Article
Pathology
Natalie M. Rizzo, Lynette M. Sholl, Chia-Sui Kao, Kristine M. Cornejo, Ankur R. Sangoi, Michelle S. Hirsch, Katrina Collins, Jennifer B. Gordetsky, Fabiola A. Reyes Curcio, Christopher D. M. Fletcher, Thomas M. Ulbright, Andres M. Acosta
Summary: This study analyzed a series of non-metastasizing and metastasizing SCTs using next-generation DNA sequencing and found that non-metastasizing SCTs were mainly driven by CTNNB1 and APC gene variants, while metastasizing SCTs were mainly caused by variants in TP53, MDM2, CDKN2A/CDKN2B, and TERT genes.
Article
Pediatrics
Giorgio Persano, Alessandro Crocoli, Maria Debora De Pasquale, Raffaele Cozza, Rita Alaggio, Francesca Diomedi Camassei, Federico Beati, Pierluigi Di Paolo, Cristina Martucci, Alessandro Inserra
Summary: Burned-out testicular tumors are a distinct clinical entity characterized by nodal or visceral metastases as clinical manifestations without a clinically or radiologically evident primary testicular lesion. These tumors are associated with systemic symptoms, higher levels of tumor markers, increased treatment-related toxicity, and poorer outcomes compared to primary testicular tumors. Further research is needed to better understand burned-out testicular tumors and develop more effective therapeutic strategies.
FRONTIERS IN PEDIATRICS
(2021)
Review
Oncology
Jane Belfield, Charlotte Findlay-Line
Summary: This article provides a detailed description of the use of ultrasound in germ cell tumours and offers guidance on performing an ultrasound examination. It also includes the classification of germ cell tumours and describes the key features of different types of tumours. The challenges and pitfalls of ultrasound are discussed, as well as other applications of ultrasound in this patient group.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Duygu Has Simsek, Caner Civan, Meltem Ekenel, Serkan Kuyumcu, Yasemin Sanli
Summary: Overexpression of prostate-specific membrane antigen (PSMA) is demonstrated in various tumors, and radionuclide therapies directed at PSMA might be effective in treating PSMA-avid malignancies. A case study of a 46-year-old male with progressive metastatic testicular mixed germ cell tumor showed mixed response in Ga-68-PSMA PET/CT after Lu-177-PSMA therapy, suggesting the need for further optimization of treatment strategies.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Liza O'Donnell, Laura F. Dagley, Michael Curley, Annalucia Darbey, Peter J. O'Shaughnessy, Thorsten Diemer, Adrian Pilatz, Daniela Fietz, Peter G. Stanton, Lee B. Smith, Diane Rebourcet
Summary: In this study, Sertoli cell-enriched proteins in testicular interstitial fluid (TIF) were identified and found to play potential roles in regulating somatic cell-cell communication and testis function.
Review
Pathology
Charles C. Guo, Bogdan Czerniak
Summary: The development of somatic-type malignancy in testicular germ cell tumor is a major challenge in the diagnosis and treatment of testicular cancer. Most somatic-type malignancies are derived from teratoma and occur more frequently in metastases. Different histologic types can be observed, and their prognosis varies. Timely surgical resection is an effective treatment for most patients.
Review
Oncology
Deaglan J. Mchugh, Jack P. Gleeson, Darren R. Feldman
Summary: Testicular germ cell tumor is the most common solid tumor in adolescent and young adult men. There have been advancements in its management over the past 50 years, but relapse or platinum-refractory disease remains a concern with potential fatal outcomes.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Immunology
Xiangyang Yao, Hui Zhou, Chen Duan, Xiaoliang Wu, Bo Li, Haoran Liu, Yangjun Zhang
Summary: By comprehensively analyzing TGCT patient data, we found significant differences in gene expression and alternative splicing (AS) between embryonal carcinoma and seminoma, while mixed cell tumors were intermediate. Gene ontology enrichment analyses identified transcriptional regulatory pathways enriched in both differentially expressed and spliced genes and revealed a clear correlation between gene expression and AS events. We identified crucial AS-related molecules (SOX2 and HDAC9) that regulate gene expression and validated their involvement in embryonal carcinoma and seminoma cell lines. Differences in somatic mutations between subtypes were also observed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Zhiran Li, Yunhao Wu, Yangbo Fu, Xia Chen, Xi Zhao, Xiaolong Wu, Yajuan Lu, Hui He, Cong Shen, Bo Zheng, Jun Yu, Fei Sun
Summary: This study investigates the communication mechanism between CySC lineage cells and germ cells in Drosophila testes, and reveals the involvement of translation initiation factor eIF5, along with eIF1A or eIF2 gamma, in maintaining the homeostasis of the stem cell population and preventing the formation of TGCTs.
STEM CELL RESEARCH & THERAPY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yu-Chin Wu, Chia-Hung Kao, Shung-Shung Sun, Te-Chun Hsieh
Summary: We report a case of a 20-year-old male diagnosed with metastatic embryonal carcinoma, which was subsequently confirmed as burned-out testicular mixed germ cell tumor.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Pathology
Jeffrey A. Stump, Andres M. Acosta, Rumeal D. Whaley, Liang Cheng, Andrew M. Fang, Soroush Rais-Bahrami, Jennifer B. Gordetsky
Summary: Treatment for testicular germ cell tumors (GCTs) typically involves orchiectomy and chemotherapy, with rare cases requiring neoadjuvant chemotherapy prior to surgery. Research shows that the pathology of orchiectomy often differs from metastatic tissue in patients undergoing neoadjuvant chemotherapy, and those with no remaining testicular disease have a better prognosis.
Review
Pathology
Charles C. Guo, Bogdan Czerniak
Summary: The development of somatic-type malignancy in testicular germ cell tumor presents a diagnostic and treatment challenge in testicular cancer. Most somatic-type malignancies are derived from teratoma, with yolk sac tumor being the other common type. They occur more frequently in metastases than in primary testicular tumors. Somatic-type malignancies exhibit various histologic types, including sarcoma, carcinoma, embryonic-type neuroectodermal tumor, nephroblastoma-like tumor, and hematologic malignancy. Sarcoma, especially rhabdomyosarcoma, is the majority type in primary testicular tumors, whereas carcinoma, particularly adenocarcinoma, is most common in metastases. Somatic-type malignancies derived from testicular germ cell tumors share immunohistochemical profiles with their histologic counterparts in other organs, but the presence of isochromosome 12p can aid in differential diagnosis. The presence of somatic-type malignancy in the primary testicular tumor may not worsen the prognosis, but the development of somatic-type malignancy in metastasis is associated with poor prognosis. Additionally, somatic-type carcinoma is likely to have a worse prognosis than somatic-type sarcoma. Although somatic-type malignancies have a poor response to cisplatin-based chemotherapy, timely surgical resection is an effective treatment for most patients.
Article
Multidisciplinary Sciences
Harshita Dubey, Garima Jain, Chandan Kumar, Amar Ranjan, Atul Batra, Santosh Kumar Chellapuram, Swati Gupta, Harsh Goel, Anil Sharma, Pranay Tanwar
Summary: This article reports a case of an adult male presenting with an intra-abdominal mass, inguinal lymphadenopathy, and deranged kidney function test. Bone marrow aspirate smear showed metastatic tumor cells, while bone marrow biopsy was unremarkable. High serum β-HCG levels indicated a germ cell lesion. Lymph node biopsy and immunomarkers confirmed metastatic foci from a germ cell tumor and were managed according to standard protocol. Rarely, bone marrow aspirate can be positive for malignancy while biopsy turns out to be negative. Additionally, bone marrow metastasis of germ cell tumors should be considered in cases like this.
Article
Oncology
Eduardo R. M. Cabral, Marilia F. Pacanhella, Andre V. H. Lengert, Mariana B. dos Reis, Leticia F. Leal, Marcos A. de Lima, Aline L. V. de Silva, Icaro A. Pinto, Rui M. Reis, Mariana T. Pinto, Flavio M. Carcano
Summary: In this study, the mutation profile and copy number variation of the KRAS gene in testicular germ cell tumors (TGCT) were evaluated. It was found that KRAS copy number gain was common in TGCT and associated with worse prognosis. Additionally, several potentially targetable gene variants were identified in TGCT. These findings provide potential strategies for clinical management using targeted therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Ankita Kaushik, Deepa Bhartiya
Summary: This study investigates the development of testicular germ cell tumors (T2GCT) in mice exposed to diethylstilbestrol (DES) during early life. It reveals that neonatal DES exposure affects testicular stem cells and leads to infertility, reduced sperm counts, and tumor-like changes. The study also highlights the potential of the mouse model for understanding cancer initiation, cancer stem cells, and developing effective therapies.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biology
Cheng Wang, Mingtao Huang, Congcong Chen, Yuancheng Li, Na Qin, Zijian Ma, Jingyi Fan, Linnan Gong, Hui Zeng, Liu Yang, Xianfeng Xu, Jun Zhou, Juncheng Dai, Guangfu Jin, Zhibin Hu, Hongxia Ma, Fengwei Tan, Hongbing Shen
Summary: The study demonstrated the significant role of adenosine-to-inosine (A-to-I) RNA editing in tumorigenesis of lung adenocarcinoma (LUAD) through evaluating RNA editing sites, consensus clustering, and establishing a model for accurate distinction of a new subtype. The new subtype EC3 was associated with poor prognosis, independent of classic molecular subtype classification based on gene expression or DNA methylation, highlighting the potential application of RNA editing in cancer molecular subtyping and clinical treatment.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Letter
Critical Care Medicine
Meng Zhu, Yanqian Huang, Hongxia Ma, Hongbing Shen
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Ci Song, Jun Lv, Chengxiao Yu, Meng Zhu, Canqing Yu, Yu Guo, Ling Yang, Yiping Chen, Zhengming Chen, Tao Jiang, Hongxia Ma, Guangfu Jin, Hongbing Shen, Zhibin Hu, Liming Li
Summary: The study found that adhering to a healthy lifestyle can significantly reduce the risk of liver cancer, with a more dramatic protective effect for individuals with hepatitis B surface antigen (HBsAg) positive.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Sabine Schmid, Mei Jiang, M. Catherine Brown, Aline Fares, Miguel Garcia, Joelle Soriano, Mei Dong, Sera Thomas, Takashi Kohno, Leticia Ferro Leal, Nancy Diao, Juntao Xie, Zhichao Wang, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Swiatkowska, Dana Mates, Milan Savic, Angela S. Wenzlaff, Curtis C. Harris, Neil E. Caporaso, Hongxia Ma, Guillermo Fernandez-Tardon, Matthew J. Barnett, Gary Goodman, Michael P. A. Davies, Monica Perez-Rios, Fiona Taylor, Eric J. Duell, Ben Schoettker, Hermann Brenner, Angeline Andrew, Angela Cox, Alberto Ruano-Ravina, John K. Field, Loic Le Marchand, Ying Wang, Chu Chen, Adonina Tardon, Sanjay Shete, Matthew B. Schabath, Hongbing Shen, Maria Teresa Landi, Brid M. Ryan, Ann G. Schwartz, Lihong Qi, Lori C. Sakoda, Paul Brennan, Ping Yang, Jie Zhang, David C. Christiani, Rui Manuel Reis, Kouya Shiraishi, Rayjean J. Hung, Wei Xu, Geoffrey Liu
Summary: This study developed and tested pragmatic approaches to account for the missing EGFR-mutation-status in epidemiologic datasets of non-small cell lung cancers (NSCLC). By developing a regression model and using restriction and imputation methods, the study successfully evaluated the clinical impact of EGFR-status on NSCLC.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Fangyuan Zheng, Xuelin Dou, Liqiang Zhang, Jie Jin, Yanli Zhang, Bingcheng Liu, Li Meng, Xiaofan Zhu, Zesheng Lu, Yueping Jia, Huilan Liu, Hai Lin, Li Zhou, Xielan Zhao, Wei Yang, Hui Sun, Sixuan Qian, Hongxia Ma, Runhui Wu, Leping Zhang, Qian Jiang
Summary: The study found that TKI-related symptoms, mother's low education level, and age are significantly associated with HRQoL in children with CML. Children and their parents have different priorities in terms of HRQoL.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Siyuan Lv, Rui Qin, Yangqian Jiang, Hong Lv, Qun Lu, Shiyao Tao, Lei Huang, Cong Liu, Xin Xu, Qingru Wang, Mei Li, Zhi Li, Ye Ding, Ci Song, Tao Jiang, Hongxia Ma, Guangfu Jin, Yankai Xia, Zhixu Wang, Shanshan Geng, Jiangbo Du, Yuan Lin, Zhibin Hu
Summary: This study investigated the associations between maternal dietary patterns during different gestational periods and infant's neurodevelopment at 1 year of age. The results showed that adherence to the 'Aquatic products, Fresh vegetables and Homonemeae' dietary pattern in the second trimester and the 'Aquatic products and Homonemeae' pattern in the third trimester was associated with decreased risk of developmental delays in cognitive, gross motor, and receptive communication skills in infants.
Article
Oncology
Xiaoxia Wei, Xiangxiang Jiang, Xu Zhang, Xikang Fan, Mengmeng Ji, Yanqian Huang, Jing Xu, Rong Yin, Yuzhuo Wang, Meng Zhu, Lingbin Du, Juncheng Dai, Guangfu Jin, Lin Xu, Zhibin Hu, Dong Hang, Hongxia Ma
Summary: The study findings suggest that neuroticism is associated with an increased risk of incident lung cancer, and this association is strengthened by genetic susceptibility to lung cancer. Furthermore, there is an interaction between neuroticism and genetic risk.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ruyang Zhang, Sipeng Shen, Yongyue Wei, Ying Zhu, Yi Li, Jiajin Chen, Jinxing Guan, Zoucheng Pan, Yuzhuo Wang, Meng Zhu, Junxing Xie, Xiangjun Xiao, Dakai Zhu, Yafang Li, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angela Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Juncheng Dai, Hongxia Ma, Yang Zhao, Zhibin Hu, Rayjean J. Hung, Christopher Amos, Hongbing Shen, Feng Chen, David C. Christiani
Summary: In this study, important gene-gene interactions that influence the risk of non-small cell lung cancer (NSCLC) were identified and enriched in the 5p15.33 and 6p21.32 regions. These findings have the potential to improve lung cancer screening models.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiangxiang Jiang, Na Qin, Tingting Hua, Xiaoxia Wei, Yuancheng Li, Congcong Chen, Linnan Gong, Su Liu, Cheng Wang, Rong Yin, Yue Jiang, Juncheng Dai, Lin Xu, Hongbing Shen, Hongxia Ma
Summary: This study provides a comprehensive characterization of super-enhancers (SEs) in lung adenocarcinoma (LUAD) and emphasizes their clinical significance in LUAD therapy. The findings highlight the different regulatory mechanisms of SEs in cancer compared to normal SEs and their association with crucial tumor-related pathways.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Dong Hang, Xiaolin Yang, JiaYi Lu, Chong Shen, Juncheng Dai, Xiangfeng Lu, Guangfu Jin, Zhibin Hu, Dongfeng Gu, Hongxia Ma, Hongbing Shen
Summary: This study identified a panel of plasma metabolites associated with hepatocellular carcinoma (HCC) and established a potential model for predicting HCC risk based on metabolites analysis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Chang Zhang, Qi Sun, Xu Zhang, Na Qin, Zhening Pu, Yayun Gu, Caiwang Yan, Meng Zhu, Juncheng Dai, Cheng Wang, Ni Li, Guangfu Jin, Hongxia Ma, Zhibin Hu, Erbao Zhang, Fengwei Tan, Hongbing Shen
Summary: Epigenetic alterations play a significant role in human carcinogenesis. The activation mechanism and oncogenic role of KIAA1429 in lung adenocarcinoma (LUAD) were explored in this study. Copy number amplification of KIAA1429 in LUAD led to poor overall survival and its regulation was found to affect LUAD proliferation and metastasis.
CANCER COMMUNICATIONS
(2022)
Article
Oncology
Cheng Wang, Juncheng Dai, Na Qin, Jingyi Fan, Hongxia Ma, Congcong Chen, Mingxing An, Jing Zhang, Caiwang Yan, Yayun Gu, Yuan Xie, Yuanlin He, Yue Jiang, Meng Zhu, Ci Song, Tao Jiang, Jia Liu, Jun Zhou, Nanxi Wang, Tingting Hua, Shuang Liang, Lu Wang, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Guangfu Jin, Dongxin Lin, Zhibin Hu, Hongbing Shen
Summary: This study presents the largest whole-genome sequencing study of NSCLC in individuals of Chinese ancestry, identifying common and low-frequency loci and cancer predisposition genes associated with NSCLC risk. The study also highlights the significant effect of promoter variants on NSCLC risk. These findings have been validated in independent case-control and prospective cohort studies.
Article
Oncology
Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu, Mengting Sun, Xue Wu, Yang Shao, Qianghu Wang, Juncheng Dai, Mantang Qiu, Jinke Wang, Qin Zhang, Lin Xu, Hongbing Shen, Rong Yin
Summary: This study demonstrates that circulating tumor DNA can be used as a marker for monitoring minimal residual disease in early-to-mid-stage non-small cell lung cancer patients, and can predict the recurrence of high-risk patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Na Qin, Cheng Wang, Congcong Chen, Liu Yang, Su Liu, Jun Xiang, Yuan Xie, Shuang Liang, Jun Zhou, Xianfeng Xu, Xiaoyu Zhao, Meng Zhu, Guangfu Jin, Hongxia Ma, Juncheng Dai, Zhibin Hu, Hongbing Shen
Summary: Detection of mCAs can serve as a new indicator for lung cancer risk, and it may be combined with PRS for personalized risk stratification of lung cancer.
Article
Oncology
Xu Zhang, Na Qin, Jingyi Fan, Chang Zhang, Qi Sun, Yayun Gu, Meng Zhu, Erbao Zhang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Zhibin Hu, Hongbing Shen
Summary: This study identified the causal variant rs3769823 in chromosome 2q33.1 and explored its biological functions in non-small cell lung cancer (NSCLC). The variant was found to inhibit the proliferation and metastasis of lung cancer cells and was involved in the apoptosis pathway.
CANCER BIOLOGY & MEDICINE
(2022)
