Article
Medicine, Research & Experimental
Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu, Fangyun Xie
Summary: This study reveals that FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma (NPC) through the TIE1-mediated PI3K/AKT signaling pathway, suggesting that targeting the FLI1/TIE1 signaling pathway could be a potential therapeutic strategy to enhance the efficacy of radiotherapy in NPC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Genetics & Heredity
Huichao Huang, Ying Fu, Yankun Duan, Ye Zhang, Miaolong Lu, Zhuchu Chen, Maoyu Li, Yongheng Chen
Summary: This study investigates the profiles of global proteome, acetylome, and phosphoproteome in 5-8 F cells upon SAHA induction, and explores the crosstalk between these data sets. The results demonstrate the interconnectivity of acetylation and phosphorylation signaling networks, and suggest that SAHA-mediated HDAC inhibition may alter acetylation and phosphorylation of viral proteins, leading to reprogramming of cellular signaling pathways and anti-tumor effects in NPC cells.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, E. A. R. Engku Nur Syafirah, Yusuf Wada, Zaidah Abdul Rahman, Suhana Ahmad, Rohimah Mohamud, Norhafiza Mat Lazim, Chan Yean Yean
Summary: This study found that the prevalence of nasopharyngeal carcinoma in dermatomyositis patients is 3.3%, with higher rates in certain regions like Hong Kong, Malaysia, and Singapore. There is a higher incidence among male patients aged 40 and above, with many cases of NPC being diagnosed after the onset of dermatomyositis. Screening for NPC in older dermatomyositis patients, especially in the Asian region, is therefore essential.
Review
Oncology
Fangrui Zhao, Dashuai Yang, Xiangpan Li
Summary: Nasopharyngeal carcinoma is a malignant tumor mainly found in East and Southeast Asia. Radical radiotherapy is the primary treatment for this type of cancer. However, interruptions in radiotherapy can lead to reduced effectiveness and potential tumor progression. This review examines the effects of radiotherapy interruption and explores possible measures to address this issue.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Hao Chen, Lining Wei, Min Luo, Xiaochen Wang, Chaohua Zhu, Huixian Huang, Xu Liu, Heming Lu, Yahua Zhong
Summary: This study revealed that PAD4 was upregulated in NPC cells, and LINC00324 promoted NPC malignancy by upregulating PAD4 to activate the PI3K/AKT pathway. Additionally, PAD4 expression was negatively regulated by miR-3164.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Engineering, Biomedical
Yuxun Ding, Xiaohui Xiao, Lingli Zeng, Qiuping Shang, Wei Jiang, Sha Xiong, Xiaohui Duan, Jun Shen, Ruibing Wang, Jinshan Guo, Yue Pan
Summary: By developing RGD-targeted platinum-based nanoparticles, targeted chemoradiotherapy for NPC can be achieved with improved delivery efficiency of cisplatin. RPNs act as radiotherapy sensitizer and chemotherapy agents, leading to remarkable therapeutic outcome in synergistic chemoradiotherapy for NPC.
BIOACTIVE MATERIALS
(2021)
Article
Otorhinolaryngology
Khodayar Goshtasbi, Brandon M. Lehrich, Jack L. Birkenbeuel, Arash Abiri, Jeremy P. Harris, Edward C. Kuan
Summary: The study investigated the treatment and outcome of nasopharyngeal carcinoma (NPC), revealing that survival is influenced by various clinical and sociodemographic factors. Optimal overall survival was found with chemoradiotherapy (CRT) or radiotherapy (RT) for different stages of NPC, with additional benefits seen in surgery plus CRT for certain patients. Patients of Asian/Pacific Islander race had better survival outcomes, while nonendemic histology cases were not well characterized.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Genetics & Heredity
Haizhou Liu, Mengqin Yuan, Ramkrishna Mitra, Xu Zhou, Min Long, Wanyue Lei, Shunheng Zhou, Yu-e Huang, Fei Hou, Christine M. Eischen, Wei Jiang
Summary: CTpathway is a new crosstalk-based pathway enrichment analysis method that effectively identifies cancer risk pathways with higher accuracy, reproducibility, and speed, showing great potential for various cancer types.
Article
Oncology
Danxian Jiang, Yin Li, Jinxin Cao, Lianghe Sheng, Xinhai Zhu, Meng Xu
Summary: The CDCA gene family is upregulated in nasopharyngeal carcinoma (NPC) and its expression is associated with adverse prognosis. High expression of CDCA8 is not only associated with poor prognosis, but also with decreased immune infiltration and downregulation of immune checkpoint blockade-related genes in NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jianbin Zhang, Yan Jiang, Ye Yu, Jiangping Li
Summary: This study evaluated the combination of TORC1/2 inhibitor sapanisertib and chemotherapy drug cisplatin for nasopharyngeal carcinoma (NPC) treatment. The results showed that sapanisertib effectively decreased NPC cell viability and proliferation, and acted synergistically with cisplatin to induce cell arrest and apoptosis. Sapanisertib had minimal effects on normal cells and also reduced NPC cell migration. These findings were evident in both in vitro and in vivo models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Oncology
Tsung-You Tsai, Yung-Chih Chou, Yi-An Lu, Chung-Jan Kang, Shiang-Fu Huang, Chun-Ta Liao, Kai-Ping Chang
Summary: The study revealed that radiologic extranodal extension (rENE) is a significant prognostic factor in nasopharyngeal carcinoma. Both ungraded and unambiguous advanced rENE were associated with worse overall survival and distant metastasis-free survival, highlighting their importance in prognostic evaluation.
Article
Oncology
Xin-Bin Pan, Yang Liu, Shi-Ting Huang, Su Pei, Kai-Hua Chen, Song Qu, Ling Li, Xiao-Dong Zhu
Summary: The study found that V30 of the parotid glands is a major predictive factor for grades 2-3 xerostomia in nasopharyngeal carcinoma patients, while the dose and volume of the submandibular glands are not independent predictive factors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Chen Xu, Shuai He, Ya-Qing Zhou, Chu-Jun Liu, Shu-Qiang Liu, Wan Peng, Yu-Xiang Liu, Pan-Pan Wei, Jin-Xin Bei, Chun-Ling Luo
Summary: The study reveals that RBM47 is frequently upregulated in nasopharyngeal carcinoma (NPC) specimens and associated with poor prognosis, acting as a transcriptional factor and modulator of alternative splicing in cooperation with hnRNPM to promote NPC progression. This suggests that RBM47 and hnRNPM could serve as prognostic factors and potential therapeutic targets for NPC.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Oncology
Tiancong Liu, Chao Ji, Yang Sun, Weiliang Bai
Summary: High expression of HOXA9 is significantly associated with advanced tumor stage and poorer survival in nasopharyngeal carcinoma patients, serving as an independent prognostic factor.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Dan Li, Hai-Ke Lei, Xiao-Lei Shu, Xin Zhang, Hong-Lei Tu, Feng Wang, Yu-Wei Wang, Ying Wang, Jiang-Dong Sui
Summary: Health insurance programs are effective in preventing financial hardship in cancer patients. However, little is known about how health insurance policies influence the prognosis of patients with nasopharyngeal carcinoma in Southwest China. This study investigated the association of insurance types and self-paying rates with NPC-specific mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)