Review
Polymer Science
Mohammad Javad Javid-Naderi, Javad Behravan, Negar Karimi-Hajishohreh, Shirin Toosi
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Otorhinolaryngology
In Gul Kim, Yanru Wu, Su A. Park, Ji Suk Choi, Seong Keun Kwon, Seung Hong Choi, Kyeong Cheon Jung, Jung-Woog Shin, Eun-Jae Chung
Summary: This study evaluated the potential of a double-layered polymeric scaffold and a custom-designed mesenchymal stem cell-based bioreactor system for esophageal tissue engineering. The results showed that electrospun polyurethane scaffolds cultured in a custom bioreactor can be a promising approach for esophageal reconstruction.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2023)
Article
Mathematics, Applied
Prakash Kumar, G. P. Raja Sekhar
Summary: This paper develops a mathematical model to study fluid flow, nutrient transport, and cell growth inside a bioreactor. The model includes deformable scaffold material, biphasic mixture theory equations, Stokes equation for flow, advection-diffusion-reaction equation for nutrient balance, Contois equation for cell growth, and the use of Laplace transformation to handle time-dependent terms. The study investigates nutrient outreach in the scaffold region, factors affecting nutrient concentration, and computes total mass transfer rate for nutrient distribution across different regions of the bioreactor.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Parinaz Abdollahiyan, Fatemeh Oroojalian, Maryam Hejazi, Miguel de la Guardia, Ahad Mokhtarzadeh
Summary: 3D bioprinting techniques in tissue engineering have shown great potential in constructing hard organs and tissues, such as bone and cartilage. However, the main challenge lies in replicating the complex structures of natural tissues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hao Chen, Dai-Ling Li, Andy Deng-Chi Chuang, Banendu Sunder Dash, Jyh-Ping Chen
Summary: The study prepared core-sheath nanofibers with different structures for tendon tissue engineering, and demonstrated that the combined effects of aligned fibers and PRP could enhance cell proliferation rates and gene expression in tenocytes. Additionally, dynamic cell culture in a bioreactor with cyclic tension stimulation could accelerate tendon maturation in vitro, leading to improved cell proliferation rates and maintenance of tenogenic phenotype compared to static culture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Keisuke Suzuki, Makoto Komura, Kazuko Obana, Hiroko Komura, Ryoko Inaki, Jun Fujishiro, Kan Suzuki, Yasuhide Nakayama
Summary: The orthotopic in-body tissue architecture (iBTA) technique involving interposing a tubular mold at the esophageal defect site can regenerate a substitute esophagus with esophageal epithelium and collagenous wall, providing a novel treatment for esophageal atresia with various gap lengths including long-gap esophageal atresia (LGEA).
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Biotechnology & Applied Microbiology
Sunita Brimmer, Pengfei Ji, Aditya K. Birla, Sundeep G. Keswani, Christopher A. Caldarone, Ravi K. Birla
Summary: The field of biological pumps focuses on the development of tubular grafts that generate intraluminal pressure. They can be used in cardiac tissue engineering and have applications as standalone devices. Many fabrication technologies and materials have been tested, and bioreactors have been used to replicate the in vivo environment. This article provides an overview of the field, discussing progress, fabrication methods, biomaterial platforms, and challenges.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Parinaz Abdollahiyan, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Tissue engineering in regenerative medicine utilizes cells, substrates, and physiologically active biomolecules to generate advanced therapeutic methods, while nanotechnology can accelerate tissue repair by providing dynamic three-dimensional nano-environments.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Multidisciplinary
Riccardo Gottardi, Kim Moeller, Roberto Di Gesu, Rocky S. Tuan, Martijn van Griensven, Elizabeth R. Balmayor
Summary: The study utilized hyperelastic biphasic 3D printed PLGA scaffolds to mimic the native insertion side, and cultured constructs in dual fluidic bioreactors to achieve regional differentiation towards tenogenic or chondrogenic fate. This system has been validated as a potential platform to form the tendon enthesis and will be further optimized for the fabrication of distinctly biphasic constructs in future studies.
FRONTIERS IN MATERIALS
(2021)
Article
Engineering, Biomedical
Sangil Min, David Cleveland, In Kap Ko, Ji Hyun Kim, Hee Jo Yang, Anthony Atala, James J. Yoo
Summary: By incorporating vascular endothelial growth factor (VEGF) into the vascular scaffold, improved angiogenic capability was achieved, promoting vascularization, reducing apoptosis of implanted cells, and forming hybrid renal tubule-like structures.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Fushi Wang, Xinjie Cai, Ya Shen, Liuyan Meng
Summary: This review discusses the effects of various types of scaffold materials on cell-scaffold interaction in tissue engineering. It elaborates on the influence of the physical, chemical, mechanical, and biological characteristics of scaffold materials on cell-scaffold interaction. The review also examines the role of scaffold components, degradation process, and degraded products in cell-scaffold interactions. Furthermore, it summarizes the latest research progress on cell-scaffold interactions among various engineered tissues or organs in the oral and craniofacial region.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Jianhua Zhang, Esther Wehrle, Marina Rubert, Ralph Mueller
Summary: Three-dimensional (3D) bioprinting is a promising approach for tissue engineering, allowing precise placement of cells and biomaterials to mimic complex microstructures of biological tissues. Bioprinted tissues can benefit from exposure to fluid mechanical cues provided by bioreactor systems, aiding in tissue development and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shu Pan, Ziqing Shen, Tian Xia, Ziyin Pan, Yibo Dan, Jianfeng Li, Hongcan Shi
Summary: Pluronic F127-based modification of 3D printing scaffold showed excellent biocompatibility, benefiting the attachment and proliferation of bone marrow mesenchymal stem cells. Furthermore, a hybrid graft was constructed by combining the modified scaffold with decellularized matrix, showing great potential in tracheal replacement and reconstruction.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Review
Engineering, Biomedical
Kenichi Arai, Takahiro Kitsuka, Koichi Nakayama
Summary: The safety and efficacy of new drugs are typically tested in animals, but differences in drug responses and potential cardiac side effects have led to many drug development projects being discontinued. Alternative methods to animal testing are needed. Tissue engineering techniques can create three-dimensional cardiac constructs from hiPSC-CMs, providing a new approach for drug screening.
Review
Biotechnology & Applied Microbiology
Jiang-Nan Fu, Xing Wang, Meng Yang, You-Rong Chen, Ji-Ying Zhang, Rong-Hui Deng, Zi-Ning Zhang, Jia-Kuo Yu, Fu-Zhen Yuan
Summary: This article reviews the advances in osteochondral tissue engineering and discusses various strategies including scaffold design, material types, fabrication techniques, and functional properties. Although there are still challenges and difficulties, research in this field is of great importance for repairing OC defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Rishikesh Pandey, Renjie Zhou, Rosalie Bordett, Ciera Hunter, Kristine Glunde, Ishan Barman, Tulio Valdez, Christine Finck
JOURNAL OF BIOPHOTONICS
(2019)
Article
Cell Biology
Adam Mitchell, Heather Wanczyk, Todd Jensen, Christine Finck
Article
Immunology
Christopher Nold, Todd Jensen, Kathleen O'Hara, Julie Stone, Steven M. Yellon, Anthony T. Vella
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Wael N. Sayej, Michael S. Isakoff, Joseph A. DiGiuseppe, Douglas Moote, Fabiola Balarezo, Christine Finck, Jeffrey S. Hyams
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2020)
Article
Pediatrics
Todd Jensen, Heather Wanczyk, Shefali Thaker, Christine Finck
Summary: The study aimed to investigate the potential use of stem cells from esophageal atresia patients for tissue regeneration. Despite small tissue samples obtained from patients, successful expansion and cultivation of stem cells were achieved, showing differences in gene expression profiles. These findings may serve as a basis for further research and applications in tissue regeneration.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Cell Biology
Kiersten Giusto, Heather Wanczyk, Todd Jensen, Christine Finck
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm newborns caused by high levels of oxygen exposure. While there is no cure for BPD, research using animal and in vitro models to test treatments has shown some success. However, lack of standardization in methods poses challenges for clinical translation.
DISEASE MODELS & MECHANISMS
(2021)
Review
Physiology
Heather Wanczyk, Todd Jensen, Daniel J. Weiss, Christine Finck
Summary: Lung transplantation remains the main option for individuals with end-stage lung failure, but facing limitations such as a shortage of suitable donor lungs and immune rejection post-transplantation. To address these issues, research is being conducted on using decellularized biocompatible lung scaffolds reseeded with autologous lung cells for tissue regeneration. However, gaps still exist in understanding the reseeding methods of important cell populations and the spatiotemporal interactions between different cell populations necessary for proper lung growth and function.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Nathan Gasek, Heon E. Park, Juan J. Uriarte, Franziska E. Uhl, Robert A. Pouliot, Alexander Riveron, Tovah Moss, Zachary Phillips, Jessica Louie, Ishna Sharma, Benefsha Mohammed, Jacob Dearborn, Patrick C. Lee, Todd Jensen, John Garner, Christine Finck, Daniel J. Weiss
Summary: Pleural and tracheal injuries remain significant challenges, and the development of sealants based on alginate and gelatin biomaterials show promise in effectively addressing these issues. These sealants demonstrate strong mechanical characteristics, minimal toxicity, and successful performance in vitro and in vivo models, providing a platform for further clinical investigations.
ACTA BIOMATERIALIA
(2021)
Article
Pediatrics
A. B. Montgomery, C. Finck
Summary: New symptoms associated with Covid-19, such as fever, shortness of breath, gastrointestinal illness, and coagulopathy, continue to appear as the disease spreads globally. This case study presents a 17-year-old male who developed massive hemopneumothorax and was incidentally found to be positive for Covid-19. It is suspected that the primary pneumothorax may have been caused by a bleb, and the hemothorax could have been induced by the coagulopathic state from the Covid-19 infection.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Pediatrics
Jillian Giblin, Melissa Santos, Christine Finck
Summary: Bariatric surgery is an effective intervention for severe obesity in adolescents, but it can lead to deficiencies in vitamins and minerals. This article reviews a case of thiamine deficiency in a teenage girl following sleeve gastrectomy, discussing the clinical presentation, diagnosis, and treatment.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2022)
Review
Genetics & Heredity
Ana Menendez, Heather Wanczyk, Joanne Walker, Beiyan Zhou, Melissa Santos, Christine Finck
Summary: Obesity is an increasingly serious health problem, affecting both children and adults. Childhood obesity, associated with conditions like cardiovascular disease, type 2 diabetes, and metabolic syndrome, is often accompanied by chronic low-grade inflammation. Factors such as epigenetics, the gut microbiome, and the intrauterine environment are believed to play a role in the development of pediatric obesity. Understanding the initial molecular and cellular changes during obesity can aid in early intervention and prevention of adult comorbidities.
Article
Pediatrics
A. B. Montgomery, K. Dukleska, F. Balarezo, D. Moote, C. Finck
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2020)
Article
Pediatrics
A. B. Montgomery, J. Han, J. M. Healy, C. Finck
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2020)
Article
Oncology
Adam Mitchell, Heather Wanczyk, Todd Jensen, Christine Finck
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
Article
Pediatrics
Jonathan Wong, Sue Goodine, Kate Samela, Katherine S. Vance, Beth Chatfield, Zhu Wang, Wael N. Sayej
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2020)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.