Article
Orthopedics
Xin-ping Li, Ping Zhang, Shi-wen Zhu, Ming-hui Yang, Xin-bao Wu, Xie-yuan Jiang
Summary: This study focused on aged patients with femoral intertrochanteric fracture under the co-management model of orthopedics and geriatrics, and found that age, complications, and anti-osteoporosis treatment were key factors affecting postoperative all-cause mortality. Early treatment with Zoledronic Acid was beneficial for the survival of elderly patients with intertrochanteric fracture.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Endocrinology & Metabolism
Moritz Weigl, Roland Kocijan, James Ferguson, Gabriele Leinfellner, Patrick Heimel, Xaver Feichtinger, Peter Pietschmann, Johannes Grillari, Jochen Zwerina, Heinz Redl, Matthias Hackl
Summary: MicroRNAs play a regulatory role in bone homeostasis, and circulating microRNAs are considered as potential biomarkers for bone health. This study investigated the impact of anti-osteoporotic treatments on circulating microRNAs in OVX and SHAM rats, revealing that these treatments can reverse bone loss and modulate specific miRNA expressions. The findings suggest that bone-related miRNAs could serve as promising biomarkers for monitoring treatment efficacy in osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Medicine, General & Internal
Masashi Uehara, Yukio Nakamura, Takako Suzuki, Masaki Nakano, Jun Takahashi
Summary: This study compared the efficacy and safety of ibandronate and zoledronic acid in Japanese postmenopausal osteoporotic patients, finding that both drugs significantly and safely improved bone turnover markers and BMD during 30 months of treatment. The ZOL group tended to exhibit greater gains in BMD compared to the IBN group, warranting further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Marwa Y. Shaheen, Amani M. Basudan, Abdurahman A. Niazy, Jeroen J. J. P. van den Beucken, John A. Jansen, Hamdan S. Alghamdi
Summary: The study demonstrates that systemic intravenous administration of zoledronate either before or after surgery improves the regeneration of bone defects grafted with inorganic cancellous bovine bone particles in osteoporotic conditions. However, continued pre- and post-surgical zoledronate treatment did not show a favorable effect on bone repair.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Fu-Chun Chang, Pao-Yao Chuang, Ching-Yu Lee, Chien-Yin Lee, Ying-Chao Chou, Tsan-Wen Huang, Kuo-Chin Huang, Hsin-Nung Shih, Mel S. Lee
Summary: A retrospective cohort study compared the outcomes of osteoporotic intertrochanteric fractures patients treated with dynamic hip screw (DHS) alone and DHS with bone-substitute augmentation. The use of bone-substitute augmentation was found to prevent complications, improve functional outcomes, and reduce postoperative issues such as lag-screw sliding and varus collapse. Additional prospective studies are needed to confirm these findings.
BIOMEDICAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Lothar Seefried, Franca Genest, Jasmin Baumann, Anke Heidemeier, Rainer Meffert, Franz Jakob
Summary: A study showed that single-dose intravenous zoledronic acid combined with vitamin D can improve the resolution of bone marrow lesions and reduce pain within 6 weeks.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
B. M. Churilla, S. Perera, S. L. Greenspan, N. M. Resnick, M. P. Kotlarczyk
Summary: The study highlights the benefits of zoledronic acid on bone health in cognitively impaired older adults, reducing fracture risk. Results show that in individuals with cognitive impairment, those who received zoledronic acid had significantly greater bone mineral density at the total hip and femoral neck.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Masafumi Kashii, Takashi Kamatani, Shingo Abe, Ayanori Yoshida, Kengo Yamamoto, Kota Koizumi, Naoko Mizuno, Kohji Kuriyama, Hideki Yoshikawa
Summary: This study assessed the tolerability of once-yearly zoledronic acid infusion within one to two weeks after hip fracture surgery and identified risk factors for acute-phase reactions and decrease in serum calcium concentration. The results showed that the infusion was well tolerated with the use of antipyretic analgesics and active vitamin D analog. Higher inflammatory condition and high bone turnover may increase the risk of acute-phase reactions and hypocalcemia.
Article
Geriatrics & Gerontology
Robin Jalbert, Hubert Blain, Mehdi Boudissa, Catherine Bioteau, Thibault Parent, Melanie Arnaud, Jerome Tonetti, Gaetan Gavazzi, Sabine Drevet
Summary: This study assessed the prevalence of contraindications for the use of zoledronic acid in elderly patients admitted to an orthogeriatric unit after a low-energy hip fracture. The majority of the patients did not have contraindications for zoledronic acid administration, suggesting the potential for improved prognosis with this treatment.
Review
Pharmacology & Pharmacy
Yu-Hsuan Hsu, Chia-Chun Li, Fu-Wen Liang, Zi-Yang Peng, Yin-Fan Chang, Jason C. Hsu, Huang-Tz Ou, Chih-Hsing Wu
Summary: This study found that the use of bisphosphonates is associated with a lower risk of mortality in patients with osteoporosis, especially when administered intravenously. These findings support the rational use of bisphosphonates in post-fracture care.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dan Zhao, Dexuan Xiao, Mengting Liu, Jiajie Li, Shuanglin Peng, Qing He, Yue Sun, Jingang Xiao, Yunfeng Lin
Summary: In this study, a novel nanoparticle tFNA-KLT was synthesized and shown to effectively prevent the occurrence of BRONJ by accelerating angiogenesis.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
K. Zhu, J. Zhang, C. Zhang, Z. Zhao, J. Gao, X. Li, X. Xia, X. Xu, T. Zhang, J. Guan
Summary: The study found that in elderly patients with femoral neck fractures, treatment with zoledronic acid can effectively increase bone density and reduce the level of bone metabolism markers.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Gang Luo, Zhiguo Chen, Jiacheng Liu, Weidong Ni, Wei Huang
Summary: This study aimed to determine the efficacy and safety of posttraumatic antifibrinolysis with multidose tranexamic acid (TXA) in reducing perioperative hidden blood loss (HBL) in elderly intertrochanteric fracture patients. The results showed that early posttraumatic antifibrinolysis with multidose TXA can effectively reduce perioperative HBL, especially for patients injured within 24 hours. The application of TXA beyond 72 hours of injury was ineffective.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Jorge B. Cannata-Andia, Natalia Carrillo-Lopez, Osvaldo D. Messina, Neveen A. T. Hamdy, Sara Panizo, Serge L. Ferrari
Summary: Vascular calcification, low bone mass, and fragility fractures are frequently observed in ageing subjects, with potential common mechanisms that need further research to understand their interplay.
Article
Orthopedics
Haidong Cui, Kai Chen, Shujun Lv, Chaoqun Yuan, Youhua Wang
Summary: Factors affecting perioperative hidden blood loss in intertrochanteric fractures include internal fixation, age, fracture type, anesthesia method, anticoagulant use, and bone density. Patients at risk for hidden blood loss should be intervened early to prevent complications.
BMC MUSCULOSKELETAL DISORDERS
(2021)