Article
Cardiac & Cardiovascular Systems
Xianglan Liu, Wujian He, Xulin Hong, Duanbin Li, Zhezhe Chen, Yao Wang, Zhaoyang Chen, Yi Luan, Wenbin Zhang
Summary: This study investigated the relationship between fibrous cap thickness (FCT) and plaque rupture and/or thrombosis using optical coherence tomography (OCT). It found that plaques with FCT between 65 and 80 μm were independently associated with an increased risk of plaque rupture and/or thrombosis compared with plaques with FCT > 80 μm.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Cardiac & Cardiovascular Systems
Alexander G. Truesdell, Mirvat A. Alasnag, Prashant Kaul, Syed Tanveer Rab, Robert F. Riley, Michael N. Young, Wayne B. Batchelor, Akiko Maehara, Frederick G. Welt, Ajay J. Kirtane, ACC Interventional Counci
Summary: Coronary angiography has been the standard for diagnosing coronary artery disease and guiding percutaneous coronary intervention (PCI). Intravascular imaging (IVI) technologies are used in conjunction with angiography to better assess plaque morphology and optimize PCI. IVI has utility in preintervention assessment, procedural guidance, and postintervention evaluation. IVI's role in reducing major adverse cardiac events in complex lesions is emerging, and further studies are underway. This paper provides an overview of available IVI technologies, reviews evidence supporting their use in PCI, and advocates for broader utilization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Xing Luo, Ying Lv, Xiaoxuan Bai, Jinyu Qi, Xiuzhu Weng, Shaoyu Liu, Xiaoyi Bao, Haibo Jia, Bo Yu
Summary: Plaque erosion (PE) is a significant pathological mechanism in acute coronary syndrome (ACS), with unique characteristics. There are differences in pathophysiological mechanisms, biomarkers, and clinical outcomes between PE and plaque rupture (PR). Understanding the pathogenesis of PE is crucial for accurate diagnosis and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Mohan Satish, Anastasios Roumeliotis, David Power, Anton Camaj, Johny Nicolas, Daniel Feldman, Davis Jones, Keisuke Yasumura, Frans Beerkens, Saman Suleman, George Dangas
Summary: The use of intracoronary imaging (ICI) during percutaneous coronary intervention (PCI) has been proven to effectively improve cardiovascular outcomes, especially for high-risk subgroups. However, there is limited data from randomized controlled trials, and the overall utilization rate of ICI varies between different countries and centers. Potential benefits of ICI include accurate identification of lesions suitable for PCI, improved characterization of lesions, and optimization of stent placement. Available modalities of ICI include intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Teruo Sekimoto, Shunya Sato, Hiroyoshi Mori, Hiroki Tanisawa, Hiroaki Tsujita, Seita Kondo, Hiroshi Suzuki, Toshiro Shinke
Summary: This case report presents a 42-year-old female patient with anxiety disorder, who was diagnosed with anterior non-ST-elevation myocardial infarction. The combination of ELCA and DCB was used to treat severe stenosis caused by organizing thrombus due to erosion healing. The patient showed significant reduction in plaque burden and maintained lumen size after the procedure, with no restenosis and symptom-free during follow-up.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyohei Usami, Hiroaki Watabe, Tomoya Hoshi, Shunsuke Sakai, Daigo Hiraya, Akira Sato, Masaki Ieda
Summary: This study aimed to investigate the relationship between periprocedural myocardial injury (PMI) and plaque characteristics detected by multidetector computed tomography (MDCT) and cardiac magnetic resonance imaging (CMR). The results showed that MDCT and CMR can play an important role in the detection of high-risk lesions for PMI following elective percutaneous coronary intervention (PCI).
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Teruo Sekimoto, Hiroyoshi Mori, Shinji Koba, Taito Arai, Naoki Matsukawa, Rikuo Sakai, Yuya Yokota, Shunya Sato, Hideaki Tanaka, Ryota Masaki, Yosuke Oishi, Kunihiro Ogura, Ken Arai, Kosuke Nomura, Koshiro Sakai, Hiroaki Tsujita, Seita Kondo, Shigeto Tsukamoto, Hiroshi Suzuki, Toshiro Shinke
Summary: This study compared the clinical features and lipid profiles of fibrous plaque and lipid-rich plaque in causing acute coronary syndrome (ACS). The study found significant differences in the characteristics and lipid profiles between fibrous plaque and lipid-rich plaque, while there were some similarities between lipid-rich plaque and plaque rupture.
Article
Cardiac & Cardiovascular Systems
Xing Luo, Minghao Liu, Shengfang Wang, Yuwu Chen, Xiaoyi Bao, Ying Lv, Shan Zhang, Biyi Xu, Xiuzhu Weng, Xiaoxuan Bai, Ming Zeng, Chen Zhao, Ji Li, Haibo Jia, Bo Yu
Summary: In this study, it was found that docosahexaenoic acid (DHA), salicylic acid, and proline could be used as non-invasive biomarkers to differentiate plaque erosion (PE) and plaque rupture (PR) in ST-segment elevation myocardial infarction (STEMI).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jasmine Melissa Madsen, Henning Kelbaek, Lars Nepper-Christensen, Mia Ravn Jacobsen, Kiril Aleksov Ahtarovski, Dan Eik Hofsten, Lene Holmvang, Frants Pedersen, Hans -Henrik Tilsted, Jens Aaroe, Svend Eggert Jensen, Bent Raungaard, Christian Juhl Terkelsen, Lars Kober, Thomas Engstrom, Jacob Thomsen Lonborg
Summary: This study aimed to investigate the outcomes of STEMI patients treated with PCI without stenting. The results showed that patients treated without stenting, who had no significant residual stenosis and stable flow after initial PCI, had comparable event rates to patients treated with immediate stenting.
Article
Cardiac & Cardiovascular Systems
Reza Fazel, Robert W. Yeh, David J. Cohen, Sunil Rao, Siling Li, Yang Song, Eric A. Secemsky
Summary: The use of intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) has been increasing among Medicare beneficiaries in the USA. IVI-guided PCI is associated with lower rates of major adverse cardiovascular events and target lesion revascularization compared with standard angiographic guidance.
EUROPEAN HEART JOURNAL
(2023)
Review
Cell Biology
Chinmay Khandkar, Mahesh V. Madhavan, James C. Weaver, David S. Celermajer, Keyvan Karimi Galougahi
Summary: This article summarizes the different atherothrombotic substrates and etiologies of acute coronary syndromes, as well as the role of intravascular imaging in treating these patients, and discusses the opportunities for more individualized treatment.
Review
Cardiac & Cardiovascular Systems
Athanasios Moulias, Rafail Koros, Angeliki Papageorgiou, Panagiotis Patrinos, Panagiota Spyropoulou, Angeliki Vakka, Maria Bozika, Georgios Vasilagkos, Anastasios Apostolos, Kassiani-Maria Nastouli, Grigorios Tsigkas, Periklis Davlouros
Summary: Coronary bifurcation refers to a coronary artery stenosis adjacent to a significant side branch. It is a complex subgroup of lesions with lower procedural success rates and higher rates of adverse outcomes. In recent years, there has been a growing focus on the use of intravascular imaging, particularly optical coherence tomography (OCT), to improve outcomes in bifurcation percutaneous coronary interventions (PCI).
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Duanbin Li, Ya Li, Cao Wang, Hangpan Jiang, Liding Zhao, Xulin Hong, Maoning Lin, Yi Luan, Xiaohua Shen, Zhaoyang Chen, Wenbin Zhang
Summary: This study aimed to investigate the influence of elevated glycated hemoglobin A1c (HbA1c) on plaque vulnerability and lipid variability. The results showed that elevated HbA1c was associated with thinner plaque fibrous cap, increased lipid index, and higher macrophage index. This association was also observed in non-diabetic patients. Moreover, elevated HbA1c levels increased the variability of lipid profiles.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Juhwan Lee, Gabriel T. R. Pereira, Yazan Gharaibeh, Chaitanya Kolluru, Vladislav N. Zimin, Luis A. P. Dallan, Justin N. Kim, Ammar Hoori, Sadeer G. Al-Kindi, Giulio Guagliumi, Hiram G. Bezerra, David L. Wilson
Summary: This study developed an automated method for detecting lipidous plaque and assessing fibrous cap thickness in IVOCT images. The method showed excellent discriminability in detecting lipid plaque and accurately measuring fibrous cap thickness. It has the potential to enable highly automated and comprehensive evaluations of TCFAs.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Vikas Thondapu, Chris Mamon, Eric K. W. Poon, Osamu Kurihara, Hyung Oh Kim, Michele Russo, Makoto Araki, Hiroki Shinohara, Erika Yamamoto, Jouke Dijkstra, Mark Tacey, Hang Lee, Andrew Ooi, Peter Barlis, Ik-Kyung Jang
Summary: The study found that high ESSG is independently associated with plaque rupture, while high ESSG, ESS, and OSI are associated with plaque erosion. Furthermore, ESSG is higher at rupture sites, OSI is higher at erosion sites, and ESS is similar between the two.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Yoshiyasu Minami, Makoto Araki, Osamu Kurihara, Tsunenari Soeda, Taishi Yonetsu, Zhao Wang, Iris McNulty, Hang Lee, Sunao Nakamura, Ik-Kyung Jang
Summary: This study identified three optical coherence tomography predictors for a favorable vascular response to statin therapy: large thin-cap area, high macrophage index, and layered plaque. Favorable vascular response to statin was correlated with signs of decreased inflammation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Masahiro Hoshino, Yoshihisa Kanaji, Rikuta Hamaya, Yoshinori Kanno, Masahiro Hada, Masao Yamaguchi, Yohei Sumino, Eisuke Usui, Tadashi Murai, Tetsumin Lee, Taishi Yonetsu, Tsunekazu Kakuta
Summary: This study demonstrated that thermodilution-derived coronary flow capacity (T-CFC) can improve risk stratification and provides incremental prognostic value for patients with deferred revascularisation, showing significant improvement in prediction of vessel-oriented composite endpoints (VOCE) and major adverse cardiac events (MACE).
Article
Cardiac & Cardiovascular Systems
Shun Nakamura, Taishi Yonetsu, Masahiro Hoshino, Masahiro Hada, Masao Yamaguchi, Yoshihisa Kanaji, Tomoyo Sugiyama, Taichi Nakamura, Junji Matsuda, Yu Hatano, Tomoyuki Umemoto, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study revealed the anatomical-functional discordance between QCA-DS and dPR(WFP) in intermediate lesions, with different predictors for mismatch and reverse mismatch.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Taishi Yonetsu, Tsunekazu Kakuta
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Shunsuke Kuroda, Shingo Matsumoto, Takahide Sano, Takeshi Kitai, Taishi Yonetsu, Shun Kohsaka, Sho Torii, Takuya Kishi, Issei Komuro, Ken-Ichi Hirata, Koichi Node, Yuya Matsue
Summary: The study evaluated the performance of the 4C Mortality Score in Japanese COVID-19 patients and found it to be effective in predicting in-hospital mortality and composite endpoints.
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Makoto Araki, Yoshiyasu Minami, Tsunenari Soeda, Taishi Yonetsu, Iris McNulty, Hang Lee, Sunao Nakamura, Ik-Kyung Jang
Summary: The study found that the layer index was greater in multilayer pattern, interrupted layer phenotype, at culprit plaque, lipid-rich plaque, and in cases with culprit plaque rupture.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Makoto Araki, Taishi Yonetsu, Osamu Kurihara, Akihiro Nakajima, Hang Lee, Tsunenari Soeda, Yoshiyasu Minami, Takumi Higuma, Shigeki Kimura, Masamichi Takano, Bryan P. Yan, Tom Adriaenssens, Niklas F. Boeder, Holger M. Nef, Chong Jin Kim, Iris McNulty, Filippo Crea, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: The study found that the prevalence of lipid-rich plaques, cholesterol crystals, and calcifications increases with age in patients with plaque erosion. Younger patients were more likely to experience ST-segment-elevation myocardial infarction, while older patients were more likely to have larger diameter stenosis, lipid-rich plaques, and calcifications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Lena Marie Seegers, Makoto Araki, Akihiro Nakajima, Taishi Yonetsu, Yoshiyasu Minami, Junya Ako, Tsunenari Soeda, Osamu Kurihara, Takumi Higuma, Shigeki Kimura, Tom Adriaenssens, Holger M. Nef, Hang Lee, Iris McNulty, Tomoyo Sugiyama, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: This study revealed age-related sex differences in culprit plaque morphology and vulnerability in patients with acute coronary syndrome. Compared to men, women showed a significant increase in plaque rupture and vulnerability with age. This finding is important for further understanding the pathogenesis of acute coronary syndrome.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seokhun Yang, Masahiro Hoshino, Bon-Kwon Koo, Taishi Yonetsu, Jinlong Zhang, Doyeon Hwang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Jagat Narula
Summary: The study found that high-risk plaque features and plaque burden at coronary CT angiography were associated with coronary pressure and flow, and could independently predict the occurrence of cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Makoto Araki, Tomoyo Sugiyama, Akihiro Nakajima, Taishi Yonetsu, Lena Marie Seegers, Damini Dey, Hang Lee, Iris McNulty, Yumi Yasui, Yun Teng, Tatsuhiro Nagamine, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: Vascular inflammation plays a crucial role in the development of ACS, and PCAT attenuation is higher in ACS patients compared to SAP patients.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rikuta Hamaya, Taishi Yonetsu, Norio Aoyama, Yuka Shiheido-Watanabe, Akira Tashiro, Takayuki Niida, Mitsuaki Isobe, Yasuhiro Maejima, Takanori Iwata, Tetsuo Sasano
Summary: This study aimed to investigate the relationship between dental health and incident cardiovascular disease (CVD) in patients with known CVD. The results showed that missing teeth were associated with a higher risk of major adverse cardiovascular events (MACE), and the risk increased with the number of missing teeth.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tatsuhiro Nagamine, Masahiro Hoshino, Taishi Yonetsu, Tomoyo Sugiyama, Yoshihisa Kanaji, Kazuki Matsuda, Kodai Sayama, Hiroki Ueno, Kai Nogami, Yoshihiro Hanyu, Toru Misawa, Masahiro Hada, Eisuke Usui, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study aimed to evaluate the diagnostic efficacy of preprocedural coronary CT imaging in identifying subsequently performed optical coherence tomography-defined plaque rupture or erosion at culprit lesions in patients with non-ST-segment-elevation acute myocardial infarction. The study found that preprocedural comprehensive coronary CT imaging can accurately and noninvasively identify optical coherence tomography-defined culprit lesions. Rating: 8
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Taishi Yonetsu, Kohei Wakabayashi, Takuya Mizukami, Myong Hwa Yamamoto, Sakiko Yasuhara, Seita Kondo, Yosuke Oishi, Toshitaka Okabe, Tomoyo Sugiyama, Makoto Araki, Masamichi Takano, Nobuaki Kobayashi, Shigeki Kimura, Yosuke Yamakami, Satoru Suwa, Sunao Nakamura, Satoru Mitomo, Tsunekazu Kakuta, Eisuke Usui, Takumi Higuma, Junya Ako, Yoshiyasu Minami, Masamichi Iwasaki, Junya Shite, Amane Kozuki, Shigeru Saito, Koki Shishido, Hiroyuki Okura, Genki Naruse, Shiro Uemura, Teruyoshi Kume, Mamoru Nanasato, Tomotaka Dohi, Takashi Ashikaga, Hiromasa Otake, Hiroyoshi Mori, Teruo Sekimoto, Yoichiro Sugizaki, Toshiro Shinke
Summary: The ATLAS-OCT trial investigates the feasibility of OCT-guided primary PCI for STEMI and aims to identify the suitable patient group for OCT-guided PCI. It is a prospective, multicenter registry study that will record clinical outcomes and adverse cardiac events.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Marie Seegers, Doreen DeFaria Yeh, Taishi Yonetsu, Tomoyo Sugiyama, Yoshiyasu Minami, Tsunenari Soeda, Makoto Araki, Akihiro Nakajima, Haruhito Yuki, Daisuke Kinoshita, Keishi Suzuki, Takayuki Niida, Hang Lee, Iris McNulty, Sunao Nakamura, Tsunekazu Kakuta, Valentin Fuster, Ik-Kyung Jang
Summary: Optical coherence tomography can identify layered plaques in vivo. This study found that layered plaques in men are more likely to exhibit features of vascular inflammation and vulnerability, as well as evidence of previous plaque rupture, compared to women.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Review
Multidisciplinary Sciences
Brett E. Bouma, Johannes F. de Boer, David Huang, Ik-Kyung Jang, Taishi Yonetsu, Cadman L. Leggett, Rainer Leitgeb, David D. Sampson, Melissa Suter, Ben J. Vakoc, Martin Villiger, Maciej Wojtkowski
Summary: This article introduces the principles, applications, and future prospects of optical coherence tomography (OCT). By explaining the principles and origins of signals for different instrument configurations, as well as image processing and interpretation methods, the article comprehensively analyzes the application of OCT in biological and medical imaging.
NATURE REVIEWS METHODS PRIMERS
(2022)