Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

(2018) Anna Yoney et al.   eLife

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

(2017) Maxwell Z. Wilson et al.   MOLECULAR CELL

TGF-β Family Signaling in Early Vertebrate Development

(2017) Joseph Zinski et al.   Cold Spring Harbor Perspectives in Biology

Cellular Decision Making by Non-Integrative Processing of TLR Inputs

(2017) Ryan A. Kellogg et al.   Cell Reports

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

(2016) Kyle M. Loh et al.   CELL

Pluripotent stem cells as a model for embryonic patterning: From signaling dynamics to spatial organization in a dish

(2016) Idse Heemskerk et al.   DEVELOPMENTAL DYNAMICS

Self-organization of human embryonic stem cells on micropatterns

(2016) Alessia Deglincerti et al.   Nature Protocols

Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation

(2016) Keisuke Sako et al.   Cell Reports

Coco is a dual activity modulator of TGFβ signaling

(2015) Alessia Deglincerti et al.   DEVELOPMENT

A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain

(2015) Antonius L. van Boxtel et al.   DEVELOPMENTAL CELL

Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

(2015) Julien Dubrulle et al.   eLife

NANOG and CDX2 Pattern Distinct Subtypes of Human Mesoderm during Exit from Pluripotency

(2014) Sasha Mendjan et al.   Cell Stem Cell

Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning

(2014) Benoit Sorre et al.   DEVELOPMENTAL CELL

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Accurate information transmission through dynamic biochemical signaling networks

(2014) J. Selimkhanov et al.   SCIENCE

Rate of environmental change determines stress response specificity

(2013) J. W. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling Long-Term Signaling: Receptor Dynamics Determine Attenuation and Refractory Behavior of the TGF-  Pathway

(2013) P. Vizan et al.   Science Signaling

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

Dynamics of TGF-  signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4

(2012) A. Warmflash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

(2010) Dianne Sako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

(2009) Sebastian J. Arnold et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY