Article
Engineering, Environmental
Xuemei Zeng, Pengjie Li, Shuangqian Yan, Bi-Feng Liu
Summary: The combination of nanomaterials and nanotechnologies in nanomedicine has attracted intensive attention and made significant advances in tumor treatment. However, the passive nature of currently used nanomaterial carriers limits their therapeutic efficiency. An active nanomaterial carrier with tumor-taxis-like behavior holds the potential to further improve tumor targeting and therapeutic efficiency. This study demonstrates a tumor microenvironment responsive disassemblable approach using tumor-targeted Escherichia coli bacteria linked with degradable zeolitic imidazolate framework-8 (ZIF-8) through disulfide bond-contained polymers. The approach shows promise in delivering multiple drugs into deep tumor tissue and improving tumor inhibition efficacy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Taranom Mobasheri, Elham Rayzan, Mahsima Shabani, Mina Hosseini, Ghanbar Mahmoodi Chalbatani, Nima Rezaei
Summary: Research focuses on developing new therapeutic strategies for neuroblastoma, targeting different genes and utilizing nano-drug delivery systems to improve treatment efficacy. The combination of specific drug targets and nano-drug delivery systems may lead to lower systemic side effects and improved therapeutic effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jie Wang, Yue Dong, Peng Ma, Yu Wang, Fangyu Zhang, Bocheng Cai, Peng Chen, Bi-Feng Liu
Summary: Cancer is a difficult-to-treat disease due to its high mortality rate and lack of effective diagnostic and treatment tools. Recent advancements in micro-/nanorobot technology provide opportunities for the development of cancer theragnostic platforms, which can enable precise drug delivery and improved permeation.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Medicinal
Siavash Iravani, Rajender S. Varma
Summary: Alginate has been extensively studied for its hydrophilicity, biocompatibility, and bioavailability, making it a promising material for controlled drug delivery and cancer therapy. Future research should focus on developing novel alginate-based systems using advanced drug delivery techniques for non-invasive and targeted cancer treatment.
Review
Biochemistry & Molecular Biology
Chen Lin, Ye-Zi Chen, Bo Wu, Meng-Ting Yang, Chao-Qi Liu, Yun Zhao
Summary: The incidence of malignant tumors, particularly in younger individuals, is increasing and poses a significant threat to human life. Ultrasound micro/nanobubbles, acting as a noninvasive and highly specific antitumor strategy, can effectively destroy tumor tissue guided by ultrasound. Additionally, micro/nanobubbles are utilized as drug carriers, facilitating drug release at targeted regions and showing promise for drug delivery and therapeutic monitoring. However, further research on sonoporation mechanisms, ultrasound parameters, drug types, and doses is necessary before clinical translation of this technology. This paper reviews recent literature on experimental and clinical studies of ultrasound biomaterial-modified micro/nanobubbles therapy in vitro and in vivo.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Xiangjun Chen, Mingyi Hou, Xinzhong Zhang, Haixin Liu, Wenting Li, Wei Hong
Summary: Nanoscale structures have been developed for various functions in cancer therapy, including diagnosis, biomedical visualization, tissue regeneration, and drug delivery. By using biocompatible chitosan oligosaccharides and gold nanorods, a drug delivery system was designed that effectively delivered drugs to tumor sites and selectively targeted cancer cells. The system also had drug release capability and magnetic resonance imaging functionality, showing promising outcomes for tumor diagnosis and treatment.
MOLECULAR PHARMACEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Peng Zhang, Guihua Ye, Guofeng Xie, Jie Lv, Xianhai Zeng, Wei Jiang
Summary: Cancer is a highly lethal disease with increasing incidence. However, current tumor treatment often faces challenges of poor efficacy and significant side effects. Nanomaterials with unique physical and chemical properties enable targeted drug delivery to tumors, improving therapeutic effects while reducing damage to normal cells. This review summarizes recent advancements of nanomaterials in tumor targeted therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Donghyun Lee, Soonmin Kwon, Seok-Young Jang, Eunyoung Park, Yeeun Lee, Heebeom Koo
Summary: Photodynamic therapy (PDT) faces challenges in tumor treatment, including drug delivery, light delivery, and tumor microenvironment. Nanoparticles have shown promising potential to overcome these challenges as drug carriers. Various approaches such as physicochemical optimization, ligand modification, and stimuli-responsive release have been explored in experiments, but more research is needed.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Xiaoxuan Xu, Yao Wu, Xindi Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang
Summary: By regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM, intratumor ECM barriers can be effectively overcome, leading to improved drug delivery and anticancer efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Jun Yin, Chengcheng Ouyang, Shuwei Shen, Yaxin Zhou, Guoyi He, Heng Zhang, Kai Zhou, Guoguang Chen, Lili Ren
Summary: In this study, a smart nano drug delivery platform was designed and synthesized for the combination of chemotherapy and photodynamic therapy in cancer treatment. The nanoparticles exhibited good stability and hemocompatibility, and showed higher antitumor activity and lower systemic toxicity under laser irradiation.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biotechnology & Applied Microbiology
Mingpeng Liu, Xiaocui Fang, Yanlian Yang, Chen Wang
Summary: Receptor-targeting peptides are extensively pursued for improving drug binding specificity and accumulation at the site of interest, and are widely recognized as candidates of novel therapeutics due to their high specificity and biocompatibility.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ikuhiko Nakase, Moe Miyai, Kosuke Noguchi, Mamoru Tamura, Yasuyuki Yamamoto, Yushi Nishimura, Mika Omura, Kota Hayashi, Shiroh Futaki, Shiho Tokonami, Takuya Iida
Summary: In this study, we demonstrate the application of light-induced assembly for drug delivery system which enhances the accumulation and penetration of biofunctional molecules in cell membranes through superradiance-mediated photothermal convection.
Article
Chemistry, Multidisciplinary
Chencheng Xue, Hui Zhang, Xuan Wang, Haoyu Du, Lu Lu, Yang Fei, Yanan Li, Yuchen Zhang, Menghuan Li, Zhong Luo
Summary: This study presents a bio-inspired protein nanocomplex that efficiently eliminates tumors through enhanced ferroptosis therapy. The complex induces pronounced ferroptosis in tumor cells and targets tumor cell membrane for enhanced uptake, demonstrating superior antitumor effects with no obvious adverse effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Abiodun Ayo, Pirjo Laakkonen
Summary: The article discusses a new treatment strategy utilizing tumor-targeting peptides to deliver drugs, as well as the structure-function relationship data of different tumor-targeting peptides. The importance of improving peptide activity and conjugation strategies is also highlighted.
Article
Chemistry, Multidisciplinary
Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: Nano-Pt loaded liposomal system enhances photodynamic therapy and chemotherapy in cancer treatment by increasing oxygen supply and releasing nanoparticles for better penetration, leading to inhibited tumor growth and extended survival without toxicity in animal models.
Article
Oncology
Enrica Balza, Sebastiano Carlone, Sonia Carta, Patrizia Piccioli, Vanessa Cossu, Cecilia Marini, Gianmario Sambuceti, Anna Rubartelli, Patrizia Castellani
Summary: The study found that the combination of cisplatin and proton exchanger inhibitors is significantly more effective in treating triple negative breast cancer, while using proton exchanger inhibitors alone is more effective in another type of breast cancer. These treatments also lead to changes in the number of immune cells, which have a positive impact on tumor infiltration.
Article
Biochemistry & Molecular Biology
Cecilia Marini, Vanessa Cossu, Matteo Bauckneht, Sonia Carta, Francesco Lanfranchi, Francesca D'Amico, Silvia Ravera, Anna Maria Orengo, Chiara Ghiggi, Filippo Ballerini, Paolo Durando, Sabrina Chiesa, Alberto Miceli, Maria Isabella Donegani, Silvia Morbelli, Silvia Bruno, Gianmario Sambuceti
Summary: This study found that PBMCs in patients with Hodgkin's lymphoma exhibit selective mitochondrial and ER redox stress, particularly in lymphocytes, even before chemotherapy exposure.
Editorial Material
Biochemistry & Molecular Biology
Fabio Pastorino, Chiara Brignole
Article
Biochemistry & Molecular Biology
Enrico Rango, Fabio Pastorino, Chiara Brignole, Arianna Mancini, Federica Poggialini, Salvatore Di Maria, Claudio Zamperini, Giulia Iovenitti, Anna Lucia Fallacara, Samantha Sabetta, Letizia Clementi, Massimo Valoti, Silvia Schenone, Adriano Angelucci, Mirco Ponzoni, Elena Dreassi, Maurizio Botta
Summary: Si306, an anticancer agent, has shown favorable activity against neuroblastoma models. However, its sub-optimal aqueous solubility poses a limitation for its development. In this study, Si306 was encapsulated into liposomes and modified with an antibody specific for neuroblastoma cells. The modified liposomes demonstrated increased cellular targeting and cytotoxic activity. In animal experiments, Si306 encapsulated in targeted liposomes showed significantly higher tumor uptake and improved survival rates.
Article
Biochemistry & Molecular Biology
Fabio Pastorino, Mario Capasso, Chiara Brignole, Serena Giglio, Veronica Bensa, Sueva Cantalupo, Vito Alessandro Lasorsa, Annalisa Tondo, Rossella Mura, Angela Rita Sementa, Alberto Garaventa, Mirco Ponzoni, Loredana Amoroso
Summary: Neuroblastoma is the most common extracranial solid tumor in childhood. The prognosis for patients with metastatic relapse or refractory disease is poor. The integration of genome sequencing into standard clinical practice is necessary for personalized therapy. In this study, whole exome sequencing was performed on two patients with relapsed NB, and actionable genetic variations were identified and treated accordingly. The results demonstrate the feasibility of incorporating clinical WES into pediatric oncology practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Vito Amodio, Simona Lamba, Rosaria Chila, Chiara M. Cattaneo, Benedetta Mussolin, Giorgio Corti, Giuseppe Rospo, Enrico Berrino, Claudio Tripodo, Federica Pisati, Alice Bartolini, Maria Costanza Aquilano, Silvia Marsoni, Gianluca Mauri, Caterina Marchio, Sergio Abrignani, Federica Di Nicolantonio, Giovanni Germano, Alberto Bardelli
Summary: Patients with DNA mismatch repair deficiency (MMRd) in colorectal cancer (CRC) often respond to immune checkpoint blockade therapies, while those with mismatch repair-proficient (MMRp) tumors generally do not. MMRp CRCs with variable fractions of MMRd cells may impact immune surveillance. Modulation of the MMRd fraction in MMR heterogeneous tumors can enhance their immunogenicity.
Article
Biochemistry & Molecular Biology
Elisabetta Marini, Marco Marino, Giulia Gionfriddo, Federica Maione, Marta Pandini, Daniele Oddo, Marta Giorgis, Barbara Rolando, Federica Blua, Simone Gastaldi, Serena Marchio, Sandra Kovachka, Francesca Spyrakis, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Summary: In this study, a series of compounds were designed where the BRAF kinase inhibitor encorafenib was conjugated to pomalidomide through different linkers. The synthesized compounds maintained their ability to inhibit the kinase activity of mutated BRAF and showed inhibitory effects on tumor cell lines.
Article
Chemistry, Multidisciplinary
Alessandro Marchetti, Alessandro Gori, Anna Maria Ferretti, Daniel Arenas Esteban, Sara Bals, Claudia Pigliacelli, Pierangelo Metrangolo
Summary: Finite 3D structures with controlled morphology can be achieved in the out-of-equilibrium self-assembly of Au NPs using a spherical peptide-gold superstructure (PAuSS) as a template, resulting in a transient 3D-branched Au-nanoshell (BAuNS) stabilized by sodium dodecyl sulphate (SDS). The BAuNS dismantles and regresses to PAuSS through equilibrium of SDS concentration gradient over time in the sample solution, causing NP disassembly. The assembly and disassembly of BAuNS promote temporary interparticle plasmonic coupling, enabling reversible and tunable changes in their plasmonic properties, which is highly desirable for the development of optoelectronic nanodevices.
Article
Oncology
Francesco Lanfranchi, Liliana Belgioia, Michela Marcenaro, Elisa Zanardi, Giorgia Timon, Mattia Riondato, Veronica Giasotto, Jeries Paolo Zawaideh, Laura Tomasello, Guglielmo Mantica, Nataniele Piol, Marco Borghesi, Paolo Traverso, Camilla Satragno, Daniele Panarello, Claudio Scaffidi, Andrea Romagnoli, Sara Elena Rebuzzi, Angela Coco, Bruno Spina, Silvia Morbelli, Gianmario Sambuceti, Carlo Terrone, Salvina Barra, Giuseppe Fornarini, Matteo Bauckneht
Summary: Metastatic disease is the main cause of morbidity and mortality in prostate cancer. Metastases-directed therapies, such as stereotactic radiotherapy, may be a better option for prostate cancer patients with less than five metastases, as they can avoid systemic toxicity and potentially improve oncological outcomes. Using [68Ga]Ga-prostate-specific membrane antigen-11 (PSMA) Positron Emission Tomography/Computed Tomography imaging as a guide for metastases-directed therapy has shown to positively impact the oncological outcome of oligometastatic prostate cancer patients.
Article
Oncology
Fabio Pastorino, Mario Capasso, Chiara Brignole, Vito A. Lasorsa, Veronica Bensa, Patrizia Perri, Sueva Cantalupo, Serena Giglio, Massimo Provenzi, Marco Rabusin, Elvira Pota, Monica Cellini, Annalisa Tondo, Maria A. De Ioris, Angela R. Sementa, Alberto Garaventa, Mirco Ponzoni, Loredana Amoroso
Summary: Approximately 50% of high-risk neuroblastomas (NB) relapse within two years after treatment, and additional therapeutic options are needed for relapsed or refractory patients. The identification of ALK somatic mutations or amplification is crucial for the treatment of these patients. ALK inhibitors may have a significant role in treating high-risk, ALK-mutated NB patients in the era of precision medicine.
Article
Biochemistry & Molecular Biology
Sonia Spinelli, Vanessa Cossu, Mario Passalacqua, Jacob B. Hansen, Lucrezia Guida, Mirko Magnone, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi
Summary: The ABA/LANCL system regulates glucose uptake, mitochondrial respiration, and proton gradient dissipation in myocytes. The study aimed to investigate its role in human white and brown adipocyte thermogenesis. LANCL1/2 overexpression increases mitochondrial number, respiration rates, and transcription of thermogenic genes; while silencing LANCL1/2 reduces these effects. ABA-treated mice lacking LANCL2 but overexpressing LANCL1 also show enhanced transcription of receptors for browning hormones in brown adipose tissue. The ABA/LANCL system controls human brown and beige adipocyte thermogenesis through a signaling pathway involving AMPK, PGC-1 alpha, Sirt1, and ERR alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Arnoldo Piccardo, Francesco Fiz, Gianluca Bottoni, Luca Foppiani, Domenico Albano, Francesco Bertagna, Ugo Catrambone, Federica Mariani, Beatrice Sambucco, Michela Massollo, Giorgio Treglia, Pierpaolo Trimboli
Summary: This review examines the prognostic value of endogenously stimulated thyroglobulin (ptTg) in predicting disease-specific outcomes in children with differentiated thyroid cancer (DTC). Twelve studies involving 1043 children were included, and the findings suggest that ptTg is a strong prognostic parameter for identifying disease persistence, relapse, and metastases in pediatric DTC patients.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Oncology
Cecilia Marini, Vanessa Cossu, Francesco Lanfranchi, Sonia Carta, Francesca Vitale, Francesca D'Amico, Matteo Bauckneht, Silvia Morbelli, Maria Isabella Donegani, Silvia Chiola, Stefano Raffa, Luca Sofia, Tania Di Raimondo, Filippo Ballerini, Chiara Ghiggi, Paolo Durando, Silvia Ravera, Mattia Riondato, Anna Maria Orengo, Silvia Bruno, Sabrina Chiesa, Gianmario Sambuceti
Summary: Previous studies have found redox stress in PBMCs of HL patients, indicating ER oxidative damage. This study aimed to investigate whether this stress also occurs in non-HL patients. The results showed that HL patients had increased mitochondrial ROS generation, MDA levels, and H6PD activity in PBMCs. FDG uptake in the myocardium was also increased in HL patients. These findings suggest that HL is associated with ER redox stress involving PBMCs and the myocardium.