Collateral Sensitivity of Parthenolide via NF-κB and HIF-α Inhibition and Epigenetic Changes in Drug-Resistant Cancer Cell Lines

Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway

(2018) Jin-jun Wu et al.   PHYTOMEDICINE

Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells

(2018) Jae-Rim Heo et al.   PHYTOMEDICINE

The role of HIF-1α in chemo-/radioresistant tumors

(2018) Yu Xia et al.   OncoTargets and Therapy

Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway

(2018) Hua Li et al.   Oncology Letters

Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology

(2018) Mona Dawood et al.   Frontiers in Pharmacology

Parthenolide suppresses hypoxia-inducible factor-1α signaling and hypoxia induced epithelial-mesenchymal transition in colorectal cancer

(2017) Se Lim Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships

(2017) Sonthaya Umsumarng et al.   PHYTOMEDICINE

Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone towards multi-factorial drug-resistant cancer cells

(2017) Victor Kuete et al.   PHYTOMEDICINE

Cancer combination therapy of the sesquiterpenoid artesunate and the selective EGFR-tyrosine kinase inhibitor erlotinib

(2017) Thomas Efferth   PHYTOMEDICINE

Benzophenones and xanthone derivatives from Garcinia schomburgkiana -induced P-glycoprotein overexpression in human colorectal Caco-2 cells via oxidative stress-mediated mechanisms

(2017) Cherdsak Boonyong et al.   PHYTOMEDICINE

Quantification of hypoxia-related gene expression as a potential approach for clinical outcome prediction in breast cancer

(2017) Abderrahim El Guerrab et al.   PLoS One

Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity

(2017) Sami Hamdoun et al.   Oncotarget

Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway

(2017) Minting Lin et al.   Oncotarget

The association between expression of hypoxia inducible factor-1α and multi-drug resistance of acute myeloid leukemia

(2017) Peipei Xu et al.   Translational Cancer Research

Pharmacogenomics of Scopoletin in Tumor Cells

(2016) Ean-Jeong Seo et al.   MOLECULES

Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells

(2016) Victor Kuete et al.   PHYTOMEDICINE

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

(2016) Prasad R. Dandawate et al.   SEMINARS IN CANCER BIOLOGY

Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines

(2016) Edna Ooko et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role of p53 in cancer drug resistance and targeted chemotherapy

(2016) Karin Hientz et al.   Oncotarget

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib

(2015) Qiaoli Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

The Synergistic Effect of SAHA and Parthenolide in MDA-MB231 Breast Cancer Cells

(2015) Daniela Carlisi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells

(2015) Qingying Luo et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Parthenolide induces apoptosis in colitis-associated colon cancer, inhibiting NF-κB signaling

(2015) SE LIM KIM et al.   Oncology Letters

Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells

(2015) Mohamed Saeed et al.   Frontiers in Pharmacology

Mechanisms of resistance to EGFR tyrosine kinase inhibitors

(2015) Lihua Huang et al.   Acta Pharmaceutica Sinica B

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison: Figure 1

(2015) Agnes Görlach et al.   BIOCHEMICAL JOURNAL

The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein—a well-known, yet poorly understood drug transporter

(2014) Maen Zeino et al.   INVESTIGATIONAL NEW DRUGS

Effect of parthenolide on growth and apoptosis regulatory genes of human cancer cell lines

(2014) Anees A. Al-Fatlawi et al.   PHARMACEUTICAL BIOLOGY

Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking

(2014) Mohamed Saeed et al.   PHYTOMEDICINE

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

NF- B Regulates Radioresistance Mediated By  1-Integrin in Three-Dimensional Culture of Breast Cancer Cells

(2013) K. M. Ahmed et al.   CANCER RESEARCH

NF-κB p65/p52 plays a role in GDNF up-regulating Bcl-2 and Bcl-w expression in 6-OHDA-induced apoptosis of MN9D cell

(2013) Jun Ping Cao et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Drug rechallenge and treatment beyond progression—implications for drug resistance

(2013) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives

(2012) Giuseppe Giannini et al.   Future Medicinal Chemistry

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities

(2011) Vivek Bhakta Mathema et al.   INFLAMMATION

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells

(2010) Yun Dai et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through the NF-κB pathway in MCF-7 cells

(2010) Xuedong Wang et al.   FEBS LETTERS

Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro

(2010) Jun-Wei Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY