Article
Cell Biology
Honghai Li, Jieqing Lv, Jindao Wang, Haifeng Wang, Liang Luo
Summary: Gastric cancer leads to a large number of deaths worldwide, and despite efforts to treat this cancer, the survival rate of gastric cancer patients remains unsatisfactory. Increasing evidence shows that miR-29c-3p inhibits cancer progression. However, the mechanism of miR-29c-3p in gastric cancer is not fully understood. This study aimed to analyze the underlying mechanism of miR-29c-3p in gastric cancer.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Immunology
Jian Guo, Ruiya Zhang, Yiqing Zhao, Junping Wang
Summary: The study found that miR-29c-3p was significantly downregulated in UC patients and experimental colitis mice, while LIF was upregulated. By suppressing LIF, miR-29c-3p promotes gut inflammation and modulates the pathogenesis of UC.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyuan Chen, Chao Liu, Le Ji, Ning Wang, Yanan Liu, Min Wang, Litao Ruan
Summary: Our study demonstrated that circACC1 is upregulated in GC tissues, predicts poorer overall survival in GC patients, and promotes cell proliferation by regulating the miR-29c-3p/FOXP1 pathway, highlighting the key role of the circACC1/miR-29c-3p/FOXP1 network in gastric cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Yan Hu, Jingjing Li, Haifeng Luo, Wenli Song, Jiyuan Yang
Summary: The study identified COL1A1, COL1A2, COL6A3, and SULF1 as significantly upregulated genes in stomach adenocarcinomas through ONCOMINE analysis, with a strong correlation between their expression and TNM stage. Low transcriptional levels of these genes were associated with longer overall survival in gastric cancer patients according to Kaplan-Meier analysis. Additionally, there was a close relationship between the expression of these genes and immune cell infiltration, indicating their potential as prognostic biomarkers and indicators of immune status in gastric cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hanne Devos, Jerome Zoidakis, Maria G. Roubelakis, Agnieszka Latosinska, Antonia Vlahou
Summary: The collagen family consists of 28 proteins, mainly expressed in the extracellular matrix (ECM) and characterized by a triple-helix structure. Collagens undergo various maturation steps, including post-translational modifications (PTMs) and cross-linking. These proteins are associated with several diseases, with fibrosis and bone diseases being the most prominent. This review focuses on type I collagen (collagen I), the most abundant ECM protein highly implicated in disease, particularly on its predominant chain collagen type I alpha 1 (COL1A1). The regulators and interactors of COL1A1 are discussed, highlighting the need for a comprehensive analysis considering all molecular levels simultaneously.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wang-Sheng Chen, Xu Zhang, Zheng-Fei Zhao, Xiang-Ming Che
Summary: The study found that MBNL1-AS1 suppresses the proliferation of colorectal cancer cells by regulating the miR-29c-3p/BVES signaling pathway. This suggests that the MBNL1-AS1/miR-29c-3p/BVES axis may be a potential therapeutic target for colorectal cancer.
Article
Cell Biology
Bojie Lin, Jiangying Zhu, Guoqian Yin, Mingde Liao, Guanyu Lin, Yuyong Yan, Dan Huang, Siding Lu
Summary: This study demonstrates that DLX5 promotes hair follicle stem cell (HFSC) differentiation by modulating the c-MYC/miR-29c-3p/NSD1 axis. DLX5 is highly expressed in differentiated HFSCs and transcriptionally activates c-MYC expression to induce HFSC differentiation. c-MYC suppresses miR-29c-3p expression, leading to NSD1-mediated HFSC differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Heng Zhang, Xinmei Li, Mengmeng Jia, Jing Ji, Zhaoxu Wu, Xian Chen, Dianke Yu, Yuxin Zheng, Yanjie Zhao
Summary: This study constructed a ceRNA regulatory network in COE-induced lung squamous cell carcinoma using RNA sequencing and database analysis.The findings suggest that H19 functions as a ceRNA to increase COL1A1 expression by sponging miR-29a-3p, thereby promoting COE-induced cell malignant transformation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biotechnology & Applied Microbiology
HongXia Chen, YunFeng Fu, ZiXiang Guo, XiaoDong Zhou
Summary: This study discovered that miR-29 c-3p improves PCOS by targeting Foxo3 and participating in insulin function. MiR-29 c-3p is downregulated in PCOS, while Foxo3 is upregulated. Upregulated miR-29 c-3p or downregulated Foxo3 promotes cell proliferation and inhibits apoptosis in ovarian tumor cells. It also restores sex hormone levels and improves glucose metabolism in PCOS rats.
Article
Genetics & Heredity
Jingwei Ma, Meng Zhu, Xiaofeng Ye, Bo Wu, Tao Wang, Muyuan Ma, Tao Li, Ning Zhang
Summary: This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The study found that PSAT1 expression was related to the clinical manifestations and prognosis of gastric cancer. Six microRNAs associated with gastric cancer were identified, and a model for predicting bone metastasis in gastric cancer was constructed.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Haofeng Liu, Qiu Xue, Hongzhou Cai, Xiaohui Jiang, Guangxin Cao, Tie Chen, Yuan Chen, Ding Wang
Summary: This study reveals the significance and mechanism of RUNX3-mediated circDYRK1A in suppressing glutamine metabolism in gastric cancer (GC) via the miR-889-3p/FBXO4 axis, which leads to the attenuation of malignant phenotypes in GC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yongmeng Li, Yanfei Liu, Kai Jin, Rui Dong, Cun Gao, Libo Si, Zitong Feng, Huiying Zhang, Hui Tian
Summary: MTFR1 is upregulated in LUAD and associated with poor clinicopathologic features and prognosis. Overexpression of MTFR1 promotes proliferation, invasion, migration, glycolytic capacity, and inhibits apoptosis of LUAD cells. MTFR1 may exert its functions through the AMPK/mTOR signaling pathway and is targeted by miR-29c-3p. Targeting MTFR1 could be an effective therapeutic strategy for LUAD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Deepak Narayanan Iyer, Dominic Chi-Chung Foo, Oswens Siu-Hung Lo, Timothy Ming-Hun Wan, Xue Li, Ryan Wai-Yan Sin, Roberta Wen-Chi Pang, Wai-Lun Law, Lui Ng
Summary: MiR-509-3p is overexpressed in colorectal cancer and associated with aggressive disease presentation. It inhibits the expression of tumor suppressor PHLPP2 by directly binding to its 3'UTR. The high expression of miR-509-3p in tumor-adjacent normal tissues is associated with poor prognosis in CRC.
Article
Biotechnology & Applied Microbiology
Zengxi Yang, Xi OuYang, Liang Zheng, Lizhen Dai, Wenjuan Luo
Summary: In this study, it was found that LINC00265 is significantly upregulated in gastric cancer (GC) and promotes GC cell proliferation through the miR-144-3p/CBX4 axis.
Article
Cell Biology
Aitao Nai, Huihui Zeng, Qiong Wu, Zirui He, Shuwen Zeng, Shoaib Bashir, Feng Ma, Jie He, Wei Wan, Meng Xu
Summary: In this study, we found that overexpression of LOX in gastric carcinoma is associated with poor prognosis and may affect the development of gastric cancer through regulating the HIF1A-AS2/RP11-366L20.2-miR-29c axis, promoting M2 macrophage polarization, tumor immune escape, and enhancing drug resistance of tumor cells to chemotherapeutic drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Juan Liao, Jiangwei Xiao, Yunfeng Zhou, Zilin Liu, Chunhui Wang
MOLECULAR MEDICINE REPORTS
(2015)
Article
Multidisciplinary Sciences
Juan Liao, Shichao Wen, Lipeng Cao, Yunfeng Zhou, Zhisong Feng
Review
Oncology
Mengting Xia, Yunfeng Zhou, Jiajie Yu, Wenwen Chen, Xiaotao Huang, Juan Liao
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Qiangnu Zhang, Qian Cheng, Mengting Xia, Xiaotao Huang, Xiaoyan He, Juan Liao
FRONTIERS IN ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Cong Yuan, Xue-Mei Lin, Yan Ou, Qian Cheng, Lin Cai, Ping Zhou, Juan Liao
Summary: The disappearance of regular arrangement of collecting venules (RAC) in gastric corpus mucosa in chronic active and inactive gastritis is caused by the elongation of gastric foveolae. A length of gastric foveolae more than 181.53 µm was found to predict the invisibility of RAC with high sensitivity and specificity.