Article
Pharmacology & Pharmacy
Huang Wen, Pekka Poutiainen, Enkhzaya Batnasan, Leena Latonen, Vesa-Pekka Lehto, Wujun Xu
Summary: Mesoporous silicon nanoparticles (PSi NPs) are a promising nanomedicine platform with the ability of radiolabeling, drug loading, and cancer targeting. The functionalized NPs showed good radiochemical and colloidal stability, and exhibited enhanced cellular uptake and improved chemotherapy in vitro.
Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Lisa Claire du Toit, Patrick Hulisani Demana, Yahya Essop Choonara
Summary: Cardiovascular diseases are a major cause of death, and high levels of LDL cholesterol can contribute to the development of atherosclerosis. Researchers have designed a system for detecting LDL and releasing drugs for disease management. In animal experiments, this system has been shown to reduce total cholesterol levels and increase HDL levels, suggesting its potential use in the treatment of cardiovascular diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Xiongmin Mao, Guanyi Wang, Zijian Wang, Chen Duan, Xiaoliang Wu, Hua Xu
Summary: This review comprehensively summarizes the recent advances in lipid nanoparticles (LNPs) for the precision diagnosis and treatment of renal cell carcinoma (RCC). It introduces the chemical compositions of LNPs and modification strategies for enhanced tumor targeting. The authors also discuss the ongoing and foreseeable biomedical applications of LNPs.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Yosif Almoshari
Summary: This review summarizes the multifunctional role of cubosomes in cancer treatment and their latest developments.
Review
Chemistry, Multidisciplinary
Arne Matteo Joergensen, Richard Wibel, Andreas Bernkop-Schnuerch
Summary: Cationic and ionizable cationic lipids have been widely used as auxiliary agents with associated adverse effects. However, their toxic potential can be minimized if they are rapidly degraded to endogenously occurring metabolites. Biodegradable cationic and ionizable cationic lipids have shown promising results in terms of functionality and safety. This review provides an overview of these lipids, including their synthesis, cleavage by endogenous enzymes, toxicity, application in drug delivery systems, and use as preservatives, as well as guidance for their design and future developments.
Article
Chemistry, Multidisciplinary
Zepeng He, Zhicheng Le, Yi Shi, Lixin Liu, Zhijia Liu, Yongming Chen
Summary: We report a powerful strategy using the Ugi four-component reaction to modulate ionizable lipids (ILs) for mRNA delivery. Through a simplified screening process, we identified high-performing ILs for in vivo mRNA delivery. The structure of ILs controls organ-selective mRNA delivery, while the isomeric design of ILs affects the in vivo efficacy. This work provides important insights for the rapid discovery and rational design of IL candidates in mRNA therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Maria Chiarpotti, Gabriel S. Longo, Mario G. Del Popolo
Summary: In this study, the adsorption of nanoparticles coated with CPP on membranes containing acidic lipids was characterized using a molecular theory. The results show that electrostatic interactions, modulated by entropic effects, provide the driving force and regulate the adsorption kinetics of CPP-coated particles on acidic membranes. Adsorption free energy profiles allow to quantify the adsorption energy, and reveal that nanoparticles attachment and detachment from the membrane surface are restrained by free energy barriers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Sang M. Lee, Qiang Cheng, Xueliang Yu, Shuai Liu, Lindsay T. Johnson, Daniel J. Siegwart
Summary: The study identified an ionizable lipid series (4A3) with a citronellol-based (Cit) periphery as the best performer out of 91 amino lipids, showing superior lipid fusion and improved mRNA delivery efficacy in vivo through Selective ORgan Targeting (SORT). These findings demonstrate how lipid unsaturation promotes mRNA delivery and how lipid mixing can enhance efficacy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Biomaterials
Mikhail Khorenko, Juliana Pfeifer, Joanna Napp, Anna Meschkov, Frauke Alves, Ute Schepers, Claus Feldmann
Summary: Theranostic inorganic-organic hybrid nanoparticles (IOH-NPs) with a cocktail of chemotherapeutic and cytostatic drugs have been developed. These IOH-NPs exhibit red to deep-red emission for optical imaging and show superior therapeutic effects in cell viability assays and angiogenesis studies. The nanoparticles also demonstrate synergistic anti-cancer and cytotoxic efficacy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Julia Giselbrecht, Shashank Reddy Pinnapireddy, Fatih Alioglu, Haider Sami, Daniel Sedding, Frank Erdmann, Christopher Janich, Michaela Schulz-Siegmund, Manfred Ogris, Udo Bakowsky, Andreas Langner, Jeroen Bussmann, Christian Woelk
Summary: This study investigates in vivo nucleic acid delivery using simpler models to overcome the limitations of in vitro experiments in predicting in vivo efficacy. The results demonstrate that the OH4:DOPE formulation is effective in transfecting complex tissues and zebra fish embryos.
Review
Pharmacology & Pharmacy
Espoir K. Kambale, Joelle Quetin-Leclercq, Patrick B. Memvanga, Ana Beloqui
Summary: Diabetes is a chronic condition with high blood glucose levels that cannot be cured. Managing diabetes involves a healthy lifestyle, exercise, and medication. Nanoparticulate delivery systems have shown promise in enhancing the effectiveness of herbal treatments for diabetes, but further clinical trials are needed.
Article
Nanoscience & Nanotechnology
Sergio Scalzo, Anderson K. Santos, Heloisa A. S. Ferreira, Pedro A. Costa, Pedro H. D. M. Prazeres, Natalia J. A. da Silva, Lays C. Guimaraes, Mario de Morais e Silva, Marco T. R. Rodrigues Alves, Celso T. R. Viana, Itamar C. G. Jesus, Alice P. Rodrigues, Alexander Birbrair, Anderson O. Lobo, Frederic Frezard, Michael J. Mitchell, Silvia Guatimosim, Pedro Pires Goulart Guimaraes
Summary: Gene therapy using lipid nanoparticles (LNPs) as delivery vectors has shown promising potential for cardiac regeneration and gene correction in inherited cardiomyopathies. In this study, a mini-library of engineered LNPs was developed for the efficient delivery of pDNA to cardiomyocytes. The lead LNP formulation achieved enhanced gene expression in vitro and in vivo, with negligible toxicity and without affecting cardiac cell function. These findings highlight LNPs as a promising approach to improve gene therapy for cardiovascular disease treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Materials Science, Biomaterials
Jon Ander Nieto-Garai, Francesc-Xabier Contreras, Aroa Arboleya, Maier Lorizate
Summary: Viral entry is a sequential process involving the attachment of the virus to the host cell and the introduction of its genetic material. Both cellular and viral lipids play crucial roles in viral entry. This article summarizes the specific roles of lipids and lipid membrane nanostructures in viral attachment, fusion, and immune evasion, and discusses the limitations of commonly used techniques for studying protein-lipid interactions, as well as emerging tools in this field.
Review
Chemistry, Multidisciplinary
Guanyou Lin, Miqin Zhang
Summary: The potential of theranostic nanoparticles in tumor treatment is widely recognized due to their ability to integrate multifaceted functionalities into a single nanosystem. These nanoparticles typically consist of an inorganic core for imaging and therapeutic functions, bioinert coatings for improved biocompatibility, controlled drug-loading-release modules, and targeting ligands for specific cell uptake. The design and assembly of these functionalities require sophisticated molecular design and precise execution. Ligand chemistry plays a decisive role in translating theoretical designs into functionalized theranostic nanoparticles. This Account reviews the properties and utilities of capping ligands, drug-loading ligands, and targeting ligands in theranostic nanoparticles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)