Review
Allergy
Thomas B. Casale, Michael B. Foggs, Ronald C. Balkissoon
Summary: Studies have shown that long-acting muscarinic antagonists (LAMAs) as an add-on treatment can improve lung function and asthma control in patients with asthma who are suboptimally responsive to inhaled corticosteroids and long-acting beta(2)-agonists. LAMA treatment is a reasonable option for patients with uncontrolled asthma with ICS plus LABA or ICS alone.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Ching -Fu Weng, Chien-Chih Wu, Mei-Hsuan Wu, Fang-Ju Lin
Summary: This retrospective cohort study compared the differences in acute exacerbation (AE) and cardiovascular events among patients with COPD receiving different LAMA/LABA fixed-dose combinations (FDCs). The results showed that patients treated with UMEC/VI or GLY/IND had a lower risk of severe AE compared to those receiving TIO/OLO. Additionally, GLY/IND users tended to have a lower risk of cardiovascular events compared to TIO/OLO users.
Article
Urology & Nephrology
Cosimo De Nunzio, Antonio Nacchia, Carmen Gravina, Beatrice Turchi, Giacomo Gallo, Alberto Trucchi, Ferdinando DI Giacomo, Giuseppe Disabato, Antonio Franco, Lorenzo Rovesti, Riccardo Lombardo, Antonio Cicione, Andrea Tubaro
Summary: This study analyzed real-life data from the Eudra-Vigilance Database on adverse events related to antimuscarinic and beta-3-agonist treatment. The results showed that female patients had a higher risk of adverse events, and there was a significant risk of acute urinary retention in older individuals.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Respiratory System
Su Yeon Lee, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh
Summary: Treatment with bronchodilators such as LAMA or LABA was effective in improving lung function in patients with bronchiectasis, regardless of concurrent treatments that also improve lung function. Baseline lung function had a significant negative correlation with response to bronchodilator treatment.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Respiratory System
Kenneth R. Chapman, Robert A. Wise, Benjamin M. Scirica, Deepak L. Bhatt, Sami Z. Daoud, Dan Lythgoe, Esther Garcia Gil
Summary: The study found that in patients with moderate-to-very severe COPD and cardiovascular comorbidities, using aclidinium in conjunction with beta-blockers can improve lung function, reduce the rate of COPD exacerbations, and not increase the risk of major adverse cardiovascular events.
RESPIRATORY RESEARCH
(2021)
Article
Respiratory System
Mineo Katsumata, Tomoyuki Fujisawa, Yosuke Kamiya, Yuko Tanaka, Chiaki Kamiya, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Masato Maekawa, Mitsutoshi Setou, Hiroshi Watanabe, Koji Ikegami, Takafumi Suda
Summary: Long-acting muscarinic antagonists (LAMAs) have a direct enhancing effect on airway ciliary functions and may improve impaired mucociliary clearance in asthma and COPD.
BMC PULMONARY MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Alena Randakova, Jan Jakubik
Summary: Cholinergic signalling disruption through muscarinic receptors is linked to various pathologies, with potential therapeutic benefits found in selective muscarinic agonists. The identical orthosteric binding site across all muscarinic receptor subtypes makes the development of affinity-based selective agonists nearly impossible. Functionally selective and biased agonists show promise for selectively targeting individual muscarinic receptor subtypes.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Respiratory System
Kazuya Tanimura, Susumu Sato, Yukio Fujita, Yoshifumi Yamamoto, Takashi Hajiro, Nobuyuki Horita, Tomotaka Kawayama, Shigeo Muro
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of combining short-acting muscarinic antagonist (SAMA) therapy with a long-acting beta-2 agonist (LABA) for patients with stable COPD. The results showed that the additional use of SAMA plus LABA had significant improvements in pulmonary function, dyspnea, and health-related quality of life compared to LABA treatment, with minimal adverse effects.
CHRONIC RESPIRATORY DISEASE
(2023)
Article
Respiratory System
Mingjin Yang, Yishi Li, Youfan Jiang, Shuliang Guo, Jian-Qing He, Don D. Sin
Summary: Long-acting muscarinic antagonist (LAMA)/long-acting β-agonist (LABA) combination therapy significantly improves clinical symptoms and health status in patients with chronic obstructive pulmonary disease (COPD) and reduces exacerbation risk. However, there is concern that it may increase the risk of cardiovascular disease in COPD patients. This study aims to determine the impact of LAMA/LABA combination therapy on cardiovascular disease risk in COPD patients.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Medicine, General & Internal
Stephen A. Brunton, D. Kyle Hogarth
Summary: In the latest report of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023, the use of long-acting beta(2)-agonist/inhaled corticosteroids (LABA/ICS) is not recommended in patients with COPD. However, there is still significant use of LABA/ICS in current prescribing patterns. This review compares the efficacy and safety of combination therapy with long-acting muscarinic antagonist (LAMA) and LABA vs LABA/ICS and highlights the superior outcomes of LAMA/LABA combinations. The GOLD 2023 report recommends treatment with LABA and LAMA combination in COPD patients with persistent dyspnea, with initiation of ICS based on symptoms, blood eosinophil count, and exacerbation history.
POSTGRADUATE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Maria Gabriella Matera, Paola Rogliani, Giuseppe Novelli, Mario Cazzola
Summary: This narrative review discusses the possible impact of genetic variations on bronchodilator response. Studies have mainly focused on three SNPs in the ADRB2 gene, and other uncommon variants may also contribute to individual variability in salbutamol response. There is also evidence of a link between SNPs and ethnic/age profiles regarding bronchodilator response. However, replication of pharmacogenetic results is limited and often the observed response does not match the expected outcome based on SNP identification. Further research integrating multi-omics approaches and epigenetic factors is needed.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Alberto Papi, Leonardo M. Fabbri, Huib A. M. Kerstjens, Paola Rogliani, Henrik Watz, Dave Singh
Summary: Long-acting muscarinic antagonists (LAMAs) play an important role in the management of asthma, particularly in patients with poorly controlled asthma, with proven efficacy and safety. Tiotropium, as the first LAMA, has been approved as an add-on therapy for asthma patients. Single-inhaler triple therapies have also been approved or are in clinical development for asthma management.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Urology & Nephrology
Kazuna Tsubouchi, Hisatomi Arima, Makiko Abe, Hiroshi Matsuzaki, Kosuke Tominaga, Aiko Fujikawa, Naotaka Gunge, Takeshi Miyazaki, Yu Okabe, Nobuyuki Nakamura, Hirofumi Matsuoka, Shota Okutsu, Kazuhiro Tada, Nobuhiro Haga
Summary: This meta-analysis investigated the effect of pharmacotherapy for overactive bladder on urinary tract infection. The results showed that antimuscarinic agents significantly increased the incidence of urinary tract infection and lower urinary tract symptoms and dysfunction, while beta 3-adrenoceptor agonists did not.
JOURNAL OF UROLOGY
(2023)
Article
Respiratory System
Pei-An Liao, Sheng-Wei Pan, Chun-Yu Chen, Chung-Yeh Deng, Yaa-Hui Dong
Summary: This study aimed to examine the prescription patterns of LABA/LAMA FDC and LABA/ICS FDC for COPD patients in real-world practice. It found temporal trends, variations in healthcare provider, and differences in patient characteristics among patients who initiated these therapies.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Clinical Neurology
Shishuang Cui, Fang Fang, Peijing Cui, Qianwen Jiang, Shaoqing Xu, Zhihong Xu, Jia'An Hu, Feika Li
Summary: The use of beta-adrenoceptor acting drugs is associated with the risk of dementia. Beta 2-agonists are associated with a decreased risk of dementia, while non-selective beta-antagonists are associated with an increased risk of dementia.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Xin Yang, Feng Liu, Jiawei Zheng, Wenke Cheng, Chao Zhao, Ji Di
Summary: This study found that female users of oral contraceptives may have a reduced risk of glioma compared to non-users, but there was no clear association between oral contraceptive use and the risk of meningioma. Long-term use of oral contraceptives may significantly decrease the risk of glioma.
WORLD NEUROSURGERY
(2021)
Review
Pediatrics
Nana Huo, Kun Zhang, Li Wang, Lina Wang, Wenhui Lv, Wenke Cheng, GuangZhu Jia
Summary: The study suggests that maternal overweight or obesity increases the risk of infant mortality, while maternal underweight may lower this risk. Further large-scale prospective studies are needed to confirm these findings.
FRONTIERS IN PEDIATRICS
(2021)
Review
Clinical Neurology
Bing Yuan, Tong Yang, Tao Yan, Wenke Cheng, Xiancong Bu
Summary: High D-dimer levels may be associated with the risks of total stroke and ischemic stroke, but not with hemorrhagic stroke. Additionally, high D-dimer levels on admission may predict adverse clinical outcomes in patients with AIS or TIA.
FRONTIERS IN NEUROLOGY
(2021)
Review
Nutrition & Dietetics
Xiangying Qi, Wenyan Zhang, Mingxiu Ge, Qiang Sun, Lei Peng, Wenke Cheng, Xuepeng Li
Summary: The meta-analysis investigated the association between dairy product intake and the risk of endometriosis, discovering that overall dairy intake was linked to a reduced risk of endometriosis, particularly with high-fat dairy and cheese intake potentially lowering the risk of developing the condition. However, a higher intake of butter may be associated with an increased risk of endometriosis. Further studies are needed to validate these findings.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Wenke Cheng, Maciej Rosolowski, Julia Boettner, Steffen Desch, Alexander Jobs, Holger Thiele, Petra Buettner
Summary: This meta-analysis suggests that decreased CEC is strongly associated with the risk of CAD, independent of HDL-C level. However, decreased CEC seems not to be related to cardiovascular mortality. Meanwhile, CEC is linearly negatively correlated with the risk of CAD.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Siwei Chen, Wenke Cheng
Summary: The study found that elevated total cholesterol, LDL-c, and non-HDL-c were related to the incidence of hypertension in Chinese adult males. Triglycerides, however, were not significantly associated. After adjusting for BMI, the relationship between HDL-c and hypertension shifted from no association to a positive correlation. The BN model showed that age, BMI, fasting plasma glucose (FPG), and total cholesterol were strongly associated with hypertension incidence.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Wenke Cheng, Lili Wang, Siwei Chen
Summary: The study found that there were significant differences in lipid profiles between hypertensive and normotensive populations, with total cholesterol and LDL levels closely associated with hypertension incidence. In women, atherogenic coefficient was found to have a good predictive value for the occurrence of hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Guizhi Deng, Yunjie Li, Wenke Cheng
Summary: The study aimed to investigate the relationship between lipid profile and prevalence of hypertension in Chinese adult women. The results showed that TC, LDL-c, and non-HDL-c were positively associated with hypertension prevalence, while HDL-c was negatively associated with hypertension prevalence but became nonsignificant after full adjustment for variables.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wenke Cheng, Jingqi Zhuang, Siwei Chen
Summary: This study investigated the relationship between atherosclerotic indices and the prevalence of hypertension in Chinese adults without type 2 diabetes mellitus. The results showed that atherosclerotic indices were higher in the hypertensive population compared to the normotensive population, and systolic and diastolic blood pressure were positively correlated with these indices. The cholesterol index and non-HDL-C were identified as independent risk factors for hypertension prevalence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Wenke Cheng, Fanliang Kong, Siwei Chen
Summary: This study investigated the association between four insulin resistance surrogate markers and the prevalence of hypertension. The results showed that TyG-BMI and METS-IR were independent risk factors for hypertension, and TyG-BMI had a higher predictive value.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Medicine, General & Internal
Wenke Cheng, Georg Fuernau, Steffen Desch, Anne Freund, Hans-Josef Feistritzer, Janine Poess, Christian Besler, Philipp Lurz, Petra Buettner, Holger Thiele
Summary: Mild therapeutic hypothermia (MTH) does not affect the levels of Galectin-3 (Gal-3) in patients with cardiogenic shock complicating acute myocardial infraction (AMI) compared to the control group. Gal-3 is a relatively stable biomarker, independent of age, sex, and BMI, and Gal-3 levels at admission might predict the risk of 30-day all-cause mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Fanliang Kong, Junhao Huang, Chunhua Xu, Tingyuan Huang, Grace Wen, Wenke Cheng
Summary: This study investigates the relationship between two novel inflammatory markers, SIRI and SII, and their association with all-cause and cardiovascular disease mortality in the obese population. The findings suggest that both SIRI and SII are independent risk factors for mortality, with SIRI showing a stronger predictive ability than SII.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Cardiac & Cardiovascular Systems
Wenke Cheng, Georg Fuernau, Steffen Desch, Anne Freund, Hans-Josef Feistritzer, Janine Poess, Petra Buettner, Holger Thiele
Summary: This study aimed to investigate the effect of mild therapeutic hypothermia on monocyte chemoattractant protein-1 (MCP-1) levels in patients with cardiogenic shock complicating acute myocardial infarction. The results showed that the cooling phase of hypothermia had no significant effect on MCP-1 levels in patients, but MCP-1 levels significantly increased after rewarming.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Obstetrics & Gynecology
Fengxia Wang, Wenyan Zhang, Wenke Cheng, Nana Huo, Shenfeng Zhang
Summary: Women with preeclampsia have a decreased risk of breast cancer and an increased risk of ovarian cancer compared to the general population. Further analysis showed that the risk of breast cancer decreased in parous women, women with full-term pregnancies, and women with increasing parity in the preeclampsia population, regardless of their menopausal status and the sex of their offspring.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Review
Obstetrics & Gynecology
Rong Sun, Yan Chu, Yan Gao, Wenke Cheng, Shan Gao
Summary: This study evaluated the efficacy and safety of endocrine therapy in high-risk pre- or postmenopausal women through Bayesian network meta-analysis. The results showed that endocrine therapy reduced the risks of certain types of breast cancer but increased the risks of other diseases. Different drugs had different effects on the risks of different types of breast cancer, highlighting the importance of weighing the benefits and risks of therapy for rational individualized treatment.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)