Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

(2019) Atsushi Taguchi et al.   Nature Microbiology

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

(2019) Niccolò Morè et al.   mBio

Induced conformational changes activate the peptidoglycan synthase PBP1B

(2018) Alexander J. F. Egan et al.   MOLECULAR MICROBIOLOGY

The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli

(2018) Alejandro Montón Silva et al.   Frontiers in Microbiology

Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins

(2018) Katharina Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PBP1B Glycosyltransferase and Transpeptidase Activities Play Different Essential Roles during the De Novo Regeneration of Rod Morphology in Escherichia coli

(2017) Dev K. Ranjit et al.   JOURNAL OF BACTERIOLOGY

A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells

(2017) Sónia Castanheira et al.   mBio

The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli

(2017) Ghee Chuan Lai et al.   PLoS Genetics

Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing

(2017) Selvi C. Ersoy et al.   EBioMedicine

Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine

(2017) Elisabeth Thulin et al.   EBioMedicine

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

(2017) Sophie Leclercq et al.   Scientific Reports

PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus

(2016) Liana C. Chan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

(2016) Jason M. Peters et al.   CELL

SuperSegger: robust image segmentation, analysis and lineage tracking of bacterial cells

(2016) Stella Stylianidou et al.   MOLECULAR MICROBIOLOGY

SEDS proteins are a widespread family of bacterial cell wall polymerases

(2016) Alexander J. Meeske et al.   NATURE

The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli

(2016) Katharina Peters et al.   mBio

Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

(2016) Jean-Emmanuel Hugonnet et al.   eLife

Mechanical Genomics Identifies Diverse Modulators of Bacterial Cell Stiffness

(2016) George K. Auer et al.   Cell Systems

Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously

(2016) Hongbaek Cho et al.   Nature Microbiology

Profiling of β-Lactam Selectivity for Penicillin-Binding Proteins in Escherichia coli Strain DC2

(2015) Ozden Kocaoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The quantitative and condition-dependent Escherichia coli proteome

(2015) Alexander Schmidt et al.   NATURE BIOTECHNOLOGY

Activities and regulation of peptidoglycan synthases

(2015) Alexander J. F. Egan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

(2015) Andrew N Gray et al.   eLife

Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B

(2014) A. J. F. Egan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongated Structure of the Outer-Membrane Activator of Peptidoglycan Synthesis LpoA: Implications for PBP1A Stimulation

(2014) Nicolas L. Jean et al.   STRUCTURE

A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus

(2014) Joshua W. Modell et al.   PLOS BIOLOGY

A Genome-Wide Screen for Bacterial Envelope Biogenesis Mutants Identifies a Novel Factor Involved in Cell Wall Precursor Metabolism

(2014) Catherine Paradis-Bleau et al.   PLoS Genetics

L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia

(2013) Peilong Lu et al.   CELL RESEARCH

Redundancy in the periplasmic adaptor proteins AcrA and AcrE provides resilience and an ability to export substrates of multidrug efflux

(2013) Helen E. Smith et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lipoprotein Activators Stimulate Escherichia coli Penicillin-Binding Proteins by Different Mechanisms

(2013) Tania J. Lupoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Osmolality-Dependent Relocation of Penicillin-Binding Protein PBP2 to the Division Site in Caulobacter crescentus

(2012) J. Hocking et al.   JOURNAL OF BACTERIOLOGY

Cooperativity of peptidoglycan synthases active in bacterial cell elongation

(2012) Manuel Banzhaf et al.   MOLECULAR MICROBIOLOGY

Three redundant murein endopeptidases catalyse an essential cleavage step in peptidoglycan synthesis ofEscherichia coliK12

(2012) Santosh Kumar Singh et al.   MOLECULAR MICROBIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Molecular aspects of bacterial pH sensing and homeostasis

(2011) Terry A. Krulwich et al.   NATURE REVIEWS MICROBIOLOGY

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

(2011) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

(2010) Catherine Paradis-Bleau et al.   CELL

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

(2010) Athanasios Typas et al.   CELL

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Deletion of penicillin-binding protein 5 (PBP5) sensitises Escherichia coli cells to β-lactam agents

(2010) Sujoy K. Sarkar et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Acid stress response in Escherichia coli: mechanism of regulation of gadA transcription by RcsB and GadE

(2010) Marie-Pierre Castanié-Cornet et al.   NUCLEIC ACIDS RESEARCH

Acid and Base Stress and Transcriptomic Responses in Bacillus subtilis

(2008) J. C. Wilks et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY