Review
Medicine, Research & Experimental
Nerea Cuesta-Gomez, Gerard J. Graham, John D. M. Campbell
Summary: Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for treating inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory, and regenerative potentials. MSCs can be obtained from various tissues, with bone marrow being the most commonly used starting material for clinical applications. Understanding the expression of chemokine receptors and ligands by MSCs from different tissues is crucial for predicting their therapeutic potential.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Marta S. Carvalho, Laura Alves, Isabel Bogalho, Joaquim M. S. Cabral, Claudia L. da Silva
Summary: The study found that aging impairs the proliferative and osteogenic capacities of MSC, but exposure to ECM derived from young cells can help rejuvenate aged MSC. The ECM plays a crucial role in the quantity and quality of MSC, especially in terms of osteogenic differentiation capacity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Anatomy & Morphology
Amirah Zulkifli, Raja Elina Ahmad, Shaliny Krishnan, Peggy Kong, Hui Yin Nam, Tunku Kamarul
Summary: Tendon injuries are difficult to treat due to the limited repair ability of tendon tissues. Mesenchymal stem cells (MSC) therapy shows promise in enhancing tendon repair, especially under hypoxic conditions. This review focuses on the role of hypoxia-inducible factor-1-alpha (HIF-1 alpha) in mediating MSC tenogenic differentiation pathways and discusses the interaction between HIF-1 alpha and fibroblast growth factor-2 (FGF-2) and transforming growth factor-beta 1 (TGF beta 1). Strategies to stabilize HIF-1 alpha can improve the efficacy of MSC therapy for tendon repair.
Review
Pharmacology & Pharmacy
Rui Alvites, Mariana Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Ana Colette Mauricio
Summary: Mesenchymal Stem/Stromal Cells (MSCs) have high clinical value and have been extensively studied. Their immunomodulatory influence occurs through both direct and paracrine routes, but the mechanisms are not fully understood. This review summarizes the immunoregulatory capacity of MSCs and their secretion products, with a focus on migration, homing, direct cell action, and paracrine activity, and explores related techniques.
Review
Cell Biology
Mohamad Mahjoor, Arshia Fakouri, Simin Farokhi, Hojjatollah Nazari, Hamed Afkhami, Fatemeh Heidari
Summary: The skin is essential for the innate and adaptive immune systems, but skin lesions can have undesirable consequences. Mesenchymal stromal cells (MSCs) are being increasingly used for skin wound treatment due to their advantages in promoting healing. The oxygen concentration has an impact on MSC biology, and expanding MSCs in a hypoxic environment can enhance their effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Veterinary Sciences
Jasmin Bagge, Lise Charlotte Berg, Jennifer Janes, James N. MacLeod
Summary: The study indicated that the chondrogenic and osteogenic differentiation performance of equine BM-MSCs declined as early as in yearlings, while AT-MSCs showed minimal chondrogenic potential but were affected later by donor age in terms of osteogenesis (calcium deposition). The findings emphasize the importance of considering donor age and selecting MSCs for cell-based treatment of orthopedic injuries, as well as providing insight on when to implement or potentially cryopreserve cells.
BMC VETERINARY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Dragan Primorac, Martin Cemerin, Vid Matisic, Vilim Molnar, Marko Strbad, Lenart Girandon, Lucija Zenic, Miomir Knezevic, Stephen Minger, Denis Polancec
Summary: The COVID-19 pandemic has had a significant impact globally and the overaggressive immune reaction in response to the virus can lead to ARDS. Mesenchymal stromal cell therapy presents a potential treatment option for severe patients.
Review
Pharmacology & Pharmacy
Shunling Yuan, Guangfeng Li, Jinbo Zhang, Xiao Chen, Jiacan Su, Fengjin Zhou
Summary: Osteoarthritis (OA) is a degenerative disease characterized by cartilage damage and severe pain. Current therapies fail to halt OA progression, creating a need for alternative approaches. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) offer potential as a regenerative treatment for OA, possessing anti-inflammatory properties and promoting cartilage healing. MSC-EVs have advantages over cell-based therapies, and researchers are exploring strategies to enhance their delivery and efficacy. This article reviews the potential use of MSC-EVs in treating OA, discussing benefits, challenges, and the possibility of using allogeneic and autologous MSC-EVs.
Article
Cell Biology
Michael Selle, Johanna Dorothea Koch, Alina Ongsiek, Linnea Ulbrich, Weikang Ye, Zhida Jiang, Christian Krettek, Claudia Neunaber, Sandra Noack
Summary: Ageing is associated with increased bone marrow fat and decreased bone volume, leading to bone diseases like osteoporosis. The study analyzed human bone marrow-derived mesenchymal stem cells (hBMSCs) and found that the characteristics and functions of these cells are affected by donor age and sex.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Cell & Tissue Engineering
Jacques Galipeau
Summary: Experimental evidence shows that host macrophages play a crucial role in mediating the anti-inflammatory properties of MSCs, while non-phagocytosed MSCs induce tissue macrophages to express IL-10, shaping the immune environment. MSC-derived factors such as IL-6, IDO, and TSG-6 directly influence macrophage polarization, highlighting a necessary functional relationship between MSCs and host macrophages in modulating inflammatory response.
Article
Environmental Sciences
Hana Najahi, Nicola Alessio, Tiziana Squillaro, Gea Oliveri Conti, Margherita Ferrante, Giovanni Di Bernardo, Umberto Galderisi, Imed Messaoudi, Sergio Minucci, Mohamed Banni
Summary: This study evaluated the effects of different size microplastics present in water bottles on human mesenchymal stromal cells. The results showed that microplastic treatments led to a decrease in cell proliferation, altered differentiation potential, and loss of osteocyte phenotype. This indicates that environmental microplastics can be bioavailable for cell uptake and may result in irreversible diseases.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cell Biology
Wenguang Liu, Alexander S. Brodsky, Meng Feng, Yajun Liu, Jing Ding, Chathuraka T. Jayasuriya, Qian Chen
Summary: Aging OA-MSC in human osteoarthritic cartilage can lead to cell senescence, fibrosis, and inflammation, expressing a pro-inflammatory senescence associated secretory phenotype that may contribute to OA pathogenesis. OAC acts as the main recipient of inflammatory signals by expressing receptors of cytokines. Through replication-driven OAC dedifferentiation and MSC senescence, OA-MSC becomes an internal source of sterile inflammation in human cartilage joint.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Sara Bucar, Andre Dargen de Matos Branco, Marcia F. Mata, Joao Coutinho Milhano, Iris Caramalho, Joaquim M. S. Cabral, Ana Fernandes-Platzgummer, Claudia L. da Silva
Summary: The study compared the capacity of MSC from different sources to expand UCB CD34(+) cells ex vivo, with AT-derived MSC showing superior expansion potential and maintenance of primitive cells. UCM-derived MSC demonstrated inferior hematopoietic supportive capacity compared to MSC from adult tissues. Further research is needed to determine the impact of HPL on the hematopoietic supportive capacity of MSC.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Siddharth Shanbhag, Neha Rana, Salwa Suliman, Shaza Bushra Idris, Kamal Mustafa, Andreas Stavropoulos
Summary: This study investigated the influence of bi-calcium phosphates (BCPs) on mesenchymal stromal cells (MSCs) and MSC-macrophage interactions in an inflammatory microenvironment. The results showed that BCPs significantly regulated MSC gene expressions toward a pro-healing phenotype under both inflammatory and non-inflammatory conditions, with little effect on MSC secretory profiles. In the presence of macrophages, BCPs positively regulated both gene expression and cytokine secretion of MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Jasper Iske, Tomohisa Matsunaga, Hao Zhou, Stefan G. Tullius
Summary: The transplantation of aged organs may have negative effects on recipients due to the accumulation of senescent cells, which can promote aging in recipient cells through the secretion of pro-inflammatory molecules. Studies have shown that transplanting old organs may limit the physical reserve of recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Piotr Poplawski, Saleh Alseekh, Urszula Jankowska, Bozena Skupien-Rabian, Roksana Iwanicka-Nowicka, Helena Kossowska, Anna Fogtman, Beata Rybicka, Joanna Boguslawska, Anna Adamiok-Ostrowska, Karolina Hanusek, Jan Hanusek, Marta Koblowska, Alisdair R. Fernie, Agnieszka Piekielko-Witkowska
Summary: This study analyzed the transcriptome, proteome, and metabolome of ccRCC cells and identified molecules associated with the renal tumor microenvironment, which can serve as valuable non-invasive biomarkers detectable in plasma.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Dominika Klimczak-Tomaniak, Julia Haponiuk-Skwarlinska, Marek Kuch, Leszek Paczek
Summary: This article reviews the interaction between microRNA and oxidative stress in heart failure. Multiple microRNAs are found to be involved in the oxidative stress processes associated with heart failure development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Anna Fogtman, Sarah Baatout, Bjorn Baselet, Thomas Berger, Christine E. Hellweg, Piers Jiggens, Chiara La Tessa, Livio Narici, Petteri Nieminen, Laure Sabatier, Giovanni Santin, Uwe Schneider, Ulrich Straube, Kevin Tabury, Walter Tinganelli, Linda Walsh, Marco Durante
Summary: Human spaceflight is evolving into sustainable space exploration, with plans to regularly visit the Moon and prepare for manned missions to Mars by 2030. However, the exposure to space radiation poses a major challenge that needs to be addressed for the safety of astronauts. Quantifying and managing the health risks and electronics damage caused by space radiation are urgent priorities for further research and development. The ESA/SciSpacE Space Radiation White Paper identifies these topics and emphasizes the need for understanding the complex radiation environment and developing effective countermeasures.
Review
Biochemistry & Molecular Biology
Agnieszka Kulesza, Leszek Paczek, Anna Burdzinska
Summary: The molecular mechanisms underlying the immunomodulatory properties of MSCs and the role of PGE2 and COX-2 in these properties are not fully understood. This article summarizes previous observations regarding the role of PGE2 and COX-2 in the immunomodulatory properties and other vital functions of MSCs. The most consistent results suggest that MSC-derived PGE2 inhibits the early maturation of dendritic cells, suppresses the proliferation of activated lymphocytes, and stimulates the differentiation of macrophages into M2 phenotype. COX-2/PGE2 also plays an important role in maintaining the basic life functions of MSCs and affects the formation of niches conducive to hematopoiesis and carcinogenesis.
Review
Immunology
Krzysztof Mucha, Michal Pac, Leszek Paczek
Summary: Thanks to omics technologies, we have gained a better understanding of the pathogenesis of many diseases in the last decade. However, the risk factors for most autoimmune diseases are still unknown.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Genetics & Heredity
Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y. Zhang, Olivia Balderes, Simone Sanna-Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, Hernan Trimarchi, Ben Sprangers, Daniel C. Cattran, Heather Reich, York Pei, Pietro Ravani, Kresimir Galesic, Dita Maixnerova, Vladimir Tesar, Benedicte Stengel, Marie Metzger, Guillaume Canaud, Nicolas Maillard, Francois Berthoux, Laureline Berthelot, Evangeline Pillebout, Renato Monteiro, Raoul Nelson, Robert J. Wyatt, William Smoyer, John Mahan, Al-Akash Samhar, Guillermo Hidalgo, Alejandro Quiroga, Patricia Weng, Raji Sreedharan, David Selewski, Keefe Davis, Mahmoud Kallash, Tetyana L. Vasylyeva, Michelle Rheault, Aftab Chishti, Daniel Ranch, Scott E. Wenderfer, Dmitry Samsonov, Donna J. Claes, Oleh Akchurin, Dimitrios Goumenos, Maria Stangou, Judit Nagy, Tibor Kovacs, Enrico Fiaccadori, Antonio Amoroso, Cristina Barlassina, Daniele Cusi, Lucia Del Vecchio, Giovanni Giorgio Battaglia, Monica Bodria, Emanuela Boer, Luisa Bono, Giuliano Boscutti, Gianluca Caridi, Francesca Lugani, GianMarco Ghiggeri, Rosanna Coppo, Licia Peruzzi, Vittoria Esposito, Ciro Esposito, Sandro Feriozzi, Rosaria Polci, Giovanni Frasca, Marco Galliani, Maurizio Garozzo, Adele Mitrotti, Loreto Gesualdo, Simona Granata, Gianluigi Zaza, Francesco Londrino, Riccardo Magistroni, Isabella Pisani, Andrea Magnano, Carmelita Marcantoni, Piergiorgio Messa, Renzo Mignani, Antonello Pani, Claudio Ponticelli, Dario Roccatello, Maurizio Salvadori, Erica Salvi, Domenico Santoro, Guido Gembillo, Silvana Savoldi, Donatella Spotti, Pasquale Zamboli, Claudia Izzi, Federico Alberici, Elisa Delbarba, Michal Florczak, Natalia Krata, Krzysztof Mucha, Leszek Paczek, Stanislaw Niemczyk, Barbara Moszczuk, Malgorzata Panczyk-Tomaszewska, Malgorzata Mizerska-Wasiak, Agnieszka Perkowska-Ptasinska, Teresa Baczkowska, Magdalena Durlik, Krzysztof Pawlaczyk, Przemyslaw Sikora, Marcin Zaniew, Dorota Kaminska, Magdalena Krajewska, Izabella Kuzmiuk-Glembin, Zbigniew Heleniak, Barbara Bullo-Piontecka, Tomasz Liberek, Alicja Debska-Slizien, Tomasz Hryszko, Anna Materna-Kiryluk, Monika Miklaszewska, Maria Szczepanska, Katarzyna Dyga, Edyta Machura, Katarzyna Siniewicz-Luzenczyk, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Dariusz Runowski, Norbert Kwella, Dorota Drozdz, Ireneusz Habura, Florian Kronenberg, Larisa Prikhodina, David van Heel, Bertrand Fontaine, Chris Cotsapas, Cisca Wijmenga, Andre Franke, Vito Annese, Peter K. Gregersen, Sreeja Parameswaran, Matthew Weirauch, Leah Kottyan, John B. Harley, Hitoshi Suzuki, Ichiei Narita, Shin Goto, Hajeong Lee, Dong Ki Kim, Yon Su Kim, Jin-Ho Park, BeLong Cho, Murim Choi, Ans Van Wijk, Ana Huerta, Elisabet Ars, Jose Ballarin, Sigrid Lundberg, Bruno Vogt, Laila-Yasmin Mani, Yasar Caliskan, Jonathan Barratt, Thilini Abeygunaratne, Philip A. Kalra, Daniel P. Gale, Ulf Panzer, Thomas Rauen, Juergen Floege, Pascal Schlosser, Arif B. Ekici, Kai-Uwe Eckardt, Nan Chen, Jingyuan Xie, Richard P. Lifton, Ruth J. F. Loos, Eimear E. Kenny, Iuliana Ionita-Laza, Anna Koettgen, Bruce A. Julian, Jan Novak, Francesco Scolari, Hong Zhang, Ali G. Gharavi
Summary: Genome-wide association analyses have identified 30 risk loci for IgA nephropathy, a progressive form of kidney disease. Functional annotations of potential causal genes suggest inflammatory signaling pathways and cytokine ligand-receptor pairs as potential new drug targets. These findings provide valuable insights into the genetic basis of IgA nephropathy and offer potential avenues for developing therapeutic interventions.
Article
Medicine, General & Internal
Michal Gniewkiewicz, Katarzyna Czerwinska, Katarzyna Zielniok, Magdalena Durlik
Summary: This study investigated the association between circulating DSAs and their characteristics with renal allograft long-term outcomes. The detection of DSAs at the time of biopsy and their C1q-binding capacity were found to be independent predictors of inferior renal allograft function and graft failure in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Michal Gniewkiewicz, Katarzyna Czerwinska, Katarzyna Zielniok, Magdalena Durlik
Summary: This retrospective study analyzed the impact of resolved preformed, persistent preformed, and de novo anti-HLA DSAs on long-term renal allograft outcomes in kidney transplant recipients. The study found that the presence of persistent preformed DSAs and the development of de novo DSAs were associated with inferior graft outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Natalia Korytowska-Przybylska, Sylwia Michorowska, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Joanna Giebultowicz
Summary: Chronic kidney disease (CKD) is diagnosed using serum creatinine or cystatin C levels, but more sensitive biomarkers are needed. This study aims to verify the correlation between saliva and serum levels of trimethylamine N-oxide (TMAO) in CKD patients. The results show a good correlation between TMAO levels in saliva and serum, suggesting that saliva can be used for non-invasive monitoring of renal failure in CKD.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, General & Internal
Mieszko Lachota, Katarzyna Zielniok, Daniel Palacios, Minoru Kanaya, Leena Peena, Hanna Julie Hoel, Merete Thune Wiiger, Lise Kveberg, Wojciech Hautz, Radoslaw Zagozdzon, Karl-Johan Malmberg
Summary: Research has found that the chemokine receptor repertoire of peripheral blood NK cells changes during NK cell differentiation and is closely associated with the migratory response of different NK cell subsets. Simultaneous stimulation of CXCR1/2 and CX3CR1 receptors can synergistically enhance the migratory response of NK cells. The lack of naturally occurring chemokine-chemokine receptor pairs in human cancers may explain the exclusion of NK cells from the tumor microenvironment.
Article
Immunology
Paulina Nazaruk, Ignacy Tkaczyk, Marta Monticolo, Anna Maria Jedrzejczak, Natalia Krata, Leszek Paczek, Bartosz Foroncewicz, Krzysztof Mucha
Summary: The study evaluated the role of SARS-CoV-2 infection history in the vaccination schedules of kidney and liver transplant recipients and patients with chronic kidney disease (CKD). The results showed that patients with a COVID-19 history had higher antibody levels after two doses compared to three doses. Two doses also resulted in a longer median time to infection. The study suggests that vaccination schedules should take into account vaccine response rate and COVID-19 history.
Article
Cardiac & Cardiovascular Systems
Milena Michalska, Tadeusz Grochowiecki, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Tomasz Jakimowicz, Andrzej Cacko, Katarzyna Jama, Albert Stec, Ewa Sikorska, Slawomir Nazarewski, Zbigniew Galazka
Summary: This study investigated the changes in NETosis markers in patients with thoracoabdominal aortic aneurysms undergoing t-Branch stent-graft implantation. The results showed that NETs play a significant role in the complex processes after the surgery, and a new marker for NETosis, ssDNA, was discovered.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Piotr Wilkowski, Ewa Hryniewiecka, Kornelia Jasinska, Leszek Paczek, Michal Ciszek
Summary: This observational study suggests that treating patients with recurrent UTIs in an outpatient setting with high doses of oral amoxicillin with clavulanic acid can effectively reduce treatment failure and recurrence.
ANNALS OF TRANSPLANTATION
(2023)
Article
Surgery
Tomasz Pilecki, Bozena Czarkowska-Paczek, Wojciech Lisik, Slawomir Nazarewski, Leszek Paczek
Summary: Hypertension is a risk factor for graft failure and mortality among kidney transplant recipients. Monitoring blood pressure and adequate treatment contribute to longer survival of the graft and recipient.
ANNALS OF TRANSPLANTATION
(2023)