Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Article
Chemistry, Multidisciplinary
Amal Alfawaz, Khalid Alzahrani, Abdurahman Niazy, Hamdan Alghamadi, Rhodanne Lambarte, Abeer Beagan, Latifah Alfhaid, Khalid Alotaibi, Abdullah Alswieleh
Summary: A platform technology based on inorganic/organic nanoparticles for carrying drugs could be of enormous potential benefit in treating cancer. In this study, a new nanoplatform based on mesoporous silica nanoparticles (MSNs) conjugated with poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes was reported as a candidate for stimuli-responsive intracellular drug delivery system.
APPLIED SCIENCES-BASEL
(2022)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Chemistry, Applied
Shiyuan Peng, Baihao Huang, Yizhen Lin, Gongcui Pei, Lijuan Zhang
Summary: This study investigated the application of mesoporous silica nanoparticles (MSN) in drug delivery. The results showed that the structure and surface modification of MSN affect the drug loading and release properties. Hexagonal pore MSN-NH2 and MSN-PDA demonstrated better combined release performance in terms of pH-responsive performance and sustained release effect.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Polymer Science
Khalid M. Alotaibi, Abdurrahman A. Almethen, Abeer M. Beagan, Latifah H. Alfhaid, Maqusood Ahamed, Ahmed M. El-Toni, Abdullah M. Alswieleh
Summary: A new pH-responsive nanosystem based on mesoporous silica nanoparticles (MSNs) was developed for cancer therapy, featuring a gatekeeper PDEAEMA and further modification to encapsulate the anti-cancer drug doxorubicin (DOX). The fabricated nanoplatform exhibited significant drug release and cytotoxicity in acidic media, suggesting its potential as a nanocarrier for anti-cancer drugs.
Article
Chemistry, Applied
Silvia Leccese, Thomas Onfroy, Adjele Wilson, Diana Kirilovsky, Sandra Casale, Saremble Guira, Mohamed Selmane, Claude Jolivalt, Alberto Mezzetti
Summary: This study focuses on the immobilization of the photoactive Orange Carotenoid Protein (OCP) on mesoporous silica nanoparticles and investigates its structural characterization. The results highlight the enhanced immobilization of OCP by pre-photoactivation, leading to photochromic nanoparticles. The study also explores the possibility of releasing OCP from the nanoparticles and suggests potential applications in nanoscale optical devices and antioxidant drug delivery.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Xiaowei Xie, Tianxiang Yue, Wenting Gu, Weiyi Cheng, Li He, Weiye Ren, Fanzhu Li, Ji-Gang Piao
Summary: This paper discusses the use of surface-functionalized mesoporous silica nanoparticles (MSN) as delivery vehicles for siRNA in cancer therapy. The advantages of using MSNs for siRNA loading and strategies to improve cellular uptake and endosomal escape are highlighted. Attention is also paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Materials Science, Ceramics
Eva Krakor, Sven Saniternik, Isabel Gessner, Robert Frohnhoven, Michael Wilhelm, Marco Drexelius, Nurgul Tosun, Ines Neundorf, Sanjay Mathur
Summary: Intensive and overuse of antibiotics have led to a rise in antibiotic resistance globally, creating a demand for alternative treatments. Metal ions like copper, silver, and zinc have been used to inhibit microorganism growth for centuries. This study focuses on the synthesis of metal and oxide nanoparticles immobilized on hollow mesoporous silica capsules (HMSCs) for efficient antimicrobial effects against both Gram-positive and Gram-negative bacteria. The results show promising potential for metal-loaded capsules as antibacterial delivery vehicles, providing sustained bacterial inhibition over several hours.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Engineering, Chemical
Sahar Porrang, Nader Rahemi, Soodabeh Davaran, Majid Mahdavi, Belal Hassanzadeh, Amin Mohammad Gholipour
Summary: This paper investigates the uniformly surface modification of mesoporous silica nanoparticles using DBD plasma, characterizing the nanoparticles' structure and properties through different methods, exploring the release of the model drug Dox on nanocarriers, and studying the impact of modified nanocarriers on MCF-7 cells.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Chemistry, Multidisciplinary
Jinglu Zhou, Zhen Wen, Shilun Yan, Hui Guo, Chuyue Zhou
Summary: By functional modification of the surface of mesoporous silica nanoparticles (MSNs) with a pH-sensitive polymer, we have successfully synthesized pH-sensitive drug nanocarriers with excellent physicochemical properties. These nanocarriers can effectively deliver drugs to tumor cells through pH-responsive and sustained release, leading to significant inhibition of tumor cells.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Parya Kazemzadeh, Khalil Sayadi, Ali Toolabi, Jalil Sayadi, Malihe Zeraati, Narendra Pal Singh Chauhan, Ghasem Sargazi
Summary: Mesoporous silica nanoparticles (MSNs) are widely used in drug delivery applications due to their favorable biocompatibility and controlled drug release properties. However, more research, such as in vivo biocompatibility studies and toxicity studies, is needed to advance this field.
FRONTIERS IN CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Hua Yan, Jiangtao Dong, Xuan Huang, Xuezhong Du
Summary: Two novel stimuli-responsive drug delivery systems were successfully created using upconversion nanoparticle-embedded mesoporous silica nanovehicles controlled by bovine serum albumin or myoglobin via Se-Se linkages. These systems showed controlled release of drugs in tumor microenvironments and promising prospects in targeted drug delivery for cancer chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Shumin Li, Liang Zhao, Yining Yao, Zhengying Gu, Chao Liu, Wenli Hu, Ye Zhang, Qian Zhao, Chengzhong Yu
Summary: The integration of different types of metal-organic frameworks (MOFs) into hybrid MOF-on-MOF heterostructures has been extensively studied to increase the diversity of MOF-on-MOF hybrids. This study reports the structure regulation of MOF-on-MOF hybrids by controlling the nucleation and growth of guest MOFs. By using ZIF-90 as the host and ZIF-8 as the guest, binary ZIF-90@ZIF-8 complexes with different structures were successfully synthesized, enhancing the structural diversity of MOF-on-MOF materials.
Article
Engineering, Chemical
Pan Zhu, Yujing Ma, Jun Li, Yang Jin, Haitao Cai, Chun Xu, Minggang Huang, Ming Chen
Summary: Artificial photosynthesis is a feasible solution for the synthesis of hydrogen peroxide (H2O2), which is both a clean fuel and an environmentally friendly oxidant. In this study, a hydrophobic silver-based coordination polymer, PhC2Ag, was used to achieve the photocatalytic generation of H2O2 in a benzyl alcohol (BA)/water two-phase system. It was found that a low-pH aqueous solution and decreasing the volume of the aqueous phase were beneficial for H2O2 synthesis.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Tao Yang, Yaowei Jin, Yingchu Wang, Aiguo Kong, Yue Chen, Yingying Zou, Chao Liu, Guangfeng Wei, Chengzhong Yu
Summary: A covalent furan-benzimidazole-linked polymer (Furan-BILP) membrane is reported as a photocatalyst for the production of clean H2O2 in pure water. The membrane delivers clean H2O2 solution directly with a high production rate. The strategy of combining molecular engineering and macrostructural engineering may be applied to design other coordination organic polymer photocatalysts with improved performance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ling Yuan, Chaoqi Zhang, Yingying Zou, Tong Bao, Jing Wang, Cheng Tang, Aijun Du, Chengzhong Yu, Chao Liu
Summary: Constructing MOF-on-MOF heterojunction with elaborate charge transfer and interface can greatly enhance the photocatalytic properties of MOFs. In this study, a Step-scheme (S-scheme) MIL125-NH2@CoFe Prussian blue analogue (PBA) heterojunction was reported for the first time. The designed MOF-on-MOF heterojunction demonstrated significantly enhanced photocatalytic activity for degrading various organic pollutants, which was attributed to the internal electric field and increased active site exposure.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Chemical
Pan Zhu, Yujing Ma, Jun Li, Yang Jin, Haitao Cai, Chun Xu, Minggang Huang, Ming Chen
Summary: A type of organic coordination polymer photocatalyst (PhC2Ag) that can respond to visible light was successfully synthesized. The PhC2Ag with a nanorods structure exhibits good hydrophobicity and shows promising potential in the elimination of organic pollutants. The characterization results confirm the photoexcited carrier separation ability of PhC2Ag, which has a band gap of 2.63 eV. Experimental findings suggest that the superoxide and hydroxyl radicals are the dominant active species in the PhC2Ag photocatalytic system. Theoretical calculations reveal the superior migration ability of photogenerated electrons due to their smaller effective mass. This research provides support for the practical application of PhC2Ag and its derivatives in fields such as photocatalytic degradation, hydrogen evolution, and hydrogen peroxide production.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Jun Zhang, Sukitha Kothalawala, Chengzhong Yu
Summary: In the past decade, nanopesticides have been rapidly developed as effective and safe alternatives to conventional pesticides. Various nanotechnologies, such as pesticide nanoemulsions, polymer-based nanopesticides, and metal/metal oxide nanoparticle-based pesticides, have been extensively reviewed. Engineered silica nanomaterials (ESNs) have shown promising potential as carriers in nanopesticides for modern agriculture. However, there is limited research specifically on ESN-based nanopesticides. This comprehensive review provides an introduction to synthetic technology, formation mechanism, and surface engineering technology. The advantages of ESN-based pesticide formulation and their structure-function relationship are discussed in detail. Moreover, the challenges and future research in ESN-based nanopesticide development are also discussed.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Multidisciplinary
Chaoqi Zhang, Ling Yuan, Chao Liu, Zimeng Li, Yingying Zou, Xinchan Zhang, Yue Zhang, Zhiqiang Zhang, Guangfeng Wei, Chengzhong Yu
Summary: An elaborate design enables the precise control of Zn/Co bimetallic zeolite imidazole frameworks (ZnCo-ZIFs) and makes them excellent 2e-ORR electrocatalysts. The control at both atomic and nano-scale regulates the role of water molecules and adjusts the coordination unsaturation degree of active sites. The optimized ZnCo-ZIF exhibits high 2e(-) selectivity and H2O2 yield, paving a new avenue for the development of multivariate MOFs as advanced 2e-ORR electrocatalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Ye Zhang, Zhengying Gu, Wenli Hu, Shumin Li, Yining Yao, Chengzhong Yu
Summary: Bubble-like manganese silicate nanoparticles have attracted much attention due to their wide range of applications, but there is still debate over their formation mechanisms. In this study, we revisit the formation of these nanoparticles and demonstrate a solid-to-hollow conversion process. An intermediate solid MnxOy(CO3)mSiz is formed during the hydrothermal reaction, and its thermal decomposition leads to the transformation from solid to hollow structure. Finally, bubble-like manganese silicate nanoparticles are formed. These findings are expected to provide insights for designing other hollow metal silicate nanoparticles.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chunhong Xia, Ling Yuan, Hao Song, Chaoqi Zhang, Zimeng Li, Yingying Zou, Jiaxin Li, Tong Bao, Chengzhong Yu, Chao Liu
Summary: Reported here is the spatial specific S-scheme heterojunction design by introducing a novel semiconducting pair with a S-scheme mechanism in a purpose-designed Janus core-shell-structured hollow morphology for photocatalytic oxygen reduction reaction (ORR) and H2O2 production. The TiO2@RF photocatalyst with the spatial specific Janus design shows high H2O2 yield and solar-to-chemical conversion efficiency, surpassing other reported photocatalysts under similar reaction conditions. This work paves the way for the design of next-generation photocatalysts for green synthesis of H2O2 production.
Review
Pharmacology & Pharmacy
He Xian, Yue Zhang, Chengzhong Yu, Yue Wang
Summary: mRNA technology has gained significant attention for its therapeutic potential, but stabilizing mRNA molecules is crucial for its widespread applications. This review focuses on the recent progress in nanobiotechnology-enabled strategies for stabilizing mRNA and improving delivery. It introduces the factors that destabilize mRNA and reviews the molecular and nanotechnology approaches for mRNA stabilization. The impact of formulation processing on mRNA stability, including freezing and lyophilization, and the challenges and future directions are also discussed.
Article
Pharmacology & Pharmacy
Yue Zhang, He Xian, Ekaterina Strounina, Kimberley S. Gunther, Matthew J. Sweet, Chen Chen, Chengzhong Yu, Yue Wang
Summary: In this study, tetrasulphide bridged mesoporous organosilica nanoparticles (MONs) were found to have enhanced transfection performance of plasmid DNA (pDNA) in dendritic cell (DC) lines compared to conventional mesoporous silica nanoparticles (MSNs). This enhancement is attributed to the glutathione (GSH) depletion capability of MONs, which increases the activation of the mammalian target of rapamycin complex 1 (mTORc1) pathway and enhances translation and protein expression. The increased transfection efficiency was only observed in high GSH cell lines, validating the mechanism. This study provides a new design principle for nano delivery systems targeting pDNA delivery to DCs.
Article
Chemistry, Multidisciplinary
Feixiang Ding, Junyan Liu, Kelong Ai, Chun Xu, Xiaoyuan Mao, Zhaoqian Liu, Haihua Xiao
Summary: This study presents a tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic therapy to simultaneously activate pyroptosis and the cGAS-STING pathway in a light-controlled manner. The approach involves the use of oxidation-sensitive nanoparticles loaded with a photosensitizer and decitabine nanomicelles to restore the expression of gasdermin and STING. The study demonstrates the potential of this strategy for targeted photoimmunotherapy in immunotolerant tumors.
ADVANCED MATERIALS
(2023)
Review
Medicine, General & Internal
Pooyan Makvandi, Hao Song, Cynthia K. Y. Yiu, Rossella Sartorius, Ehsan Nazarzadeh Zare, Navid Rabiee, Wei-Xi Wu, Ana Claudia Paiva-Santos, Xiang-Dong Wang, Cheng-Zhong Yu, Franklin R. Tay
Summary: Fungi and bacteria cause numerous pathogen-related infections and diseases in humans. To specifically target and combat these pathogenic species, novel antimicrobials have been developed. This review highlights the cell wall features and antimicrobial mechanisms of these microorganisms, as well as the design of selective antimicrobials. The recent advances in antimicrobial immunomodulation strategy are also discussed.
MILITARY MEDICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Huiyun Li, Yusong Yuan, Lingpu Zhang, Chun Xu, Hailin Xu, Zhiwei Chen
Summary: This study demonstrates a novel strategy to modulate macrophage polarization for the treatment of osteoarthritis. By reducing intracellular ROS levels and regulating mitochondrial function, a ROS-responsive nanoparticle successfully repolarized M1 macrophages into M2 phenotypes, promoting chondrocyte proliferation and viability while inhibiting apoptosis. In vivo experiments confirmed the anti-inflammatory and cartilage-protective effects of this nanoparticle.
Review
Engineering, Biomedical
Farzaneh Afkhami, Golriz Rostami, Chun Xu, Laurence J. Walsh, Ove A. Peters
Summary: This study reviewed the histological results of various dental lasers used for vital pulp therapy. The findings suggest that lasers can effectively reduce inflammation, accelerate healing, and increase dentinal bridge thickness. Combining lasers with pulp capping agents enhances the success rate of vital pulp therapy.
LASERS IN MEDICAL SCIENCE
(2023)
