Article
Immunology
Akemi Kosaka, Kei Ishibashi, Toshihiro Nagato, Hidemitsu Kitamura, Yukio Fujiwara, Syunsuke Yasuda, Marino Nagata, Shohei Harabuchi, Ryusuke Hayashi, Yuki Yajima, Kenzo Ohara, Takumi Kumai, Naoko Aoki, Yoshihiro Komohara, Kensuke Oikawa, Yasuaki Harabuchi, Masahiro Kitada, Hiroya Kobayashi, Takayuki Ohkuri
Summary: Activation of the STING signaling pathway is crucial in anti-tumor immunity, while CD47 overexpression in breast cancer patients is associated with poor survival. Combination therapy with cGAMP and an antagonistic anti-CD47 mAb inhibits tumor growth, enhances phagocytosis of tumor cells, and induces systemic anti-tumor immune responses relying on STING and type I IFN signaling.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Elana R. Shaw, Lindsey B. Rosen, Aristine Cheng, Kerry Dobbs, Ottavia M. Delmonte, Elise M. N. Ferre, Monica M. Schmitt, Luisa Imberti, Virginia Quaresima, Michail S. Lionakis, Luigi D. Notarangelo, Steven M. Holland, Helen C. Su
Summary: Levels and activity of anti-type 1 interferon autoantibodies peak during acute coronavirus disease 2019 and decrease thereafter. Despite lower levels, most patients in convalescence still have some ability to neutralize type 1 interferon. Identifying these autoantibodies in healthy individuals before critical viral disease develops may be challenging.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Rheumatology
Albin Bjork, Rui Da Silva Rodrigues, Elina Richardsdotter Andersson, Jorge I. Ramirez Sepulveda, Johannes Mofors, Marika Kvarnstrom, Vilija Oke, Elisabet Svenungsson, Iva Gunnarsson, Marie Wahren-Herlenius
Summary: This study found that patients with SLE on no or light treatment developed augmented antibody responses to viral antigens, which were associated with markers of type I IFN system activation at the RNA and protein levels.
Article
Immunology
Sebastian Ochoa, Li Ding, Samantha Kreuzburg, Jennifer Treat, Steven M. Holland, Christa S. Zerbe
Summary: Patients with autoantibodies to interferon-gamma (IFN-gamma) may develop severe nontuberculous mycobacterial infections. However, the novel use of daratumumab in a patient with these autoantibodies resulted in clinical and radiographic improvement.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Shubo Wen, Xintong Li, Xiangyu Lv, Kai Liu, Jingqiang Ren, Jingbo Zhai, Yang Song
Summary: Interferon (IFN) is a crucial antiviral cytokine involved in host defense against virus invasion. Pathogens have developed strategies to escape the IFN-mediated immune response. This review focuses on the mechanisms mediated by Npro of pestiviruses to counteract IFN production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Wen-I. Lee, Yao-Fan Fang, Jing-Long Huang, Huey-Ling You, Meng-Ying Hsieh, Wan-Ting Huang, Chi-Jou Liang, Chen-Chen Kang, Ting-Shu Wu
Summary: It is not uncommon to find the presence of anti-interferon-gamma autoantibodies (AutoAbs-IFN-gamma) in patients with persistent non-tuberculous mycobacterial (NTM) infections characteristic of adult-onset immunodeficiency syndrome. The immune disturbances in this disorder are still not well understood. By quantifying the levels of AutoAbs-IFN-gamma and comparing them with healthy controls, it was found that the abnormal distribution of immune cell subpopulations may be correlated with the presence of AutoAbs-IFN-gamma.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Claudia Guenther, Christine Wolf, Louisa Fennen, Sarah Roesing, Stefan Beissert, Martin Aringer, Min Ae Lee-Kirsch
Summary: Treatment with anifrolumab, a monoclonal antibody, can lead to fast and sustained remission of CLE lesions in SLE patients, and the reduction in IFN-stimulated gene expression suggests that ISGs could serve as valuable biomarkers in CLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manoj Puthia, Jan K. Marzinek, Ganna Petruk, Gizem Erturk Bergdahl, Peter J. Bond, Jitka Petrlova
Summary: This study demonstrates that APOE has anti-bacterial activity against several Gram-negative bacterial strains and exhibits significant binding affinity for lipopolysaccharide and heparin. Molecular dynamics simulations reveal the binding region in helix 4 of APOE as a primary site for interaction with these molecules through electrostatic interactions.
Review
Oncology
Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang, Xiaobo Li
Summary: Interferons have a dual effect on cancer immune response, with both anti-cancer and immune escape-promoting effects. They regulate each step of the cancer immunity cycle, contributing to our understanding of the mechanisms of IFNs in regulating cancer immunity. Recent studies have highlighted the critical roles of IFNs in the success of cancer therapy strategies.
Review
Immunology
Zhijie Jian, Rui Ma, Ling Zhu, Huidan Deng, Fengqin Li, Jun Zhao, Lishuang Deng, Siyuan Lai, Xiangang Sun, Huaqiao Tang, Zhiwen Xu
Summary: This article reviews the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, emphasizing the significance of this research in understanding the pathogenesis of arthritis virus and developing vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Martin Killian, Fabien Colaone, Philippe Haumont, Carole Nicco, Olivier Cerles, Sandrine Chouzenoux, Pascal Cathebras, Nicolas Rochereau, Blandine Chanut, Mireille Thomas, Norbert Laroche, Fabien Forest, Geraldine Grouard-Vogel, Frederic Batteux, Stephane Paul
Summary: This study evaluated the immunogenicity, efficacy and tolerance of IFN-Kinoid in a mouse model of Sjogren's syndrome, showing that IFN-K induced a disease-modifying anti-IFN alpha antibody response, reduced type 1 IFN signature, and improved disease features, paving the way for further clinical development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Alessandra Pierangeli, Massimo Gentile, Giuseppe Oliveto, Federica Frasca, Leonardo Sorrentino, Luigi Matera, Raffaella Nenna, Agnese Viscido, Matteo Fracella, Laura Petrarca, Gabriella D'Ettorre, Giancarlo Ceccarelli, Fabio Midulla, Guido Antonelli, Carolina Scagnolari
Summary: Children generally develop milder symptoms after SARS-CoV-2 infection compared to older adults. Recent research shows that children have a pre-activated innate immune response, which leads to a more effective anti-viral response upon infection. In this study, the expression levels of type I and III interferons (IFNs) were analyzed in different age groups of SARS-CoV-2 infected and non-infected individuals. The results suggest that age-related differences exist in the IFN response, with children having higher basal transcription levels of IFNs and adults showing overexpression of IFN-stimulated genes (ISGs). The findings contribute to our understanding of the protective IFN response against SARS-CoV-2 based on age.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Zhenyu Lin, Jie Wang, Nian Zhang, Jianshu Yi, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Kun Qian, Jianhe Sun, Yuqiang Cheng
Summary: This study cloned goose IRF1 (GoIRF1) and conducted bioinformatics analyses to compare its protein homology with IRF1 in other species. The results showed that GoIRF1 induces the expression of interferons, proinflammatory cytokines, and ISGs in geese, playing an important role in antiviral innate immunity.
VETERINARY RESEARCH
(2022)
Review
Immunology
Dan Zhang, Aaron T. Irving
Summary: The interferon pathway is the first line of defense against viral infections in mammals, and it induces the expression of interferon-stimulated genes (ISGs). The antiviral function of ISGs has been extensively studied in mice and humans. Bats, as an important viral reservoir, can coexist with pathogenic viruses without showing signs of disease, but limited data are available on the role of ISGs in bats. This review summarizes the current understanding of conserved and bat-specific ISGs and their known antiviral functions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear
Summary: IFN-lambda has antiviral effects during pregnancy, but its effects depend on the gestational stage. Infection with ZIKV earlier in pregnancy enhances transplacental transmission. IFN-lambda signaling in maternal tissues causes fetal resorption and intrauterine growth restriction in dams with robust ZIKV infection. Maternal IFN-lambda signaling also contributes to pregnancy pathology induced by poly(I.C) treatment.
