Review
Oncology
Jiahua Liu, Runzi Zheng, Yanghuan Zhang, Shuting Jia, Yonghan He, Jing Liu
Summary: This review provides an overview of the molecular mechanisms, microenvironmental factors, and therapeutic strategies of skin aging and melanoma, and discusses potential common targets between melanoma and cell senescence.
Review
Biochemistry & Molecular Biology
Tareq Saleh, Ashraf I. Khasawneh, Nisreen Himsawi, Jumana Abu-Raideh, Vera Ejeilat, Ahmed M. Elshazly, David A. Gewirtz
Summary: Senescence is a cellular stress response characterized by growth arrest, gene expression changes, and oncogene activation, including HPV. It plays a crucial role in cervical cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Deledda, Emanuele Giordano, Fernanda Velluzzi, Giovanna Flore, Sara Franceschelli, Lorenza Speranza, Patrizio Ripari
Summary: Living organisms need to consume energy for survival. Cellular energy exchanges produce waste products that can contribute to cellular aging and damage if not properly disposed of. Many genes are associated with aging, with some promoting it and others blocking it. Calorie restriction has been found to promote longevity pathways, and research is exploring CR-mimetic substances that can have the same effect. Certain phytonutrients and minerals have been found to promote a longer and healthier life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Oscar Salvador Barrera-Vazquez, Juan Carlos Gomez-Verjan, Gil Alfonso Magos-Guerrero
Summary: Cellular senescence is a condition that involves significant changes in gene expression and cell proliferation arrest. Recent studies have suggested that pharmacological elimination of senescent cells can delay, prevent, and improve adverse outcomes related to age. Through the use of chemoinformatic tools in natural product chemical databases, new senolytic compounds candidates were discovered.
Review
Cell Biology
Huantong Zhang, Han Zhou, Xin Shen, Xingchen Lin, Yuke Zhang, Yiyi Sun, Yi Zhou, Lei Zhang, Dayong Zhang
Summary: Cellular senescence is closely associated with metabolic diseases, and removing senescent cells can alleviate or postpone the onset and progression of metabolic diseases. Targeting senescent cells has emerged as an alternative therapy for the treatment of metabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Emily Dookun, Joao F. Passos, Helen M. Arthur, Gavin D. Richardson
Summary: Ageing is the biggest risk factor for impaired cardiovascular health, and it is associated with an increased prevalence of cardiovascular disease and a poorer prognosis. Recent studies have shown that the accumulation of senescent cells contributes to the progression of cardiovascular disease through the expression of proinflammatory and profibrotic proteins, leading to efforts to find pharmacological therapeutics that can eliminate senescent cells specifically.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Biology
Deepika Raman, Charlotte Chene, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Veronique Clement, Frederic Batteux, Shazib Pervaiz
Summary: Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). A pilot study on a murine model of sclerodermatous cGVHD showed that treatment with the senolytic combination of dasatinib and quercetin (DQ) significantly improved physical and tissue-specific features associated with cGVHD pathogenesis. The study suggests the involvement of senescent cells in cGVHD and highlights the potential therapeutic strategy of using DQ.
Article
Dermatology
Yuki Fukui, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Tetsuya Ikawa, Yuta Norimatsu, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano
Summary: The study found that VASH-1 levels were higher in patients with systemic sclerosis (SSc), especially in those with diffuse skin involvement and interstitial lung disease. Serum VASH-1 levels were positively correlated with skin score, negatively correlated with lung function parameters and KL-6 levels, and unrelated to surfactant protein D levels. In SSc, upregulation of VASH-1 in skin and sera is linked to dermal and pulmonary fibrotic changes, while its contribution to SSc vasculopathy appears limited.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell Biology
Shuqiao Zhang, Yilu Zheng, Xinyu Li, Shijun Zhang, Hao Hu, Weihong Kuang
Summary: This study established a prognostic model for hepatocellular carcinoma (HCC) based on cellular senescence-related gene expression and identified four key genes associated with HCC progression, providing important information for clinical decision-making.
Article
Rheumatology
Y. -h. Chiu, J. Spierings, J. M. van Laar, J. K. de Vries-Bouwstra, M. van Dijk, R. Goldschmeding
Summary: This study found that EndMT and fibroblast senescence are more abundant in skin biopsies from SSc patients. This indicates that both senescence and EndMT are involved in the pathway leading to skin fibrosis and may serve as valuable biomarkers and targets for novel therapeutic interventions.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Immunology
Qi Wang, Chen-Long Li, Li Wu, Jing-Yi Hu, Qi Yu, Sheng-Xiao Zhang, Pei-Feng He
Summary: This study proposes a novel molecular subtyping methodology for patients with Systemic Sclerosis (SSc) and develops a diagnostic model based on machine learning to aid in clinical treatment. Potential molecular targets for therapy have been identified, offering novel perspectives for the treatment and investigation of SSc.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Charmaine van Eeden, Desiree Redmond, Naima Mohazab, Maggie J. J. Larche, Andrew L. L. Mason, Jan Willem Cohen Tervaert, Mohammed S. S. Osman
Summary: This study aimed to assess the prevalence of ME/CFS in early limited cutaneous systemic sclerosis (lcSSc) patients and determine if alterations in mitochondrial gene expression and mtDNA integrity could be used to distinguish between fatigued and non-fatigued patients. ME/CFS-related symptoms were assessed through questionnaires, and the expression of mitochondrial gene transcripts and mtDNA integrity were quantified. The study found that SSc patients with ME/CFS could be differentiated from non-fatigued patients through mitochondrial gene analysis, specifically with reduced expression of ND4 and CyB and increased expression of Cox7C. ND4 and CyB expression were also correlated with disease severity indicators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Irene Rosa, Eloisa Romano, Bianca Saveria Fioretto, Khadija El Aoufy, Silvia Bellando-Randone, Marco Matucci-Cerinic, Mirko Manetti
Summary: Currently, only a few studies have investigated the role of the lymphatic vascular system in the pathogenesis of systemic sclerosis (SSc). This study aimed to explore the possibility of lymphatic endothelial cells undergoing an endothelial-to-myofibroblast transition (Ly-EndMT) and contributing to skin fibrosis in SSc. The results demonstrated the presence of lymphatic endothelial cells in intermediate stages of the Ly-EndMT process exclusively in the fibrotic skin of SSc patients, suggesting that Ly-EndMT might be a previously overlooked pathogenic process linking peripheral microlymphatic dysfunction and skin fibrosis development in SSc.
Article
Medicine, General & Internal
Hirohito Kotani, Ayumi Yoshizaki, Kazuki M. Matsuda, Yuta Norimatsu, Ai Kuzumi, Maiko Fukayama, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Yoshihide Asano, Koji Oba, Shinichi Sato
Summary: Systemic sclerosis (SSc) patients have significantly higher serum calponin 3 levels compared to healthy controls, with the high level group showing increased skin thickness scores and a higher frequency of joint pain. Serum calponin 3 levels may serve as a biomarker for the severity of skin sclerosis and joint involvement in SSc.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Giorgia Leodori, Chiara Pellicano, Valerio Basile, Amalia Colalillo, Luca Navarini, Antonietta Gigante, Francesca Gulli, Mariapaola Marino, Umberto Basile, Edoardo Rosato
Summary: This study aimed to evaluate the longitudinal association between basal serum adiponectin and skin thickness in systemic sclerosis (SSc) patients. The results showed a correlation between decreased serum adiponectin levels and increased skin thickness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
