
Summary: This study aimed to analyze the prevalence of errors and associated costs with the implementation of an image-based workflow management system during the antineoplastic compounding process. Results showed that Phocus Rx system effectively prevented errors reaching patients and was cost-effective from the hospital's perspective.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Pharmacology & Pharmacy
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Almudena Ribed, Rosa Romero Jimenez, Irene Iglesias Peinado, Ana Herranz-Alonso, Maria Sanjurjo-Saez
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2020)
Article
Health Care Sciences & Services
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Cristina Villanueva-Bueno, Ana Herranz-Alonso, Maria Sanjurjo-Saez
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Oncology
Estela Garcia-Martin, Vicente Escudero-Vilaplana, Barbara Fox, Roberto Collado-Borrell, Belen Marzal-Alfaro, Maria Sanchez-Isac, Maria Luisa Solano-Garzon, Ricardo Gonzalez del Val, Jose Manuel Cano-Gonzalez, Nuria Perez de Lucas, Ana Isabel Bravo-Guillen, Javier Valero-Salinas, Eva Gonzalez-Haba, Maria Sanjurjo, Miguel Martin
Summary: The study found that end-of-life cancer care in the clinical practice of the hospital tended to be aggressive, with a significant proportion of patients receiving anti-cancer treatments close to death. However, the quality of care did not meet the high standards set by the Earle criteria. While more than half of the patients received hospice services before death, in some cases, this care started only shortly before the patients passed away.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Health Care Sciences & Services
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Almudena Ribed, Cristina Gonzalez-Anleo, Maite Martin-Conde, Rosa Romero-Jimenez, Irene Iglesias-Peinado, Ana Herranz-Alonso, Maria Sanjurjo-Saez
JMIR MHEALTH AND UHEALTH
(2020)
Article
Oncology
Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Cristina Villanueva-Bueno, Rosa Alvarez, Ana Herranz, Maria Sanjurjo
Summary: This case report describes a possible case of acute pancreatitis induced by the interaction between imatinib and gefitinib. The patient received supportive treatment but eventually passed away 3 months after discontinuation of the two drugs.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2021)
Article
Oncology
Vicente Escudero-Vilaplana, Antonio Calles, Roberto Collado-Borrell, Maria Belen Marzal-Alfaro, Carlos Polanco, Carmen Garrido, Jorge Suarez, Aurora Ortiz, Marilena Appierto, Marta Comellas, Luis Lizan
FRONTIERS IN ONCOLOGY
(2020)
Article
Environmental Sciences
Ana Rosa Rubio-Salvador, Vicente Escudero-Vilaplana, Jose Antonio Marcos Rodriguez, Irene Mangues-Bafalluy, Beatriz Bernardez, Carlos Garcia Collado, Roberto Collado-Borrell, Maria Dolores Alvarado Fernandez, Jose Ignacio Chacon Lopez-Muniz, Maria Yebenes Cortes, Manuel Gomez Barrera, Miguel Angel Calleja-Hernandez
Summary: Patients with lung cancer are at higher risk of developing VTE, leading to increased healthcare costs, with hospitalizations being the main drivers of cost.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Carmen Guadalupe Rodriguez-Gonzalez, Esther Chamorro-de-Vega, Maricela Valerio, Miguel Angel Amor-Garcia, Francisco Tejerina, Milagros Sancho-Gonzalez, Alvaro Narrillos-Moraza, Alvaro Gimenez-Manzorro, Silvia Manrique-Rodriguez, Marina Machado, Maria Olmedo, Vicente Escudero-Vilaplana, Cristina Villanueva-Bueno, Beatriz Torroba-Sanz, Alejandra Melgarejo-Ortuno, Juan Vicente-Valor, Ana Herranz, Emilio Bouza, Patricia Munoz, Maria Sanjurjo
Summary: This study reported on 1255 adult cases receiving anti-COVID-19 treatment at a Spanish hospital in March 2020, revealing the severity of illness and the impact of treatment measures on some patients. The study found that factors such as age, underlying conditions like cardiovascular disease and diabetes, as well as certain abnormal biochemical markers, were closely associated with the risk of death.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Oncology
Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Maria del Monte-Millan, Angela Hoyo-Munoz, Patricia Gomez Martinez-Sagrera, Jose Luis Revuelta-Herrero, Belen Marzal-Alfaro, Eva Gonzalez-Haba, Sara Lopez-Tarruella Cobo, Yolanda Jerez Gilarranz, Ana Herranz, Maria Sanjurjo, Miguel Martin
Summary: The study analyzed the incidence, characteristics, and severity of diarrhea in cancer patients treated with targeted oral antineoplastic agents, identifying that more than a third of patients experienced diarrhea, and that taking the medication on an empty stomach was significantly associated with an increased risk of diarrhea.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Maria Belen Marzal-Alfaro, Vicente Escudero-Vilaplana, Jose Luis Revuelta-Herrero, Roberto Collado-Borrell, Ana Herranz-Alonso, Maria Sanjurjo-Saez
Summary: This study aimed to develop a structured guide to support hospital pharmacist responsibilities in CAR-T cell therapy programs in Europe. A multidisciplinary team defined key tasks and issued recommendations to improve patient safety and treatment efficacy, creating a checklist to ensure compliance with standard operating procedures. The guide provides safety recommendations for CAR-T therapy management and standardizes hospital pharmacists' responsibilities within the team.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cristina Villanueva-Bueno, Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Alvaro Gimenez-Manzorro, Almudena Ribed, Belen Marzal-Alfaro, Jose Luis Revuelta-Herrero, Eva Gonzalez-Haba, Ana Herranz, Maria Sanjurjo
Summary: Oral antineoplastic agents (OAAs) are high-risk drugs that may increase the risk of bleeding, difficulty in wound healing, or produce alterations in coagulation and/or platelet aggregation. Most OAAs require perioperative monitoring, and only a small number have specific recommendations for temporary suspension before surgery. This review provides a comprehensive guide for healthcare professionals to manage OAAs during the perioperative process.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Pharmacology & Pharmacy
Angela Hoyo-Munoz, Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Mariana Bastos-Oreiro, Ana Herranz-Alonso, Maria Sanjurjo-Saez
Summary: This case report describes a 74-year-old female with pulmonary RDD who responded to thalidomide treatment after failing multiple previous therapies. Thalidomide induced remission in this refractory pulmonary RDD case, showing rapid onset of action and lasting responses, offering an exciting treatment option for this life-threatening condition.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Juan Vicente-Valor, Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Sara Perez-Ramirez, Cristina Villanueva-Bueno, Alvaro Narrillos-Moraza, Sebastian Garcia-Sanchez, Manel Beamud-Cortes, Ana Herranz, Maria Sanjurjo
Summary: Abiraterone and enzalutamide, ARPIs for mCRPC, have high risk of PDIs. This study found that at least two-thirds of patients treated with ARPIs experienced PDIs, with polypharmacy and treatment with enzalutamide associated with higher risk.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Oncology
Juan Vicente-Valor, Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Cristina Lopez-Lopez, Cristina Villanueva-Bueno, Jose Luis Revuelta-Herrero, Paula Ruiz-Briones, Beatriz Somoza-Fernandez, Ana Herranz, Maria Sanjurjo
Summary: The combination of spironolactone with abiraterone in patients with mCRPC may compromise the therapeutic effectiveness of abiraterone due to potential androgenic effects of spironolactone. Despite the potential benefits for cardiac conditions, combining spironolactone with abiraterone may lead to disease progression, as evidenced by rising PSA levels and tumor progression observed in two cases discussed. Strategies to address this interaction could involve alternative medications such as eplerenone, with a multidisciplinary approach recommended for evaluation by cardiologists and oncologists.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)