Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pediatrics
Idun Holmdahl, Anastasia Filiou, Katarina Stenberg Hammar, Anna Asarnoj, Magnus P. Borres, Marianne van Hage, Gunilla Hedlin, Cilla Soderhall, Jon R. Konradsen
Summary: This study followed children with acute wheeze during early childhood to age 7 and found that acute wheeze caused by rhinovirus infection at inclusion was the main associated factor for developing persistent asthma. Cases who developed asthma also required more hospital time and care after inclusion.
Review
Immunology
Heidi Makrinioti, Andrew Bush, James Gern, Sebastian Lennox Johnston, Nikolaos Papadopoulos, Wojciech Feleszko, Carlos A. Camargo, Kohei Hasegawa, Tuomas Jartti
Summary: Bronchiolitis is a common cause of hospitalization in infants and is associated with a higher risk of childhood asthma development. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex and involve immune responses to respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Logan C. Dearborn, Marnie F. Hazlehurst, Christine T. Loftus, Adam A. Szpiro, Kecia N. Carroll, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Kaja Z. LeWinn, Nicole R. Bush, Joel D. Kaufman, Catherine J. Karr
Summary: This study found that early life air pollution can influence the development of asthma and wheezing in children aged 4-6 years with a history of bronchiolitis. The research was conducted by observing and evaluating a longitudinal cohort from six US cities, estimating the exposure of these children to fine particulate matter, nitrogen dioxide, and ozone pollution from ages 1 to 3 years, and controlling for other factors. The results showed that for every 2 ppb increase in ozone concentration, the risk of developing asthma in children increased by 1.4 times, and the risk of developing wheezing increased by 1.3 times.
Article
Immunology
Ryohei Shibata, Zhaozhong Zhu, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Perez-Losada, Ignacio Ramos-Tapia, Stephen Teach, Carlos A. Camargo, Kohei Hasegawa
Summary: Using tIgE and virus data, we identified phenotypes of infant bronchiolitis and studied their association with asthma development and biological characteristics. We found 4 phenotypes, and infants with the tIgE(high)virus(RSV-low/RV) phenotype had a significantly higher risk for developing asthma. These phenotypes also exhibited different biological characteristics, such as depleted type I interferon and enriched antigen presentation pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Pekka Hurme, Reetta Sahla, Beate Ruckert, Tero Vahlberg, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Maria Soderlund-Venermo, Cezmi Akdis, Tuomas Jartti
Summary: This study found differences in cytokine response profiles between sole RV and dual RV-HBoV1-induced first wheezing episodes. The RV-HBoV1 group showed lower expression of cytokines compared to the RV group during acute illness and convalescence. The association between hospitalization time and virus group and cytokine response suggests that certain cytokines may be related to shorter hospital stays in the RV-HBoV1 coinfection group.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Virology
Erwan Sallard, Katarzyna Niespodziana, Maja Bajic, Thomas Schlederer, Peter Errhalt, Ann-Kathrin Behrendt, Stefan Wirth, Almut Meyer-Bahlburg, Anja Ehrhardt, Rudolf Valenta, Malik Aydin
Summary: Rhinoviruses (RV) are found to contribute significantly to asthma exacerbations, especially RV species C, which may cause severe development in vulnerable patient groups. Patients with atopic wheezing have higher levels of RV-specific IgG for species A and species C. This study adds important observations to the existing data on pediatric and adolescent exacerbation, highlighting the relevance of RV species in susceptible pediatric patients.
Article
Medicine, General & Internal
Christian Rosas-Salazar, Tatiana Chirkova, Tebeb Gebretsadik, James Chappell, R. Stokes Peebles, William Dupont, Samadhan J. Jadhao, Peter J. Gergen, Larry J. Anderson, Tina Hartert
Summary: This study aimed to assess the association between RSV infection and childhood asthma. The findings show that not being infected with RSV during infancy is associated with a significantly reduced risk of developing childhood asthma.
Article
Public, Environmental & Occupational Health
Isis F. Baroni, Geneva D. Mehta, Ashley F. Sullivan, Carlos A. Camargo Jr, Orianne Dumas
Summary: The study found no association between exposure to household cleaning products in infancy and the development of recurrent wheeze or asthma in children.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2023)
Article
Virology
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Nikolaos G. Papadopoulos, Margarete Focke-Tejkl, Peter Errhalt, Jon R. Konradsen, Cilla Soderhall, Marianne van Hage, Gunilla Hedlin, Rudolf Valenta
Summary: Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. Increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor.
Article
Pediatrics
Julie Magnier, Valerie Julian, Aurelien Mulliez, Alexandra Usclade, Emmanuelle Rochette, Bertrand Evrard, Flore Amat, Carole Egron
Summary: The study revealed that male infants with a family history of allergies may be at higher risk for asthma at school age following their first episode of acute bronchiolitis. Additionally, rhinovirus infection and specific gene may have significant associations with asthma at age seven.
Article
Pediatrics
Mari D. Takashima, Keith Grimwood, Peter D. Sly, Stephen B. Lambert, Robert S. Ware
Summary: This study evaluated the interaction between rhinovirus and potentially pathogenic bacteria in early infancy and their association with wheezing and asthma. The results showed that rhinovirus infection increased the risk of wheezing before age 2 years, while Haemophilus influenzae infection increased the odds of asthma at age 5-7 years. Microbes may have an etiologic role in wheezing and asthma.
PEDIATRIC PULMONOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Makiko Nanishi, Aruna Chandran, Xiuhong Li, Joseph B. Stanford, Akram N. Alshawabkeh, Judy L. Aschner, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, James E. Gern, Tina Hartert, Julie Herbstman, Gurjit K. Khurana Hershey, Alison E. Hipwell, Margaret R. Karagas, Catherine J. Karr, Leslie D. Leve, Augusto A. Litonjua, Cindy T. McEvoy, Rachel L. Miller, Emily Oken, T. Michael O'Shea, Nigel Paneth, Scott T. Weiss, Robert O. Wright, Rosalind J. Wright, Kecia N. Carroll, Xueying Zhang, Qi Zhao, Edward Zoratti, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Based on large-scale cohort data, this study found that infants hospitalized with bronchiolitis are at a higher risk for developing asthma. There is quantitative heterogeneity in different racial and ethnic groups.
Article
Cardiac & Cardiovascular Systems
Geneva D. Mehta, Anna Chen Arroyo, Zhaozhong Zhu, Janice A. Espinola, Jonathan M. Mansbach, Kohei Hasegawa, Carlos A. Camargo Jr
Summary: The history of severe bronchiolitis in infancy is associated with decreased lung function at the age of 6, potentially increasing the risk of chronic respiratory illnesses in the future.
RESPIRATORY MEDICINE
(2023)
Article
Allergy
Heidi Makrinioti, Paraskevi Maggina, John Lakoumentas, Paraskevi Xepapadaki, Stella Taka, Spyridon Megremis, Maria Manioudaki, Sebastian L. Johnston, Maria Tsolia, Vassiliki Papaevangelou, Nikolaos G. Papadopoulos
Summary: A machine learning model was developed to predict wheeze exacerbations after hospitalized acute bronchiolitis in infants. The study found that virus type (such as rhinovirus) and clinical severity were significant predictors of wheeze exacerbation incidence and persistence over a 3-year follow-up period.
FRONTIERS IN ALLERGY
(2021)
Article
Dermatology
Carolina Iturriaga, Maria Francisca Bustos, Catalina Le Roy, Rocio Rodriguez, Lorena Cifuentes, Sergio Silva-Valenzuela, Cristian Vera-Kellet, Francisca Cristi, Guillermo Perez-Mateluna, Carolina Cabalin, Rodrigo Hoyos-Bachiloglu, Carlos A. Camargo, Arturo Borzutzky
Summary: This study evaluated the association of obesity with atopic dermatitis (AD) in children from Chile. The study found that children with AD had similar rates of obesity as healthy controls, but showed sex-specific associations of abdominal obesity and AD.
PEDIATRIC DERMATOLOGY
(2023)
Article
Emergency Medicine
Margaret E. Samuels-Kalow, Jingya Gao, Krislyn M. Boggs, Carlos A. Camargo Jr, Kori S. Zachrison
Summary: The study found significant regionalization of pediatric emergency care. Although there was no significant variation in regionalization based on insurance status, there were differences in network density and transfer rates. Further research is needed to understand the factors influencing transfer decisions and how these patterns may vary by state.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Emergency Medicine
Rebecca E. Cash, Christopher L. Bennett, Krislyn M. Boggs, Margaret E. Samuels-Kalow, Monica Saxena, Melissa Pasao, Ali S. Raja, Carlos A. Camargo Jr
Summary: This study examines the gender differences in first authorship and characteristics in the Society for Academic Emergency Medicine (SAEM) Annual Meeting abstracts and resulting manuscript publications. It found that a minority of abstracts and publications had female first authors, and abstracts with female first authors took longer to achieve manuscript publication. Moreover, a significant proportion of female first author abstracts resulted in male first author publications.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Emergency Medicine
Gregory A. Peters, Rebecca E. Cash, Scott A. Goldberg, Alexander J. Ordoobadi, Carlos A. Camargo Jr
Summary: The study aimed to analyze the characteristics of EMS activations for asthma/COPD exacerbations in the US, including demographics, clinical features, and EMS response. A large nationwide sample from 2018 to 2019 was used, and the data showed that 5% of 9-1-1 activations were for asthma/COPD exacerbation. Most patients were adults, with a higher proportion of females in adult patients and males in pediatric patients. The majority of activations occurred in urban settings, and advanced life support units managed most cases. Inhaled bronchodilators and systemic corticosteroid therapy were commonly administered to patients.
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ruby H. N. Nguyen, Emily A. Knapp, Xiuhong Li, Carlos A. Camargo, Elisabeth Conradt, Whitney Cowell, Karen J. Derefinko, Amy J. Elliott, Alexander M. Friedman, Gurjit K. Khurana Hershey, Julie A. Hofheimer, Barry M. Lester, Cindy T. McEvoy, Jenae M. Neiderhiser, Emily Oken, Steven J. Ondersma, Sheela Sathyanarayana, Meagan E. Stabler, Annemarie Stroustrup, Irene Tung, Monica McGrath
Summary: This study analyzed cross-sectional data from 21,905 pregnancies enrolled in the ECHO program in the United States. The study identified characteristics associated with opioid use during pregnancy, including race, pregnancy period, parity, tobacco use, illegal drug use, and maternal depression.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Immunology
Tadao Ooka, Zhaozhong Zhu, Liming Liang, Juan C. Celedon, Brennan Harmon, Andrea Hahn, Eugene P. Rhee, Robert J. Freishtat, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Through integrated genetics-metabolomics analysis, genetically driven metabolites associated with asthma development and genetic loci associated with both these metabolites and asthma susceptibility were identified in this high-risk population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Dominique Lauque, Anna Khalemsky, Zoubir Boudi, Linda Ostlundh, Chang Xu, Mohammed Alsabri, Churchill Onyeji, Jacqueline Cellini, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Shan W. Liu, Carlos A. Camargo, Anna Slagman, Michael Christ, Adam J. Singer, Charles-Henri Houze-Cerfon, Elhadi H. Aburawi, Karim Tazarourte, Lisa Kurland, Phillip D. Levy, James H. Paxton, Dionyssios Tsilimingras, Vijaya Arun Kumar, David G. Schwartz, Eddy Lang, David W. Bates, Gabriele Savioli, Shamai A. Grossman, Abdelouahab Bellou
Summary: This systematic review and meta-analysis aimed to determine the association between emergency department length of stay (EDLOS) and in-hospital mortality (IHM). The analysis of multiple studies showed a significant association between EDLOS over 24 hours and IHM in ICU-admitted patients, as well as a correlation between low EDLOS and IHM in non-ICU admitted patients. This highlights the importance of minimizing prolonged stays in the emergency department and providing special attention to patients admitted after a short ED stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Makiko Nanishi, Aruna Chandran, Xiuhong Li, Joseph B. Stanford, Akram N. Alshawabkeh, Judy L. Aschner, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, James E. Gern, Tina Hartert, Julie Herbstman, Gurjit K. Khurana Hershey, Alison E. Hipwell, Margaret R. Karagas, Catherine J. Karr, Leslie D. Leve, Augusto A. Litonjua, Cindy T. McEvoy, Rachel L. Miller, Emily Oken, T. Michael O'Shea, Nigel Paneth, Scott T. Weiss, Robert O. Wright, Rosalind J. Wright, Kecia N. Carroll, Xueying Zhang, Qi Zhao, Edward Zoratti, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Based on large-scale cohort data, this study found that infants hospitalized with bronchiolitis are at a higher risk for developing asthma. There is quantitative heterogeneity in different racial and ethnic groups.
Letter
Emergency Medicine
Krislyn M. Boggs, Rebecca E. Cash, Dorsey Glew, Piroz Bahar, Kohei Hasegawa, Ali S. Raja, Carlos A. Camargo Jr
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Pediatrics
Aruna Chandran, Mohamad Burjak, Joshua Petimar, Ghassan Hamra, Melissa M. Melough, Anne L. Dunlop, Brittney M. Snyder, Augusto A. Litonjua, Tina Hartert, James Gern, Akram N. Alshawabkeh, Judy Aschner, Carlos A. Camargo, Dana Dabelea, Cristiane S. Duarte, Assiamira Ferrara, Jody M. Ganiban, Frank Gilliland, Diane R. Gold, Monique Hedderson, Julie B. Herbstman, Christine Hockett, Margaret R. Karagas, Jean M. Kerver, Kathleen A. Lee-Sarwar, Barry Lester, Cindy T. McEvoy, Zhongzheng Niu, Joseph B. Stanford, Rosalind Wright, Emily Zimmerman, Shohreh Farzan, Zhumin Zhang, Emily Knapp
Summary: This study aimed to evaluate the association between the Healthy, Hunger-Free Kids Act (HHFKA) and youth body mass index (BMI). The results showed that the implementation of HHFKA was associated with a significant decrease in BMIz among school-aged youths in the US. The findings suggest that interventions in school meal programs represent a key opportunity to combat the childhood obesity epidemic.
Article
Geriatrics & Gerontology
Jeffrey M. Caterino, Julie A. Stephens, Randell Wexler, Carlos A. Camargo, Katherine M. Hunold, Lai Wei, David Hains, Lauren T. Southerland, Jason J. Bischof, Andrew Schwaderer
Summary: The study found that there were no significant differences in urinary antimicrobial peptide (AMPs) levels between older and younger adults, but older adults had lower levels of a specific AMP, hBD-2. This finding has implications for the potential use of urinary AMPs as diagnostic markers and will facilitate further exploration into the role of innate immunity in urinary tract infection susceptibility in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedon, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Summary: This study investigates the role of DNA methylation in the severity of bronchiolitis in infants. The authors analyze blood DNA methylation data from hospitalized infants and identify differentially methylated CpGs associated with disease severity. These CpGs are found to be differentially methylated in blood immune cells and enriched in various tissues, cells, and pathways. Additionally, they are also associated with respiratory and immune traits. The study highlights the importance of DNA methylation in understanding the pathobiology of bronchiolitis and its severity.
NATURE COMMUNICATIONS
(2023)
Article
Dermatology
Carolina Cabalin, Guillermo Perez-Mateluna, Carolina Iturriaga, Carlos A. Camargo, Arturo Borzutzky
Summary: This study investigated the effects of oral cholecalciferol supplementation on vitamin D receptor (vdr), Cathelicidin Antimicrobial Peptide (camp/LL-37), and Thymic Stromal Lymphopoietin (tslp) in children with atopic dermatitis (AD). The results showed that oral vitamin D3 supplementation improved serum 25-hydroxyvitamin D levels, AD severity, and increased the expression of vdr and camp in lesional skin of children with AD, providing mechanistic clues for its effects.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Meeting Abstract
Allergy
Zhaozhong Zhu, Robert Freishtat, Brennan Harmon, Andrea Hahn, Stephen Teach, Marcos Perez-Losada, Kohei Hasegawa, Carlos Camargo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Emergency Medicine
Rebecca E. Cash, Anjali J. Kaimal, Margaret E. Samuels-Kalow, Krislyn M. Boggs, Maeve F. Swanton, Carlos A. Camargo Jr
Summary: This study examined out-of-hospital deliveries and high-risk complications treated by EMS clinicians in the U.S. Most out-of-hospital deliveries involved patients between the ages of 20-34 and occurred on weekdays. There were disparities in the level of care and access to definitive care based on maternal and community factors.
PREHOSPITAL EMERGENCY CARE
(2023)