Journal
CURRENT OSTEOPOROSIS REPORTS
Volume 17, Issue 4, Pages 217-225Publisher
SPRINGER
DOI: 10.1007/s11914-019-00516-y
Keywords
Notch signaling; Jagged-1; Bone biology; Musculoskeletal metabolism; Mesenchymal progenitor cells; Osteoblasts
Categories
Funding
- National Institutes of Health [F32DE026346]
Ask authors/readers for more resources
Purpose of ReviewThis article reviews the past 2years of research on Notch signaling as it relates to bone physiology, with the goal of reconciling seemingly discrepant findings and identifying fruitful areas of potential future research.Recent FindingsConditional animal models and high-throughput omics have contributed to a greater understanding of the context-dependent role of Notch signaling in bone. However, significant gaps remain in our understanding of how spatiotemporal context and epigenetic state dictate downstream Notch phenotypes.SummaryBiphasic activation of Notch signaling orchestrates progression of mesenchymal progenitor cells through the osteoblast lineage, but there is a limited understanding of ligand- and receptor-specific functions. Paracrine Notch signaling through non-osteoblastic cell types contributes additional layers of complexity, and we anticipate impactful future work related to the integration of these cell types and signaling mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available