Journal
APMIS
Volume 124, Issue 7, Pages 567-573Publisher
WILEY
DOI: 10.1111/apm.12550
Keywords
Cervical cancer; long non-coding RNA; Hox transcript antisense intergenic RNA; rs920778 polymorphism; cancer susceptibility
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Funding
- National Natural Science Funds [81502261, 81502262]
- Postdoctoral Science Foundation of China [2015M570634, 2015M570635]
- Henan Provincial Health and Family Planning Commission [201503009, 201503045]
- Postdoctoral Science Foundation of Henan Province [2014021]
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We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio-resistance in human cervical cancer. Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer predisposition in other malignancies, we herein investigated the association between rs920778 status and cervical cancer susceptibility in a Chinese population. Using the specific TaqMan PCR assay, we genotyped rs920778 in 215 cervical cancer patients and 430 age-matched healthy controls. As shown in our data, TT genotype of rs920778 was significantly correlated with the upregulation of HOTAIR (p=0.008). Compared with the healthy control, TT genotype and T allele notably indicated a much higher risk of cervical cancer [TT genotype: odds ratio (OR)=2.186, 95% confidence interval (CI)=1.378-3.466, p=0.003; T allele: OR=1.556, 95% CI=1.221-1.981]. In addition, we also found that the TT genotype of rs920778 was correlated with advanced tumor stage (p=0.039), highly histological grade (p=0.013), lympho node metastasis (p<0.001) and positive infection of high risk HPV (p<0.001). Among the patients who underwent concurrent chemo-radiotherapy, TT genotype carriers present notably resistance to the combination of EBRT+ICBT+cisplatin (p=0.023). In conclusion, we firstly reported that TT genotype of HOTAIR rs920778 was significantly associated with the cervical cancer susceptibility. Moreover, the TT genotype of rs920778 might be a potent prognostic marker in cervical cancer patients.
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