Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet?

Differentially methylated DNA regions in early childhood wheezing: An epigenome-wide study using saliva

(2019) Maja Popovic et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter

(2018) R. J. Lund et al.   ALLERGY

Reduced CDHR3 expression in children wheezing with rhinovirus

(2018) Katarina Stenberg Hammar et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data

(2018) Gaurav Pandey et al.   Scientific Reports

Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma

(2018) Mary Prunicki et al.   Clinical Epigenetics

GLI2 promoter hypermethylation in saliva of children with a respiratory allergy

(2018) Sabine A. S. Langie et al.   Clinical Epigenetics

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

(2018) Cheng-Jian Xu et al.   Lancet Respiratory Medicine

Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity

(2018) Marrah E. Lachowicz-Scroggins et al.   Cell Discovery

Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma

(2018) Sarah E. Reese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Integrative approach identifies corticosteroid response variant in diverse populations with asthma

(2018) Albert M. Levin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus infections change DNA methylation and mRNA expression in children with asthma

(2018) Martin Pech et al.   PLoS One

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

(2018) Erick Forno et al.   Lancet Respiratory Medicine

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

(2017) Avery DeVries et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An epigenome-wide association study of total serum IgE in Hispanic children

(2017) Wei Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The nasal methylome and childhood atopic asthma

(2017) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Nasal airway epithelial cell IL-6 and FKBP51 gene expression and steroid sensitivity in asthmatic children

(2017) Michael Fayon et al.   PLoS One

Epigenome-wide association study of asthma and wheeze in childhood and adolescence

(2017) Ryan Arathimos et al.   Clinical Epigenetics

Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

(2017) Kyung Hwa Jung et al.   Clinical Epigenetics

DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

(2017) Milena Magalhães et al.   Clinical Epigenetics

Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study

(2017) Xue Zhang et al.   PLoS One

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

(2016) Bonnie R. Joubert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Peripheral blood gene expression predicts clinical benefit from anti–IL-13 in asthma

(2016) David F. Choy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood

(2016) Maria J. Gutierrez et al.   PLoS One

Heritability and confirmation of genetic association studies for childhood asthma in twins

(2015) V. Ullemar et al.   ALLERGY

METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages

(2015) Irina Ushach et al.   CLINICAL IMMUNOLOGY

CTNNA3 and SEMA3D : Promising loci for asthma exacerbation identified through multiple genome-wide association studies

(2015) Michael J. McGeachie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An epigenome-wide association study of total serum immunoglobulin E concentration

(2015) Liming Liang et al.   NATURE

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

(2015) Harriet Corvol et al.   Nature Communications

The Association ofGSDMBandORMDL3Gene Polymorphisms With Asthma: A Meta-Analysis

(2015) Chun-Ni Zhao et al.   Allergy Asthma & Immunology Research

Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins

(2015) Therese M. Murphy et al.   Clinical Epigenetics

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

(2014) Nathalie Acevedo et al.   HUMAN MOLECULAR GENETICS

Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

(2014) Alex Poole et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids

(2014) Heung-Woo Park et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

(2014) Leah C Kottyan et al.   NATURE GENETICS

Prenatal Tobacco Smoke Exposure Is Associated with Childhood DNA CpG Methylation

(2014) Carrie V. Breton et al.   PLoS One

Respiratory health and disease in Europe: the new European Lung White Book

(2013) G. John Gibson et al.   EUROPEAN RESPIRATORY JOURNAL

Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma

(2012) Andrea Baccarelli et al.   Epigenomics

Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers

(2011) Mousheng Xu et al.   BMC Medical Genetics

Distinct epithelial gene expression phenotypes in childhood respiratory allergy

(2011) Lisa Giovannini-Chami et al.   EUROPEAN RESPIRATORY JOURNAL

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases

(2011) Hon-Cheong So et al.   GENETIC EPIDEMIOLOGY

Increase in the heritability of asthma from 1994 to 2003 among adolescent twins

(2011) Simon Francis Thomsen et al.   RESPIRATORY MEDICINE

Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis

(2010) Ruslan Dorfman et al.   PEDIATRIC PULMONOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE