Article
Biochemistry & Molecular Biology
Reihaneh Mousavi, Mohammad Alizadeh, Mohammad Asghari Jafarabadi, Lida Heidari, Roshan Nikbakht, Hossein Babaahmadi Rezaei, Majid Karandish
Summary: This study found that co-supplementation of magnesium and melatonin for 8 weeks in women with polycystic ovary syndrome (PCOS) resulted in significant improvements in hirsutism, serum TNF-alpha, and total antioxidant capacity (TAC) levels. Melatonin independently contributed to decreased serum values of TNF-alpha.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Immunology
Sima Vaez, Kazem Parivr, Fardin Amidi, Nasim Hayati Rudbari, Ashraf Moini, Naser Amini
Summary: Quercetin intake has positive effects on PCOS patients, improving oocyte and embryo grade, increasing pregnancy rate, and reducing inflammation and LH parameters.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natalia Zeber-Lubecka, Michal Ciebiera, Ewa E. Hennig
Summary: Oxidative stress is closely related to polycystic ovary syndrome (PCOS). Mitochondrial mutations may contribute to the metabolic and hormonal dysregulation observed in PCOS, while excessive reactive oxygen species (ROS) can damage oocytes and granulosa cells within the follicles, impairing fertility. Additionally, impaired oxidative phosphorylation (OXPHOS) and mitochondrial dysfunction may lead to insulin resistance (IR), further exacerbating oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Haolin Zhang, Wei Wang, Jiaming Zhao, Peijie Jiao, Lin Zeng, Hua Zhang, Yue Zhao, Li Shi, Hangqi Hu, Liyan Luo, Ii Fukuzawa, Dong Li, Rong Li, Jie Qiao
Summary: This study investigated the influence of body fat on glucose metabolism and hormone profiles in women with polycystic ovary syndrome (PCOS) compared to women without PCOS. The results showed that women with PCOS, both obese and non-obese, had more severe insulin resistance and sex-hormone disorders than women without PCOS. The effect of body fat on sex-hormone disorders was only present in women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manjula Nandakumar, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin
Summary: Oxidative stress, heat shock proteins, and vitamin D levels may be associated with polycystic ovary syndrome (PCOS). In this study, the levels of oxidative stress proteins and heat shock proteins were measured in non-obese, non-insulin resistant women with PCOS and control women. The results showed that only esterase D was elevated in PCOS, while other oxidative stress proteins and heat shock proteins were not elevated. Vitamin D levels were not correlated with any of the proteins.
Article
Nutrition & Dietetics
Mohammad Alizadeh, Majid Karandish, Mohammad Asghari Jafarabadi, Lida Heidari, Roshan Nikbakht, Hossein Babaahmadi Rezaei, Reihaneh Mousavi
Summary: The study found that co-supplementation of magnesium and melatonin significantly improved the sleep quality and total testosterone levels in PCOS patients, and melatonin supplementation alone was also associated with a significant improvement in sleep quality. Furthermore, combined melatonin and magnesium supplementation was more effective in improving serum levels of cholesterol, LDL-C, HDL-C, insulin, and HOMA-IR.
NUTRITION & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Nese Basak Turkmen, Hande Yuce, Muhterem Aydin, Asli Taslidere, Aysegul Dogan, Dilan Askin Ozek, Taha Bartu Hayal, Seyma Yasar, Osman Ciftci, Songul Unuvar
Summary: Based on the experimental results, it can be deduced that nerolidol has a significant ameliorating effect on lipid peroxidation, oxidative stress, inflammation, histopathological damage, and apoptosis accompanying PCOS in female rats.
Review
Pharmacology & Pharmacy
Hongying Shan, Renxin Luo, Xuanying Guo, Rong Li, Zhenhong Ye, Tianliu Peng, Fenting Liu, Zi Yang
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women, which is associated with infertility, menstrual irregularities, endometrial hyperplasia, and obesity. The disease and its complications are closely related to local oxidative stress imbalance in the endometrium, affecting endometrial receptivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dariusz Szukiewicz, Seweryn Trojanowski, Anna Kociszewska, Grzegorz Szewczyk
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It is a complex disorder influenced by genetic, environmental, endocrine, and behavioral factors. The primary clinical manifestations of PCOS are derived from excess androgens, while the secondary manifestations involve multiple metabolic, cardiovascular, and psychological disorders. Diet and lifestyle factors play important roles in the development and course of PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Adam T. Evans, Heidi Vanden Brink, Jessica S. Lim, Brittany Y. Jarrett, Annie W. Lin, Marla E. Lujan, Kathleen Hoeger
Summary: Circulating melatonin is elevated in women with polycystic ovary syndrome (PCOS), and altered patterns of melatonin excretion may be associated with reduced sleep quality in these women. This study found that women with PCOS had lower weekend sleep efficiency compared to controls, and the number of follicles per ovary was positively associated with overnight melatonin levels. These findings suggest that PCOS diagnostic features are related to melatonin production and sleep disturbances.
Article
Nutrition & Dietetics
Anna Bizon, Sylwia Placzkowska, Justyna Niepsuj, Marta Czwojdzinska, Marcin Lesniewski, Artur Nowak, Dagmara Pluta, Pawel Madej, Agnieszka Piwowar, Grzegorz Franik
Summary: This study found that women with Polycystic Ovary Syndrome (PCOS) did not show significant differences in body composition parameters compared to those without PCOS, but they had higher hormone concentrations, with sex hormone binding globulin and free testosterone correlating with all investigated body composition parameters only in the PCOS group. Additionally, logistic regression identified that the concentration of Anti-Mullerian hormones and body mass index could be useful parameters in differentiating women with PCOS from those with other disorders.ROC analysis further confirmed the concentration of Anti-Mullerian hormones as a powerful parameter for categorizing women as suffering from PCOS.
Article
Immunology
Qi Xie, Wenli Hong, Yuan Li, Shuyi Ling, Ziqiong Zhou, Yuqing Dai, Wenbo Wu, Ruoxin Weng, Zhisheng Zhong, Jun Tan, Yuehui Zheng
Summary: Polycystic Ovary Syndrome (PCOS) is a common reproductive endocrine disorder that can cause infertility. This study investigated the impact of inflammation and oxidative stress on granulosa cells (GCs) in PCOS patients and found that chitosan oligosaccharide (COS) can improve GC function by reducing inflammation and oxidative stress.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiyang Yao, Xin Zou, Shihe Liu, Haowen Wu, Qiyang Shen, Jihong Kang
Summary: Polycystic ovarian syndrome (PCOS) is a disorder related to reproduction, endocrine, and metabolism, and oxidative stress markers are abnormal in patients with PCOS. This study found that PCOS mice had increased oxidative stress biomarkers and damaged insulin sensitivity in skeletal muscles. High levels of testosterone caused mitochondrial dysfunction and increased reactive oxygen species (ROS) levels. Treatment with an antioxidant improved mitochondrial function and reversed insulin resistance. The findings suggest that oxidative stress contributes to skeletal muscle insulin resistance in PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dejana Rakic, Vladimir Jakovljevic, Nikola Jovic, Marija Bicanin Ilic, Aleksandra Dimitrijevic, Tatjana Vulovic, Petar Arsenijevic, Jasmina Sretenovic, Maja Nikolic, Vladimir Petrovich Fisenko, Stefani Bolevich, Gala Zarkovic, Jovana Joksimovic Jovic
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, and it has specific cardiometabolic properties. The presence of metabolic disorders in PCOS emphasizes the importance of regulating glycemic status. Sodium-glucose cotransporter type 2 inhibitors (SGLT-2is) have potential advantages in managing PCOS by improving glucose metabolism, reducing fat tissue, lowering blood pressure, reducing oxidative stress and inflammation, and protecting the cardiovascular system.
Article
Obstetrics & Gynecology
Amin Ullah, Mei-Jiao Wang, Jun-Pu Yang, Enoch Appiah Adu-Gyamfi, Armin Czika, Sanjay Kumar Sah, Qian Feng, Ying-Xiong Wang
Summary: This study investigated the expression pattern of inflammatory mRNA profiles in the ovarian tissues of a DHEA plus HFD-induced PCOS mouse model. The differentially expressed genes were found to be associated with PCOS inflammation and could potentially serve as therapeutic options against the disease.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Marziyeh Salami, Raziyeh Salami, Mohammad-Hossein Aarabi, Alireza Mafi, Seyedeh Sara Ghorbanhosseini, Rana Shafabakhsh, Zatollah Asemi
Summary: Gliomas, especially glioblastoma, are highly resistant to existing treatments and have a low prognosis, necessitating the search for new treatment options. Nutraceuticals have shown promise in inhibiting tumor growth, angiogenesis, and inducing apoptosis in cancer cells, including glioma. These compounds can target cellular signaling pathways and other mechanisms to disrupt cancer cells. Recent studies have identified potential target molecules and signaling pathways affected by nutraceuticals in glioma cells, suggesting that clinical trials and new approaches are imminent.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi, Bahman Yousefi
Summary: Osteosarcoma is the most common primary bone malignancy among children and adolescents, and its high mortality rate is mainly due to lung metastasis. Traditional chemotherapy and surgical treatment have limited efficacy in reducing metastasis rate and improving prognosis. Therefore, it is necessary to explore new therapeutic strategies to enhance the survival rate of osteosarcoma patients. Curcumin, a compound derived from Curcuma longa, has been shown to have multiple anti-cancer effects. Studies have demonstrated that curcumin can inhibit cell proliferation and induce apoptosis in osteosarcoma cells. Additionally, research has identified several signaling pathways involved in the pathogenesis of osteosarcoma, and curcumin has been evaluated for its potential to regulate these pathways and improve treatment outcomes.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Pouya Mahdavi Sharif, Parisa Maleki Dana, Zatollah Asemi
Summary: Gastrointestinal (GI) cancers are prevalent worldwide with increasing incidence. Treatment options for these cancers are limited and new strategies are needed. Resveratrol, a natural product found in fruits and plants, has been studied for its effects on microRNAs in neoplastic disorders. This review aims to illustrate the molecular pathways related to resveratrol and evaluate its impacts on microRNAs in the prevention and treatment of GI cancers.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Bahman Yousefi, Zatollah Asemi
Summary: Melatonin, a secretion of the pineal gland, has been found to have significant effects on tumor tissues, including inhibiting tumor growth, promoting apoptosis, and suppressing angiogenesis. Current therapeutic strategies for bone cancer are limited, and there is a need to better understand the molecular pathways and cellular functions associated with this disease in order to develop new treatments. This review summarizes the functions of melatonin in osteosarcoma and Ewing's sarcoma, as well as its mechanisms of action as an antitumor agent and its synergistic effects with other chemotherapy drugs.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi, Alireza Mafi
Summary: Circular RNAs (circRNAs) play important roles in the pathogenesis of Alzheimer's disease (AD) by acting as miRNA sponges or gene transcription modulators, involved in the accumulation of Aβ peptides and tau protein, and have been reported as potential diagnostic and therapeutic biomarkers in AD.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Retraction
Biochemistry & Molecular Biology
Zahra Heidarzadeh, Mansooreh Samimi, Seyed Morteza Seifati, Mahmood Dehghani Ashkezari, Shahnaz Ahmadi, Samaneh Mahmoodi, Esmat Aghadavod, Mehri Jamilian, Zatollah Asemi
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Alireza Mafi, Malihe Rezaee, Neda Hedayati, Sara Diana Hogan, Russel J. Reiter, Mohammad-Hossein Aarabi, Zatollah Asemi
Summary: Combined chemotherapy is an effective treatment for cancer patients, as it combines multiple therapeutic agents to target different aspects of cancer. 5-FU is a widely used chemotherapy agent, while melatonin has shown anti-cancer properties. This review aims to evaluate the role of melatonin as a complementary agent with 5-FU-based chemotherapy and identify their common signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Pharmacology & Pharmacy
Malihe Rezaee, Fatemeh Mohammadi, Atoosa Keshavarzmotamed, Sheida Yahyazadeh, Omid Vakili, Yaser Eshaghi Milasi, Vida Veisi, Rohollah Mousavi Dehmordi, Sepideh Asadi, Seyedeh Sara Ghorbanhosseini, Mehdi Rostami, Mina Alimohammadi, Abbas Azadi, Nushin Moussavi, Zatollah Asemi, Azadeh Aminianfar, Hamed Mirzaei, Alireza Mafi
Summary: Breast cancer is the most common cancer among women worldwide, and drug resistance is a major challenge in its treatment. Exosomal non-coding RNAs have the potential to regulate the molecular mechanisms and pathways related to breast cancer progression and drug resistance, and also serve as biomarkers for diagnosis and prognosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Atefe Rahmati, Alireza Mafi, Firooze Soleymani, Zahra Babaei Aghdam, Niloufar Masihipour, Behrooz Ghezelbash, Reza Asemi, Michael Aschner, Omid Vakili, Mina Homayoonfal, Zatollah Asemi, Mehran Sharifi, Abbas Azadi, Hamed Mirzaei, Esmat Aghadavod
Summary: Acute myeloid leukemia (AML) is a aggressive hematological malignancy with poor overall survival rates. Circular RNAs (circRNAs), a class of non-coding RNAs with a unique loop structure, have been found to be dysregulated in AML patients. These dysregulated circRNAs have been shown to regulate leukemia cell proliferation, stemness, and apoptosis in both positive and negative ways. Furthermore, circRNAs show potential as biomarkers and therapeutic targets in AML.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami, Yasaman Gholinezhad, Farnaz Aghadavood, Reza Eshraghi, Mohammad-Hossein Aarabi, Mina Homayoonfal, Zatollah Asemi, Hamed Mirzaei, Mohammad Hajijafari, Alireza Mafi, Malihe Rezaee
Summary: Polyphenols, which are abundant in regular diets, have various beneficial effects such as antioxidative, anti-inflammatory, anticancer, neuroprotective, and cardioprotective effects. Recent research has focused on the potential of polyphenols as alternative treatments for cardiac remodeling following cardiovascular diseases. Through a systematic search of online databases, it was found that polyphenols regulate vital molecules and signaling pathways associated with heart failure, such as fibrotic and hypertrophic factors, mitochondrial dysfunction, free radical production, apoptosis, and lipid profile and cellular metabolism. This study aims to provide a comprehensive review of the underlying mechanisms of different polyphenol subclasses in cardiac hypertrophy and heart failure, as well as investigate nano-drug delivery methods to optimize treatment outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Mina Homayoonfal, Hamidreza Gilasi, Zatollah Asemi, Mahmood Khaksary Mahabady, Reza Asemi, Bahman Yousefi
Summary: In recent decades, natural compounds have shown great potential in preventing and treating chronic diseases such as cancer. Quercetin, a bioactive flavonoid, has high pharmacological value and health-promoting effects due to its antioxidant and anti-inflammatory properties. Both in vitro and in vivo studies have confirmed that Quercetin has significant potential in cancer prevention and development. It exerts its anticancer effects by influencing various cellular processes and regulating signaling pathways and non-coding RNAs. This review aims to summarize the impact of Quercetin on molecular pathways and non-coding RNAs in modulating cancer-associated cellular mechanisms.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Alireza Mafi, Atoosa Keshavarzmotamed, Neda Hedayati, Zahra Yeganeh Boroujeni, Russel J. Reiter, Rohollah Mousavi Dehmordi, Mohammad Hossein Aarabi, Malihe Rezaee, Zatollah Asemi
Summary: Despite being mainly known as a regulator of circadian rhythm, melatonin has been found to play a notable role in other fundamental biological processes. It has been shown to have an inhibitory effect on tumor development, making it a potential adjunct agent for cancer treatment. In addition, melatonin has been found to impact the expression of non-coding RNAs (ncRNAs) in various disorders, including cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
