Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 5, Issue 11, Pages 5597-5609Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b01649
Keywords
growth factor; chemical immobilization; protein design; bioorthogonal approach; signal transduction; physical factor
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Funding
- KAKENNHI from JSPS [15H01810, 16F16059, 16K12902, 15F15054]
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Growth factors (GFs) are important for tissue engineering and regenerative medicine because of their interactions with cells and the extracellular matrix. Immobilization of GFs on a matrix is one way to control cell behavior. This review focuses on GF immobilization from the standpoint of chemical immobilization and design of GF proteins. In addition, the total design of environmental factors surrounding cells is discussed for future development of tissue engineering and regenerative medicine.
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