Review
Neurosciences
Yu Han, Mei Yuan, Yi-Sha Guo, Xin-Ya Shen, Zhen-Kun Gao, Xia Bi
Summary: ER stress resulting from ischemic injury initiates unfolded protein response (UPR) as a protective mechanism to maintain ER homeostasis. Mild ER stress helps cells to escape from danger signals and activate pro-survival mechanisms to rescue ischemic injury, while chronic ER stress can trigger various pro-apoptotic mechanisms, leading to detrimental effects on nerve cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Fengwu Li, Xiaokun Geng, Hangil Lee, Melissa Wills, Yuchuan Ding
Summary: The study showed that post-stroke exercise conditioning, both mild and intense, can protect the brain through regulation of SIRT1 and the ROS/ER stress pathway. These results suggest that exercise postconditioning may serve as an effective strategy for neuroprotection after stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Lei Wang, Yan Liu, Xu Zhang, Yingze Ye, Xiaoxing Xiong, Shudi Zhang, Lijuan Gu, Zhihong Jian, Hongfa Wang
Summary: Ischemic stroke is a cerebrovascular disease that can lead to severe disability and death. Current treatment methods for ischemic stroke are limited and have a narrow treatment window. Recovery of cerebral blood flow causes cerebral ischemia/reperfusion injury, in which endoplasmic reticulum stress plays a crucial role.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sarah Sameh Abdel-Hameed, Mahmoud El-Daly, Al-Shaimaa F. Ahmed, Amany A. Bekhit, Gehan H. Heeba
Summary: Stroke is a serious medical emergency that has a high mortality rate and leads to functional disability in adults. Recent research has shown that selective serotonin reuptake inhibitors (SSRIs), a popular class of antidepressants, may have positive effects on motor and cognitive function in post-stroke patients. This study investigated the potential efficacy of dapoxetine (DAP), a short-acting SSRI, in treating cerebral ischemia/reperfusion injury in rats. The results demonstrated that DAP treatment improved neurobehavioral deficits, reduced cerebral infarct volume, and histopathological damage. DAP also decreased oxidative stress, caspase-3 activity, and inflammatory mediators. These findings suggest that DAP pretreatment may improve neurological function and protect against cerebral damage by reducing inflammation, preserving oxidative balance, and suppressing cell apoptosis in brain tissues.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Letter
Neurosciences
Shitao Lv, Haiyan Yang, Pengcheng Jing, Haiying Song
Summary: Alpha-tocopherol has shown antioxidant, anti-inflammatory, and anti-apoptotic abilities in rat brain tissue, mitigating nerve damage caused by cerebral ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Jia Li, Jingzhen Zhu, Xinliang Yang, Bishao Sun, Xin Luo, Ji Zheng, Zhenqiang Fang
Summary: This study focuses on the therapeutic effect of endoplasmic reticulum stress and autophagy on protamine/lipopolysaccharide-induced interstitial cystitis. The results show that the endoplasmic reticulum stress inhibitor 4-PBA can alleviate the inflammatory response, inhibit apoptosis, and improve bladder micturition function.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Samsuzzaman, Byeong-Churl Jang
Summary: We found that tetrandrine inhibits the growth of SW872 human malignant liposarcoma cells and induces apoptosis. The growth-suppressive and apoptosis-inducing effects of tetrandrine are mediated through control of the intrinsic caspase pathway, down-regulation of XIAP and STAT-3, and triggering ER stress in SW872 cells.
Article
Immunology
Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Han
Summary: Solasonine exhibits neuroprotective effects on cerebral ischemia/reperfusion injury by reducing inflammatory responses, oxidative stress, and neuronal apoptosis, and improving neurological function and neuronal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Changsheng Yan, Yuan Ma, He Li, Jitao Cui, Xiaoyu Guo, Gang Wang, Liang Ji
Summary: The study aimed to investigate the role of endoplasmic reticulum stress (ERS) in promoting caspase-1-dependent pancreatic acinar cell pyroptosis via the protein kinase R-like ER kinase (PERK) pathway to aggravate acute pancreatitis (AP). Findings showed that ERS enhances caspase-1-dependent pyroptosis and pyroptotic injury through the PERK pathway, exacerbating AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Xiuzhen Xie, Yingqi Xu, Xiu Zhou, Pingping Su, Xumin Jiang, Zhuqing Jin
Summary: This study conducted a meta-analysis on the protective effect of Tanshinone IIA (TSA) from Danshen extract on cerebral ischemic injury. The results showed that TSA can reduce inflammation and oxidative stress, and inhibit cell apoptosis. However, more high-quality randomized controlled animal experiments are needed in the future to further validate these findings.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu
Summary: This study investigates the role of Gomisin J in cerebral ischemia-reperfusion injury and finds that it has anti-apoptotic, antioxidant, and anti-inflammatory effects, reducing the severity of the injury.
Article
Cell Biology
Negar Ghorbani, Roham Yaghubi, Jamshid Davoodi, Sara Pahlavan
Summary: Caspases are important proteases involved in cellular events such as apoptosis and inflammation. They also have non-apoptotic pro-survival functions, which are crucial in processes like cell proliferation, differentiation, and migration, as well as tumor metastasis and chemotherapy resistance. Understanding the mechanisms that regulate caspase activities is important for both mechanistic and clinical purposes. Additionally, the functions of apoptotic caspases are affected by various post-translational modifications.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Neurosciences
Wei Li, Xueqi Yang, Mao Ding, Wenjuan Shi, Yuyou Huang, Qi An, Zhifeng Qi, Yongmei Zhao
Summary: This study investigates whether intracellular zinc accumulation aggravates ischemia/reperfusion (I/R) injury through inflammatory response and inflammation-mediated neuronal apoptosis. Results show that cerebral ischemia triggers inflammation, leading to zinc accumulation and neuronal inflammation. Chelation of zinc reverses neuronal inflammation and apoptosis. Excessive zinc activation of inflammation contributes to brain injury, specifically through inflammation-induced neuronal apoptosis, providing an important mechanism for cerebral I/R injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)