Article
Materials Science, Multidisciplinary
Adnan Akman, Ludovico Andrea Alberta, Paula Milena Giraldo-Osorno, Adam Benedict Turner, Martin Hantusch, Anders Palmquist, Margarita Trobos, Mariana Calin, Annett Gebert
Summary: This study investigates the effect of minor gallium (Ga) additions to Ti-Nb alloys on corrosion resistance, cytocompatibility, and antibacterial activity. The results show that Ga addition improves the corrosion resistance and passive film properties of the alloy, and exhibits antibacterial effect against Staphylococcus aureus.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Chemistry, Physical
Shenshen Cui, Shuo Liu, Jingjun Nie, Dafu Chen, Xinbao Wu, Gaowu Qin, Erlin Zhang
Summary: Titanium and titanium alloys have been widely used in the biomedical field due to their excellent physical, chemical, and biological properties. In this study, Ti-15Mo-xAg alloys with low elastic modulus and excellent antibacterial ability were designed and prepared. The microstructure, mechanical properties, antibacterial properties, and cytocompatibility were investigated. The results showed that Ti-15Mo-10Ag alloy exhibited a strong antibacterial rate of 99.5%, good cellular compatibility, and a low elastic modulus of 85 GPa, suggesting that this alloy may be a highly competitive medical material.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Yonghua Sun, Youjie Rong, Ya Zhao, Yuyu Zhao, Ruiqiang Hang, Xiaohong Yao, Paul K. Chu
Summary: The electrochemical stability of Ni-Ti-O nanoporous layers grown on equiatomic NiTi alloy was assessed by immersion in water and phosphate buffered saline, showing no significant change in morphology, composition, and structure even after 60 days. The layers also exhibited retained corrosion resistance, antibacterial ability, and cytocompatibility, indicating their potential as coatings on NiTi biomedical implants.
Article
Materials Science, Multidisciplinary
Ya Zhao, Long Bai, Yonghua Sun, Xiaohong Yao, Xiaobo Huang, Ruiqiang Hang, Di Huang
Summary: A reliable and cost-effective method, alkali corrosion, is used to construct nanosheet layers on a nearly equiatomic nickel-titanium (NiTi) alloy. The layers are mainly composed of TiO2, Na4TiO4, and Ni(OH)(2), with Ni content increasing with NaOH concentration. Despite slightly decreased corrosion resistance due to increased specific surface area, the nanosheet layers exhibit potent antibacterial ability and can promote endothelial spreading and proliferation. The combination of good corrosion resistance, antibacterial ability, and cytocompatibility makes the nanosheet layers promising as biomedical coatings for the NiTi alloy.
Article
Materials Science, Multidisciplinary
Dong-Yang Fan, Zhe Yi, Xu Feng, Wen-Zhi Tian, Da-Ke Xu, A. M. Cristino Valentino, Qiang Wang, Hong-Chen Sun
Summary: The study revealed that TC4-5Cu/TC4 alloy exhibited strong bactericidal property against sessile S.tnutans and effective biofilm-restrained ability, with a trend of down-regulation in gene expression.
Article
Materials Science, Multidisciplinary
Weijie Weng, Arne Biesiekierski, Jixing Lin, Sertan Ozan, Yuncang Li, Cuie Wen
Summary: This study investigated the newly designed beta-type Ti-Nb-Zr-Mo (TNZM) alloys for orthopedic applications, and found that TNZM1, TNZM2, and TNZM3 exhibited higher elastic admissible strain, high hardness, good ductility, and cytocompatibility.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Physical
Xian Wei, Sujie Ma, Jiajia Meng, Hong Qing, Qing Zhao
Summary: Magnesium (Mg) and its alloys have excellent biodegradable properties and biocompatibility, making them attractive materials for orthopedic applications. The Mg-Sn-Ge ternary Mg alloys, with alloying elements naturally present in humans, were developed and investigated for their mechanical properties, degradation behavior, cytocompatibility, and hemocompatibility. Increasing the Ge content significantly improved the hardness and elastic modulus of Mg-2Sn-xGe alloys. The Mg-2Sn-3Ge alloy displayed outstanding biodegradability, and the degradation products weakened at higher Ge levels. The Mg-2Sn-xGe alloys exhibited favorable biocompatibility and hemocompatibility, except for the Mg-2Sn-2Ge alloy.(c) 2023 Published by Elsevier B.V.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Biomedical
M. A. Hussein, A. Madhan Kumar, M. A. Azeem, A. A. Sorour, S. Saravanan
Summary: This study aimed to fabricate a new Ti-30Nb-3Ag alloy with enhanced in vitro corrosion and antibacterial properties. The results showed that the alloy exhibited improved microstructure, hardness, antibacterial capability, and corrosion resistance. Therefore, Ti-30Nb-3Ag alloy has the potential to be a competitive bioimplant material for orthopedic and dental uses.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Jithin Vishnu, Andrea Voss, Volker Hoffmann, Ludovico Andrea Alberta, Adnan Akman, Balakrishnan Shankar, Annett Gebert, Mariana Calin
Summary: Low-modulus beta-type Ti-45Nb alloy is a promising implant material with good mechanical biocompatibility, non-toxicity, and outstanding corrosion resistance. This study proposes a novel method to develop bioactive and antibacterial surfaces on Ti-45Nb alloy by incorporating gallium ions into hydroxyapatite. The results show that the combination of gallium and hydroxyapatite has great potential for local delivery of gallium ions and consequent antibacterial protection during bone regeneration.
Article
Chemistry, Multidisciplinary
Richard Bright, Andrew Hayles, Jonathan Wood, Neethu Ninan, Dennis Palms, Rahul M. Visalakshan, Anouck Burzava, Toby Brown, Dan Barker, Krasimir Vasilev
Summary: Inspired by natural topography on insect wings, researchers explored replicating these nanostructures on biomaterials to reduce implant-associated infections. They discovered that hydrothermal etching can create nanoscale protrusions on titanium surfaces, with different etching times and cation choices affecting the bactericidal properties. The study suggests that bactericidal titanium surfaces can be optimized for specific pathogens.
Article
Materials Science, Coatings & Films
Xianda Xue, Libin Lu, Donglei He, Yingchun Guan, Yan Li
Summary: The study introduced silver microparticles on the surface of TZNT alloy using a laser surface modification method to improve its antibacterial behavior. The presence of Ag microparticles was confirmed through various analyses, and they exhibited high antibacterial properties and good cytocompatibility.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Chemistry, Physical
Zhijun Guo, Yizhou Huang, Chunchun Sun, Zengxing He, Yunfeng Li, Hua Qiu, Delin Yuan, Jinyong Zhang, Chenglin Chu, Baolong Shen
Summary: In this study, a series of Ti-Zr-Mo alloys were systematically investigated for their phase composition, microstructure, mechanical properties, corrosion resistance, biocompatibility, and osteointegration performance. The Ti-18Zr-13Mo alloy exhibited the highest strength and hardness, as well as good corrosion resistance, making it a promising option for orthopedic applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Physical
Rongfa Zhang, Sheng Zhong, Lilan Zeng, Hongyu Li, Rongfang Zhao, Shufang Zhang, Xinting Duan, Jingsong Huang, Ying Zhao
Summary: The study found that MAO coatings with proper magnesium contents can improve the cytocompatibility of Ti-6Al-4V alloys, while coatings with excessively high magnesium content have poor cytocompatibility.
Article
Materials Science, Multidisciplinary
Mian Chen, Xiao-Qiao Wang, Er-Lin Zhang, Yi-Zao Wan, Jian Hu
Summary: This study investigated the different fluorine chemical compositions on titanium surfaces, demonstrating that coatings composed of metal fluorides exhibited superior antibacterial effect and cell compatibility. This provides a new perspective for optimizing surface modification methods of fluorinated biomaterials for biomedical applications.
Article
Biotechnology & Applied Microbiology
Jiawei Xu, Yanjin Lu, Xiyun Pan, Desong Zhan, Qiang Wang, Ning Zhang
Summary: The 3D-printed porous TC4-6Cu alloy was found to inhibit the biofilm formation of P. gingivalis and exhibit significant antibacterial ability. The antibacterial rates of the alloy against adherent and planktonic bacteria were 98.05% and 73.92%, respectively. The alloy also induced oxidative stress to kill bacteria by producing reactive oxygen species (ROS) and causing protein leakage from bacterial cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Martina Cazzola, Jacopo Barberi, Sara Ferraris, Andrea Cochis, Grzegorz Cempura, Aleksandra Czyrska-Filemonowicz, Lia Rimondini, Silvia Spriano
Summary: This research aims to develop an antibacterial and osteoconductive Ti6Al4V surface by using chemical etching-oxidation treatment and in situ reduction of silver nanoparticles. The study found that the concentration and addition time of the silver precursor affect the distribution and release of silver in the surface oxide layer. The silver concentration in the samples determines their bactericidal and cytotoxic abilities.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Sara Ferraris, Ingrid Corazzari, Francesco Turci, Andrea Cochis, Lia Rimondini, Silvia Spriano, Jonathan Massera, Enrica Verne
Summary: In this study, silicate and borosilicate bioactive glasses were synthesized and characterized. The antioxidant activity of the glasses was correlated to their surface properties, and it was found that boron enhanced glass reactivity while strontium and magnesium played a stabilizing role. The glasses were also found to have a scavenging potential against reactive oxygen species, and they exhibited a protective effect on viable cells.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Engineering, Biomedical
F. Bartolomeu, O. Carvalho, M. Gasik, F. S. Silva
Summary: A home-made 3D Multi-Material Laser Powder Bed Fusion (3DMMLPBF) technology was used to manufacture novel multi-material Ti6Al4V-CoCrMo parts. This system allows for the construction of 3D Multi-Material transitions between distinct materials, point-by-point and layer-by-layer. The functional transition between Ti6Al4V and CoCrMo was analyzed and found to have a solid metallurgical bonding and 3D mechanical interlocking.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Francesca Gamna, Seiji Yamaguchi, Andrea Cochis, Sara Ferraris, Ajay. Kumar, Lia Rimondini, Silvia Spriano
Summary: The main unmet medical need of bone implants is multifunctional activity, including their ability to induce rapid and physiological osseointegration, counteract bacterial biofilm formation, and prevent in situ chronic inflammation at the same time. This research added antioxidant ability to bone implant surfaces by grafting polyphenols of a green tea extract, without compromising other functionalities.
Article
Nanoscience & Nanotechnology
Maria L. Alfieri, Giacomo Riccucci, Sara Ferraris, Andrea Cochis, Alessandro C. Scalia, Lia Rimondini, Lucia Panzella, Silvia Spriano, Alessandra Napolitano
Summary: In this study, organic thin films based on caffeic acid (CA) were successfully deposited on polished and chemically pre-treated Ti6Al4V alloys by exploiting hexamethylenediamine (HMDA) as a crosslinking agent. The surface pre-treatment of the titanium substrate influenced the exposed groups on the coatings. These findings open up new possibilities for the development of innovative titanium surfaces with thin coatings from naturally occurring phenols for bone contact implants.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Francesca Gamna, Amanda M. Wiecek, Andrea Cochis, Jacopo Barberi, Alessandro C. Scalia, Lia Rimondini, Silvia Spriano
Summary: This study aims to couple a chemically treated Ti6Al4V surface with alpha-TP to confer local antibacterial activity for orthopedic and dental prosthetic devices. The coating of alpha-TP resulted in a continuous and homogeneous surface with hydrophilicity and effective antibacterial behavior. On the other hand, the functionalized surface showed poor antibacterial properties and hydrophobic behavior. Cytocompatibility evaluation demonstrated that the coating treatment was more compatible with human mesenchymal stem cells compared to the functionalization.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Virginia Alessandra Gobbo, Mari Lallukka, Francesca Gamna, Mirko Prato, Alessandra Vitale, Sara Ferraris, Ziba Najmi, Andrea Cochis, Lia Rimondini, Jonathan Massera, Silvia Spriano
Summary: This research focuses on developing a protocol to attach nisin, an antimicrobial peptide, to a nanotextured titanium alloy surface. The coated surface shows high surface energy, suitable for tissue integration, and releases nisin over a period longer than 1 day. The antibacterial properties were confirmed by reduced metabolic activity and viable adhered colonies of Staphylococcus aureus. This study demonstrates the potential of using chemically treated titanium surfaces coupled with nisin for bioactive and antibacterial tissue integration.
APPLIED SURFACE SCIENCE
(2023)
Article
Oncology
Michela Giulia Clavenna, Marta La Vecchia, Marika Sculco, Soni Joseph, Elettra Barberis, Elia Amede, Marta Mellai, Silvia Brossa, Giulia Borgonovi, Pietro Occhipinti, Renzo Boldorini, Elisa Robotti, Barbara Azzimonti, Elisa Bona, Edoardo Pasolli, Daniela Ferrante, Marcello Manfredi, Anna Aspesi, Irma Dianzani
Summary: A study found a connection between gut microbiota and colorectal cancer. By analyzing the microbiota and metabolome directly from colon polyps, the researchers identified different bacterial and metabolite signatures that can distinguish between low- and high-grade dysplastic polyps. They also discovered bacterial genera and species enriched in the early stages of tumor development, which may act as drivers of carcinogenesis. Additionally, they revealed that changes in bacterial composition were accompanied by differences in metabolite profiles, indicating the involvement of gut bacteria in the production and consumption of these metabolites. These findings provide valuable insights into the role of specific bacteria in colon carcinogenesis and offer possibilities for microbiota-based preventative measures.
Review
Biochemistry & Molecular Biology
Barbara Azzimonti, Chiara Ballacchino, Paola Zanetta, Marie Angele Cucci, Chiara Monge, Margherita Grattarola, Chiara Dianzani, Giuseppina Barrera, Stefania Pizzimenti
Summary: Mounting evidence suggests that the microbiota plays a crucial role in the development of human diseases, including skin cancer, and is linked to oxidative stress, which is involved in the pathogenesis of various diseases. However, the connection between microbiota, oxidative stress, and skin cancer remains largely unexplored. This review discusses the current knowledge on these topics and proposes potential therapeutic strategies.
Article
Biochemistry & Molecular Biology
Paola Zanetta, Diletta Francesca Squarzanti, Alessia di Coste, Angela Amoruso, Marco Pane, Barbara Azzimonti
Summary: Fusobacterium nucleatum and Porphyromonas gingivalis, as main periodontopathogens, have a key role in oral squamous cell carcinoma by promoting cell proliferation, invasion, and persistent inflammation. This study investigated the influence of different growth media on the activity of Lactobacillus-derived cell-free supernatants (CFSs). The results showed that CFSs produced in the novel Terreno Industriale Lattobacilli (TIL) media exhibited improved efficacy against the pathogens compared to those produced in the standard MRS media. This research highlights the importance of considering growth conditions in evaluating the effectiveness of probiotics and their metabolites.
Article
Polymer Science
Matteo Bergoglio, Ziba Najmi, Andrea Cochis, Marta Miola, Enrica Verne, Marco Sangermano
Summary: This study presents a novel approach for fabricating bioactive glass reinforced scaffolds using 3D printing technology. The composite scaffold, made from a bio-based acrylate resin derived from soybean oil and a reactive diluent called isobornyl acrylate, showed improved mechanical behavior compared to traditional mould-synthetized samples. The addition of bioactive glass particles did not significantly affect the curing process or the cytocompatibility of the scaffold, but resulted in higher metabolic activity and increased cell attachment on the scaffold surfaces.
Article
Materials Science, Multidisciplinary
Aydin Bordbar-Khiabani, Michael Gasik
Summary: This study reports the electrochemical behavior of additively manufactured patterned titanium alloys in different simulated conditions. The corrosion resistance of titanium alloys increases with increasing immersion time in all cases. Under severe inflammatory conditions, albumin, lactate, and H2O2 have a synergistic effect on decreasing the corrosion resistance of patterned titanium layers.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Review
Microbiology
Paola Savoia, Barbara Azzimonti, Roberta Rolla, Elisa Zavattaro
Summary: The skin and gut host various microorganisms that interact with the immune system and affect immune tolerance and inflammation. Changes in the skin microbiota have been observed in skin diseases, including skin cancer. Modulating the microbiota could be a potential therapeutic option for advanced skin cancers.
Article
Engineering, Multidisciplinary
Beatriz Ferreira Fernandes, Neusa Silva, Joana Faria Marques, Mariana Brito Da Cruz, Laura Tiainen, Michael Gasik, Oscar Carvalho, Filipe Samuel Silva, Joao Carames, Antonio Mata
Summary: This in vitro study evaluated the cellular response of human osteoblasts, gingival fibroblasts, and S. oralis when in contact with zirconia implant surfaces functionalized with BaTiO3, which has piezoelectric properties. The results suggest that these surfaces are not cytotoxic to peri-implant cells and may promote faster initial osteoblast differentiation. Additionally, they can inhibit the growth of S. oralis over time by acting as a bacteriostatic agent.
Review
Engineering, Biomedical
F. Melo-Fonseca, O. Carvalho, M. Gasik, G. Miranda, F. S. Silva
Summary: Significant advancements in research and technology have led to remarkable findings on the physiological dynamics of the human body. The transition from two-dimensional culture systems to three-dimensional dynamic cultures has allowed for a closer mimic of the complex physiological environment. This review focuses on mechanical stimulation devices and their potential for improvement to enhance mechanobiology studies.
BIO-DESIGN AND MANUFACTURING
(2023)
