Article
Oncology
Marine Perrier, Marie-Amelie Ordan, Coralie Barbe, Camille Mazza, Damien Botsen, Johanna Moreau, Yohann Renard, Mathilde Brasseur, Barbara Tailliere, Philippe Regnault, Eric Bertin, Olivier Bouche
Summary: The feasibility and acceptability of handgrip strength measurement in digestive cancer outpatients was assessed in the FIGHTDIGO study, aiming to evaluate the relationship between muscle strength and functional/nutritional markers in this population. Results showed a significant association between handgrip strength and BMI/nutritional status, while dynapenia was only linked to functional impairment.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Nutrition & Dietetics
Pierre Martin, Damien Botsen, Mathias Brugel, Eric Bertin, Claire Carlier, Rachid Mahmoudi, Florian Slimano, Marine Perrier, Olivier Bouche
Summary: This study aimed to evaluate the relationship between pre-therapeutic handgrip strength and chemotherapy-induced toxicity in digestive cancer patients. The results showed that dynapenia was not an independent predictive factor for overall DLT and neurotoxicity, but could be a predictive factor for chemotherapy-induced anemia and asthenia.
Article
Immunology
Tung-Wei Kao, Tao-Chun Peng, Wei-Liang Chen, Yu-Chiao Chi, Chi-Ling Chen, Wei-Shiung Yang
Summary: The study found a positive association between serum leptin levels and the risk of dynapenia, while a negative association was observed with the risk of sarcopenia in both male and female elderly individuals. Further investigation is needed to understand the biological mechanisms underlying these associations.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Geriatrics & Gerontology
Brian C. Clark
Summary: This article discusses the neural mechanisms underlying age-related muscle weakness, and their relevance to the development of therapies for sarcopenia and mobility limitations in the elderly. It highlights the role of impaired neural activation in age-related weakness and explores the multifactorial nature of these mechanisms.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Leatha A. Clark, Todd M. Manini, Nathan P. Wages, Janet E. Simon, David W. Russ, Brian C. Clark
Summary: The study revealed that the presence of meaningful leg extensor weakness in older adults can lead to changes in neural excitability, with neural excitability variables and thigh lean mass explaining part of the variability in muscle strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
Do-Youn Lee, Sunghoon Shin
Summary: This study investigated the association between chronic kidney disease (CKD) and dynapenia in Korean elderly individuals. The results showed a significant association between CKD and dynapenia, especially in women. The prevalence of dynapenia also increased significantly with the stage of CKD.
Article
Medicine, General & Internal
Soo Yeon Park, Kyoung Ho Yoon, Sung Hyun Hwang, Taeg Su Ko, Hee Sung Lee
Summary: Weakening muscle strength around the knee makes it more susceptible to aging-related damage. This study found an association between knee flexor muscle strength and its cross-sectional area (CSA), and observed that both flexor muscle strength and CSA decrease with aging.
Article
Geriatrics & Gerontology
Bernd Kowall
Summary: The results of the chair-stand test are associated with the risk of type 2 diabetes, with poorer results indicating a higher risk. However, among obese individuals, the results of the test do not modify the risk of diabetes.
Review
Endocrinology & Metabolism
Han Na Jung, Chang Hee Jung, You-Cheol Hwang
Summary: Recent research has shown that sarcopenia in young people can be caused by factors other than aging, contrary to previous studies that focused on age-related reduction in muscle mass and function. The risk of sarcopenia starts in early adulthood and leads to more severe muscle dysfunction later in life. Despite its clinical significance, research on youth-onset sarcopenia is still in its early stages.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Physiology
Brian C. Clark, Seward Rutkove, Elmer C. Lupton, Carlos J. Padilla, W. David Arnold
Summary: With advancing age, deficits in skeletal muscle function are attributed to various physiological and morphological changes, leading to loss of muscle size and quality. Rapid and simple assessment tools for muscle quality are needed, with electrical impedance myography (EIM) showing potential as a reliable measure for evaluating muscle mass and quality in older adults.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Nanami Nasu, Sonoko Yasui-Yamada, Natsumi Kagiya, Mami Takimoto, Yumiko Kurokawa, Yoshiko Tani-Suzuki, Hideya Kashihara, Yu Saito, Masaaki Nishi, Mitsuo Shimada, Yasuhiro Hamada
Summary: This study found that the loss of muscle strength is a stronger prognostic factor for patients with GI and HBP cancers than the loss of muscle mass. Therefore, measuring muscle strength is crucial for all patients.
Review
Endocrinology & Metabolism
Marcela Zembura, Pawel Matusik
Summary: Sarcopenic obesity (SO) is highly prevalent in children and adolescents and is associated with various adverse health outcomes. There is a need for consensus on the definition, standardized evaluation methods, and age and gender thresholds for SO in different ethnicities in the pediatric population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Nathan P. Wages, Mohamed H. Mousa, Leatha A. Clark, Dallin Tavoian, W. David Arnold, Sherif M. Elbasiouny, Brian C. Clark
Summary: Weakness is a significant risk factor for functional limitations and disability in older adults with sarcopenia. Slowed motor unit firing rates (MUFRs) are found to be mechanistically linked with clinically meaningful weakness in older adults.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Geriatrics & Gerontology
Stuart M. Phillips, Kyle J. Lau, Alysha C. D'Souza, Everson A. Nunes
Summary: This study reviewed systematic reviews on the effects of HMB supplementation on muscle growth and muscle loss in ageing and clinical populations. The majority of reviews concluded that HMB supplementation did not affect muscle strength or physical function, and there was controversy regarding its impact on increasing muscle mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Arturo Orea-Tejeda, Robinson Robles-Hernandez, Dulce Gonzalez-Islas, Luz Jimenez-Gallardo, Laura Gochicoa-Rangel, Armando Castorena-Maldonado, Rafael Hernandez-Zenteno, Alvaro Montanez-Orozco, Benigno Valderrabano-Salas
Summary: This study demonstrates an association between lower lung function and the coexistence of obesity with dynapenia and sarcopenia in patients with post-COVID-19 syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Damien Botsen, Marie-Amelie Ordan, Coralie Barbe, Camille Mazza, Marine Perrier, Johanna Moreau, Mathilde Brasseur, Yohann Renard, Barbara Tailliere, Florian Slimano, Eric Bertin, Olivier Bouche
Article
Oncology
Damien Botsen, Elise Lepoix, Camille Mazza, Mathilde Brasseur, Anne Grange, Florian Slimano, Olivier Bouche
SUPPORTIVE CARE IN CANCER
(2019)
Article
Gastroenterology & Hepatology
Q. Laurent-Badr, C. Barbe, M. Brugel, V Hautefeuille, J. Volet, S. Grelet, E. Desot, D. Botsen, S. Deguelte, A. Pitta, N. Abdelli, M. Brasseur, L. De Mestier, C. Neuzillet, O. Bouche
DIGESTIVE AND LIVER DISEASE
(2020)